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The map label for this gene is pyrB

Identifier: 116624588

GI number: 116624588

Start: 6912453

End: 6913361

Strand: Direct

Name: pyrB

Synonym: Acid_5512

Alternate gene names: 116624588

Gene position: 6912453-6913361 (Clockwise)

Preceding gene: 116624587

Following gene: 116624589

Centisome position: 69.36

GC content: 62.93

Gene sequence:

>909_bases
ATGCCAGCCGGACTACTCGGAATCGAGGAGTTGGGCCGCGCCGAGATCGAAGCCATCCTGTCGCGAGCCAAGGATTTTCA
GCCGCTGCAGAGCCAGAGCTTGAAAAAACTGGACACCCTGCGCGGCAAGATGATCGTCAATCTCTTCTTCGAAGCCTCCA
CCCGTACCCGGACCAGCTTCGAGATCGCCGCCAAGCGTCTCGGCGCCGACGCCATCTCCATCACTGCGTCAGGCTCCAGC
GTATCCAAGGGCGAATCGCTCGTCGATACCCTGAACACCCTCGGCGCCATGCGCCCTGACGCCATCGTGATGCGCCACTC
CGCCAGCGGCGCTCCGCATTTTCTGGCACGCTACCTGCCCACGCCAATCATCAACGCGGGCGACGGTACTCACGAACATC
CGACCCAGGCGCTGCTCGATGCCCGCACCATCCTCGACCGCTGCGGACAGCTCGATGGCCTCAAGGTCGCCATCATCGGC
GATATCGCCCATAGCCGCGTGGCTCGCAGCAATGTCCACCTGCTCAGCAAATTCGGCGCGAAGATCGTGCTCTGCGGCCC
CGCGTCGCTTCTCCCCGTGGAGCTCGCGCAGCTCGCGCCCGGCGTGGTTCTTACCACCGATATCCGCGATGCCATCAAGG
ACGCCGACGTGATCATGATGCTCCGCGTCCAGCTCGAACGCCAGCACGAAGCCTCGTTCCCCGCCAGCGAGTACTTTCGA
TTCTACGGCCTCCAACTCGCCCACCTGGACCTCGCCAAACCCGAGGCCATCGTGATGCACCCCGGCCCCATCAATCGAGG
CCGCGAGCTCTCCAGCGAGGTGGCCGATTTCCAGCGTTCCGTGATCCTCAATCAGGTCGAAAACGGTATCGCGGTACGTA
TGGCGGTGCTCGAAAAGGTGATTGGATAG

Upstream 100 bases:

>100_bases
CCGACACCGAAATCATCGAAGTCAAATTCCAGGAGATAGACGGCATGGAAAAAGTACTGATGGTGGAGAAAGTGGCGGGC
GAGGCGGCATAGGAACCGCC

Downstream 100 bases:

>100_bases
CATGCCGATCGTGATCAGGAACGGACGGGTCATCGACCCTGCATCGAACACGGACCGCGTCGCCGACGTGTTCATTGTCG
ATGGACGCATCGCCGGCGTC

Product: aspartate carbamoyltransferase

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPAGLLGIEELGRAEIEAILSRAKDFQPLQSQSLKKLDTLRGKMIVNLFFEASTRTRTSFEIAAKRLGADAISITASGSS
VSKGESLVDTLNTLGAMRPDAIVMRHSASGAPHFLARYLPTPIINAGDGTHEHPTQALLDARTILDRCGQLDGLKVAIIG
DIAHSRVARSNVHLLSKFGAKIVLCGPASLLPVELAQLAPGVVLTTDIRDAIKDADVIMMLRVQLERQHEASFPASEYFR
FYGLQLAHLDLAKPEAIVMHPGPINRGRELSSEVADFQRSVILNQVENGIAVRMAVLEKVIG

Sequences:

>Translated_302_residues
MPAGLLGIEELGRAEIEAILSRAKDFQPLQSQSLKKLDTLRGKMIVNLFFEASTRTRTSFEIAAKRLGADAISITASGSS
VSKGESLVDTLNTLGAMRPDAIVMRHSASGAPHFLARYLPTPIINAGDGTHEHPTQALLDARTILDRCGQLDGLKVAIIG
DIAHSRVARSNVHLLSKFGAKIVLCGPASLLPVELAQLAPGVVLTTDIRDAIKDADVIMMLRVQLERQHEASFPASEYFR
FYGLQLAHLDLAKPEAIVMHPGPINRGRELSSEVADFQRSVILNQVENGIAVRMAVLEKVIG
>Mature_301_residues
PAGLLGIEELGRAEIEAILSRAKDFQPLQSQSLKKLDTLRGKMIVNLFFEASTRTRTSFEIAAKRLGADAISITASGSSV
SKGESLVDTLNTLGAMRPDAIVMRHSASGAPHFLARYLPTPIINAGDGTHEHPTQALLDARTILDRCGQLDGLKVAIIGD
IAHSRVARSNVHLLSKFGAKIVLCGPASLLPVELAQLAPGVVLTTDIRDAIKDADVIMMLRVQLERQHEASFPASEYFRF
YGLQLAHLDLAKPEAIVMHPGPINRGRELSSEVADFQRSVILNQVENGIAVRMAVLEKVIG

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI18105007, Length=308, Percent_Identity=34.4155844155844, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI38788445, Length=305, Percent_Identity=27.2131147540984, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI2367364, Length=310, Percent_Identity=33.8709677419355, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1786469, Length=323, Percent_Identity=27.2445820433437, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790703, Length=321, Percent_Identity=28.3489096573209, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=325, Percent_Identity=34.1538461538462, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6322331, Length=316, Percent_Identity=36.0759493670886, Blast_Score=168, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24642586, Length=271, Percent_Identity=37.6383763837638, Blast_Score=160, Evalue=9e-40,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): PYRB_SOLUE (Q01V56)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_826744.1
- ProteinModelPortal:   Q01V56
- SMR:   Q01V56
- STRING:   Q01V56
- GeneID:   4426272
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_5512
- NMPDR:   fig|234267.9.peg.5240
- eggNOG:   COG0540
- HOGENOM:   HBG579429
- OMA:   MNRGLEI
- PhylomeDB:   Q01V56
- HAMAP:   MF_00001
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082
- PRINTS:   PR00100
- PRINTS:   PR00101
- TIGRFAMs:   TIGR00670

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.2

Molecular weight: Translated: 32637; Mature: 32506

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAGLLGIEELGRAEIEAILSRAKDFQPLQSQSLKKLDTLRGKMIVNLFFEASTRTRTSF
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHH
EIAAKRLGADAISITASGSSVSKGESLVDTLNTLGAMRPDAIVMRHSASGAPHFLARYLP
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCC
TPIINAGDGTHEHPTQALLDARTILDRCGQLDGLKVAIIGDIAHSRVARSNVHLLSKFGA
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCC
KIVLCGPASLLPVELAQLAPGVVLTTDIRDAIKDADVIMMLRVQLERQHEASFPASEYFR
EEEEECCCCHHHHHHHHHCCCEEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHH
FYGLQLAHLDLAKPEAIVMHPGPINRGRELSSEVADFQRSVILNQVENGIAVRMAVLEKV
HHCCEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IG
HC
>Mature Secondary Structure 
PAGLLGIEELGRAEIEAILSRAKDFQPLQSQSLKKLDTLRGKMIVNLFFEASTRTRTSF
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHH
EIAAKRLGADAISITASGSSVSKGESLVDTLNTLGAMRPDAIVMRHSASGAPHFLARYLP
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCC
TPIINAGDGTHEHPTQALLDARTILDRCGQLDGLKVAIIGDIAHSRVARSNVHLLSKFGA
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCC
KIVLCGPASLLPVELAQLAPGVVLTTDIRDAIKDADVIMMLRVQLERQHEASFPASEYFR
EEEEECCCCHHHHHHHHHCCCEEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHH
FYGLQLAHLDLAKPEAIVMHPGPINRGRELSSEVADFQRSVILNQVENGIAVRMAVLEKV
HHCCEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IG
HC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA