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The map label for this gene is comEC [H]

Identifier: 116625478

GI number: 116625478

Start: 8042972

End: 8045506

Strand: Reverse

Name: comEC [H]

Synonym: Acid_6424

Alternate gene names: 116625478

Gene position: 8045506-8042972 (Counterclockwise)

Preceding gene: 116625479

Following gene: 116625471

Centisome position: 80.73

GC content: 67.42

Gene sequence:

>2535_bases
TTGCGTTACTTTGCGGCTTTGCGGGCGGCGCCGGGCAGAGCGTCATGCTCGCTGCTACAATCGCCTTTTGCATTGAAGAA
CCCTCTCCTGGGTCCCCTGGCTGCCATCGCCGCGGGCATCCTGGCCTTCCGGTTTGTAGCCTTCGGCCAAACTGAAATTC
TCGCTGGGACCGGCGCCTTCTTCCTCCTCGGAGTGCTCGCCTTGTGGCGCGGCGCCCGCGTCCTCGGCGGCCTCTGCTGT
CTCCTCGGATTCTTCTTCGCCGGCGCCTTCGATGCGCGCGTCCATCTCCCTGGCTCTCCGCCCGAGCTCGACGCCACCGG
CCGCGAGGTCGTGATCGTGGAAGGCTGCGTGGTCGAACCGCCCGCGATTTCCGGGGAGCGCGAGCGCTTCCTGCTCGAGC
TCGACCGCAACGCCCGCGCGCAGGTCACGCTTTATACCAAGCCCGGCCAGACGCTGCCGCCGCTCCGCTATGGCCAGAAG
ATCGAGCTCGATGGCAAGGTCCGCGTGCCGCGCAACTTCGGAAATCCCGGCGCCTTCGACTACCGGCGCTTCCTGGTACG
GCAGGATATCTACTGGACTGTCTCGGCCTCAGCCGGCGATGTTCGCGCGCTGCCCGGCCGCTGCGGCTCCTGGTTCCCCA
AGGCGATGATGGACCTGCGCGCCGCCGCGCTCGCCCGCATCGAGCAGCTCTACCCCAACGACGCCTACCGCTCCGGGATG
ATGGAGGCCATCCTGATCGGCCAGTCCTTCCAGCTACAGAAGGTCTGGACGGAGCAGTATCGCTCCACCGGAACCTTCCA
CGCACTCGTAATCTCCGGCACACACGTGGCCGTGCTCGCCGCCTTTTTGCTGTTTCTGCTGCGCATTTGCTTGGTGCCCG
AGAGCCTCGCTCTCTTCATCACCGTGCTCGCCGCGTGGCTCTACGCGCTGGTGACCGGTTGGCAGACGCCATGCGTGCGA
TCGGCCGCCGGGCTCACGCTCTTCATGATCGCCGGCTATTTCTATCGCGAGCGCCGCATCATGAACCTGCTGGCCGCCGT
CGCGCTCGGCTTCCTGCTGTTCGACCCCGACCAGCTGTTCGACGCCAGCTTCCAGCTCACGTTTCTCGCCGTGGGATTCC
TCGGGGCCTTCGCCGCCCCCGCCATCGCAGCCACGTCGGGTCCGCTCGGGGCAGGGCTCCGCGAACTGTCCGACGTGGGA
CGCGACCCGCACCTGGAGCCGCGCTCCGCCCAGTTCCGCATCGAGCTGCGCCTGCTCGCCGAAACCTTGCGCGCACCGTC
GTGGGTGGTGACGGCGCCCGCACGCGCCGTGCTCTTCGTCTACGAAATCGTCCTCACCTCCGCGGTGGTGCAACTCGGGC
TCGCGCTCCCCATGGTGGTCTACTTTCACCGCCTGGGATTCTCCGGCCTTTCCGCCAATGCCTTCGTGGTTCCCCTGATG
GGCTTCGTAGTGCCGGTCGGCTTCGTCGCCATCTTCACCGGCTGGGCCTGGGTTGCGCGGATCGCGGGAATGCTGCTCTG
GGCCTCGCAAAAAGTAGTCTGGTACCACGCTGGCCTGGAGCCGAGCTGGCGCATTCCGACGCCGCCGGTATGGCTCGGCG
TCGCGCTCGCCGCCGCCCTCATCGCGGCCGCGATCTGGCGCGCGCGCTGGGCCGCGGCCCCCGTCGCGGGCCTGATCGCG
CTGCTCTTGTGGCACCCCTTCGCGCCCGACGTCCATCGCGGAGAAATGGAACTGACCGCGATCGATGTCGGCCAGGGCGA
CAGTCTCCTGGTCGTCTTCCCCGATGGCAAACGCATGCTGGTGGATGGCGGGGGTATCCCCGCGTTCGGACGCATCGCGC
GCTCGCAGCTCGATATCGGCGAAGACGTGGTCGCCCCGTACCTCTGGGATCGCGGCATGCGCTCCGTCGATATCGTCGCG
CTCTCCCACGCTCACGAAGATCACAGCGGCGGCCTCGCGGCGCTGATCTCAGACTTCCATCCGCGCGAGCTCTGGACCGG
CGCCACGCCGGATGGCCCGGAGTGGGAGGCAGTGCGCGTTAAAGCCGTGCAGGTGGGCGCCAAGATCGTCCCGCTGCGCG
CTCCCGCCCGCTTCGCGTTCGGCGGCACCACGCTCGAGGTGCTCGCGCCCACGCCGGATTACCTGCCGTTCGACACGCCC
AAGAACAACGACTCCCTGGTACTGCGCGCCACATTCGGCGAACGCAGCTTCCTGCTCAGCGGCGATATGGAACGGGGCGT
GGAGCAGCAGATGCTTTGGACAGACACGGTCCGCCCCACGGATATTCTGAAGGTGGCCCACCACGGCAGCCGCACCAGCA
GCACCGAGGAATTCCTGAGCGCGCTGCACCCGGCCTTCGCCGTGATCTCAGCCGGCTTCGAGAACAGCTACGGCCATCCC
CACGCCACCGTGGTCGAGCGCCTCCGCGATCATCACGCTGAGATCCTGCGCACCGATCTCGACGGCCTGATCACGATCCG
CACGAACGGCCGCCGCGTCGCGGTAGAGACCTACAATCAGGACCGCGACCGTTAA

