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The map label for this gene is lacZ [H]

Identifier: 116624944

GI number: 116624944

Start: 7361706

End: 7364213

Strand: Direct

Name: lacZ [H]

Synonym: Acid_5873

Alternate gene names: 116624944

Gene position: 7361706-7364213 (Clockwise)

Preceding gene: 116624943

Following gene: 116624945

Centisome position: 73.87

GC content: 64.71

Gene sequence:

>2508_bases
ATGGTCTCAGACATGAATCTCCGAAAGTCCCCCGCCTCCGGCCTGACGCGCCGGGAGCTCTTCCAGGCGGCCTCCGCCGT
GATCGCCGGAGCAGCCCTCACCTCCACCTCTTCCGCCGCCACCGGCGCCCCCACCGTCCGCCGCCTCACCACTGGATGGG
AACACTACCGCGGCGGCCTCGGCGGAGTCTGGGAAGTCTGGCGCGGCAAAGCCGCCAGCGATAACGTCGCCTGGGACACG
GTCGCCATCCCGCACTGCTTCAATGCCTTCGACGCCGTCGATCCCGACCACGCCTACTACGAAGGTCCCGGCTGGTACCG
CACCAGCTTCATGCCCCAGAATCCCTTCCCCAACGGGCGCATCCTGCTGCACTTCGAAGGCGCCGGTCAGAAGAGCGAAG
TCTTCGTCGGCCTGGAACGCGCCGGCGCCCATGTAGGCGGCTACGACGAGTTCACCATCGACATCACCGACGCCGCCGCG
CGCGCCGCCAAGCGCCCCGACGCCAAGGGCCAGGTGCAGCTCGCCGTGCTCTGCGACAACTCGCGCAATCCGGAGATGAT
CCCCTCCGACCTCAGCGATTTCAACCGCTACGGCGGGCTCTATCGCCACGTCAACCTCGCCTACGCGCCGGCCATCAGCA
TCGAACACGTGCAGATCGACAGCACCACCGTCGCCGGCAAATCCGACGTCTCCGTGAAGGCGCGCCTCTACAATCCGGGC
GGCCTGAAGGATGCCGTGCAGGTGGAAATCACGGTCACCGACGCTGCCGGGAAAGCCGTACATACTTCGACGAAATCCCT
GCCCGCGTGGACCGGCGAGCAGGAACTGGCCTCCTTCCCCGTCGCCAATCCGGCACTCTGGTCGCCGAAGACGCCGAATC
TCTACCGCTGCTCCGTCACCGTCAAAAGTCCCCACGGCGAACAGCAGGTGGAAGACCGCTTCGGCCTGCGCTGGTTCGAA
TTCCCCAAGAAAGGACTCTTCCACCTCAACGGCGAGAAACTCTTCCTCCGTGGCACGCAGCGCCACGAAGATCACGCCGG
ACTCGCCGCCGCCCTCACCGACGACCTTATCCGCCAGGAGTTCCACCTCGCCAAAGAGATGGGCTGCAACTTCATCCGCC
TGGGGCATTACCAGGGATCCCGCCTCGCGCTCCAGATGGCCGACGAACTCGGCCTCGTGGTCTGGGAAGAGATCCCCTGG
TGCCGCGGCGGCGTGGGCGGCGAACAGTATCGCGAGCAGGCGCGCCGCATGCTCCGCAATATGATCGACCAGCACCGCAA
CCACCCCTCGGTGATCTTCTGGGGCCTCGGCAACGAGAACGATTGGCCCGGCGATTTCGAGGTCTTCGACGAAAAGGCCG
TGCGCGCCTTCATGAGCGAGCTCAACGAAATCGCCCACAAAGCCGACCCCTCGCGCATGACCGCAATCCGCCGCTGCCCC
TTCGCCGCCGACGTTCCCGACGTCTACTCGCCCTCCATCTGGGCCGGTTGGTATAGCGGCCGCTATACCGAATACAAGGC
TTCCACCGAGAAGGAGGCCAAAAAGATCGATCGCATGCTGCACATCGAGTGGGGCGGCGATAGTCACGCCCGCCGCCACT
CCGAAGATCCCGACACCGTGATCGCCAAAATCTCCACCGGCCAGGGCGTCGAGGAAAAGGATCGCGCCTACCTGCTGACC
GGCGGCACCACCCGCGCCTCCAAGGACGGCGATTGGAGCGAGACTTACATCTGCAACCTCTTCGACTGGCACCTCAAAGA
GCAGGAGACTATGGATTTCCTGCCCGGCAGCGCCATGTGGGTCTTCAAAGATTTCTCCACGCCGCTGCGCCCGGAAAATC
CCGTCCCTCGCATGAACCAGAAGGGCGTGGTGGAGCGCGACATGACGCCCAAGGAAGGCTACTACGTCTTCCAGTCATAC
TGGGCCGAAAAGCCCATGGCACGCATTTACGGCCACACCTGGCCGATCCGATGGGGCGCCGCCGGCGAGCAGAAGATGGT
CAAGGTCTACTCCAACTGCGCCTCCGCCGAGCTCTTTCTCAATGGCAAATCCTGCGGCGTGAAGCAGCGCAATAGTCAGG
ACTTCCCGTGCGCCGGATTGCGCTGGATGGTCCCCTTCCAGGCCGGCGAAAATCATCTGCGCGTGGTCGCCGCCAAAGGC
GCGGTGAAAGTCGCCGACGAGACCCGCTTCCGCTACCAGATCGAGAAGTGGGACAAGCCCGCCAAATTCGTCCTCGAAGA
GACCGGCCGCGAAGGCGCCGTGGTCACCCTACAGGCCCGCCTGCTGGATGCCAAGGGTGTCCAGTGCCTGGACGCGCGCA
CCGCCGTCCGTTTTGCGATCGCCGGCGATGGCGAACTGCTCCAGAACCTCGGGACCTCGACCGGTTCCCGCCAGGTGGAA
CTCTACAACGGCCGCGCCATCATTCGGGCGCGCTTGAAGCCGGGCGAAGCCGCGGTCACCGTCTCCGCGGAAAAACTGCC
GACCGCCCTCTTGACGGTCAAGACTTAA

Upstream 100 bases:

>100_bases
TGTCGAGCCGCTCCTTCTTCGCCGCAATCGAAGCCAGCACCGGATCCATGCGCTCTCAGGCATACCACGCGTGGGATGTT
TTCACAAATATAGCGTTAAA

Downstream 100 bases:

>100_bases
CCCCACAGGCGGCAGCCAGGCCGCCTGTTATGCTAGCGTCATAAACAGGAATGCGACTTTTCCGTCCATTGAAAACCGGC
CTGATGACCGCCGCGCTCTG

Product: glycoside hydrolase family protein

Products: NA

Alternate protein names: Beta-gal; Lactase [H]

Number of amino acids: Translated: 835; Mature: 835

Protein sequence:

>835_residues
MVSDMNLRKSPASGLTRRELFQAASAVIAGAALTSTSSAATGAPTVRRLTTGWEHYRGGLGGVWEVWRGKAASDNVAWDT
VAIPHCFNAFDAVDPDHAYYEGPGWYRTSFMPQNPFPNGRILLHFEGAGQKSEVFVGLERAGAHVGGYDEFTIDITDAAA
RAAKRPDAKGQVQLAVLCDNSRNPEMIPSDLSDFNRYGGLYRHVNLAYAPAISIEHVQIDSTTVAGKSDVSVKARLYNPG
GLKDAVQVEITVTDAAGKAVHTSTKSLPAWTGEQELASFPVANPALWSPKTPNLYRCSVTVKSPHGEQQVEDRFGLRWFE
FPKKGLFHLNGEKLFLRGTQRHEDHAGLAAALTDDLIRQEFHLAKEMGCNFIRLGHYQGSRLALQMADELGLVVWEEIPW
CRGGVGGEQYREQARRMLRNMIDQHRNHPSVIFWGLGNENDWPGDFEVFDEKAVRAFMSELNEIAHKADPSRMTAIRRCP
FAADVPDVYSPSIWAGWYSGRYTEYKASTEKEAKKIDRMLHIEWGGDSHARRHSEDPDTVIAKISTGQGVEEKDRAYLLT
GGTTRASKDGDWSETYICNLFDWHLKEQETMDFLPGSAMWVFKDFSTPLRPENPVPRMNQKGVVERDMTPKEGYYVFQSY
WAEKPMARIYGHTWPIRWGAAGEQKMVKVYSNCASAELFLNGKSCGVKQRNSQDFPCAGLRWMVPFQAGENHLRVVAAKG
AVKVADETRFRYQIEKWDKPAKFVLEETGREGAVVTLQARLLDAKGVQCLDARTAVRFAIAGDGELLQNLGTSTGSRQVE
LYNGRAIIRARLKPGEAAVTVSAEKLPTALLTVKT

Sequences:

>Translated_835_residues
MVSDMNLRKSPASGLTRRELFQAASAVIAGAALTSTSSAATGAPTVRRLTTGWEHYRGGLGGVWEVWRGKAASDNVAWDT
VAIPHCFNAFDAVDPDHAYYEGPGWYRTSFMPQNPFPNGRILLHFEGAGQKSEVFVGLERAGAHVGGYDEFTIDITDAAA
RAAKRPDAKGQVQLAVLCDNSRNPEMIPSDLSDFNRYGGLYRHVNLAYAPAISIEHVQIDSTTVAGKSDVSVKARLYNPG
GLKDAVQVEITVTDAAGKAVHTSTKSLPAWTGEQELASFPVANPALWSPKTPNLYRCSVTVKSPHGEQQVEDRFGLRWFE
FPKKGLFHLNGEKLFLRGTQRHEDHAGLAAALTDDLIRQEFHLAKEMGCNFIRLGHYQGSRLALQMADELGLVVWEEIPW
CRGGVGGEQYREQARRMLRNMIDQHRNHPSVIFWGLGNENDWPGDFEVFDEKAVRAFMSELNEIAHKADPSRMTAIRRCP
FAADVPDVYSPSIWAGWYSGRYTEYKASTEKEAKKIDRMLHIEWGGDSHARRHSEDPDTVIAKISTGQGVEEKDRAYLLT
GGTTRASKDGDWSETYICNLFDWHLKEQETMDFLPGSAMWVFKDFSTPLRPENPVPRMNQKGVVERDMTPKEGYYVFQSY
WAEKPMARIYGHTWPIRWGAAGEQKMVKVYSNCASAELFLNGKSCGVKQRNSQDFPCAGLRWMVPFQAGENHLRVVAAKG
AVKVADETRFRYQIEKWDKPAKFVLEETGREGAVVTLQARLLDAKGVQCLDARTAVRFAIAGDGELLQNLGTSTGSRQVE
LYNGRAIIRARLKPGEAAVTVSAEKLPTALLTVKT
>Mature_835_residues
MVSDMNLRKSPASGLTRRELFQAASAVIAGAALTSTSSAATGAPTVRRLTTGWEHYRGGLGGVWEVWRGKAASDNVAWDT
VAIPHCFNAFDAVDPDHAYYEGPGWYRTSFMPQNPFPNGRILLHFEGAGQKSEVFVGLERAGAHVGGYDEFTIDITDAAA
RAAKRPDAKGQVQLAVLCDNSRNPEMIPSDLSDFNRYGGLYRHVNLAYAPAISIEHVQIDSTTVAGKSDVSVKARLYNPG
GLKDAVQVEITVTDAAGKAVHTSTKSLPAWTGEQELASFPVANPALWSPKTPNLYRCSVTVKSPHGEQQVEDRFGLRWFE
FPKKGLFHLNGEKLFLRGTQRHEDHAGLAAALTDDLIRQEFHLAKEMGCNFIRLGHYQGSRLALQMADELGLVVWEEIPW
CRGGVGGEQYREQARRMLRNMIDQHRNHPSVIFWGLGNENDWPGDFEVFDEKAVRAFMSELNEIAHKADPSRMTAIRRCP
FAADVPDVYSPSIWAGWYSGRYTEYKASTEKEAKKIDRMLHIEWGGDSHARRHSEDPDTVIAKISTGQGVEEKDRAYLLT
GGTTRASKDGDWSETYICNLFDWHLKEQETMDFLPGSAMWVFKDFSTPLRPENPVPRMNQKGVVERDMTPKEGYYVFQSY
WAEKPMARIYGHTWPIRWGAAGEQKMVKVYSNCASAELFLNGKSCGVKQRNSQDFPCAGLRWMVPFQAGENHLRVVAAKG
AVKVADETRFRYQIEKWDKPAKFVLEETGREGAVVTLQARLLDAKGVQCLDARTAVRFAIAGDGELLQNLGTSTGSRQVE
LYNGRAIIRARLKPGEAAVTVSAEKLPTALLTVKT

Specific function: Unknown

COG id: COG3250

COG function: function code G; Beta-galactosidase/beta-glucuronidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI268834192, Length=565, Percent_Identity=23.3628318584071, Blast_Score=101, Evalue=3e-21,
Organism=Escherichia coli, GI1787903, Length=621, Percent_Identity=25.6038647342995, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1786539, Length=282, Percent_Identity=27.6595744680851, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI48994920, Length=355, Percent_Identity=23.943661971831, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17510825, Length=594, Percent_Identity=22.8956228956229, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24651745, Length=646, Percent_Identity=24.4582043343653, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24655438, Length=646, Percent_Identity=23.374613003096, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI19922582, Length=646, Percent_Identity=23.374613003096, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI62471735, Length=646, Percent_Identity=23.374613003096, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003344
- InterPro:   IPR008979
- InterPro:   IPR006101
- InterPro:   IPR013812
- InterPro:   IPR006104
- InterPro:   IPR006102
- InterPro:   IPR006103
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00703 Glyco_hydro_2; PF02836 Glyco_hydro_2_C; PF02837 Glyco_hydro_2_N [H]

EC number: =3.2.1.23 [H]

Molecular weight: Translated: 92927; Mature: 92927

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSDMNLRKSPASGLTRRELFQAASAVIAGAALTSTSSAATGAPTVRRLTTGWEHYRGGL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHCCCC
GGVWEVWRGKAASDNVAWDTVAIPHCFNAFDAVDPDHAYYEGPGWYRTSFMPQNPFPNGR
CCHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCEECCCCEEEECCCCCCCCCCCE
ILLHFEGAGQKSEVFVGLERAGAHVGGYDEFTIDITDAAARAAKRPDAKGQVQLAVLCDN
EEEEECCCCCCCEEEEEHHHCCCCCCCCCEEEEEECHHHHHHHCCCCCCCCEEEEEEECC
SRNPEMIPSDLSDFNRYGGLYRHVNLAYAPAISIEHVQIDSTTVAGKSDVSVKARLYNPG
CCCCCCCCCHHHHHHHHCCEEEEEEEEEECCEEEEEEEECCEEECCCCCCEEEEEEECCC
GLKDAVQVEITVTDAAGKAVHTSTKSLPAWTGEQELASFPVANPALWSPKTPNLYRCSVT
CCCCEEEEEEEEECCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEE
VKSPHGEQQVEDRFGLRWFEFPKKGLFHLNGEKLFLRGTQRHEDHAGLAAALTDDLIRQE
EECCCCHHHHHHHHCCEEEECCCCCCEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
FHLAKEMGCNFIRLGHYQGSRLALQMADELGLVVWEEIPWCRGGVGGEQYREQARRMLRN
HHHHHHHCCCEEEEECCCCCEEEEEEHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
MIDQHRNHPSVIFWGLGNENDWPGDFEVFDEKAVRAFMSELNEIAHKADPSRMTAIRRCP
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
FAADVPDVYSPSIWAGWYSGRYTEYKASTEKEAKKIDRMLHIEWGGDSHARRHSEDPDTV
CCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHCEEEEEEECCCCHHHCCCCCCCEE
IAKISTGQGVEEKDRAYLLTGGTTRASKDGDWSETYICNLFDWHLKEQETMDFLPGSAMW
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEHEHHCCCCHHHHCCCCCEEE
VFKDFSTPLRPENPVPRMNQKGVVERDMTPKEGYYVFQSYWAEKPMARIYGHTWPIRWGA
EEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEHHHHHHCCCCHHHHCCCCCCEEECC
AGEQKMVKVYSNCASAELFLNGKSCGVKQRNSQDFPCAGLRWMVPFQAGENHLRVVAAKG
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECC
AVKVADETRFRYQIEKWDKPAKFVLEETGREGAVVTLQARLLDAKGVQCLDARTAVRFAI
CEEECCCCEEEEEEHHCCCCHHHHHHHCCCCCCEEEEEEEEECCCCCEEEECCEEEEEEE
AGDGELLQNLGTSTGSRQVELYNGRAIIRARLKPGEAAVTVSAEKLPTALLTVKT
ECCHHHHHHCCCCCCCEEEEEECCEEEEEEECCCCCEEEEEEHHHCCEEEEEECC
>Mature Secondary Structure
MVSDMNLRKSPASGLTRRELFQAASAVIAGAALTSTSSAATGAPTVRRLTTGWEHYRGGL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHCCCC
GGVWEVWRGKAASDNVAWDTVAIPHCFNAFDAVDPDHAYYEGPGWYRTSFMPQNPFPNGR
CCHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCEECCCCEEEECCCCCCCCCCCE
ILLHFEGAGQKSEVFVGLERAGAHVGGYDEFTIDITDAAARAAKRPDAKGQVQLAVLCDN
EEEEECCCCCCCEEEEEHHHCCCCCCCCCEEEEEECHHHHHHHCCCCCCCCEEEEEEECC
SRNPEMIPSDLSDFNRYGGLYRHVNLAYAPAISIEHVQIDSTTVAGKSDVSVKARLYNPG
CCCCCCCCCHHHHHHHHCCEEEEEEEEEECCEEEEEEEECCEEECCCCCCEEEEEEECCC
GLKDAVQVEITVTDAAGKAVHTSTKSLPAWTGEQELASFPVANPALWSPKTPNLYRCSVT
CCCCEEEEEEEEECCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEE
VKSPHGEQQVEDRFGLRWFEFPKKGLFHLNGEKLFLRGTQRHEDHAGLAAALTDDLIRQE
EECCCCHHHHHHHHCCEEEECCCCCCEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
FHLAKEMGCNFIRLGHYQGSRLALQMADELGLVVWEEIPWCRGGVGGEQYREQARRMLRN
HHHHHHHCCCEEEEECCCCCEEEEEEHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
MIDQHRNHPSVIFWGLGNENDWPGDFEVFDEKAVRAFMSELNEIAHKADPSRMTAIRRCP
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
FAADVPDVYSPSIWAGWYSGRYTEYKASTEKEAKKIDRMLHIEWGGDSHARRHSEDPDTV
CCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHCEEEEEEECCCCHHHCCCCCCCEE
IAKISTGQGVEEKDRAYLLTGGTTRASKDGDWSETYICNLFDWHLKEQETMDFLPGSAMW
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEHEHHCCCCHHHHCCCCCEEE
VFKDFSTPLRPENPVPRMNQKGVVERDMTPKEGYYVFQSYWAEKPMARIYGHTWPIRWGA
EEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEHHHHHHCCCCHHHHCCCCCCEEECC
AGEQKMVKVYSNCASAELFLNGKSCGVKQRNSQDFPCAGLRWMVPFQAGENHLRVVAAKG
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECC
AVKVADETRFRYQIEKWDKPAKFVLEETGREGAVVTLQARLLDAKGVQCLDARTAVRFAI
CEEECCCCEEEEEEHHCCCCHHHHHHHCCCCCCEEEEEEEEECCCCCEEEECCEEEEEEE
AGDGELLQNLGTSTGSRQVELYNGRAIIRARLKPGEAAVTVSAEKLPTALLTVKT
ECCHHHHHHCCCCCCCEEEEEECCEEEEEEECCCCCEEEEEEHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA