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The map label for this gene is pepP [H]

Identifier: 116625552

GI number: 116625552

Start: 8146090

End: 8147679

Strand: Reverse

Name: pepP [H]

Synonym: Acid_6499

Alternate gene names: 116625552

Gene position: 8147679-8146090 (Counterclockwise)

Preceding gene: 116625555

Following gene: 116625549

Centisome position: 81.76

GC content: 63.14

Gene sequence:

>1590_bases
ATGCGTATCCCCAAGATTTCATTCGGTGTTATCCTGCTGGCCGGCATCGCATTCGCAGCCGACAGCACCCCGTGGAAGGT
CGCGCCGGCGCCGCCCGCCTCCTGGCAGCGCGACCGGGTGGCCGATCTCACGGCGCGCCGCAAGGCCGTGATGGACCAGA
TCGGCGACCACGCCATCCTTATGTTGTTCGCCGCGGAGCCGCGTAACTATGCCAATGACGTCGATTGGCCGTTCCGGCAG
GAGAATGACTTCTTCTATCTGACTGGCCTCACCCAGCCCGGCGCGACGCTCATGCTGATTCCCTCCGCGGGAAAAATGCG
GGAAATCGTGTTTCTGCCGCGTGCCAACCCCGCCCAGGAAACCTGGACCGGCCACATGCTGACCCACGCGGAAGCGCGTG
AAATATCGGGCATACAGGATGTGTTTGACGCATCCCAGGTGAACGGCCTGCTGAGCGCTCTCGTGCCGCGGGCACGCGCC
GTGCTCACCGAACTCCCCGCTACTGGCGGACGGGGAGGCCGCGGCGGACGCGGCGGAGCCGACGCCGGCGTGCCGCTGGA
CGTCCCTGTCTGGAGCCTCGAGATCGCCAAGCCCATCGAGTACGCAGCCAAGGAAGAACTACAGCTCTACATGATTCTTC
CCGCGCGACCCAATGCGGTGGAGTGCCGGCGCGAGCAGGAATTCGCAGGGAAACTCGCCTCGGTCGGCGCGGGACTCACC
ATCAAGGATGCGTCCACGATCTTCAACACGTTACGGCGGGTCAAATCGCAGCGCGAAATCGACCTGCTGCAGCATGCGGT
CGATATCACAGCCGAGGCATTCCAGCGCGCCTACGCCTTCGCCGTTCCGGGCACTCCGGAGTACGAAATCCAGGCGCAGT
TCGAGTTCACGTTCCTGCGCCGCAATGCCCACTGGGGCTACCCCTGCATCGTGGGTTCCGGGGTCAATGCCACGACGCTG
CACTACGAAACCAACAAGGACACCATGAAGGATGGAGACCTTCTGTTGATGGACGATGCCGCCGAGTTCGACCAATACAG
CGTGGACGTGACCCGCACTGTCCCGGTCAACGGGAAGTTTTCCAGTGAGCAGGCCGATATTTACCGGCTGGTGTGGGCCG
CGCAGCAGGCCGGTTTCTCCGCGGCCAAGCCGGGGCATGCCGCCAGCGATATCCAGGGCGCGGCCAACGAGGTCTTCAAG
CAAGGTCTATTCAAGCTGGGACTCATCACCGACGCCAAGAGCGATGCCCAGATGAAGATCTGGTTCAATCACGGCATCAG
CCACGGCATCGGGCTCAACGTCCACGACCCGGGCGGCAAGGAACTGCAGCCCGGTATGGTGGTCACGGTGGAGCCCGGCC
TCTACTTCCGTCCCGACGCGCTGGAGAATCTCCCCAAGACGCCGGAGATGGAGAAGTTCCGCGAGGCCGTGCGCCCAGCC
TTCGAGAAATACAAGGGCATCGGAGTTCGACTGGAGGACGATGTTCTCATCACCAACGCGGAGCCAAGGGTAATGTCGGC
CGCGGTTCCCTCAAAGCTCGAAGAGGTGGAAGCGAGTATCGCCAAGCTCCGCCAGACGGCGAAGAACTGA

Upstream 100 bases:

