Click here to switch to the map view.

The map label for this gene is kdsA [H]

Identifier: 116625269

GI number: 116625269

Start: 7791898

End: 7792686

Strand: Reverse

Name: kdsA [H]

Synonym: Acid_6214

Alternate gene names: 116625269

Gene position: 7792686-7791898 (Counterclockwise)

Preceding gene: 116625270

Following gene: 116625265

Centisome position: 78.2

GC content: 66.92

Gene sequence:

>789_bases
GTGCCGATTGAGTTCAGCGATTTCGGCAAGCGGCTGGTCCTGATCGCGGGACCGTGCGTGATCGAGAGCGAAGAGCACGT
CCACCGCATGGCGCGCGGCATCCGCGCCGCGGTGGGCGAGTTCGTCTTTAAGGCGAGCTTCGACAAAGCCAACCGTACCA
GCGCCGGCGCGTACCGCGGTCCAGGCCTGAAAGAGGGATTGCGAATTCTGGCCGGCGTGAAGGCCGAGGGCTTCCCGATT
CTGACCGACATCCACGAGCCGGCGCAGGCGGAGGCCGCGGCGGAAGTCGTGGATATCCTGCAGATCCCGGCGTTCCTCTG
CCGGCAGACCGACCTCTTGGTCGCGGCCGGCCGGACGGGACGGATTGTCAACATCAAGAAGGGCCAGTTCGTGGCGCCGC
ACGATATCTACCGCGCGGCGGACAAGGTGGCATCCACAGGGAACACGCAGGTGGTGCTGACCGAACGCGGTTCAAGCTTC
GGCTACAACAACCTGGTCGTCGATATGCGCGGGTTGAAGATCATGCGCGACGCCGGCTGGCCGGTGGTCTTCGACGCCAC
GCACAGTGTGCAATTGCCCGGCGGCGCGGGCGCGACGTCCGGCGGCCAGCCCGAGTTCATCGCCCCGCTCGCGCGCGCGG
CGGTCGCGGTCGGCATCGACGGAGTTTTTGTGGAGACGCACGATGCGCCCGAGAAGGCGCTCTCCGATGGCGCGAATGCG
CTGCGGCTCGATCTCCTCGCCGATTTCTGGCGGGGGCTGCTGAAGGTGGATGCGGCGGTGAAGGGGTAG

Upstream 100 bases:

>100_bases
AAGCCGATGGAACCGCATCCGTTGTTCAAGGCCTTCATCGGCGCCGCATGGGAATATCGCATGCGAAGGCTATCGGCGAT
TGAGGAGCCCCTGTTCTCCC

Downstream 100 bases:

>100_bases
GGTGTGCGAATTCGAAGTTCAGCCCCTCAGAATGCGATCGTATTCCGCGTGAGTGCCGATCCAGAACCAGACGACGTCTT
CCCCATCCAACTGGGCGAGA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MPIEFSDFGKRLVLIAGPCVIESEEHVHRMARGIRAAVGEFVFKASFDKANRTSAGAYRGPGLKEGLRILAGVKAEGFPI
LTDIHEPAQAEAAAEVVDILQIPAFLCRQTDLLVAAGRTGRIVNIKKGQFVAPHDIYRAADKVASTGNTQVVLTERGSSF
GYNNLVVDMRGLKIMRDAGWPVVFDATHSVQLPGGAGATSGGQPEFIAPLARAAVAVGIDGVFVETHDAPEKALSDGANA
LRLDLLADFWRGLLKVDAAVKG

Sequences:

>Translated_262_residues
MPIEFSDFGKRLVLIAGPCVIESEEHVHRMARGIRAAVGEFVFKASFDKANRTSAGAYRGPGLKEGLRILAGVKAEGFPI
LTDIHEPAQAEAAAEVVDILQIPAFLCRQTDLLVAAGRTGRIVNIKKGQFVAPHDIYRAADKVASTGNTQVVLTERGSSF
GYNNLVVDMRGLKIMRDAGWPVVFDATHSVQLPGGAGATSGGQPEFIAPLARAAVAVGIDGVFVETHDAPEKALSDGANA
LRLDLLADFWRGLLKVDAAVKG
>Mature_261_residues
PIEFSDFGKRLVLIAGPCVIESEEHVHRMARGIRAAVGEFVFKASFDKANRTSAGAYRGPGLKEGLRILAGVKAEGFPIL
TDIHEPAQAEAAAEVVDILQIPAFLCRQTDLLVAAGRTGRIVNIKKGQFVAPHDIYRAADKVASTGNTQVVLTERGSSFG
YNNLVVDMRGLKIMRDAGWPVVFDATHSVQLPGGAGATSGGQPEFIAPLARAAVAVGIDGVFVETHDAPEKALSDGANAL
RLDLLADFWRGLLKVDAAVKG

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=258, Percent_Identity=46.5116279069767, Blast_Score=227, Evalue=5e-61,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 27782; Mature: 27651

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIEFSDFGKRLVLIAGPCVIESEEHVHRMARGIRAAVGEFVFKASFDKANRTSAGAYRG
CCCCHHHHCCEEEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PGLKEGLRILAGVKAEGFPILTDIHEPAQAEAAAEVVDILQIPAFLCRQTDLLVAAGRTG
CCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
RIVNIKKGQFVAPHDIYRAADKVASTGNTQVVLTERGSSFGYNNLVVDMRGLKIMRDAGW
CEEEECCCCEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCEEEEECCCC
PVVFDATHSVQLPGGAGATSGGQPEFIAPLARAAVAVGIDGVFVETHDAPEKALSDGANA
CEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCH
LRLDLLADFWRGLLKVDAAVKG
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIEFSDFGKRLVLIAGPCVIESEEHVHRMARGIRAAVGEFVFKASFDKANRTSAGAYRG
CCCHHHHCCEEEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PGLKEGLRILAGVKAEGFPILTDIHEPAQAEAAAEVVDILQIPAFLCRQTDLLVAAGRTG
CCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
RIVNIKKGQFVAPHDIYRAADKVASTGNTQVVLTERGSSFGYNNLVVDMRGLKIMRDAGW
CEEEECCCCEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCEEEEECCCC
PVVFDATHSVQLPGGAGATSGGQPEFIAPLARAAVAVGIDGVFVETHDAPEKALSDGANA
CEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCH
LRLDLLADFWRGLLKVDAAVKG
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA