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The map label for this gene is rnr [H]

Identifier: 116624573

GI number: 116624573

Start: 6891899

End: 6893353

Strand: Reverse

Name: rnr [H]

Synonym: Acid_5497

Alternate gene names: 116624573

Gene position: 6893353-6891899 (Counterclockwise)

Preceding gene: 116624574

Following gene: 116624572

Centisome position: 69.17

GC content: 64.33

Gene sequence:

>1455_bases
ATGAACAATCACCAGGTGGACCTGGCCTCGATCGCCAGGCAGGAAATGATTGACCACGGCTTCCAGCCCGACATGCCGCC
GGAAGCCACCCAACAGGCCGAGAAATCGAGCCAAGCGGTGCCCGCCGGACTGAAGGATCTGACCGCGCTGCTGTGGTCTT
CCATCGACAACGACGATTCGCGCGACCTGGACCAGATCGAGTGGGCGGAACGCACGCCTGCGGGAATTCGCGTGCTTGTG
GCGATCGCGGACGTGGATAGCGCGGTCGCGAAGGGTTCGCCAGCCGACCGGCACGCCGCCAGCGAAACGACTTCAGTGTA
CGCGCAGATCCGGACCTTCCCGATGCTGCCGTTGAAGCTCTCCACGGACCGCACGTCGCTCAATGAGAACGAGAATCGCG
CGGCGGTGGTGATCGAGATGACGGTGTGCGCCGAAGGTTCGATCGGCGCCAACAGCATTTATCGCGCGCTGGTTCGCAAT
CGCGCCCAGTTGACCTACAGCGCAGTGGGCGCGTGGCTCGAAGGCAAGGGGTCGATGCCCGCGAAGGTGGCGTCCTCGGC
GGAGTTGCAGCAGCAGCTTCAATTGCAGAACGAAGCGGCGCACTGCATGCGCGCGGCTCGCGACCGATTGGGCGCGCTCA
CGTTCGACCGCGCCGAACTGCAGGCGACCGTGGAGAACGGGAGGGTGAGCGGGATCGATGCGCGCCGCGCGAACACCTCC
TCGCGGCTGATCGAAGATTTCATGATCGGCGCCAACGAAGTGATGGCGCAGACGCTGCGCTCGGCGGGCGTAACGTCCAT
TCGTCGCGTAGTGAAAGATCCGGAACGATGGCCGCGCATGGTGGAGCTGGCGGCAACATATGGATACCACTTGCCGCCGG
ATCCGGACCCGGCCGCGCTTAATGCGATGCTAGTGGCGCGCAAGAAGGCAGACCCCGACCATTTCGCGGATGTGTCGCTC
ACGGTGCTGAAGTTGATGGGGCCGGGTGAATATGTGGCGTCCCGTCCGGGGACAGAAGCGACCGGCCACTTCGGCCTCGC
GGCACACGATTATACGCACTCCACCGCGCCCAATCGGCGGTTTGCAGATCTGGTGACGCAGCGCCTGGTCAAGGCGCTCG
CCGCCCGCCAACGCTCGCCATATAGCGATGCAGAACTCGATTCCATCGCGGCCAATTGCACCTTAAAGGAAGACAATGCG
CGCAAGGTGCAGCGCGCGATGGTGAAGCGCCTCGCCGCGGTCGCGCTGGCCGGACGGGTGGGGCAAACGTTCTCCGCGGT
GGTCACGGGCGTGACGCCGAAGGGAGTGTTCGTGCGCATCACCGACCCTCCCGTGGAAGGCCGCCTGATGCGCGGTGAAG
AGGGACTGGATGTTGGCGACCGCGTGCAGGTGACGCTGTTGAACACCGATGCGGCGCGCGGGTTTATCGATTTCGGGAGT
AGACAAGATGGCTAA

Upstream 100 bases:

>100_bases
GTGCATACACTGGGCGCGATCACGCCGATTGGCGGCGTCTGCTTTATCGCGGCTTGGCTGCTGCTTGCTTACTACTTCAT
CGCGCAACGGGCATAGACTC

Downstream 100 bases:

>100_bases
TATGTTGAGGCATACTTTGGCGACGCTGGCCTATCGCGGGAACAAGGCGCTGCAAGGCGCGCCGCCGGAATTCGCGACGT
ACGAGGCGGGACGGACGCCG

Product: exoribonuclease II

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MNNHQVDLASIARQEMIDHGFQPDMPPEATQQAEKSSQAVPAGLKDLTALLWSSIDNDDSRDLDQIEWAERTPAGIRVLV
AIADVDSAVAKGSPADRHAASETTSVYAQIRTFPMLPLKLSTDRTSLNENENRAAVVIEMTVCAEGSIGANSIYRALVRN
RAQLTYSAVGAWLEGKGSMPAKVASSAELQQQLQLQNEAAHCMRAARDRLGALTFDRAELQATVENGRVSGIDARRANTS
SRLIEDFMIGANEVMAQTLRSAGVTSIRRVVKDPERWPRMVELAATYGYHLPPDPDPAALNAMLVARKKADPDHFADVSL
TVLKLMGPGEYVASRPGTEATGHFGLAAHDYTHSTAPNRRFADLVTQRLVKALAARQRSPYSDAELDSIAANCTLKEDNA
RKVQRAMVKRLAAVALAGRVGQTFSAVVTGVTPKGVFVRITDPPVEGRLMRGEEGLDVGDRVQVTLLNTDAARGFIDFGS
RQDG

Sequences:

>Translated_484_residues
MNNHQVDLASIARQEMIDHGFQPDMPPEATQQAEKSSQAVPAGLKDLTALLWSSIDNDDSRDLDQIEWAERTPAGIRVLV
AIADVDSAVAKGSPADRHAASETTSVYAQIRTFPMLPLKLSTDRTSLNENENRAAVVIEMTVCAEGSIGANSIYRALVRN
RAQLTYSAVGAWLEGKGSMPAKVASSAELQQQLQLQNEAAHCMRAARDRLGALTFDRAELQATVENGRVSGIDARRANTS
SRLIEDFMIGANEVMAQTLRSAGVTSIRRVVKDPERWPRMVELAATYGYHLPPDPDPAALNAMLVARKKADPDHFADVSL
TVLKLMGPGEYVASRPGTEATGHFGLAAHDYTHSTAPNRRFADLVTQRLVKALAARQRSPYSDAELDSIAANCTLKEDNA
RKVQRAMVKRLAAVALAGRVGQTFSAVVTGVTPKGVFVRITDPPVEGRLMRGEEGLDVGDRVQVTLLNTDAARGFIDFGS
RQDG
>Mature_484_residues
MNNHQVDLASIARQEMIDHGFQPDMPPEATQQAEKSSQAVPAGLKDLTALLWSSIDNDDSRDLDQIEWAERTPAGIRVLV
AIADVDSAVAKGSPADRHAASETTSVYAQIRTFPMLPLKLSTDRTSLNENENRAAVVIEMTVCAEGSIGANSIYRALVRN
RAQLTYSAVGAWLEGKGSMPAKVASSAELQQQLQLQNEAAHCMRAARDRLGALTFDRAELQATVENGRVSGIDARRANTS
SRLIEDFMIGANEVMAQTLRSAGVTSIRRVVKDPERWPRMVELAATYGYHLPPDPDPAALNAMLVARKKADPDHFADVSL
TVLKLMGPGEYVASRPGTEATGHFGLAAHDYTHSTAPNRRFADLVTQRLVKALAARQRSPYSDAELDSIAANCTLKEDNA
RKVQRAMVKRLAAVALAGRVGQTFSAVVTGVTPKGVFVRITDPPVEGRLMRGEEGLDVGDRVQVTLLNTDAARGFIDFGS
RQDG

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=507, Percent_Identity=26.8244575936884, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI190014623, Length=449, Percent_Identity=23.8307349665924, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI190014625, Length=449, Percent_Identity=23.8307349665924, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI87082383, Length=497, Percent_Identity=28.7726358148893, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1787542, Length=409, Percent_Identity=28.8508557457213, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI212645896, Length=417, Percent_Identity=25.1798561151079, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24649634, Length=361, Percent_Identity=25.4847645429363, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 52391; Mature: 52391

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00018 EF_HAND_1 ; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNHQVDLASIARQEMIDHGFQPDMPPEATQQAEKSSQAVPAGLKDLTALLWSSIDNDDS
CCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
RDLDQIEWAERTPAGIRVLVAIADVDSAVAKGSPADRHAASETTSVYAQIRTFPMLPLKL
CCHHHHHHHHCCCCCEEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
STDRTSLNENENRAAVVIEMTVCAEGSIGANSIYRALVRNRAQLTYSAVGAWLEGKGSMP
CCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AKVASSAELQQQLQLQNEAAHCMRAARDRLGALTFDRAELQATVENGRVSGIDARRANTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHCCCCCCCCCCCCCCHH
SRLIEDFMIGANEVMAQTLRSAGVTSIRRVVKDPERWPRMVELAATYGYHLPPDPDPAAL
HHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHH
NAMLVARKKADPDHFADVSLTVLKLMGPGEYVASRPGTEATGHFGLAAHDYTHSTAPNRR
HHHHHHHCCCCCCHHHHHHHEEHHHCCCCHHHHCCCCCCCCCCCCEEECCCCCCCCCCHH
FADLVTQRLVKALAARQRSPYSDAELDSIAANCTLKEDNARKVQRAMVKRLAAVALAGRV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHC
GQTFSAVVTGVTPKGVFVRITDPPVEGRLMRGEEGLDVGDRVQVTLLNTDAARGFIDFGS
CHHHHHHHCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCCHHCCCC
RQDG
CCCC
>Mature Secondary Structure
MNNHQVDLASIARQEMIDHGFQPDMPPEATQQAEKSSQAVPAGLKDLTALLWSSIDNDDS
CCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
RDLDQIEWAERTPAGIRVLVAIADVDSAVAKGSPADRHAASETTSVYAQIRTFPMLPLKL
CCHHHHHHHHCCCCCEEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
STDRTSLNENENRAAVVIEMTVCAEGSIGANSIYRALVRNRAQLTYSAVGAWLEGKGSMP
CCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AKVASSAELQQQLQLQNEAAHCMRAARDRLGALTFDRAELQATVENGRVSGIDARRANTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHCCCCCCCCCCCCCCHH
SRLIEDFMIGANEVMAQTLRSAGVTSIRRVVKDPERWPRMVELAATYGYHLPPDPDPAAL
HHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHH
NAMLVARKKADPDHFADVSLTVLKLMGPGEYVASRPGTEATGHFGLAAHDYTHSTAPNRR
HHHHHHHCCCCCCHHHHHHHEEHHHCCCCHHHHCCCCCCCCCCCCEEECCCCCCCCCCHH
FADLVTQRLVKALAARQRSPYSDAELDSIAANCTLKEDNARKVQRAMVKRLAAVALAGRV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHC
GQTFSAVVTGVTPKGVFVRITDPPVEGRLMRGEEGLDVGDRVQVTLLNTDAARGFIDFGS
CHHHHHHHCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCCHHCCCC
RQDG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]