>100_bases
AGACATTACATTGGCGCAAAGATCCCCGGTGGGGTTACTCAATCGGGTCAGGATGCGCATCTCTCGCCTACAATAGTGGG
ATACCCCTTCCGGAGGATTG

Downstream 100 bases:

>100_bases
CGATTGCCCAACGCCGGCGTGATGCCAAGGCCGCTGTTTTTTGATGGGACGAGGATAGCGGTATAAGTGTCCTCACGATG
TTTTCGCGCCGGTCAAACGA

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MRIPKISFGVILLAGIAFAADSTPWKVAPAPPASWQRDRVADLTARRKAVMDQIGDHAILMLFAAEPRNYANDVDWPFRQ
ENDFFYLTGLTQPGATLMLIPSAGKMREIVFLPRANPAQETWTGHMLTHAEAREISGIQDVFDASQVNGLLSALVPRARA
VLTELPATGGRGGRGGRGGADAGVPLDVPVWSLEIAKPIEYAAKEELQLYMILPARPNAVECRREQEFAGKLASVGAGLT
IKDASTIFNTLRRVKSQREIDLLQHAVDITAEAFQRAYAFAVPGTPEYEIQAQFEFTFLRRNAHWGYPCIVGSGVNATTL
HYETNKDTMKDGDLLLMDDAAEFDQYSVDVTRTVPVNGKFSSEQADIYRLVWAAQQAGFSAAKPGHAASDIQGAANEVFK
QGLFKLGLITDAKSDAQMKIWFNHGISHGIGLNVHDPGGKELQPGMVVTVEPGLYFRPDALENLPKTPEMEKFREAVRPA
FEKYKGIGVRLEDDVLITNAEPRVMSAAVPSKLEEVEASIAKLRQTAKN

Sequences:

>Translated_529_residues
MRIPKISFGVILLAGIAFAADSTPWKVAPAPPASWQRDRVADLTARRKAVMDQIGDHAILMLFAAEPRNYANDVDWPFRQ
ENDFFYLTGLTQPGATLMLIPSAGKMREIVFLPRANPAQETWTGHMLTHAEAREISGIQDVFDASQVNGLLSALVPRARA
VLTELPATGGRGGRGGRGGADAGVPLDVPVWSLEIAKPIEYAAKEELQLYMILPARPNAVECRREQEFAGKLASVGAGLT
IKDASTIFNTLRRVKSQREIDLLQHAVDITAEAFQRAYAFAVPGTPEYEIQAQFEFTFLRRNAHWGYPCIVGSGVNATTL
HYETNKDTMKDGDLLLMDDAAEFDQYSVDVTRTVPVNGKFSSEQADIYRLVWAAQQAGFSAAKPGHAASDIQGAANEVFK
QGLFKLGLITDAKSDAQMKIWFNHGISHGIGLNVHDPGGKELQPGMVVTVEPGLYFRPDALENLPKTPEMEKFREAVRPA
FEKYKGIGVRLEDDVLITNAEPRVMSAAVPSKLEEVEASIAKLRQTAKN
>Mature_529_residues
MRIPKISFGVILLAGIAFAADSTPWKVAPAPPASWQRDRVADLTARRKAVMDQIGDHAILMLFAAEPRNYANDVDWPFRQ
ENDFFYLTGLTQPGATLMLIPSAGKMREIVFLPRANPAQETWTGHMLTHAEAREISGIQDVFDASQVNGLLSALVPRARA
VLTELPATGGRGGRGGRGGADAGVPLDVPVWSLEIAKPIEYAAKEELQLYMILPARPNAVECRREQEFAGKLASVGAGLT
IKDASTIFNTLRRVKSQREIDLLQHAVDITAEAFQRAYAFAVPGTPEYEIQAQFEFTFLRRNAHWGYPCIVGSGVNATTL
HYETNKDTMKDGDLLLMDDAAEFDQYSVDVTRTVPVNGKFSSEQADIYRLVWAAQQAGFSAAKPGHAASDIQGAANEVFK
QGLFKLGLITDAKSDAQMKIWFNHGISHGIGLNVHDPGGKELQPGMVVTVEPGLYFRPDALENLPKTPEMEKFREAVRPA
FEKYKGIGVRLEDDVLITNAEPRVMSAAVPSKLEEVEASIAKLRQTAKN

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=483, Percent_Identity=27.536231884058, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI149589008, Length=516, Percent_Identity=27.3255813953488, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI260593665, Length=301, Percent_Identity=31.5614617940199, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI260593663, Length=262, Percent_Identity=32.0610687022901, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1789275, Length=495, Percent_Identity=31.7171717171717, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788728, Length=281, Percent_Identity=28.4697508896797, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790282, Length=299, Percent_Identity=25.0836120401338, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508215, Length=545, Percent_Identity=26.7889908256881, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71989583, Length=292, Percent_Identity=25.6849315068493, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320922, Length=444, Percent_Identity=25.6756756756757, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321118, Length=298, Percent_Identity=29.5302013422819, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357079, Length=503, Percent_Identity=27.8330019880716, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI19920384, Length=489, Percent_Identity=27.6073619631902, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 57985; Mature: 57985

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPKISFGVILLAGIAFAADSTPWKVAPAPPASWQRDRVADLTARRKAVMDQIGDHAIL
CCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
MLFAAEPRNYANDVDWPFRQENDFFYLTGLTQPGATLMLIPSAGKMREIVFLPRANPAQE
EEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEEECCCCCCCC
TWTGHMLTHAEAREISGIQDVFDASQVNGLLSALVPRARAVLTELPATGGRGGRGGRGGA
CCCCCEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DAGVPLDVPVWSLEIAKPIEYAAKEELQLYMILPARPNAVECRREQEFAGKLASVGAGLT
CCCCCCCCCEEEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEE
IKDASTIFNTLRRVKSQREIDLLQHAVDITAEAFQRAYAFAVPGTPEYEIQAQFEFTFLR
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEEEEEEE
RNAHWGYPCIVGSGVNATTLHYETNKDTMKDGDLLLMDDAAEFDQYSVDVTRTVPVNGKF
ECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEEEEECCCCC
SSEQADIYRLVWAAQQAGFSAAKPGHAASDIQGAANEVFKQGLFKLGLITDAKSDAQMKI
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEE
WFNHGISHGIGLNVHDPGGKELQPGMVVTVEPGLYFRPDALENLPKTPEMEKFREAVRPA
EEECCCCCCCEEEEECCCCCCCCCCEEEEECCCCEECCHHHHCCCCCCCHHHHHHHHHHH
FEKYKGIGVRLEDDVLITNAEPRVMSAAVPSKLEEVEASIAKLRQTAKN
HHHHCCCCEEEECCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIPKISFGVILLAGIAFAADSTPWKVAPAPPASWQRDRVADLTARRKAVMDQIGDHAIL
CCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
MLFAAEPRNYANDVDWPFRQENDFFYLTGLTQPGATLMLIPSAGKMREIVFLPRANPAQE
EEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEEECCCCCCCC
TWTGHMLTHAEAREISGIQDVFDASQVNGLLSALVPRARAVLTELPATGGRGGRGGRGGA
CCCCCEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DAGVPLDVPVWSLEIAKPIEYAAKEELQLYMILPARPNAVECRREQEFAGKLASVGAGLT
CCCCCCCCCEEEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEE
IKDASTIFNTLRRVKSQREIDLLQHAVDITAEAFQRAYAFAVPGTPEYEIQAQFEFTFLR
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEEEEEEE
RNAHWGYPCIVGSGVNATTLHYETNKDTMKDGDLLLMDDAAEFDQYSVDVTRTVPVNGKF
ECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEEEEECCCCC
SSEQADIYRLVWAAQQAGFSAAKPGHAASDIQGAANEVFKQGLFKLGLITDAKSDAQMKI
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEE
WFNHGISHGIGLNVHDPGGKELQPGMVVTVEPGLYFRPDALENLPKTPEMEKFREAVRPA
EEECCCCCCCEEEEECCCCCCCCCCEEEEECCCCEECCHHHHCCCCCCCHHHHHHHHHHH
FEKYKGIGVRLEDDVLITNAEPRVMSAAVPSKLEEVEASIAKLRQTAKN
HHHHCCCCEEEECCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]