Upstream 100 bases:

>100_bases
CCATGTACTCCATTGGCGGCTAAAAGCCTCACCCCACCGCCGGTAGCACCTGCTGCGCTTCGACAACTGTGGTGGGGAAT
GCCCTCTTTCCCACTCTTCT

Downstream 100 bases:

>100_bases
GGAGCGGTCTCTCACGGTCTTTTGCCGCGGCGGGGGAAGAGCGGGACGAAGTCTCCATCCTGGCAAGAAACCGGCTCGTT
TGCGCTCTCTGGTAAATGCT

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 844; Mature: 844

Protein sequence:

>844_residues
MRYFAALRAAPGRASCSLLQSPFALKNPLLGPLAAIAAGILAFRFVAFGQTEILAGTGAFFLLGVLALWRGARVLGGLCC
LLGFFFAGAFDARVHLPGSPPELDATGREVVIVEGCVVEPPAISGERERFLLELDRNARAQVTLYTKPGQTLPPLRYGQK
IELDGKVRVPRNFGNPGAFDYRRFLVRQDIYWTVSASAGDVRALPGRCGSWFPKAMMDLRAAALARIEQLYPNDAYRSGM
MEAILIGQSFQLQKVWTEQYRSTGTFHALVISGTHVAVLAAFLLFLLRICLVPESLALFITVLAAWLYALVTGWQTPCVR
SAAGLTLFMIAGYFYRERRIMNLLAAVALGFLLFDPDQLFDASFQLTFLAVGFLGAFAAPAIAATSGPLGAGLRELSDVG
RDPHLEPRSAQFRIELRLLAETLRAPSWVVTAPARAVLFVYEIVLTSAVVQLGLALPMVVYFHRLGFSGLSANAFVVPLM
GFVVPVGFVAIFTGWAWVARIAGMLLWASQKVVWYHAGLEPSWRIPTPPVWLGVALAAALIAAAIWRARWAAAPVAGLIA
LLLWHPFAPDVHRGEMELTAIDVGQGDSLLVVFPDGKRMLVDGGGIPAFGRIARSQLDIGEDVVAPYLWDRGMRSVDIVA
LSHAHEDHSGGLAALISDFHPRELWTGATPDGPEWEAVRVKAVQVGAKIVPLRAPARFAFGGTTLEVLAPTPDYLPFDTP
KNNDSLVLRATFGERSFLLSGDMERGVEQQMLWTDTVRPTDILKVAHHGSRTSSTEEFLSALHPAFAVISAGFENSYGHP
HATVVERLRDHHAEILRTDLDGLITIRTNGRRVAVETYNQDRDR

Sequences:

>Translated_844_residues
MRYFAALRAAPGRASCSLLQSPFALKNPLLGPLAAIAAGILAFRFVAFGQTEILAGTGAFFLLGVLALWRGARVLGGLCC
LLGFFFAGAFDARVHLPGSPPELDATGREVVIVEGCVVEPPAISGERERFLLELDRNARAQVTLYTKPGQTLPPLRYGQK
IELDGKVRVPRNFGNPGAFDYRRFLVRQDIYWTVSASAGDVRALPGRCGSWFPKAMMDLRAAALARIEQLYPNDAYRSGM
MEAILIGQSFQLQKVWTEQYRSTGTFHALVISGTHVAVLAAFLLFLLRICLVPESLALFITVLAAWLYALVTGWQTPCVR
SAAGLTLFMIAGYFYRERRIMNLLAAVALGFLLFDPDQLFDASFQLTFLAVGFLGAFAAPAIAATSGPLGAGLRELSDVG
RDPHLEPRSAQFRIELRLLAETLRAPSWVVTAPARAVLFVYEIVLTSAVVQLGLALPMVVYFHRLGFSGLSANAFVVPLM
GFVVPVGFVAIFTGWAWVARIAGMLLWASQKVVWYHAGLEPSWRIPTPPVWLGVALAAALIAAAIWRARWAAAPVAGLIA
LLLWHPFAPDVHRGEMELTAIDVGQGDSLLVVFPDGKRMLVDGGGIPAFGRIARSQLDIGEDVVAPYLWDRGMRSVDIVA
LSHAHEDHSGGLAALISDFHPRELWTGATPDGPEWEAVRVKAVQVGAKIVPLRAPARFAFGGTTLEVLAPTPDYLPFDTP
KNNDSLVLRATFGERSFLLSGDMERGVEQQMLWTDTVRPTDILKVAHHGSRTSSTEEFLSALHPAFAVISAGFENSYGHP
HATVVERLRDHHAEILRTDLDGLITIRTNGRRVAVETYNQDRDR
>Mature_844_residues
MRYFAALRAAPGRASCSLLQSPFALKNPLLGPLAAIAAGILAFRFVAFGQTEILAGTGAFFLLGVLALWRGARVLGGLCC
LLGFFFAGAFDARVHLPGSPPELDATGREVVIVEGCVVEPPAISGERERFLLELDRNARAQVTLYTKPGQTLPPLRYGQK
IELDGKVRVPRNFGNPGAFDYRRFLVRQDIYWTVSASAGDVRALPGRCGSWFPKAMMDLRAAALARIEQLYPNDAYRSGM
MEAILIGQSFQLQKVWTEQYRSTGTFHALVISGTHVAVLAAFLLFLLRICLVPESLALFITVLAAWLYALVTGWQTPCVR
SAAGLTLFMIAGYFYRERRIMNLLAAVALGFLLFDPDQLFDASFQLTFLAVGFLGAFAAPAIAATSGPLGAGLRELSDVG
RDPHLEPRSAQFRIELRLLAETLRAPSWVVTAPARAVLFVYEIVLTSAVVQLGLALPMVVYFHRLGFSGLSANAFVVPLM
GFVVPVGFVAIFTGWAWVARIAGMLLWASQKVVWYHAGLEPSWRIPTPPVWLGVALAAALIAAAIWRARWAAAPVAGLIA
LLLWHPFAPDVHRGEMELTAIDVGQGDSLLVVFPDGKRMLVDGGGIPAFGRIARSQLDIGEDVVAPYLWDRGMRSVDIVA
LSHAHEDHSGGLAALISDFHPRELWTGATPDGPEWEAVRVKAVQVGAKIVPLRAPARFAFGGTTLEVLAPTPDYLPFDTP
KNNDSLVLRATFGERSFLLSGDMERGVEQQMLWTDTVRPTDILKVAHHGSRTSSTEEFLSALHPAFAVISAGFENSYGHP
HATVVERLRDHHAEILRTDLDGLITIRTNGRRVAVETYNQDRDR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=722, Percent_Identity=25.3462603878116, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 92073; Mature: 92073

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFAALRAAPGRASCSLLQSPFALKNPLLGPLAAIAAGILAFRFVAFGQTEILAGTGAF
CCHHHHHHCCCCCCHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHH
FLLGVLALWRGARVLGGLCCLLGFFFAGAFDARVHLPGSPPELDATGREVVIVEGCVVEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECEEECC
PAISGERERFLLELDRNARAQVTLYTKPGQTLPPLRYGQKIELDGKVRVPRNFGNPGAFD
CCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEECCCEEECCCCCCCCCHHH
YRRFLVRQDIYWTVSASAGDVRALPGRCGSWFPKAMMDLRAAALARIEQLYPNDAYRSGM
HHHHHHHCCEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
MEAILIGQSFQLQKVWTEQYRSTGTFHALVISGTHVAVLAAFLLFLLRICLVPESLALFI
HHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHH
TVLAAWLYALVTGWQTPCVRSAAGLTLFMIAGYFYRERRIMNLLAAVALGFLLFDPDQLF
HHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DASFQLTFLAVGFLGAFAAPAIAATSGPLGAGLRELSDVGRDPHLEPRSAQFRIELRLLA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHH
ETLRAPSWVVTAPARAVLFVYEIVLTSAVVQLGLALPMVVYFHRLGFSGLSANAFVVPLM
HHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
GFVVPVGFVAIFTGWAWVARIAGMLLWASQKVVWYHAGLEPSWRIPTPPVWLGVALAAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
IAAAIWRARWAAAPVAGLIALLLWHPFAPDVHRGEMELTAIDVGQGDSLLVVFPDGKRML
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEE
VDGGGIPAFGRIARSQLDIGEDVVAPYLWDRGMRSVDIVALSHAHEDHSGGLAALISDFH
EECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHCCC
PRELWTGATPDGPEWEAVRVKAVQVGAKIVPLRAPARFAFGGTTLEVLAPTPDYLPFDTP
CHHHCCCCCCCCCCCCCEEEEEEEECCEEEEECCCCEEEECCCEEEEEECCCCCCCCCCC
KNNDSLVLRATFGERSFLLSGDMERGVEQQMLWTDTVRPTDILKVAHHGSRTSSTEEFLS
CCCCCEEEEEECCCCEEEECCCHHHCHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHH
ALHPAFAVISAGFENSYGHPHATVVERLRDHHAEILRTDLDGLITIRTNGRRVAVETYNQ
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCC
DRDR
CCCC
>Mature Secondary Structure
MRYFAALRAAPGRASCSLLQSPFALKNPLLGPLAAIAAGILAFRFVAFGQTEILAGTGAF
CCHHHHHHCCCCCCHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHH
FLLGVLALWRGARVLGGLCCLLGFFFAGAFDARVHLPGSPPELDATGREVVIVEGCVVEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECEEECC
PAISGERERFLLELDRNARAQVTLYTKPGQTLPPLRYGQKIELDGKVRVPRNFGNPGAFD
CCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEECCCEEECCCCCCCCCHHH
YRRFLVRQDIYWTVSASAGDVRALPGRCGSWFPKAMMDLRAAALARIEQLYPNDAYRSGM
HHHHHHHCCEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
MEAILIGQSFQLQKVWTEQYRSTGTFHALVISGTHVAVLAAFLLFLLRICLVPESLALFI
HHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHH
TVLAAWLYALVTGWQTPCVRSAAGLTLFMIAGYFYRERRIMNLLAAVALGFLLFDPDQLF
HHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DASFQLTFLAVGFLGAFAAPAIAATSGPLGAGLRELSDVGRDPHLEPRSAQFRIELRLLA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHH
ETLRAPSWVVTAPARAVLFVYEIVLTSAVVQLGLALPMVVYFHRLGFSGLSANAFVVPLM
HHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
GFVVPVGFVAIFTGWAWVARIAGMLLWASQKVVWYHAGLEPSWRIPTPPVWLGVALAAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
IAAAIWRARWAAAPVAGLIALLLWHPFAPDVHRGEMELTAIDVGQGDSLLVVFPDGKRML
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEE
VDGGGIPAFGRIARSQLDIGEDVVAPYLWDRGMRSVDIVALSHAHEDHSGGLAALISDFH
EECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHCCC
PRELWTGATPDGPEWEAVRVKAVQVGAKIVPLRAPARFAFGGTTLEVLAPTPDYLPFDTP
CHHHCCCCCCCCCCCCCEEEEEEEECCEEEEECCCCEEEECCCEEEEEECCCCCCCCCCC
KNNDSLVLRATFGERSFLLSGDMERGVEQQMLWTDTVRPTDILKVAHHGSRTSSTEEFLS
CCCCCEEEEEECCCCEEEECCCHHHCHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHH
ALHPAFAVISAGFENSYGHPHATVVERLRDHHAEILRTDLDGLITIRTNGRRVAVETYNQ
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCC
DRDR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]