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The map label for this gene is nadA [H]

Identifier: 116625480

GI number: 116625480

Start: 8046579

End: 8047508

Strand: Reverse

Name: nadA [H]

Synonym: Acid_6426

Alternate gene names: 116625480

Gene position: 8047508-8046579 (Counterclockwise)

Preceding gene: 116625482

Following gene: 116625479

Centisome position: 80.75

GC content: 61.83

Gene sequence:

>930_bases
ATGTTGTCCGTTACCTCTATTGCCGACGAAATCCTGGAACTCAAGAACCAGCGGCGAGCCATCCTGCTCGCGCACCATTA
CCAGGAGCCCGAAATTCAGGAACTCGCCGACGTGGTGGGCGATAGCCTCGAACTCGCCCGGAAGGCGCGCGATTTCGAAG
GCGGCGTGATCGCCTTCTGCGGCGTCTGGTTCATGGCCGAAACCGCCAAAGTGCTCAACCCCAAGCGCGTGGTGGTGGTG
CCGGATCGCGAGGCCAGTTGCAGCCTGGTGGAGAGCTGCCCCGTGGAACCCGTACGCGAGTTCCGCCTCAAGCATCCCGA
GTACGTGGTGGTCAGCTACATCAATACCTCCATCGAAGTGAAGGCCGAGAGCGATATCCTCTGCACCTCGCGCAACGCCG
TGAAGATCGTGAATTCGATTCCCGCCGAGAAGCCGGTGCTCTTCCTGCCGGACAGCAACCTGGGAAATTACGTCCGCAGA
GAGACCGGTCGCGAGAACATGAAGATCTGGCAGGGCACCTGCATCGTGCACGCGACCTTTCCGGCGCGGCGGCTGGCGCA
GGCCAGGGCCGAGCACCCCGAAGCCGAAGTGGTGGCGCACCCCGAGTGCCCCGCATCCGTGCTCGCGATGGCGGATTTCA
TCGGCTCTACCTCCGCGCTCATCGAATACTGCGTGGCCAGCAAGGCGCGCGAGTTCATCGTAATGACCGAGAGCGGCGTA
AATTATTCGCTGCGCAAGCTCGCGCCGGAGAAGCAGTTCTATTACGTGGCCAACGAAAACTGCAATTGCAGCGAATGCCC
GTACATGAAGCTCAACACGCTGGAGAAGCTGCGCGATTGCCTGCGCGACCTGCAACCGCGGGTCGAGCTCTCCGACGACA
TCATGCGGCGGGCGCTGGTCCCGCTGGAGCGAATGCTCGCGGTGAAATAA

Upstream 100 bases:

>100_bases
CAGCCCGAATGGCTGCCGTCCCATTTCGTACGTGGAGACAAGCAGGACCCGCACATCTTCATTATGGCTGGTAAACTGAA
AGCGTACTCCCTGATTCCTC

Downstream 100 bases:

>100_bases
TGAACGCCACACCCCTGGTCGATTCCTTTCACCGGGTCCACGACAATCTGCGCATCAGCGTCACCGACCGCTGCAACATC
CGGTGTTTTTACTGCATGCC

Product: quinolinate synthetase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MLSVTSIADEILELKNQRRAILLAHHYQEPEIQELADVVGDSLELARKARDFEGGVIAFCGVWFMAETAKVLNPKRVVVV
PDREASCSLVESCPVEPVREFRLKHPEYVVVSYINTSIEVKAESDILCTSRNAVKIVNSIPAEKPVLFLPDSNLGNYVRR
ETGRENMKIWQGTCIVHATFPARRLAQARAEHPEAEVVAHPECPASVLAMADFIGSTSALIEYCVASKAREFIVMTESGV
NYSLRKLAPEKQFYYVANENCNCSECPYMKLNTLEKLRDCLRDLQPRVELSDDIMRRALVPLERMLAVK

Sequences:

>Translated_309_residues
MLSVTSIADEILELKNQRRAILLAHHYQEPEIQELADVVGDSLELARKARDFEGGVIAFCGVWFMAETAKVLNPKRVVVV
PDREASCSLVESCPVEPVREFRLKHPEYVVVSYINTSIEVKAESDILCTSRNAVKIVNSIPAEKPVLFLPDSNLGNYVRR
ETGRENMKIWQGTCIVHATFPARRLAQARAEHPEAEVVAHPECPASVLAMADFIGSTSALIEYCVASKAREFIVMTESGV
NYSLRKLAPEKQFYYVANENCNCSECPYMKLNTLEKLRDCLRDLQPRVELSDDIMRRALVPLERMLAVK
>Mature_309_residues
MLSVTSIADEILELKNQRRAILLAHHYQEPEIQELADVVGDSLELARKARDFEGGVIAFCGVWFMAETAKVLNPKRVVVV
PDREASCSLVESCPVEPVREFRLKHPEYVVVSYINTSIEVKAESDILCTSRNAVKIVNSIPAEKPVLFLPDSNLGNYVRR
ETGRENMKIWQGTCIVHATFPARRLAQARAEHPEAEVVAHPECPASVLAMADFIGSTSALIEYCVASKAREFIVMTESGV
NYSLRKLAPEKQFYYVANENCNCSECPYMKLNTLEKLRDCLRDLQPRVELSDDIMRRALVPLERMLAVK

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=310, Percent_Identity=37.4193548387097, Blast_Score=213, Evalue=9e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473
- InterPro:   IPR023066 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 34784; Mature: 34784

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVTSIADEILELKNQRRAILLAHHYQEPEIQELADVVGDSLELARKARDFEGGVIAFC
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHH
GVWFMAETAKVLNPKRVVVVPDREASCSLVESCPVEPVREFRLKHPEYVVVSYINTSIEV
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCHHHHHHCCCCCEEEEEEECCEEEE
KAESDILCTSRNAVKIVNSIPAEKPVLFLPDSNLGNYVRRETGRENMKIWQGTCIVHATF
EECCCEEEECCCHHHHHHCCCCCCCEEECCCCCCHHHHHHHCCCCCCEEEECEEEEEECC
PARRLAQARAEHPEAEVVAHPECPASVLAMADFIGSTSALIEYCVASKAREFIVMTESGV
CHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCC
NYSLRKLAPEKQFYYVANENCNCSECPYMKLNTLEKLRDCLRDLQPRVELSDDIMRRALV
CCHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
PLERMLAVK
HHHHHHCCC
>Mature Secondary Structure
MLSVTSIADEILELKNQRRAILLAHHYQEPEIQELADVVGDSLELARKARDFEGGVIAFC
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHH
GVWFMAETAKVLNPKRVVVVPDREASCSLVESCPVEPVREFRLKHPEYVVVSYINTSIEV
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCHHHHHHCCCCCEEEEEEECCEEEE
KAESDILCTSRNAVKIVNSIPAEKPVLFLPDSNLGNYVRRETGRENMKIWQGTCIVHATF
EECCCEEEECCCHHHHHHCCCCCCCEEECCCCCCHHHHHHHCCCCCCEEEECEEEEEECC
PARRLAQARAEHPEAEVVAHPECPASVLAMADFIGSTSALIEYCVASKAREFIVMTESGV
CHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCC
NYSLRKLAPEKQFYYVANENCNCSECPYMKLNTLEKLRDCLRDLQPRVELSDDIMRRALV
CCHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
PLERMLAVK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA