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The map label for this gene is adk [H]

Identifier: 116625504

GI number: 116625504

Start: 8086315

End: 8086974

Strand: Direct

Name: adk [H]

Synonym: Acid_6451

Alternate gene names: 116625504

Gene position: 8086315-8086974 (Clockwise)

Preceding gene: 116625503

Following gene: 116625505

Centisome position: 81.14

GC content: 61.06

Gene sequence:

>660_bases
GTGATCCTATTGCTGTTCGGGCCTCCAGGTTGCGGCAAGGGCACGCAGGCTGCTTACTTAGCAGAGCGATTCCACATTCC
CGCGATCTCCACGGGGGAGATGTTCCGCGCCGAGTGCAAAGCCGGCACGGAAATGGGCAAGGTTGCTTGCTCGATGATTT
CAAGGGGCGGCTTCGTAAGCGACGACATTGTGAATGGCGTCGTTGCAAGCCGCACGGCGCGCCCCGATTGCGCCAACGGG
TTTCTTCTTGACGGGTATCCGCGGACGGTACCGCAGGCTATATGGTTTGCGGAACTGCTGCGGAAACGAAACCTTCCGGA
ACCGGCGGTGATGCACCTGGATGTGGCGGACGAGGCGCTGGTCGCGCGCCTGACCGCGCGCCGCCAATGTCCAAAATGCC
TGCAAATCTATAACGCGATTTCGCTGCCGCCGAAGGTGCATGGCATTTGCGACCTGGATGGTACGCCGCTGATTACTCGG
GAGGACGACCGTGAAGCGGTGATCCGCCAGCGATTGCGGGCCTACGACGAACTGACGGGTCCGATTCTGAAGTGGTACGG
ACCGAAGCTGGTGCGCGGCATCGATGGGTCAAACTCGCCGGCGGAAGTGCGGCGAGAGATCGAGAAGATCGCGATGGAAG
CAGCCTGCGTGATGGTGTAG

Upstream 100 bases:

>100_bases
CTGGCAATCGCTAGGGTGAGTTCAGACACGGTGGTCTGGTTTTTATTTACCGCCTTTATCTTTTTCTGTGGCCGGGCCGC
ACGGGTCAATGGGAGGATTT

Downstream 100 bases:

>100_bases
GGGCAAGGCGGAGCTGTAATACAGTGGCGGAACGGGGGATTTCGGGATATCCTGAAAACTCCAGTGGTTTCCATCACGCT
AGACACCGCACTGAACCTGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MILLLFGPPGCGKGTQAAYLAERFHIPAISTGEMFRAECKAGTEMGKVACSMISRGGFVSDDIVNGVVASRTARPDCANG
FLLDGYPRTVPQAIWFAELLRKRNLPEPAVMHLDVADEALVARLTARRQCPKCLQIYNAISLPPKVHGICDLDGTPLITR
EDDREAVIRQRLRAYDELTGPILKWYGPKLVRGIDGSNSPAEVRREIEKIAMEAACVMV

Sequences:

>Translated_219_residues
MILLLFGPPGCGKGTQAAYLAERFHIPAISTGEMFRAECKAGTEMGKVACSMISRGGFVSDDIVNGVVASRTARPDCANG
FLLDGYPRTVPQAIWFAELLRKRNLPEPAVMHLDVADEALVARLTARRQCPKCLQIYNAISLPPKVHGICDLDGTPLITR
EDDREAVIRQRLRAYDELTGPILKWYGPKLVRGIDGSNSPAEVRREIEKIAMEAACVMV
>Mature_219_residues
MILLLFGPPGCGKGTQAAYLAERFHIPAISTGEMFRAECKAGTEMGKVACSMISRGGFVSDDIVNGVVASRTARPDCANG
FLLDGYPRTVPQAIWFAELLRKRNLPEPAVMHLDVADEALVARLTARRQCPKCLQIYNAISLPPKVHGICDLDGTPLITR
EDDREAVIRQRLRAYDELTGPILKWYGPKLVRGIDGSNSPAEVRREIEKIAMEAACVMV

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=38.785046728972, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI7524346, Length=198, Percent_Identity=39.8989898989899, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI19923437, Length=190, Percent_Identity=37.8947368421053, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI310110345, Length=183, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI53832003, Length=183, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI8051579, Length=183, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI53832001, Length=183, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4502011, Length=209, Percent_Identity=25.3588516746411, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI28144897, Length=205, Percent_Identity=28.780487804878, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI28144899, Length=205, Percent_Identity=28.780487804878, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI22749187, Length=207, Percent_Identity=25.6038647342995, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=41.2037037037037, Blast_Score=176, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17552384, Length=208, Percent_Identity=36.0576923076923, Blast_Score=146, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17537943, Length=187, Percent_Identity=32.0855614973262, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17567503, Length=195, Percent_Identity=29.7435897435897, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=207, Percent_Identity=42.0289855072464, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=32.7956989247312, Blast_Score=111, Evalue=7e-26,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=39.4230769230769, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17737899, Length=187, Percent_Identity=35.2941176470588, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24645822, Length=187, Percent_Identity=35.2941176470588, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17647141, Length=189, Percent_Identity=29.6296296296296, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24663208, Length=189, Percent_Identity=29.6296296296296, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24009; Mature: 24009

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLLFGPPGCGKGTQAAYLAERFHIPAISTGEMFRAECKAGTEMGKVACSMISRGGFVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
DDIVNGVVASRTARPDCANGFLLDGYPRTVPQAIWFAELLRKRNLPEPAVMHLDVADEAL
HHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
VARLTARRQCPKCLQIYNAISLPPKVHGICDLDGTPLITREDDREAVIRQRLRAYDELTG
HHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHH
PILKWYGPKLVRGIDGSNSPAEVRREIEKIAMEAACVMV
HHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MILLLFGPPGCGKGTQAAYLAERFHIPAISTGEMFRAECKAGTEMGKVACSMISRGGFVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
DDIVNGVVASRTARPDCANGFLLDGYPRTVPQAIWFAELLRKRNLPEPAVMHLDVADEAL
HHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
VARLTARRQCPKCLQIYNAISLPPKVHGICDLDGTPLITREDDREAVIRQRLRAYDELTG
HHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHH
PILKWYGPKLVRGIDGSNSPAEVRREIEKIAMEAACVMV
HHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA