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The map label for this gene is exuT [H]

Identifier: 116625715

GI number: 116625715

Start: 8367387

End: 8368604

Strand: Direct

Name: exuT [H]

Synonym: Acid_6664

Alternate gene names: 116625715

Gene position: 8367387-8368604 (Clockwise)

Preceding gene: 116625714

Following gene: 116625716

Centisome position: 83.96

GC content: 61.99

Gene sequence:

>1218_bases
GTGACTGAGGCCGAAGCAGCACCGTCTCCCTTGCGCTGGAAAATGATCTCGCTCGCCTTCTTCGCGACCGTGATCAATTA
CCTCGATCGCCAGACTCTCTCCGTCGCCGCTCCCATTCTGCGCGAACAGTTCCACATGACCAATGAGGACTACTCGCGCG
TCGTCTCGGCCTTCCTGTTCGCCTACACGATCATGAACGGTCTCTCCGGCCCCATGATCGATCGCCTCGGCACACGCCTG
GGCTATGGCCTCTGCGTTGCCTGGTGGAGTATCGCCGCCGCACTGCACGCCTTCGCGCGCGGCACTCTCAGCCTCGGCAT
CTTCCGCTTCCTGCTCGGGATCGGCGAAGCCGGCAACTGGCCCGGAGCCGTGAAAGTCGTCGCCGAGTGGTTCCCCGAAA
AAGAGCGCGCCCTCGCCGCCGGACTATTCAATTCCGGCTCCGCCGTGGGCGCCATCCTCGCCCCGCCCATCGTCGCCTAT
CTGATCATCAACATCGGCTGGCAGGCCGCCTTCGGTTTCGTCGGACTCGCAGGGCTAATCTGGCTCGCTTTCTGGTTCAC
GATGTACCGCACGCCCAAAGCTCTGCCAGGCGCGCCTCCCGAGATTGTGGTTCCGGTTCGCCAGTTGCTGAATAATCGCT
TCGTCTGGGCCTTCACGTTTTCCAAAATATTCATGGACCCGGTCTGGTACTTCTACATTTTCTGGTTCCCCGAGTACCTG
AAAAACGTGCGCGGTTTCGACCTCGCCAAAATCGGCAAGTTCGCGTGGATCCCTTTCATGGTCGCCGGCTTCGGCAATAT
TCTCGGTGGCTGGCTCTCCGGCCTGCTGCTCAAGCGCGGCTACTCCGTCACGGTCGCGCGCAAAGGCTCCGTTACCTTCT
TCGCCGCCCTTATGACCTCCGCCATTCCCGCGGTGCTCGTCTCCGAAGCCTGGATGGCGATCGCATTCGTTTCCATCGCC
ATGCTCGGCTACACCGGCTCGCTCGCCAACATGCTCAGCTTCCCCGCCGACGTGTTCCCCAAGAGCGCAGTCGGCAGCGT
CTATGGCATCGCCAGCATGGGCTCGGGCTTCGGCGGCATGCTCTTCACGCTCATCACCGGCTACGTCGTGCAGCACTACT
CCTACACGCCCGTCTTTTTCGGCTTCGGCATCATGCCTCTCATCTGCGCCACCATCCTGTGGACGCTGATGGGGCCGCTC
CGGCCCGCCCGTCTATAA

Upstream 100 bases:

>100_bases
TGCGCGCCGGCACGAAATTCCCCGCGACCGGTCGCGCCGGATGGGTCGAACTCACCGTGCCCCACGTCCTGATCCACGAA
GCCGTACGGGTGGATCTCGC

Downstream 100 bases:

>100_bases
TACGAGTTCATGAATCTCGACATCCTGGGAATGCGCGAAGGAATTTCGCGAACCTACTCCGTCATTCGCCCGTTCATCCG
CCGCACTCCCGTAGTCGATA

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTEAEAAPSPLRWKMISLAFFATVINYLDRQTLSVAAPILREQFHMTNEDYSRVVSAFLFAYTIMNGLSGPMIDRLGTRL
GYGLCVAWWSIAAALHAFARGTLSLGIFRFLLGIGEAGNWPGAVKVVAEWFPEKERALAAGLFNSGSAVGAILAPPIVAY
LIINIGWQAAFGFVGLAGLIWLAFWFTMYRTPKALPGAPPEIVVPVRQLLNNRFVWAFTFSKIFMDPVWYFYIFWFPEYL
KNVRGFDLAKIGKFAWIPFMVAGFGNILGGWLSGLLLKRGYSVTVARKGSVTFFAALMTSAIPAVLVSEAWMAIAFVSIA
MLGYTGSLANMLSFPADVFPKSAVGSVYGIASMGSGFGGMLFTLITGYVVQHYSYTPVFFGFGIMPLICATILWTLMGPL
RPARL

Sequences:

>Translated_405_residues
MTEAEAAPSPLRWKMISLAFFATVINYLDRQTLSVAAPILREQFHMTNEDYSRVVSAFLFAYTIMNGLSGPMIDRLGTRL
GYGLCVAWWSIAAALHAFARGTLSLGIFRFLLGIGEAGNWPGAVKVVAEWFPEKERALAAGLFNSGSAVGAILAPPIVAY
LIINIGWQAAFGFVGLAGLIWLAFWFTMYRTPKALPGAPPEIVVPVRQLLNNRFVWAFTFSKIFMDPVWYFYIFWFPEYL
KNVRGFDLAKIGKFAWIPFMVAGFGNILGGWLSGLLLKRGYSVTVARKGSVTFFAALMTSAIPAVLVSEAWMAIAFVSIA
MLGYTGSLANMLSFPADVFPKSAVGSVYGIASMGSGFGGMLFTLITGYVVQHYSYTPVFFGFGIMPLICATILWTLMGPL
RPARL
>Mature_404_residues
TEAEAAPSPLRWKMISLAFFATVINYLDRQTLSVAAPILREQFHMTNEDYSRVVSAFLFAYTIMNGLSGPMIDRLGTRLG
YGLCVAWWSIAAALHAFARGTLSLGIFRFLLGIGEAGNWPGAVKVVAEWFPEKERALAAGLFNSGSAVGAILAPPIVAYL
IINIGWQAAFGFVGLAGLIWLAFWFTMYRTPKALPGAPPEIVVPVRQLLNNRFVWAFTFSKIFMDPVWYFYIFWFPEYLK
NVRGFDLAKIGKFAWIPFMVAGFGNILGGWLSGLLLKRGYSVTVARKGSVTFFAALMTSAIPAVLVSEAWMAIAFVSIAM
LGYTGSLANMLSFPADVFPKSAVGSVYGIASMGSGFGGMLFTLITGYVVQHYSYTPVFFGFGIMPLICATILWTLMGPLR
PARL

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=378, Percent_Identity=24.0740740740741, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI9966811, Length=386, Percent_Identity=23.5751295336788, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI21322234, Length=296, Percent_Identity=25, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI9945322, Length=367, Percent_Identity=23.433242506812, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI2367193, Length=406, Percent_Identity=31.7733990147783, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI87082320, Length=422, Percent_Identity=28.1990521327014, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789515, Length=417, Percent_Identity=27.5779376498801, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789152, Length=428, Percent_Identity=28.0373831775701, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI2367379, Length=316, Percent_Identity=31.0126582278481, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788573, Length=429, Percent_Identity=24.9417249417249, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082071, Length=388, Percent_Identity=21.3917525773196, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533556, Length=303, Percent_Identity=26.7326732673267, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533554, Length=303, Percent_Identity=26.7326732673267, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560030, Length=343, Percent_Identity=23.9067055393586, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17535049, Length=389, Percent_Identity=23.1362467866324, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129235, Length=403, Percent_Identity=24.5657568238213, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648416, Length=446, Percent_Identity=23.542600896861, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356189, Length=446, Percent_Identity=23.542600896861, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24584153, Length=408, Percent_Identity=22.3039215686275, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583789, Length=300, Percent_Identity=23, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130167, Length=393, Percent_Identity=24.4274809160305, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639764, Length=412, Percent_Identity=22.8155339805825, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573708, Length=275, Percent_Identity=21.8181818181818, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28573707, Length=275, Percent_Identity=21.8181818181818, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19920686, Length=383, Percent_Identity=22.976501305483, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24580790, Length=295, Percent_Identity=21.0169491525424, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44401; Mature: 44270

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEAEAAPSPLRWKMISLAFFATVINYLDRQTLSVAAPILREQFHMTNEDYSRVVSAFLF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AYTIMNGLSGPMIDRLGTRLGYGLCVAWWSIAAALHAFARGTLSLGIFRFLLGIGEAGNW
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PGAVKVVAEWFPEKERALAAGLFNSGSAVGAILAPPIVAYLIINIGWQAAFGFVGLAGLI
CHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
WLAFWFTMYRTPKALPGAPPEIVVPVRQLLNNRFVWAFTFSKIFMDPVWYFYIFWFPEYL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
KNVRGFDLAKIGKFAWIPFMVAGFGNILGGWLSGLLLKRGYSVTVARKGSVTFFAALMTS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHH
AIPAVLVSEAWMAIAFVSIAMLGYTGSLANMLSFPADVFPKSAVGSVYGIASMGSGFGGM
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCHHHH
LFTLITGYVVQHYSYTPVFFGFGIMPLICATILWTLMGPLRPARL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]