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The map label for this gene is yahK [H]

Identifier: 116624909

GI number: 116624909

Start: 7308716

End: 7309774

Strand: Direct

Name: yahK [H]

Synonym: Acid_5835

Alternate gene names: 116624909

Gene position: 7308716-7309774 (Clockwise)

Preceding gene: 116624908

Following gene: 116624910

Centisome position: 73.34

GC content: 60.91

Gene sequence:

>1059_bases
ATGTATAAGGCGAAGGCTTATTCGGCCGGCAGCGCGACCTCGCCGCTGGCTTCCACGACGATCGCACGCCGGGATCCGAC
CGAGCACGATGTCCAGATCGAAATTCTCTTCTGCGGCATTTGCCATTCGGATCTGCACCAGGTGCGTAATGAGTGGAGCG
GCGTGATGCCGACAGTGTACCCGTGTGTCCCGGGCCATGAGATCGTCGGACGGGTGACGGGGGTGGGCTCGGCAGTCAAG
GGGTTCAAGGCCGGCGATTTGGCGGCGGTCGGCTGCATGGTGGATTCCGACGGCACCTGCAAGGAGTGCCAGGCCGGCCT
CGAGCAGTTCTGCCCCAATTTTACTCTGACCTACAACTTCCCCGATAAGCACCTCGGCGGTGTGACGTACGGCGGGTACT
CGGAAAGCGTGGTGGTGGATCAGCGCTTTGTGCTTCACGTTCCCGCCAACCTGGGTCTTGCCGGAACCGCTCCGCTTCTC
TGCGCCGGGATCACGACATACTCGCCGATGCGCCACTGGGGCGTCACAAAAGGCAAGAAGGTGGGCGTAGTGGGACTGGG
GGGATTAGGCCACATGGGCGTGAAGTTCGCGCACGCGCTGGGCGCCCACGTGATTGTGTTCACGACCTCACCCAAGAAGA
AGGAGGATGCCATACGACTCGGCGCCGATGAAGTTGTGGTCTCGCGCAATGCCGACGAGATGACGAAGCATGCCGGCAGT
TTCGACTTCATCCTGGACGCCGTCTCCGCGGATCACGACATCAACGCTTACATTCAACTGCTGGCACGCGACGGCAACCT
CACCCTGGTGGGCGCGCCGGAGAAGCCGATGGCGGTCTCGGCATTCGGGCTGATCATGGGACGCCGCAGCCTCTCGGGGT
CACCGATAGGCGGCATTCGGGAGACTCAGGAGATGCTCGATTTTTGCGGAGCGCACGGCATCACGGCGGATGTGGAAGTG
ATCCCGATCCAGAAGGTCAACGAAGCTTACGAAAGGCTGCTCAAGACCGATGTGAAGTATCGCTTCTCAATCGATATGGC
TTCTCTGAAATCGGAGTAG

Upstream 100 bases:

>100_bases
AGATCGCGGTGCAGGGAGCTCGATATCCCGAGCATATCGAGCAAATGACGGGCCGCTAGATTTCCGATGGCGCATAAACT
ACTGAAAGGAGCATTTATAC

Downstream 100 bases:

>100_bases
GACCCGGAAGGCGGATAATGGGTGCCATGTCGGAAAGCGATATCACCCACGTCAGCGACACCGCCCTGATGGTAGCCGCG
TGCCGGGCTCTCGAATTCGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MYKAKAYSAGSATSPLASTTIARRDPTEHDVQIEILFCGICHSDLHQVRNEWSGVMPTVYPCVPGHEIVGRVTGVGSAVK
GFKAGDLAAVGCMVDSDGTCKECQAGLEQFCPNFTLTYNFPDKHLGGVTYGGYSESVVVDQRFVLHVPANLGLAGTAPLL
CAGITTYSPMRHWGVTKGKKVGVVGLGGLGHMGVKFAHALGAHVIVFTTSPKKKEDAIRLGADEVVVSRNADEMTKHAGS
FDFILDAVSADHDINAYIQLLARDGNLTLVGAPEKPMAVSAFGLIMGRRSLSGSPIGGIRETQEMLDFCGAHGITADVEV
IPIQKVNEAYERLLKTDVKYRFSIDMASLKSE

Sequences:

>Translated_352_residues
MYKAKAYSAGSATSPLASTTIARRDPTEHDVQIEILFCGICHSDLHQVRNEWSGVMPTVYPCVPGHEIVGRVTGVGSAVK
GFKAGDLAAVGCMVDSDGTCKECQAGLEQFCPNFTLTYNFPDKHLGGVTYGGYSESVVVDQRFVLHVPANLGLAGTAPLL
CAGITTYSPMRHWGVTKGKKVGVVGLGGLGHMGVKFAHALGAHVIVFTTSPKKKEDAIRLGADEVVVSRNADEMTKHAGS
FDFILDAVSADHDINAYIQLLARDGNLTLVGAPEKPMAVSAFGLIMGRRSLSGSPIGGIRETQEMLDFCGAHGITADVEV
IPIQKVNEAYERLLKTDVKYRFSIDMASLKSE
>Mature_352_residues
MYKAKAYSAGSATSPLASTTIARRDPTEHDVQIEILFCGICHSDLHQVRNEWSGVMPTVYPCVPGHEIVGRVTGVGSAVK
GFKAGDLAAVGCMVDSDGTCKECQAGLEQFCPNFTLTYNFPDKHLGGVTYGGYSESVVVDQRFVLHVPANLGLAGTAPLL
CAGITTYSPMRHWGVTKGKKVGVVGLGGLGHMGVKFAHALGAHVIVFTTSPKKKEDAIRLGADEVVVSRNADEMTKHAGS
FDFILDAVSADHDINAYIQLLARDGNLTLVGAPEKPMAVSAFGLIMGRRSLSGSPIGGIRETQEMLDFCGAHGITADVEV
IPIQKVNEAYERLLKTDVKYRFSIDMASLKSE

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=27.5675675675676, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=27.6422764227642, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=26.9021739130435, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=25.6, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=59.8853868194842, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI87082401, Length=346, Percent_Identity=34.6820809248555, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=26.517571884984, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI226510992, Length=320, Percent_Identity=27.5, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790045, Length=355, Percent_Identity=26.1971830985915, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788073, Length=259, Percent_Identity=27.7992277992278, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788407, Length=274, Percent_Identity=25.9124087591241, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=25.2225519287834, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=25.9475218658892, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=352, Percent_Identity=24.4318181818182, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=212, Percent_Identity=31.1320754716981, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=332, Percent_Identity=25.6024096385542, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=334, Percent_Identity=25.4491017964072, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=202, Percent_Identity=28.7128712871287, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=331, Percent_Identity=36.2537764350453, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6319949, Length=326, Percent_Identity=35.2760736196319, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323961, Length=331, Percent_Identity=29.9093655589124, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324486, Length=331, Percent_Identity=28.3987915407855, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=354, Percent_Identity=27.683615819209, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=331, Percent_Identity=27.190332326284, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=27.2, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=313, Percent_Identity=26.1980830670927, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=24.7282608695652, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 37544; Mature: 37544

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKAKAYSAGSATSPLASTTIARRDPTEHDVQIEILFCGICHSDLHQVRNEWSGVMPTVY
CCCCCCCCCCCCCCCHHHHHECCCCCCCCCEEEEEEEEECCHHHHHHHHHHHCCCCCEEE
PCVPGHEIVGRVTGVGSAVKGFKAGDLAAVGCMVDSDGTCKECQAGLEQFCPNFTLTYNF
CCCCCHHHHHHHHCCCHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECC
PDKHLGGVTYGGYSESVVVDQRFVLHVPANLGLAGTAPLLCAGITTYSPMRHWGVTKGKK
CHHHCCCEEECCCCCEEEECCEEEEEECCCCCCCCCCHHHHHCCCCCCCHHHCCCCCCCE
VGVVGLGGLGHMGVKFAHALGAHVIVFTTSPKKKEDAIRLGADEVVVSRNADEMTKHAGS
EEEEEECCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCCEEEEECCHHHHHHHCCC
FDFILDAVSADHDINAYIQLLARDGNLTLVGAPEKPMAVSAFGLIMGRRSLSGSPIGGIR
HHHHHHHHCCCCCHHEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHH
ETQEMLDFCGAHGITADVEVIPIQKVNEAYERLLKTDVKYRFSIDMASLKSE
HHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCEEEEEEEHHHHCCC
>Mature Secondary Structure
MYKAKAYSAGSATSPLASTTIARRDPTEHDVQIEILFCGICHSDLHQVRNEWSGVMPTVY
CCCCCCCCCCCCCCCHHHHHECCCCCCCCCEEEEEEEEECCHHHHHHHHHHHCCCCCEEE
PCVPGHEIVGRVTGVGSAVKGFKAGDLAAVGCMVDSDGTCKECQAGLEQFCPNFTLTYNF
CCCCCHHHHHHHHCCCHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECC
PDKHLGGVTYGGYSESVVVDQRFVLHVPANLGLAGTAPLLCAGITTYSPMRHWGVTKGKK
CHHHCCCEEECCCCCEEEECCEEEEEECCCCCCCCCCHHHHHCCCCCCCHHHCCCCCCCE
VGVVGLGGLGHMGVKFAHALGAHVIVFTTSPKKKEDAIRLGADEVVVSRNADEMTKHAGS
EEEEEECCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCCEEEEECCHHHHHHHCCC
FDFILDAVSADHDINAYIQLLARDGNLTLVGAPEKPMAVSAFGLIMGRRSLSGSPIGGIR
HHHHHHHHCCCCCHHEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHH
ETQEMLDFCGAHGITADVEVIPIQKVNEAYERLLKTDVKYRFSIDMASLKSE
HHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCEEEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]