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The map label for this gene is pyrC

Identifier: 116624589

GI number: 116624589

Start: 6913363

End: 6914655

Strand: Direct

Name: pyrC

Synonym: Acid_5513

Alternate gene names: 116624589

Gene position: 6913363-6914655 (Clockwise)

Preceding gene: 116624588

Following gene: 116624590

Centisome position: 69.37

GC content: 65.51

Gene sequence:

>1293_bases
ATGCCGATCGTGATCAGGAACGGACGGGTCATCGACCCTGCATCGAACACGGACCGCGTCGCCGACGTGTTCATTGTCGA
TGGACGCATCGCCGGCGTCGCCCCGAATCTCTCTTCCCCCAAGGCCGAAGTCTTCGACGCCACCGGCATGATCGTTGCGC
CTGGCTTTATCGATATGCACGTGCACCTGCGCGAGCCGGGTTTCGAACACGCCGAAACCATCGAGAGCGGCTCCCGCGCC
GCCGCCGCCGGAGGCTTCACCTCCATCTGCTGCATGCCCAACACGAAGCCGGTCAACGATAGCGCCATGGTGACCAGCTA
CATCGTGGAGCAGGCGCGCAGCAAGGCCGCGGTCAACGTCTTTCCCATCGGCGCCATCACCAAAGGCAGCGCCGGCGAAG
AACTCGCCGCCATCGGCGCCATGAAAGCCGCGGGCGCCGTCGCCATCTCAGACGACGGACTCCCCGTGATGAACGCCCGC
GTCATGCGCCGTGCCATGGAGTTTGCGCGCAGCTACGACCTCCCCATCATCCAGCACTGCGAAGATCTCAACCTCAGCGC
CGGCGGCGACATGCACGAAGGCGCCAACAGCGTCCGCTGGGGACTCCGCGGCATTCCTGCGGCCAGTGAAGATGTCATGG
TCGCCCGCGATCTCGTGCTCGCCCAGTTGACCGGCGCGCGCTATCACGTCGCCCACATCTCCACCCGCAACGCCGTCGCC
ATGGTCGAATACGGTCGCAGTCACGGCCTTCCCGTCACCTGCGAGACCACGCCGCACCACTTCGGCCTCGCCGATGCCGA
CATGGCGCCCTACGATTCCAACTATAAGATGAAGCCGCCCCTCCGCTCCTGCGGCCACCGCGACGCCATCATCGAAGGCC
TCATCGCCGGCACCATCTCCGCCATCGCCACCGACCACGCCCCTCATCCGGGGTCCGAGAAAATGCAGGAGTTCGAACGC
TGCCCCTTCGGCATCATCGGCCTCGAAACCGCCCTCGCCCTCGCCCTTGAGGAACTCGTAGCACCTGGGAAGATCACCCT
CGCCCGCCTGATCGAGCTATTCACCACCGGCCCCGAATCCGTCATGCGCCTCGGCCGCGGCACCCTAACCCCCGGCGCCC
CCGGCGACGTCACCGTCTTCAGCCCCACAGTAGAGTGGACCTACGACGTCAACCAGTCCGCCTCCCGCAGCCGCAACTCC
CCCTTCCACGCCCGCACTTTTCACGGCGGTCCGATGGCCACCATCGTGAACGGCGGCCTCAAGTGGTCTCGACAATCATC
ACACATCACTTAG

Upstream 100 bases:

>100_bases
TCCAGCGAGGTGGCCGATTTCCAGCGTTCCGTGATCCTCAATCAGGTCGAAAACGGTATCGCGGTACGTATGGCGGTGCT
CGAAAAGGTGATTGGATAGC

Downstream 100 bases:

>100_bases
CGTGATGCGTGATGCGCTACAATGAAGTCATGCGTACGACACTGGATCTTGATGACGACCTTTTGGCCGCGGCAAAACCG
CTAGCTCGTCAGCAAGGCGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MPIVIRNGRVIDPASNTDRVADVFIVDGRIAGVAPNLSSPKAEVFDATGMIVAPGFIDMHVHLREPGFEHAETIESGSRA
AAAGGFTSICCMPNTKPVNDSAMVTSYIVEQARSKAAVNVFPIGAITKGSAGEELAAIGAMKAAGAVAISDDGLPVMNAR
VMRRAMEFARSYDLPIIQHCEDLNLSAGGDMHEGANSVRWGLRGIPAASEDVMVARDLVLAQLTGARYHVAHISTRNAVA
MVEYGRSHGLPVTCETTPHHFGLADADMAPYDSNYKMKPPLRSCGHRDAIIEGLIAGTISAIATDHAPHPGSEKMQEFER
CPFGIIGLETALALALEELVAPGKITLARLIELFTTGPESVMRLGRGTLTPGAPGDVTVFSPTVEWTYDVNQSASRSRNS
PFHARTFHGGPMATIVNGGLKWSRQSSHIT

Sequences:

>Translated_430_residues
MPIVIRNGRVIDPASNTDRVADVFIVDGRIAGVAPNLSSPKAEVFDATGMIVAPGFIDMHVHLREPGFEHAETIESGSRA
AAAGGFTSICCMPNTKPVNDSAMVTSYIVEQARSKAAVNVFPIGAITKGSAGEELAAIGAMKAAGAVAISDDGLPVMNAR
VMRRAMEFARSYDLPIIQHCEDLNLSAGGDMHEGANSVRWGLRGIPAASEDVMVARDLVLAQLTGARYHVAHISTRNAVA
MVEYGRSHGLPVTCETTPHHFGLADADMAPYDSNYKMKPPLRSCGHRDAIIEGLIAGTISAIATDHAPHPGSEKMQEFER
CPFGIIGLETALALALEELVAPGKITLARLIELFTTGPESVMRLGRGTLTPGAPGDVTVFSPTVEWTYDVNQSASRSRNS
PFHARTFHGGPMATIVNGGLKWSRQSSHIT
>Mature_429_residues
PIVIRNGRVIDPASNTDRVADVFIVDGRIAGVAPNLSSPKAEVFDATGMIVAPGFIDMHVHLREPGFEHAETIESGSRAA
AAGGFTSICCMPNTKPVNDSAMVTSYIVEQARSKAAVNVFPIGAITKGSAGEELAAIGAMKAAGAVAISDDGLPVMNARV
MRRAMEFARSYDLPIIQHCEDLNLSAGGDMHEGANSVRWGLRGIPAASEDVMVARDLVLAQLTGARYHVAHISTRNAVAM
VEYGRSHGLPVTCETTPHHFGLADADMAPYDSNYKMKPPLRSCGHRDAIIEGLIAGTISAIATDHAPHPGSEKMQEFERC
PFGIIGLETALALALEELVAPGKITLARLIELFTTGPESVMRLGRGTLTPGAPGDVTVFSPTVEWTYDVNQSASRSRNSP
FHARTFHGGPMATIVNGGLKWSRQSSHIT

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=400, Percent_Identity=27.25, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI19923821, Length=445, Percent_Identity=24.9438202247191, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4503051, Length=447, Percent_Identity=23.489932885906, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI62422571, Length=447, Percent_Identity=23.489932885906, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786722, Length=434, Percent_Identity=28.110599078341, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI87082175, Length=452, Percent_Identity=26.3274336283186, Blast_Score=111, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=412, Percent_Identity=29.3689320388349, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71989490, Length=452, Percent_Identity=25.4424778761062, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI86575075, Length=436, Percent_Identity=23.394495412844, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322218, Length=389, Percent_Identity=22.879177377892, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24642586, Length=409, Percent_Identity=28.361858190709, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_SOLUE (Q01V55)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_826745.1
- ProteinModelPortal:   Q01V55
- STRING:   Q01V55
- GeneID:   4426273
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_5513
- NMPDR:   fig|234267.9.peg.5241
- eggNOG:   COG0044
- HOGENOM:   HBG724623
- OMA:   GVMNEGE
- PhylomeDB:   Q01V55
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 45655; Mature: 45523

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVIRNGRVIDPASNTDRVADVFIVDGRIAGVAPNLSSPKAEVFDATGMIVAPGFIDMH
CCEEECCCEEECCCCCCCCEEEEEEECCEEEEECCCCCCCCHHHCCCCCCEEECCEEEEE
VHLREPGFEHAETIESGSRAAAAGGFTSICCMPNTKPVNDSAMVTSYIVEQARSKAAVNV
EEECCCCCHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEE
FPIGAITKGSAGEELAAIGAMKAAGAVAISDDGLPVMNARVMRRAMEFARSYDLPIIQHC
EECCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHC
EDLNLSAGGDMHEGANSVRWGLRGIPAASEDVMVARDLVLAQLTGARYHVAHISTRNAVA
CCCCCCCCCCHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEE
MVEYGRSHGLPVTCETTPHHFGLADADMAPYDSNYKMKPPLRSCGHRDAIIEGLIAGTIS
EEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEECCCHHHCCCHHHHHHHHHHHHHH
AIATDHAPHPGSEKMQEFERCPFGIIGLETALALALEELVAPGKITLARLIELFTTGPES
HHHCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
VMRLGRGTLTPGAPGDVTVFSPTVEWTYDVNQSASRSRNSPFHARTFHGGPMATIVNGGL
HHHHCCCCCCCCCCCCEEEEECCEEEEEECCCCHHHCCCCCCEEEEECCCCEEEEEECCC
KWSRQSSHIT
CCCCCCCCCC
>Mature Secondary Structure 
PIVIRNGRVIDPASNTDRVADVFIVDGRIAGVAPNLSSPKAEVFDATGMIVAPGFIDMH
CEEECCCEEECCCCCCCCEEEEEEECCEEEEECCCCCCCCHHHCCCCCCEEECCEEEEE
VHLREPGFEHAETIESGSRAAAAGGFTSICCMPNTKPVNDSAMVTSYIVEQARSKAAVNV
EEECCCCCHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEE
FPIGAITKGSAGEELAAIGAMKAAGAVAISDDGLPVMNARVMRRAMEFARSYDLPIIQHC
EECCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHC
EDLNLSAGGDMHEGANSVRWGLRGIPAASEDVMVARDLVLAQLTGARYHVAHISTRNAVA
CCCCCCCCCCHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEE
MVEYGRSHGLPVTCETTPHHFGLADADMAPYDSNYKMKPPLRSCGHRDAIIEGLIAGTIS
EEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEECCCHHHCCCHHHHHHHHHHHHHH
AIATDHAPHPGSEKMQEFERCPFGIIGLETALALALEELVAPGKITLARLIELFTTGPES
HHHCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
VMRLGRGTLTPGAPGDVTVFSPTVEWTYDVNQSASRSRNSPFHARTFHGGPMATIVNGGL
HHHHCCCCCCCCCCCCEEEEECCEEEEEECCCCHHHCCCCCCEEEEECCCCEEEEEECCC
KWSRQSSHIT
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA