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The map label for this gene is ptpA [H]

Identifier: 116624005

GI number: 116624005

Start: 6207354

End: 6209882

Strand: Direct

Name: ptpA [H]

Synonym: Acid_4917

Alternate gene names: 116624005

Gene position: 6207354-6209882 (Clockwise)

Preceding gene: 116624004

Following gene: 116624006

Centisome position: 62.29

GC content: 63.23

Gene sequence:

>2529_bases
ATGAAGCTCCAGATTCGCGTTCTCGTGGTGGCGTGCTTCGCCATTACAGCTAGTGCCCAAGGCACGCTGGCAGATTATCA
GCGCGGCCAGGCGATGCAGGCGAAGGCCCGCGGACTGGTCGAAAACCTTCCGGGCACGCCCAACTGGATCGGCGATAGCC
GGCGCTTCTGGTACAGCCGGAGCGTGAAGGGGGGCGCGGAATTTCTGCTGGTGGATGCGGGCAGCGCGGTTAAGAGACCG
GCCTTCGATCATGAGAAACTGGCGGCAGCGATTAACGCGGCATCGGGCGAACATTACAGTGCGCTGGCGCTGCCGTTCGC
GCCGGCGACCGGCGGCCGGGGCGCGGCGGCCGCGGCGGGCCGGGGCGGCGGTCCCGCGCCGGGCGCGTTGACCTTCGCAA
ATGACGCGCAATCGATTGAGTTCGGCGCTGCCGGCTTCCTGTACAAATGTTCGTTGGCCGCCTACCAATGCACTAAGGGG
GCGGCTCTTCCCGCGGGCACGGCGGGCGCCGCAGGGCGGGGCGCTGCGCCGGAAGACGATCTGCTCGCAGCGCCGGAAGT
AGCGGAGTACAACACGCTCGACGGCGTGGAGTTCCTGACGCCCTCGCCGCAGCAGCAGGGTGGACAGGGCGGCGGCTTCC
GACGCGGCCAATCGGGATGCGCGAATCGCACGGCCGCGCAGGGCGGCGGACGCGCGGGGCGCGGCGGGGCGCAGGCGGGC
GAGCCGGTGGTGTGCACTTCTTTCGACGGCAAATGGGACGCGCTGATCGAGAACTTCAATGTGTTTCTGCGGCCGGCGGG
CAGCAGCGGGCCGGCGACGGCGCTGAGCACGGACGGGTCGGAGGGCAACTACTATACGCTGCGCTCGGTGGCGTGGTCGC
CCGATTCGAAGAAGCTGGCGGCGTACCATACGCGTCCCGGGTATGACCGGCAGGTGCATTACATCGAATCGTCGCCGGTG
GACCAGGTACAGCCGAAGCACTCGACCATCTTTTACCGGAAGCCGGGCGACGCGCTGGATATCGCGTACCCCGCGCTGTT
TGACGTGGCGAGCAAGAAGGAGATCGAGATCGATCGCGCCCTGTTCCCGAATGCCTACGACCTGACGATGCCGGTGTGGT
GGAAGGATGGGCGCGGCTTCACGTTCGAATACAATCAGCGCGGCCATCAGATCTATCGCGTGATCGAGGTAGAAGCGAAC
ACAGGCAAGGCGCGCGCGCTGATCACCGAAGAGAGTCCAACCTTCATCGATTACCAATTGCTGCCGACCGGCAAGCGCTA
CCGGTACAACCTGGACGACGGGAAGGAGATCATCTGGGGATCGGAGCGCGACGGGTGGGAGCACCTCTACCTGTACGACG
GCGTGACCGGCAAGGTGAAGAGCCAGATCACGAAAGGCAACTGGGTGCTGCGCGGCGTGGATTTCGTGGATGAAGATAAA
AAGCAGATCTGGTTTCAGGCCAGCGGTGTGAATCCGGAGCAGGATCCTTATTTCATTCACTACTACCGGATTAATTTCGA
CGGCACGGGACTTACTAAGTTGACCGAGGCCGATGGCAATCACACCGTGACTTACTCGAAGGATCGCGCTTACTACGTGG
ACAGCTGGTCGCGCGTCGATCTGCCGACGGTCTCCCAACTGCGGCGAACGGACTCCCGGACACCGGTCATGGATCTGGAG
AAGGCCGACGCGTCGGCGCTGCTGGCCGCGGGGATGCGGATGCCCGAGGTCTTCGTCGCCAAAGGGCGCGACGGGAAGAC
CGATATCTGGGGGACGATCGTACGGCCGACCAACTTCGACCCGGCGAAGAAATATCCGGTCATCGAGCAGATCTATGCGG
GACCGCAGGGATCCTTCGTGCCGAAGACGTTCACTCCGCTGCCGGCGACGCAGGCGCTGGCGGAACTCGGTTTCATCGTG
GTGCAGATCGACGGCATGGGAACCAACAATCGCGGGAAGGCCTTCCACAATATGGCCTGGAAAAACCTGGGCGATGCGGG
ATTCCCGGATCGCATTTTGTGGCACAAGGCCGCGGCTGCCAAGTATTCCTGGTACGACACGAACCGCGTCGGCATCTACG
GAACCTCGGCCGGCGGACAGAACGCGATGGGCGGGATGTTGTTTCATCCCGATTTTTACAAGGTGGCGGTGACCAACAGC
GGCTGCCATGATAACCGGATGGACAAGATCTGGTGGAACGAGTTGTGGATGAGCTGGCCGATCGGGCCGGAGTACGCAGC
GGCGTCGAATGTGGACAACGCGGCGAAGCTGCAAGGCAGGGTGCTGATCGTGATCGGCGAGATGGATAGCAATGTGGACC
CGACTTCGTCACTGCAGGTGGTGAACGCGCTGGTGAAGGCAAACAAGCATTTCGACATGATGTTCATCCCGGGGCAGAAT
CACGGCGTCCCGGTGCTGGGCAGCCAGCACTATTTGCAGGACTACTTCGTGCATCATCTGCTGGGGGTGGAGCCGCCGGA
TTGGAATCACGTGAGCGTCAACGCGGAGAGCACGGCGGGTGGCAACTGA

