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The map label for this gene is sbm [H]

Identifier: 116625524

GI number: 116625524

Start: 8112300

End: 8112710

Strand: Reverse

Name: sbm [H]

Synonym: Acid_6471

Alternate gene names: 116625524

Gene position: 8112710-8112300 (Counterclockwise)

Preceding gene: 116625525

Following gene: 116625523

Centisome position: 81.41

GC content: 61.31

Gene sequence:

>411_bases
ATGTCCCGAAAGATCATGTCACGACCGATTCGAGTACTGGTGGCGAAGCCCGGACTGGACGGGCACGACCGCGGCGCGAA
GGTGATCGCCCGCGCCCTGCGCGACGCAGGCATGGAAGTCATCTACACGGGCCTCCGCCAGACTCCGGAAATGATCGTTA
ACGCCGCCCTCCAGGAGGATGTCCAGGTCATCGGCCTTTCCATTCTCTCAGGGGCGCACAATGCCATCGTTCCGCGCGTG
ATTGAGTTACTGCGCGAGAACGATATGGAGGACGTAAAGCTGATTGTGGGCGGAATCGTACCAGATGAGGATGCCGCCCT
CCTCAAGAAACAGGGGGTCGCAGCAGTCTTCCAGCCCGGTGCTTCGCTGGATGCGATCGTCGGATTTATCCGCGGCGCGG
TGCCCGCTTGA

Upstream 100 bases:

>100_bases
GATGCCGTTCGCGCCTATGCCACACTGGGAGAGATCTGCGACGCGTTACGCGGTGTTTTTGGAACCTATACGGAAACTAC
GCATCTCTAGGCAGCAGGAA

Downstream 100 bases:

>100_bases
CCGTGCCACCCCTTCACACCTGTAGCCTGCTACACTCGTTGTTCATTGCCCCCAAGATCCGCTAAAATAATGGCTTAGCA
TCTTTGGAACCCCGACTGTA

Product: cobalamin B12-binding domain-containing protein

Products: succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MSRKIMSRPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEMIVNAALQEDVQVIGLSILSGAHNAIVPRV
IELLRENDMEDVKLIVGGIVPDEDAALLKKQGVAAVFQPGASLDAIVGFIRGAVPA

Sequences:

>Translated_136_residues
MSRKIMSRPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEMIVNAALQEDVQVIGLSILSGAHNAIVPRV
IELLRENDMEDVKLIVGGIVPDEDAALLKKQGVAAVFQPGASLDAIVGFIRGAVPA
>Mature_135_residues
SRKIMSRPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEMIVNAALQEDVQVIGLSILSGAHNAIVPRVI
ELLRENDMEDVKLIVGGIVPDEDAALLKKQGVAAVFQPGASLDAIVGFIRGAVPA

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=116, Percent_Identity=42.2413793103448, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789284, Length=116, Percent_Identity=43.9655172413793, Blast_Score=107, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144500, Length=123, Percent_Identity=42.2764227642276, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: NA

Molecular weight: Translated: 14455; Mature: 14324

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKIMSRPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEMIVNAALQED
CCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHH
VQVIGLSILSGAHNAIVPRVIELLRENDMEDVKLIVGGIVPDEDAALLKKQGVAAVFQPG
HHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCHHEECCC
ASLDAIVGFIRGAVPA
CCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRKIMSRPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEMIVNAALQED
CCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHH
VQVIGLSILSGAHNAIVPRVIELLRENDMEDVKLIVGGIVPDEDAALLKKQGVAAVFQPG
HHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCHHEECCC
ASLDAIVGFIRGAVPA
CCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Co [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-methylmalonyl-CoA [C]

Specific reaction: L-methylmalonyl-CoA = succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]