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The map label for this gene is plsC [H]

Identifier: 116624489

GI number: 116624489

Start: 6779512

End: 6780237

Strand: Direct

Name: plsC [H]

Synonym: Acid_5411

Alternate gene names: 116624489

Gene position: 6779512-6780237 (Clockwise)

Preceding gene: 116624488

Following gene: 116624496

Centisome position: 68.03

GC content: 65.43

Gene sequence:

>726_bases
GTGCTGCGCGGGCTTCGATCCATTTGGCTGTGGGCGGCGAACGTATGGCTGATTCTGCTGTGGACGGCGATCGTGGCGAC
GGTTCGGCTATTCGATCGCGATCCGCTGCGGCGCCGGACGGCGCGCACCTTCCGGCGTCTGGGGCCGGTGATGGCAATGG
TCAACCCGTGGCGCGTTGAGGTCTCCGGGGTGGAGAACGCGGATCCGGCGCGGGTGTACGTAATCGTCAGCAATCATCAG
TCGCTGGCAGATATTCCGGTGATCACGCATTTGGAGTTGGATACCAAGTGGCTGGGCAAGGCGGAGTTGTTCCGCGTGCC
GCTGCTGGGCTGGATGCTGCGCATGGCGGGCGACGTGCCGGTGGAGCGCGGCCATGCGCGCAGGGCGGCGAAGGCGATGC
TGCGCTGCGCGCGCTACCTGCGCGAGGGCTGCTCGGTGGTCTTCTTCCCGGAAGGTACGCGCTCGCGCGATGGCGCGGTG
CTGCCGTTCAATGAGGGCCCCTTCCAACTTGCGATCCGGGAACAGGCGCCGATTCTGCCATTGGTGGTGGAGGGGTCGGG
CGCCGCGCTACCGCGCAACACGTGGTTGTTCGGCGGCGCGCTGACGATCCGGCTGCGGGTTCTGCCTGCGGTGCCGGTGG
AGGGGAGGAGTGTGAAGGAGACTGCGGCATTGAGGGATGAAGTTAGGGGAATGATCGTAGCGGAGTTGGAACAACTCAGA
AAATAA

Upstream 100 bases:

>100_bases
GCGATGAAGATGGCGGGGTTCGTCGCCACGTTCGTACGTGGCGCGGAGTGGGCGGCCACCGGAAACGTGACCATTCCGGC
GCCGGACGAGTTGAAGTAGC

Downstream 100 bases:

>100_bases
CGGGCGGCCTACCTCACTTCGAAGATGCCGAAGGCGAGGCCGAAATCGCGGGGGTCGGTGGCGGGGCGGGTTACGCGGTC
CACGGACAGCGCGAGTTTCA

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MLRGLRSIWLWAANVWLILLWTAIVATVRLFDRDPLRRRTARTFRRLGPVMAMVNPWRVEVSGVENADPARVYVIVSNHQ
SLADIPVITHLELDTKWLGKAELFRVPLLGWMLRMAGDVPVERGHARRAAKAMLRCARYLREGCSVVFFPEGTRSRDGAV
LPFNEGPFQLAIREQAPILPLVVEGSGAALPRNTWLFGGALTIRLRVLPAVPVEGRSVKETAALRDEVRGMIVAELEQLR
K

Sequences:

>Translated_241_residues
MLRGLRSIWLWAANVWLILLWTAIVATVRLFDRDPLRRRTARTFRRLGPVMAMVNPWRVEVSGVENADPARVYVIVSNHQ
SLADIPVITHLELDTKWLGKAELFRVPLLGWMLRMAGDVPVERGHARRAAKAMLRCARYLREGCSVVFFPEGTRSRDGAV
LPFNEGPFQLAIREQAPILPLVVEGSGAALPRNTWLFGGALTIRLRVLPAVPVEGRSVKETAALRDEVRGMIVAELEQLR
K
>Mature_241_residues
MLRGLRSIWLWAANVWLILLWTAIVATVRLFDRDPLRRRTARTFRRLGPVMAMVNPWRVEVSGVENADPARVYVIVSNHQ
SLADIPVITHLELDTKWLGKAELFRVPLLGWMLRMAGDVPVERGHARRAAKAMLRCARYLREGCSVVFFPEGTRSRDGAV
LPFNEGPFQLAIREQAPILPLVVEGSGAALPRNTWLFGGALTIRLRVLPAVPVEGRSVKETAALRDEVRGMIVAELEQLR
K

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=184, Percent_Identity=33.1521739130435, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI15100175, Length=184, Percent_Identity=33.1521739130435, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI6041665, Length=174, Percent_Identity=32.7586206896552, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1789395, Length=212, Percent_Identity=25, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17564032, Length=186, Percent_Identity=27.4193548387097, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320151, Length=204, Percent_Identity=27.4509803921569, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281364648, Length=209, Percent_Identity=26.7942583732057, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24582856, Length=209, Percent_Identity=26.7942583732057, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24582854, Length=209, Percent_Identity=26.7942583732057, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641614, Length=184, Percent_Identity=28.804347826087, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641612, Length=184, Percent_Identity=28.804347826087, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27128; Mature: 27128

Theoretical pI: Translated: 11.52; Mature: 11.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRGLRSIWLWAANVWLILLWTAIVATVRLFDRDPLRRRTARTFRRLGPVMAMVNPWRVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEE
VSGVENADPARVYVIVSNHQSLADIPVITHLELDTKWLGKAELFRVPLLGWMLRMAGDVP
ECCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
VERGHARRAAKAMLRCARYLREGCSVVFFPEGTRSRDGAVLPFNEGPFQLAIREQAPILP
CCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCCCEEEEEECCCCEEE
LVVEGSGAALPRNTWLFGGALTIRLRVLPAVPVEGRSVKETAALRDEVRGMIVAELEQLR
EEECCCCCCCCCCCEEECCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MLRGLRSIWLWAANVWLILLWTAIVATVRLFDRDPLRRRTARTFRRLGPVMAMVNPWRVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEE
VSGVENADPARVYVIVSNHQSLADIPVITHLELDTKWLGKAELFRVPLLGWMLRMAGDVP
ECCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
VERGHARRAAKAMLRCARYLREGCSVVFFPEGTRSRDGAVLPFNEGPFQLAIREQAPILP
CCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCCCEEEEEECCCCEEE
LVVEGSGAALPRNTWLFGGALTIRLRVLPAVPVEGRSVKETAALRDEVRGMIVAELEQLR
EEECCCCCCCCCCCEEECCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9403685; 7812434 [H]