Upstream 100 bases:

>100_bases
GTTTACGTCCGTTACGGTGCGGAAAGACACTTAAAGCGCACGTGGGGCGGGCGGGCGTAAGCGTTTACAGGAGCAGGCGC
TTGTGAGAATATACCGTGAT

Downstream 100 bases:

>100_bases
GTGCGGCTCGGACTTTGCTTCTTGGCGGCGGCGGCCGCAATTGGCCAGGATCATACGGCGTGGCGCGATTATTCGGGCGG
CGCGGATTCGGCACAATATT

Product: peptidase S9 prolyl oligopeptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 842; Mature: 842

Protein sequence:

>842_residues
MKLQIRVLVVACFAITASAQGTLADYQRGQAMQAKARGLVENLPGTPNWIGDSRRFWYSRSVKGGAEFLLVDAGSAVKRP
AFDHEKLAAAINAASGEHYSALALPFAPATGGRGAAAAAGRGGGPAPGALTFANDAQSIEFGAAGFLYKCSLAAYQCTKG
AALPAGTAGAAGRGAAPEDDLLAAPEVAEYNTLDGVEFLTPSPQQQGGQGGGFRRGQSGCANRTAAQGGGRAGRGGAQAG
EPVVCTSFDGKWDALIENFNVFLRPAGSSGPATALSTDGSEGNYYTLRSVAWSPDSKKLAAYHTRPGYDRQVHYIESSPV
DQVQPKHSTIFYRKPGDALDIAYPALFDVASKKEIEIDRALFPNAYDLTMPVWWKDGRGFTFEYNQRGHQIYRVIEVEAN
TGKARALITEESPTFIDYQLLPTGKRYRYNLDDGKEIIWGSERDGWEHLYLYDGVTGKVKSQITKGNWVLRGVDFVDEDK
KQIWFQASGVNPEQDPYFIHYYRINFDGTGLTKLTEADGNHTVTYSKDRAYYVDSWSRVDLPTVSQLRRTDSRTPVMDLE
KADASALLAAGMRMPEVFVAKGRDGKTDIWGTIVRPTNFDPAKKYPVIEQIYAGPQGSFVPKTFTPLPATQALAELGFIV
VQIDGMGTNNRGKAFHNMAWKNLGDAGFPDRILWHKAAAAKYSWYDTNRVGIYGTSAGGQNAMGGMLFHPDFYKVAVTNS
GCHDNRMDKIWWNELWMSWPIGPEYAAASNVDNAAKLQGRVLIVIGEMDSNVDPTSSLQVVNALVKANKHFDMMFIPGQN
HGVPVLGSQHYLQDYFVHHLLGVEPPDWNHVSVNAESTAGGN

Sequences:

>Translated_842_residues
MKLQIRVLVVACFAITASAQGTLADYQRGQAMQAKARGLVENLPGTPNWIGDSRRFWYSRSVKGGAEFLLVDAGSAVKRP
AFDHEKLAAAINAASGEHYSALALPFAPATGGRGAAAAAGRGGGPAPGALTFANDAQSIEFGAAGFLYKCSLAAYQCTKG
AALPAGTAGAAGRGAAPEDDLLAAPEVAEYNTLDGVEFLTPSPQQQGGQGGGFRRGQSGCANRTAAQGGGRAGRGGAQAG
EPVVCTSFDGKWDALIENFNVFLRPAGSSGPATALSTDGSEGNYYTLRSVAWSPDSKKLAAYHTRPGYDRQVHYIESSPV
DQVQPKHSTIFYRKPGDALDIAYPALFDVASKKEIEIDRALFPNAYDLTMPVWWKDGRGFTFEYNQRGHQIYRVIEVEAN
TGKARALITEESPTFIDYQLLPTGKRYRYNLDDGKEIIWGSERDGWEHLYLYDGVTGKVKSQITKGNWVLRGVDFVDEDK
KQIWFQASGVNPEQDPYFIHYYRINFDGTGLTKLTEADGNHTVTYSKDRAYYVDSWSRVDLPTVSQLRRTDSRTPVMDLE
KADASALLAAGMRMPEVFVAKGRDGKTDIWGTIVRPTNFDPAKKYPVIEQIYAGPQGSFVPKTFTPLPATQALAELGFIV
VQIDGMGTNNRGKAFHNMAWKNLGDAGFPDRILWHKAAAAKYSWYDTNRVGIYGTSAGGQNAMGGMLFHPDFYKVAVTNS
GCHDNRMDKIWWNELWMSWPIGPEYAAASNVDNAAKLQGRVLIVIGEMDSNVDPTSSLQVVNALVKANKHFDMMFIPGQN
HGVPVLGSQHYLQDYFVHHLLGVEPPDWNHVSVNAESTAGGN
>Mature_842_residues
MKLQIRVLVVACFAITASAQGTLADYQRGQAMQAKARGLVENLPGTPNWIGDSRRFWYSRSVKGGAEFLLVDAGSAVKRP
AFDHEKLAAAINAASGEHYSALALPFAPATGGRGAAAAAGRGGGPAPGALTFANDAQSIEFGAAGFLYKCSLAAYQCTKG
AALPAGTAGAAGRGAAPEDDLLAAPEVAEYNTLDGVEFLTPSPQQQGGQGGGFRRGQSGCANRTAAQGGGRAGRGGAQAG
EPVVCTSFDGKWDALIENFNVFLRPAGSSGPATALSTDGSEGNYYTLRSVAWSPDSKKLAAYHTRPGYDRQVHYIESSPV
DQVQPKHSTIFYRKPGDALDIAYPALFDVASKKEIEIDRALFPNAYDLTMPVWWKDGRGFTFEYNQRGHQIYRVIEVEAN
TGKARALITEESPTFIDYQLLPTGKRYRYNLDDGKEIIWGSERDGWEHLYLYDGVTGKVKSQITKGNWVLRGVDFVDEDK
KQIWFQASGVNPEQDPYFIHYYRINFDGTGLTKLTEADGNHTVTYSKDRAYYVDSWSRVDLPTVSQLRRTDSRTPVMDLE
KADASALLAAGMRMPEVFVAKGRDGKTDIWGTIVRPTNFDPAKKYPVIEQIYAGPQGSFVPKTFTPLPATQALAELGFIV
VQIDGMGTNNRGKAFHNMAWKNLGDAGFPDRILWHKAAAAKYSWYDTNRVGIYGTSAGGQNAMGGMLFHPDFYKVAVTNS
GCHDNRMDKIWWNELWMSWPIGPEYAAASNVDNAAKLQGRVLIVIGEMDSNVDPTSSLQVVNALVKANKHFDMMFIPGQN
HGVPVLGSQHYLQDYFVHHLLGVEPPDWNHVSVNAESTAGGN

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI37577089, Length=425, Percent_Identity=25.4117647058824, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI18450280, Length=425, Percent_Identity=25.4117647058824, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI194394146, Length=392, Percent_Identity=25.5102040816327, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI16933540, Length=398, Percent_Identity=25.6281407035176, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI37577091, Length=425, Percent_Identity=24.2352941176471, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI18765694, Length=400, Percent_Identity=24.5, Blast_Score=77, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508017, Length=234, Percent_Identity=28.6324786324786, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17508019, Length=234, Percent_Identity=28.6324786324786, Blast_Score=109, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324793, Length=431, Percent_Identity=24.5939675174014, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45551969, Length=428, Percent_Identity=23.8317757009346, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45550825, Length=428, Percent_Identity=23.8317757009346, Blast_Score=102, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45553511, Length=428, Percent_Identity=23.8317757009346, Blast_Score=102, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24582032, Length=388, Percent_Identity=24.7422680412371, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 91629; Mature: 91629

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQIRVLVVACFAITASAQGTLADYQRGQAMQAKARGLVENLPGTPNWIGDSRRFWYSR
CEEEEEEHEEEHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
SVKGGAEFLLVDAGSAVKRPAFDHEKLAAAINAASGEHYSALALPFAPATGGRGAAAAAG
CCCCCCEEEEEECCCHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCC
RGGGPAPGALTFANDAQSIEFGAAGFLYKCSLAAYQCTKGAALPAGTAGAAGRGAAPEDD
CCCCCCCCEEEECCCCCCEEECCCCEEEEEEHHEEECCCCCCCCCCCCCCCCCCCCCCCC
LLAAPEVAEYNTLDGVEFLTPSPQQQGGQGGGFRRGQSGCANRTAAQGGGRAGRGGAQAG
CCCCCCCCCCCCCCCEEECCCCCHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCC
EPVVCTSFDGKWDALIENFNVFLRPAGSSGPATALSTDGSEGNYYTLRSVAWSPDSKKLA
CCEEEECCCCCHHHHHHCCEEEEEECCCCCCCEEEECCCCCCCEEEEEEEEECCCCCCEE
AYHTRPGYDRQVHYIESSPVDQVQPKHSTIFYRKPGDALDIAYPALFDVASKKEIEIDRA
EEECCCCCCCEEEEECCCCCHHCCCCCCEEEEECCCCCEEECHHHHHHHCCCCCEEEHHH
LFPNAYDLTMPVWWKDGRGFTFEYNQRGHQIYRVIEVEANTGKARALITEESPTFIDYQL
HCCCCEEEEEEEEEECCCCEEEEECCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEEEE
LPTGKRYRYNLDDGKEIIWGSERDGWEHLYLYDGVTGKVKSQITKGNWVLRGVDFVDEDK
ECCCCCEEEECCCCCEEEECCCCCCCEEEEEECCCCCHHHHHEECCCEEEEECCCCCCCC
KQIWFQASGVNPEQDPYFIHYYRINFDGTGLTKLTEADGNHTVTYSKDRAYYVDSWSRVD
EEEEEEECCCCCCCCCEEEEEEEEEECCCCCEEEEECCCCEEEEEECCCEEEECCCCCCC
LPTVSQLRRTDSRTPVMDLEKADASALLAAGMRMPEVFVAKGRDGKTDIWGTIVRPTNFD
CCHHHHHHHCCCCCCEEEHHHCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCC
PAKKYPVIEQIYAGPQGSFVPKTFTPLPATQALAELGFIVVQIDGMGTNNRGKAFHNMAW
CCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHH
KNLGDAGFPDRILWHKAAAAKYSWYDTNRVGIYGTSAGGQNAMGGMLFHPDFYKVAVTNS
HCCCCCCCCCHHHHHHHHHCEEEEECCCEEEEEECCCCCCCCCCCEEECCCEEEEEEECC
GCHDNRMDKIWWNELWMSWPIGPEYAAASNVDNAAKLQGRVLIVIGEMDSNVDPTSSLQV
CCCCCCCCCEEHHHHEEECCCCCCCHHHCCCCCHHHHCCEEEEEEECCCCCCCCCHHHHH
VNALVKANKHFDMMFIPGQNHGVPVLGSQHYLQDYFVHHLLGVEPPDWNHVSVNAESTAG
HHHHHHCCCCEEEEEECCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
GN
CC
>Mature Secondary Structure
MKLQIRVLVVACFAITASAQGTLADYQRGQAMQAKARGLVENLPGTPNWIGDSRRFWYSR
CEEEEEEHEEEHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
SVKGGAEFLLVDAGSAVKRPAFDHEKLAAAINAASGEHYSALALPFAPATGGRGAAAAAG
CCCCCCEEEEEECCCHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCC
RGGGPAPGALTFANDAQSIEFGAAGFLYKCSLAAYQCTKGAALPAGTAGAAGRGAAPEDD
CCCCCCCCEEEECCCCCCEEECCCCEEEEEEHHEEECCCCCCCCCCCCCCCCCCCCCCCC
LLAAPEVAEYNTLDGVEFLTPSPQQQGGQGGGFRRGQSGCANRTAAQGGGRAGRGGAQAG
CCCCCCCCCCCCCCCEEECCCCCHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCC
EPVVCTSFDGKWDALIENFNVFLRPAGSSGPATALSTDGSEGNYYTLRSVAWSPDSKKLA
CCEEEECCCCCHHHHHHCCEEEEEECCCCCCCEEEECCCCCCCEEEEEEEEECCCCCCEE
AYHTRPGYDRQVHYIESSPVDQVQPKHSTIFYRKPGDALDIAYPALFDVASKKEIEIDRA
EEECCCCCCCEEEEECCCCCHHCCCCCCEEEEECCCCCEEECHHHHHHHCCCCCEEEHHH
LFPNAYDLTMPVWWKDGRGFTFEYNQRGHQIYRVIEVEANTGKARALITEESPTFIDYQL
HCCCCEEEEEEEEEECCCCEEEEECCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEEEE
LPTGKRYRYNLDDGKEIIWGSERDGWEHLYLYDGVTGKVKSQITKGNWVLRGVDFVDEDK
ECCCCCEEEECCCCCEEEECCCCCCCEEEEEECCCCCHHHHHEECCCEEEEECCCCCCCC
KQIWFQASGVNPEQDPYFIHYYRINFDGTGLTKLTEADGNHTVTYSKDRAYYVDSWSRVD
EEEEEEECCCCCCCCCEEEEEEEEEECCCCCEEEEECCCCEEEEEECCCEEEECCCCCCC
LPTVSQLRRTDSRTPVMDLEKADASALLAAGMRMPEVFVAKGRDGKTDIWGTIVRPTNFD
CCHHHHHHHCCCCCCEEEHHHCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCC
PAKKYPVIEQIYAGPQGSFVPKTFTPLPATQALAELGFIVVQIDGMGTNNRGKAFHNMAW
CCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHH
KNLGDAGFPDRILWHKAAAAKYSWYDTNRVGIYGTSAGGQNAMGGMLFHPDFYKVAVTNS
HCCCCCCCCCHHHHHHHHHCEEEEECCCEEEEEECCCCCCCCCCCEEECCCEEEEEEECC
GCHDNRMDKIWWNELWMSWPIGPEYAAASNVDNAAKLQGRVLIVIGEMDSNVDPTSSLQV
CCCCCCCCCEEHHHHEEECCCCCCCHHHCCCCCHHHHCCEEEEEEECCCCCCCCCHHHHH
VNALVKANKHFDMMFIPGQNHGVPVLGSQHYLQDYFVHHLLGVEPPDWNHVSVNAESTAG
HHHHHHCCCCEEEEEECCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
GN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA