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The map label for this gene is pkwA [H]

Identifier: 116624122

GI number: 116624122

Start: 6360010

End: 6361404

Strand: Reverse

Name: pkwA [H]

Synonym: Acid_5038

Alternate gene names: 116624122

Gene position: 6361404-6360010 (Counterclockwise)

Preceding gene: 116624123

Following gene: 116624120

Centisome position: 63.83

GC content: 66.67

Gene sequence:

>1395_bases
ATGGCCAATCGCGGCGTCCTACTGGTTTTGTGCCTGAGCGCGCTGGGAACAGCGCAGGCGGCGGGGCATCCGAATTACGA
GGATGATGTGAAGCCGGTGTTTGCGCGGCGGTGTTTCGGGTGTCATTCGGCGGGCGAGATGCGCAGCGGGCTGAACCTGG
AGACGTACTCGGGAGTGCTGAAGGGCGGGTCGTCGGGCGACGTGGTAATCGCGGCGCGGGCGGCGTCGAGCATGTTGTAC
CGCGCGGTGGCGCGGGAAGATGGAGCGCCGCAGATGCCGCTGGGGCAGGCAAAATTACCTGACGCGGAGATCGCCCTGAT
TCGCGAGTGGATTGAAGGCGGTCTGCTGGAGACGGCGATGTCAGCACCGAAGGGGCCAGTGGGACCCGCGTTGGAATATC
ATCGCAGCGAGGTGAAGCAGCCGGCGGTGATGCCGGAAGCGCTCGGGGCACTGGAGTTGAAGGAACCGGCGCGGGCGCAT
CCGGTGACTGCGCTGGCGGCGAGTCCGTGGGCGCCCGTGGTGGCGATCGCGGGGCACGAGCGGGTTTACCTGTACGACTT
GGCGAAGCACAGTCCGGCCGGGGAGCTGGCCTTCCCCGAAGGCGTGCCTTATGTGCTGCGCTTCAGCCGCGACGGTGCCA
CGCTGCTGGCGGCGGGTGGGCGGGGCGTGCAACTGGGGAAGGCGGCGCTGTTCGACGTGCGTACCGGCAAACGCATCGCG
ACGATGGGAGAGGAGCGCGACATCGTACTGGCGGCGGATGTCACGGCGGATGGAAAGCTGGTCGCGCTGGGCGGTCCGGG
AAAGACGGTCAAGGTGTACGCGGTAGTGGACGGCAAGTTGAAATACGAGATCAAGAAACACACGGACTGGATCACGGCGT
TGGAATTCAGCCCCGATGGGTCGCACCTCGCGACCGGCGACCGCAGCGGCGCGATCTACCTGTGGGAAGCCGCGACGGGG
GGCACCGTAGGCGCGCTGGCCGACCACAAGGATTCGATCACGTCGCTGAGTTGGCGCGGAGACGGCGCGCTGCTGGCGTC
GGGGAGCGAGGACGGGCAGATCATCGTGTGGAATGTGAGCGACGGATTTCCAGTCGCCACCATGGCGAAGGCGCATCTGC
CGAAAGCCGCGCCGGGCCAGTACGGCACGATTCCCGGCGGAGTGCTGAGCGTGCAATTCACCAGCGAAGGTCGGATTGTC
AGCGTGGGGCGCGACTCCACCATCCGCGCATGGAGCGCGGATGGCAAGGCGCGCGGAGCGAGCGCGGCGAACGACGCGCT
ACTGACGAAGGTGGCTGTGTCGAGCGATGGGAAACTGACGATCGCGGGCGACTACAACGGCAAGGTGATCGTTTGGGACG
GCGCGACGACCGTGGTCCTGCGCGGCGGAAAGTAA

Upstream 100 bases:

>100_bases
TGATGGCGATTGTGTCGGCGTCGCCTGGGGATAAGAGTGCCTACGACGACGTGGTTTGGGCGCTGGTGAACTCCACGGAA
TTCGAATTCAATCATTGATT

Downstream 100 bases:

>100_bases
CTCCACGTCGAGCGAGTATCGGGCCAACTGCTTCAGTGCGGCAGGGGTCCCGGAAGGCTCCCCGATCCGGAGCATGGAGA
TCTGAAGATAGTAGGCTCCG

Product: WD-40 repeat-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MANRGVLLVLCLSALGTAQAAGHPNYEDDVKPVFARRCFGCHSAGEMRSGLNLETYSGVLKGGSSGDVVIAARAASSMLY
RAVAREDGAPQMPLGQAKLPDAEIALIREWIEGGLLETAMSAPKGPVGPALEYHRSEVKQPAVMPEALGALELKEPARAH
PVTALAASPWAPVVAIAGHERVYLYDLAKHSPAGELAFPEGVPYVLRFSRDGATLLAAGGRGVQLGKAALFDVRTGKRIA
TMGEERDIVLAADVTADGKLVALGGPGKTVKVYAVVDGKLKYEIKKHTDWITALEFSPDGSHLATGDRSGAIYLWEAATG
GTVGALADHKDSITSLSWRGDGALLASGSEDGQIIVWNVSDGFPVATMAKAHLPKAAPGQYGTIPGGVLSVQFTSEGRIV
SVGRDSTIRAWSADGKARGASAANDALLTKVAVSSDGKLTIAGDYNGKVIVWDGATTVVLRGGK

Sequences:

>Translated_464_residues
MANRGVLLVLCLSALGTAQAAGHPNYEDDVKPVFARRCFGCHSAGEMRSGLNLETYSGVLKGGSSGDVVIAARAASSMLY
RAVAREDGAPQMPLGQAKLPDAEIALIREWIEGGLLETAMSAPKGPVGPALEYHRSEVKQPAVMPEALGALELKEPARAH
PVTALAASPWAPVVAIAGHERVYLYDLAKHSPAGELAFPEGVPYVLRFSRDGATLLAAGGRGVQLGKAALFDVRTGKRIA
TMGEERDIVLAADVTADGKLVALGGPGKTVKVYAVVDGKLKYEIKKHTDWITALEFSPDGSHLATGDRSGAIYLWEAATG
GTVGALADHKDSITSLSWRGDGALLASGSEDGQIIVWNVSDGFPVATMAKAHLPKAAPGQYGTIPGGVLSVQFTSEGRIV
SVGRDSTIRAWSADGKARGASAANDALLTKVAVSSDGKLTIAGDYNGKVIVWDGATTVVLRGGK
>Mature_463_residues
ANRGVLLVLCLSALGTAQAAGHPNYEDDVKPVFARRCFGCHSAGEMRSGLNLETYSGVLKGGSSGDVVIAARAASSMLYR
AVAREDGAPQMPLGQAKLPDAEIALIREWIEGGLLETAMSAPKGPVGPALEYHRSEVKQPAVMPEALGALELKEPARAHP
VTALAASPWAPVVAIAGHERVYLYDLAKHSPAGELAFPEGVPYVLRFSRDGATLLAAGGRGVQLGKAALFDVRTGKRIAT
MGEERDIVLAADVTADGKLVALGGPGKTVKVYAVVDGKLKYEIKKHTDWITALEFSPDGSHLATGDRSGAIYLWEAATGG
TVGALADHKDSITSLSWRGDGALLASGSEDGQIIVWNVSDGFPVATMAKAHLPKAAPGQYGTIPGGVLSVQFTSEGRIVS
VGRDSTIRAWSADGKARGASAANDALLTKVAVSSDGKLTIAGDYNGKVIVWDGATTVVLRGGK

Specific function: May play a regulatory role during the complex growth cycle and in secondary metabolite production [H]

COG id: COG2319

COG function: function code R; FOG: WD40 repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 WD repeats [H]

Homologues:

Organism=Homo sapiens, GI18677720, Length=250, Percent_Identity=27.6, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI20143912, Length=220, Percent_Identity=26.3636363636364, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI32189425, Length=353, Percent_Identity=23.7960339943343, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI21071067, Length=159, Percent_Identity=32.0754716981132, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI16554629, Length=184, Percent_Identity=28.804347826087, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI16554627, Length=184, Percent_Identity=28.804347826087, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI62234461, Length=219, Percent_Identity=27.8538812785388, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI26665869, Length=301, Percent_Identity=22.5913621262458, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI113865883, Length=250, Percent_Identity=26.4, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI8923881, Length=234, Percent_Identity=23.9316239316239, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI102470001, Length=217, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI239787754, Length=182, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI239787760, Length=182, Percent_Identity=26.3736263736264, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI23199987, Length=213, Percent_Identity=22.0657276995305, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI239787764, Length=267, Percent_Identity=22.0973782771536, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI7657439, Length=149, Percent_Identity=29.5302013422819, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI83779014, Length=190, Percent_Identity=23.6842105263158, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5174447, Length=222, Percent_Identity=23.8738738738739, Blast_Score=66, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17568701, Length=213, Percent_Identity=27.2300469483568, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17552164, Length=213, Percent_Identity=24.4131455399061, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI72001544, Length=264, Percent_Identity=23.8636363636364, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17536759, Length=193, Percent_Identity=29.0155440414508, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554220, Length=213, Percent_Identity=23.943661971831, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534675, Length=358, Percent_Identity=22.9050279329609, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562372, Length=169, Percent_Identity=31.9526627218935, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319916, Length=233, Percent_Identity=27.0386266094421, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319926, Length=227, Percent_Identity=23.7885462555066, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17864654, Length=184, Percent_Identity=29.8913043478261, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45549090, Length=216, Percent_Identity=26.3888888888889, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356791, Length=275, Percent_Identity=23.6363636363636, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137396, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17136870, Length=126, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020472
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR015943
- InterPro:   IPR001680
- InterPro:   IPR011046
- InterPro:   IPR019782
- InterPro:   IPR019775
- InterPro:   IPR017986
- InterPro:   IPR019781 [H]

Pfam domain/function: PF00069 Pkinase; PF00400 WD40 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 48179; Mature: 48048

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS51007 CYTC ; PS00678 WD_REPEATS_1 ; PS50082 WD_REPEATS_2 ; PS50294 WD_REPEATS_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRGVLLVLCLSALGTAQAAGHPNYEDDVKPVFARRCFGCHSAGEMRSGLNLETYSGVL
CCCCCEEHEEHHHHHCCHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCHHHHHHH
KGGSSGDVVIAARAASSMLYRAVAREDGAPQMPLGQAKLPDAEIALIREWIEGGLLETAM
CCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
SAPKGPVGPALEYHRSEVKQPAVMPEALGALELKEPARAHPVTALAASPWAPVVAIAGHE
CCCCCCCCCHHHHHHHHHCCCCCCHHHHCCEECCCCCCCCCEEEEECCCCCCEEEEECCC
RVYLYDLAKHSPAGELAFPEGVPYVLRFSRDGATLLAAGGRGVQLGKAALFDVRTGKRIA
EEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCEEECCEEEEEECCCCEEE
TMGEERDIVLAADVTADGKLVALGGPGKTVKVYAVVDGKLKYEIKKHTDWITALEFSPDG
ECCCCCCEEEEEECCCCCEEEEECCCCCEEEEEEEECCEEEEEEEECCCEEEEEEECCCC
SHLATGDRSGAIYLWEAATGGTVGALADHKDSITSLSWRGDGALLASGSEDGQIIVWNVS
CEEECCCCCCEEEEEECCCCCEEEECCCCCCCCEEEEECCCCEEEECCCCCCEEEEEECC
DGFPVATMAKAHLPKAAPGQYGTIPGGVLSVQFTSEGRIVSVGRDSTIRAWSADGKARGA
CCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCEEEEECCCCCCCCC
SAANDALLTKVAVSSDGKLTIAGDYNGKVIVWDGATTVVLRGGK
CCCCCEEEEEEEECCCCCEEEEECCCCEEEEECCCEEEEEECCC
>Mature Secondary Structure 
ANRGVLLVLCLSALGTAQAAGHPNYEDDVKPVFARRCFGCHSAGEMRSGLNLETYSGVL
CCCCEEHEEHHHHHCCHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCHHHHHHH
KGGSSGDVVIAARAASSMLYRAVAREDGAPQMPLGQAKLPDAEIALIREWIEGGLLETAM
CCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
SAPKGPVGPALEYHRSEVKQPAVMPEALGALELKEPARAHPVTALAASPWAPVVAIAGHE
CCCCCCCCCHHHHHHHHHCCCCCCHHHHCCEECCCCCCCCCEEEEECCCCCCEEEEECCC
RVYLYDLAKHSPAGELAFPEGVPYVLRFSRDGATLLAAGGRGVQLGKAALFDVRTGKRIA
EEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCEEECCEEEEEECCCCEEE
TMGEERDIVLAADVTADGKLVALGGPGKTVKVYAVVDGKLKYEIKKHTDWITALEFSPDG
ECCCCCCEEEEEECCCCCEEEEECCCCCEEEEEEEECCEEEEEEEECCCEEEEEEECCCC
SHLATGDRSGAIYLWEAATGGTVGALADHKDSITSLSWRGDGALLASGSEDGQIIVWNVS
CEEECCCCCCEEEEEECCCCCEEEECCCCCCCCEEEEECCCCEEEECCCCCCEEEEEECC
DGFPVATMAKAHLPKAAPGQYGTIPGGVLSVQFTSEGRIVSVGRDSTIRAWSADGKARGA
CCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCEEEEECCCCCCCCC
SAANDALLTKVAVSSDGKLTIAGDYNGKVIVWDGATTVVLRGGK
CCCCCEEEEEEEECCCCCEEEEECCCCEEEEECCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8631732 [H]