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The map label for this gene is degP [H]

Identifier: 116624044

GI number: 116624044

Start: 6257044

End: 6258438

Strand: Reverse

Name: degP [H]

Synonym: Acid_4958

Alternate gene names: 116624044

Gene position: 6258438-6257044 (Counterclockwise)

Preceding gene: 116624047

Following gene: 116624043

Centisome position: 62.8

GC content: 60.14

Gene sequence:

>1395_bases
ATGCTCAGGATGGCTATTCTTGGCCCGATCGCCCTATTACTGGTGCCCGCCCCCGCTCTTGCCCAGACAGCCAAGCCATC
TAAACTTCTGGCCGACTATAGCGCTGCCCTGGAAGATCTGGCCCGCCTCGCCAGCCCCTCTGTGGTTCAGATCCAGGTCA
GGAGATTGGTTCCCCTCGGCAAAGCCGACTCCCAACGCACCGGTTTCGTCTCCGAACAGCAAGCTACCGGATCCGGCGTC
ATCGTTGACCCGGACGGCTATATCGTCACTAACGCTCACGTCGTGCAAAACGCCCAGCGGATCGAAGTCAAGGTCCTTCA
GAGCGATGCCAGGGGACAGGCGCCCCATGAGCACTTGATGCCCGCGAAGCTCATTGGATTGGACCGGCAGGTGGATATCG
CCGTCGTGAAGATCGAGGCACAGAATCTCCACGCGCTCTCCTTCCTCAACTCCGACAATCTCCATCAGGGCCAGTTGGTG
GTCGCCCTCGGCAGCCCGCTTGGCCTCCAGAACTCTCTCACGCAAGGCGTCGTGAGCGCTGCCACCCGCCAGTTGGATCC
GGAGAGTCCGATGGTCTATATCCAGACCGACGCTCCGATCAATCGCGGCAACAGCGGAGGCCCGTTGCTCGATATCGAAG
GGCGCATTGCCGGCATCAACACGTTAATCTTCTCGGAATCGGGCGGCAATGAAGGGATCGGGTTTGCCATCCCCGCGAAT
CTCGCGAAAGACGTGTATCAGAGGCTTCGCAAGGACGGCCGTATTCGTCGCGGTGAAATCGGAGTAATCCCCGAAACCAT
CACGCCCACTCTGGGAGCGGCCCTCGGGCTCGACATGGATTCCGGTGTCATCGTTTCGGATGTGCTGCCGGAAAGCGCGG
CGCAGGCGGCCGGAATCGAACCGGTTGACGTGGTGCTATCGATTGACGGAAAGCCAATGAGAGAGGCGCGCGACCTGATC
CTCGCCGTCTTCCAGCGCGCGCCCGGCGATCAGCTGAAACTGGAGATCCGCCGCGGCAAAGAGCGGACGTCCAAAACCGT
TGCCGTTCTCGAACGGAAGAATGAACCCAGCCAGTTGGAAGAGATCGCCAATTCAGATGCCGCGCTGGTCCGGCGCCTGG
GGATTCTTGCGGTCACGGTGGACGCAAAGGTGAATGCGATTCTACCCAACCTCAGGCGCCTTTCTGGGGTCGCCGTGGCG
GCTGTGCCGGCGGAATACGCCGGTCTGAATCCCGGGCTGTTGGCCGGCGACGTGATCTACTCGTTCAACAATCAGCGCAT
CGGTTCGCTCGAGGAACTCCGTAATGCTCTCAAGGAGAAGAAAACAGGCGATCCCATCGCTCTCCTGGTAGAGCGCTACG
GCCAATTGATCTTTGTGACTGCGAACTTGGAATAA

Upstream 100 bases:

>100_bases
GCCCAATCGCCGCCCAAATTCCCGGTATGTCTGCACTTTGCCCAATGGGTGCAGCCCCTGATCCTACATAATGAGAGAAG
CCTCGGAGGTATCTAGTCGC

Downstream 100 bases:

>100_bases
CCCGTTCACACGAACTTCGGATTTATTTTCAAGATCCTAACCCTTTTGCCCGCAAAGACTTCCGAGTCTACCGGGTTTCG
GCAGCGCCCGTTTTCGGCTT

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MLRMAILGPIALLLVPAPALAQTAKPSKLLADYSAALEDLARLASPSVVQIQVRRLVPLGKADSQRTGFVSEQQATGSGV
IVDPDGYIVTNAHVVQNAQRIEVKVLQSDARGQAPHEHLMPAKLIGLDRQVDIAVVKIEAQNLHALSFLNSDNLHQGQLV
VALGSPLGLQNSLTQGVVSAATRQLDPESPMVYIQTDAPINRGNSGGPLLDIEGRIAGINTLIFSESGGNEGIGFAIPAN
LAKDVYQRLRKDGRIRRGEIGVIPETITPTLGAALGLDMDSGVIVSDVLPESAAQAAGIEPVDVVLSIDGKPMREARDLI
LAVFQRAPGDQLKLEIRRGKERTSKTVAVLERKNEPSQLEEIANSDAALVRRLGILAVTVDAKVNAILPNLRRLSGVAVA
AVPAEYAGLNPGLLAGDVIYSFNNQRIGSLEELRNALKEKKTGDPIALLVERYGQLIFVTANLE

Sequences:

>Translated_464_residues
MLRMAILGPIALLLVPAPALAQTAKPSKLLADYSAALEDLARLASPSVVQIQVRRLVPLGKADSQRTGFVSEQQATGSGV
IVDPDGYIVTNAHVVQNAQRIEVKVLQSDARGQAPHEHLMPAKLIGLDRQVDIAVVKIEAQNLHALSFLNSDNLHQGQLV
VALGSPLGLQNSLTQGVVSAATRQLDPESPMVYIQTDAPINRGNSGGPLLDIEGRIAGINTLIFSESGGNEGIGFAIPAN
LAKDVYQRLRKDGRIRRGEIGVIPETITPTLGAALGLDMDSGVIVSDVLPESAAQAAGIEPVDVVLSIDGKPMREARDLI
LAVFQRAPGDQLKLEIRRGKERTSKTVAVLERKNEPSQLEEIANSDAALVRRLGILAVTVDAKVNAILPNLRRLSGVAVA
AVPAEYAGLNPGLLAGDVIYSFNNQRIGSLEELRNALKEKKTGDPIALLVERYGQLIFVTANLE
>Mature_464_residues
MLRMAILGPIALLLVPAPALAQTAKPSKLLADYSAALEDLARLASPSVVQIQVRRLVPLGKADSQRTGFVSEQQATGSGV
IVDPDGYIVTNAHVVQNAQRIEVKVLQSDARGQAPHEHLMPAKLIGLDRQVDIAVVKIEAQNLHALSFLNSDNLHQGQLV
VALGSPLGLQNSLTQGVVSAATRQLDPESPMVYIQTDAPINRGNSGGPLLDIEGRIAGINTLIFSESGGNEGIGFAIPAN
LAKDVYQRLRKDGRIRRGEIGVIPETITPTLGAALGLDMDSGVIVSDVLPESAAQAAGIEPVDVVLSIDGKPMREARDLI
LAVFQRAPGDQLKLEIRRGKERTSKTVAVLERKNEPSQLEEIANSDAALVRRLGILAVTVDAKVNAILPNLRRLSGVAVA
AVPAEYAGLNPGLLAGDVIYSFNNQRIGSLEELRNALKEKKTGDPIALLVERYGQLIFVTANLE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=338, Percent_Identity=35.7988165680473, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI24308541, Length=326, Percent_Identity=36.1963190184049, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI22129776, Length=288, Percent_Identity=36.1111111111111, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI7019477, Length=285, Percent_Identity=37.5438596491228, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1786356, Length=388, Percent_Identity=36.5979381443299, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI1789629, Length=396, Percent_Identity=35.8585858585859, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789630, Length=362, Percent_Identity=35.9116022099448, Blast_Score=171, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24646839, Length=336, Percent_Identity=30.952380952381, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49380; Mature: 49380

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRMAILGPIALLLVPAPALAQTAKPSKLLADYSAALEDLARLASPSVVQIQVRRLVPLG
CEEHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
KADSQRTGFVSEQQATGSGVIVDPDGYIVTNAHVVQNAQRIEVKVLQSDARGQAPHEHLM
CCCCCCCCCCCCCCCCCCCEEECCCCEEEECHHHHCCCCEEEEEEEECCCCCCCCHHHCC
PAKLIGLDRQVDIAVVKIEAQNLHALSFLNSDNLHQGQLVVALGSPLGLQNSLTQGVVSA
CHHHHCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
ATRQLDPESPMVYIQTDAPINRGNSGGPLLDIEGRIAGINTLIFSESGGNEGIGFAIPAN
HHHCCCCCCCEEEEEECCCCCCCCCCCCEEEECCEEEEEEEEEEECCCCCCCCEEEECHH
LAKDVYQRLRKDGRIRRGEIGVIPETITPTLGAALGLDMDSGVIVSDVLPESAAQAAGIE
HHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHCCCCCCCEEEEHHCCHHHHHHCCCC
PVDVVLSIDGKPMREARDLILAVFQRAPGDQLKLEIRRGKERTSKTVAVLERKNEPSQLE
CEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHEEEEECCCCHHHHH
EIANSDAALVRRLGILAVTVDAKVNAILPNLRRLSGVAVAAVPAEYAGLNPGLLAGDVIY
HHHCCHHHHHHHHCEEEEEECCCHHHHHHHHHHHCCEEEEECCHHHCCCCCCCEECCEEE
SFNNQRIGSLEELRNALKEKKTGDPIALLVERYGQLIFVTANLE
ECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure
MLRMAILGPIALLLVPAPALAQTAKPSKLLADYSAALEDLARLASPSVVQIQVRRLVPLG
CEEHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
KADSQRTGFVSEQQATGSGVIVDPDGYIVTNAHVVQNAQRIEVKVLQSDARGQAPHEHLM
CCCCCCCCCCCCCCCCCCCEEECCCCEEEECHHHHCCCCEEEEEEEECCCCCCCCHHHCC
PAKLIGLDRQVDIAVVKIEAQNLHALSFLNSDNLHQGQLVVALGSPLGLQNSLTQGVVSA
CHHHHCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
ATRQLDPESPMVYIQTDAPINRGNSGGPLLDIEGRIAGINTLIFSESGGNEGIGFAIPAN
HHHCCCCCCCEEEEEECCCCCCCCCCCCEEEECCEEEEEEEEEEECCCCCCCCEEEECHH
LAKDVYQRLRKDGRIRRGEIGVIPETITPTLGAALGLDMDSGVIVSDVLPESAAQAAGIE
HHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHCCCCCCCEEEEHHCCHHHHHHCCCC
PVDVVLSIDGKPMREARDLILAVFQRAPGDQLKLEIRRGKERTSKTVAVLERKNEPSQLE
CEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHEEEEECCCCHHHHH
EIANSDAALVRRLGILAVTVDAKVNAILPNLRRLSGVAVAAVPAEYAGLNPGLLAGDVIY
HHHCCHHHHHHHHCEEEEEECCCHHHHHHHHHHHCCEEEEECCHHHCCCCCCCEECCEEE
SFNNQRIGSLEELRNALKEKKTGDPIALLVERYGQLIFVTANLE
ECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]