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The map label for this gene is msrA2 [H]

Identifier: 116625266

GI number: 116625266

Start: 7788738

End: 7789406

Strand: Direct

Name: msrA2 [H]

Synonym: Acid_6211

Alternate gene names: 116625266

Gene position: 7788738-7789406 (Clockwise)

Preceding gene: 116625262

Following gene: 116625267

Centisome position: 78.16

GC content: 62.48

Gene sequence:

>669_bases
ATGAAGCTTTCCATGCGTACCGGCGCGGTCGCGCTTTCCGGGGCGATCGCCTGCTTCCTGACGCTGCGCGCCTTGACGGC
GGGCGAGATTCCGCCGCCGTTCGCCGACGTCCCCGCGCCCACGACCAACCAACTGGCCACTGCCGTCTTCGCCGGAGGCT
GCTTCTGGGGCGTAGAAGGCGTTTACGAGCACGTGAAGGGAGTGAAGGCGGCCGTTTCCGGTTACGCCGGCGGCCCGGCA
TCGATGGCCCACTATGATCTGGTCAGCAACGGCGATACCGGACATGCCGAGTCGGTCAAGGTGACCTACGATCCGGCGCA
AATCTCCTACGGCAAGCTGCTGCAGATCTTTTTCGCGGTGGCGCACGACCCGACCGAACTTAACCGCCAAGGTCCGGACT
GGGGCACGCAGTATCGCTCCGCCATCTTCTACTCGTCGGAGGAAGAACAGCGCGTGGCGACGGCTTATATCGAGCAACTG
AATGCCGCGAAGGCATTCTCCAAACCGATCGTGACCCAGGTCGCGCCGCTCAAGGCCTTCTACCCCGCGGAGGATTACCA
CCAGCATTTCCTGGAGCGCAATCCGACGCACCCCTACATCGTCTACAACGACCTGCCGAAGATCGCGCAGTTAAAGCGCC
GCTTCCCGGAGTTAGTGACGAAGAAGTAA

Upstream 100 bases:

>100_bases
CATCATACGCATCCTTACTTATCTTATGACGCGCCGCACCCCCGTCGCGTGGAGAGGAATCGCCGGCCTGCTATCCTGAG
GGCAGAACAGAGGGATTCCC

Downstream 100 bases:

>100_bases
GAGGGCACGCGTTGTCACGGGCGGGGTGCGATTGTTATGATCGGACCTCTTTATGCGAATACCGCTCGTCCTAACTCTCT
ACGCCGCTTGCTTGCCGGCT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKLSMRTGAVALSGAIACFLTLRALTAGEIPPPFADVPAPTTNQLATAVFAGGCFWGVEGVYEHVKGVKAAVSGYAGGPA
SMAHYDLVSNGDTGHAESVKVTYDPAQISYGKLLQIFFAVAHDPTELNRQGPDWGTQYRSAIFYSSEEEQRVATAYIEQL
NAAKAFSKPIVTQVAPLKAFYPAEDYHQHFLERNPTHPYIVYNDLPKIAQLKRRFPELVTKK

Sequences:

>Translated_222_residues
MKLSMRTGAVALSGAIACFLTLRALTAGEIPPPFADVPAPTTNQLATAVFAGGCFWGVEGVYEHVKGVKAAVSGYAGGPA
SMAHYDLVSNGDTGHAESVKVTYDPAQISYGKLLQIFFAVAHDPTELNRQGPDWGTQYRSAIFYSSEEEQRVATAYIEQL
NAAKAFSKPIVTQVAPLKAFYPAEDYHQHFLERNPTHPYIVYNDLPKIAQLKRRFPELVTKK
>Mature_222_residues
MKLSMRTGAVALSGAIACFLTLRALTAGEIPPPFADVPAPTTNQLATAVFAGGCFWGVEGVYEHVKGVKAAVSGYAGGPA
SMAHYDLVSNGDTGHAESVKVTYDPAQISYGKLLQIFFAVAHDPTELNRQGPDWGTQYRSAIFYSSEEEQRVATAYIEQL
NAAKAFSKPIVTQVAPLKAFYPAEDYHQHFLERNPTHPYIVYNDLPKIAQLKRRFPELVTKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=43.558282208589, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=43.558282208589, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=45.3703703703704, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1790665, Length=154, Percent_Identity=45.4545454545455, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=161, Percent_Identity=36.0248447204969, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=39.1566265060241, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24664627, Length=148, Percent_Identity=37.8378378378378, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664631, Length=148, Percent_Identity=37.1621621621622, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=36.8794326241135, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24238; Mature: 24238

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSMRTGAVALSGAIACFLTLRALTAGEIPPPFADVPAPTTNQLATAVFAGGCFWGVEG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHH
VYEHVKGVKAAVSGYAGGPASMAHYDLVSNGDTGHAESVKVTYDPAQISYGKLLQIFFAV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
AHDPTELNRQGPDWGTQYRSAIFYSSEEEQRVATAYIEQLNAAKAFSKPIVTQVAPLKAF
HCCCHHHCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHC
YPAEDYHQHFLERNPTHPYIVYNDLPKIAQLKRRFPELVTKK
CCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLSMRTGAVALSGAIACFLTLRALTAGEIPPPFADVPAPTTNQLATAVFAGGCFWGVEG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHH
VYEHVKGVKAAVSGYAGGPASMAHYDLVSNGDTGHAESVKVTYDPAQISYGKLLQIFFAV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
AHDPTELNRQGPDWGTQYRSAIFYSSEEEQRVATAYIEQLNAAKAFSKPIVTQVAPLKAF
HCCCHHHCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHC
YPAEDYHQHFLERNPTHPYIVYNDLPKIAQLKRRFPELVTKK
CCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]