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The map label for this gene is galK [H]

Identifier: 116625643

GI number: 116625643

Start: 8268973

End: 8270169

Strand: Reverse

Name: galK [H]

Synonym: Acid_6592

Alternate gene names: 116625643

Gene position: 8270169-8268973 (Counterclockwise)

Preceding gene: 116625646

Following gene: 116625642

Centisome position: 82.99

GC content: 67.17

Gene sequence:

>1197_bases
ATGGCCACGACCTACTTCGCCTGCTTCCACGCCGAACTCTGCGCCGCTCTGCTCCTCGTGGGCCGGCCATCCAAATCCTT
GCAGCCATCCCCAGACAGCTATCATGAGTCAATGATCTCTGCCCCCGGGCGTGTCAACCTCATTGGCGAGCACATCGATT
ATCACGGCCTCCCCGTTCTCCCCATGGCGCTCCGCCGCTCCATCCGCGTGCAATTCCAACTCCGCGGCGATCGCCGCATT
CATGCCGTCAGCGAGCCCTTCGGCGAGCGCACCTTCGAATGGACTCCCGCCCTCACCCCCGTCGCACGCGGCGATTGGGA
GAACTATCTGCGCGCCGCCGCCCAAGCCATCGCCGGACAGTGGGGCGTGCTCAACGGCATCGACGCAGCGATTGAATCCG
ACCTTCCGCCCGCCGCCGGCCTCTCCTCTTCATCGGCCCTCATCGTCGCCGTCACGCTCGCCCTCCTGCGCGCCAACCGC
ATCGCAGCCGGCTTCGAGGAACTCATGCGCATCCTCCCCGATGGCGAGCAGTTCGTCGGCACCCGCGGCGGCGGCATGGA
TCACGCCGCGTCGCTCGCCTCCCGCGCCGGCTGCGCGTCTCTCATCGAATTCACGCCGCTCACCGTCCACCACATTCCGA
TTCCGCCGGAGTGGGCCTTCCTGGTCGCCCACAGCCTGCACACGGCCGAAAAATCGGGTGCCATTCGCGAACGCTACAAC
GCCGTCCGCGCGGCAGGAGCGGCCGCGCTCTCCGAAACCGGATTCCCTTCTTACACCGCCGCGATCGATGCCTGCGACGA
ACGCGAGCTCGCGCGCATCGCCGAACCCCTCGAGCCCCTCATGCGCGATACATTCCTCCACGTGGTGACGGAAGCCCATC
GCGTCCGCGCCGCCGTGTGCGCACTCCGCGAAAATCAGCCCGCGCGCTTCGGGCAGATCCTGCTCGAAGGCCACTCCAGC
CTGCGCGACCGCCTATGCGTCAGTTGCCCCGCGCTCGATCGCCTGGTGGATTCCGCCATGGATTCGGGCGCCATCGGCGC
GCGACTCACCGGCGCCGGATTCGGCGGCTGCGCCGTAATCTTCTGCCCCCGCGCCGACCTCGCCAAAGTCCGGGAAGGCC
TCATCGAGCGCTTCTATTCCGGAGCCGCCGGTCATATTTACGAAGCAGAACCGGGCCCCGGCGCTGTAAACTCGTAG

Upstream 100 bases:

>100_bases
GAACGCCACCTAAATTAAAACGAATGCGCCGAAACCGGATGTAAGTAGCTGGAGTGTATTCACGGGATGAAATGGACTCG
CTTATTGCTTTATTGAAGTT

Downstream 100 bases:

>100_bases
TTTCCTATATGCAGCTTCATTCGCTCGATTGGATCATCGCGTTCCTATCCGTTGCGGTCTGCTTCGTCCCCGCGCTGTTC
TTCGGAAAGCGCTCCGGCAA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MATTYFACFHAELCAALLLVGRPSKSLQPSPDSYHESMISAPGRVNLIGEHIDYHGLPVLPMALRRSIRVQFQLRGDRRI
HAVSEPFGERTFEWTPALTPVARGDWENYLRAAAQAIAGQWGVLNGIDAAIESDLPPAAGLSSSSALIVAVTLALLRANR
IAAGFEELMRILPDGEQFVGTRGGGMDHAASLASRAGCASLIEFTPLTVHHIPIPPEWAFLVAHSLHTAEKSGAIRERYN
AVRAAGAAALSETGFPSYTAAIDACDERELARIAEPLEPLMRDTFLHVVTEAHRVRAAVCALRENQPARFGQILLEGHSS
LRDRLCVSCPALDRLVDSAMDSGAIGARLTGAGFGGCAVIFCPRADLAKVREGLIERFYSGAAGHIYEAEPGPGAVNS

Sequences:

>Translated_398_residues
MATTYFACFHAELCAALLLVGRPSKSLQPSPDSYHESMISAPGRVNLIGEHIDYHGLPVLPMALRRSIRVQFQLRGDRRI
HAVSEPFGERTFEWTPALTPVARGDWENYLRAAAQAIAGQWGVLNGIDAAIESDLPPAAGLSSSSALIVAVTLALLRANR
IAAGFEELMRILPDGEQFVGTRGGGMDHAASLASRAGCASLIEFTPLTVHHIPIPPEWAFLVAHSLHTAEKSGAIRERYN
AVRAAGAAALSETGFPSYTAAIDACDERELARIAEPLEPLMRDTFLHVVTEAHRVRAAVCALRENQPARFGQILLEGHSS
LRDRLCVSCPALDRLVDSAMDSGAIGARLTGAGFGGCAVIFCPRADLAKVREGLIERFYSGAAGHIYEAEPGPGAVNS
>Mature_397_residues
ATTYFACFHAELCAALLLVGRPSKSLQPSPDSYHESMISAPGRVNLIGEHIDYHGLPVLPMALRRSIRVQFQLRGDRRIH
AVSEPFGERTFEWTPALTPVARGDWENYLRAAAQAIAGQWGVLNGIDAAIESDLPPAAGLSSSSALIVAVTLALLRANRI
AAGFEELMRILPDGEQFVGTRGGGMDHAASLASRAGCASLIEFTPLTVHHIPIPPEWAFLVAHSLHTAEKSGAIRERYNA
VRAAGAAALSETGFPSYTAAIDACDERELARIAEPLEPLMRDTFLHVVTEAHRVRAAVCALRENQPARFGQILLEGHSSL
RDRLCVSCPALDRLVDSAMDSGAIGARLTGAGFGGCAVIFCPRADLAKVREGLIERFYSGAAGHIYEAEPGPGAVNS

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI48527957, Length=419, Percent_Identity=29.5942720763723, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI4503897, Length=419, Percent_Identity=29.5942720763723, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI4503895, Length=341, Percent_Identity=32.8445747800587, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1786972, Length=366, Percent_Identity=30.327868852459, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71989053, Length=407, Percent_Identity=28.992628992629, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319494, Length=257, Percent_Identity=29.5719844357977, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320212, Length=239, Percent_Identity=29.7071129707113, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24661292, Length=420, Percent_Identity=27.6190476190476, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21355577, Length=420, Percent_Identity=27.6190476190476, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24661285, Length=420, Percent_Identity=27.6190476190476, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42588; Mature: 42457

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTYFACFHAELCAALLLVGRPSKSLQPSPDSYHESMISAPGRVNLIGEHIDYHGLPVL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCHH
PMALRRSIRVQFQLRGDRRIHAVSEPFGERTFEWTPALTPVARGDWENYLRAAAQAIAGQ
HHHHHHCEEEEEEECCCCEEEEHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHCC
WGVLNGIDAAIESDLPPAAGLSSSSALIVAVTLALLRANRIAAGFEELMRILPDGEQFVG
CCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
TRGGGMDHAASLASRAGCASLIEFTPLTVHHIPIPPEWAFLVAHSLHTAEKSGAIRERYN
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHH
AVRAAGAAALSETGFPSYTAAIDACDERELARIAEPLEPLMRDTFLHVVTEAHRVRAAVC
HHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRENQPARFGQILLEGHSSLRDRLCVSCPALDRLVDSAMDSGAIGARLTGAGFGGCAVI
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEECCCCCCCEEEE
FCPRADLAKVREGLIERFYSGAAGHIYEAEPGPGAVNS
EECCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
ATTYFACFHAELCAALLLVGRPSKSLQPSPDSYHESMISAPGRVNLIGEHIDYHGLPVL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCHH
PMALRRSIRVQFQLRGDRRIHAVSEPFGERTFEWTPALTPVARGDWENYLRAAAQAIAGQ
HHHHHHCEEEEEEECCCCEEEEHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHCC
WGVLNGIDAAIESDLPPAAGLSSSSALIVAVTLALLRANRIAAGFEELMRILPDGEQFVG
CCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
TRGGGMDHAASLASRAGCASLIEFTPLTVHHIPIPPEWAFLVAHSLHTAEKSGAIRERYN
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHH
AVRAAGAAALSETGFPSYTAAIDACDERELARIAEPLEPLMRDTFLHVVTEAHRVRAAVC
HHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRENQPARFGQILLEGHSSLRDRLCVSCPALDRLVDSAMDSGAIGARLTGAGFGGCAVI
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEECCCCCCCEEEE
FCPRADLAKVREGLIERFYSGAAGHIYEAEPGPGAVNS
EECCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA