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The map label for this gene is ggt [H]

Identifier: 116623786

GI number: 116623786

Start: 5946490

End: 5948322

Strand: Reverse

Name: ggt [H]

Synonym: Acid_4698

Alternate gene names: 116623786

Gene position: 5948322-5946490 (Counterclockwise)

Preceding gene: 116623789

Following gene: 116623785

Centisome position: 59.69

GC content: 65.68

Gene sequence:

>1833_bases
ATGACGCTCAGACTCGCGGTTTCGGTTGCTGTTCTGGCGGCGGTGGTAGTGGGGCAGCAGCCTCAACGCCGCGAACGTCC
CGTGCGATTGCCCGCGCGCGGCACTCATGGGTCGGTAGCCGGAGGCACGGAATACGCTACGGAAGCCGGCATGCAGATGT
ACTTCAAGGGCGGCAACGCCGTGGATGCCGGCATCGCAGCCATGCTCGCCGCTACCGTCACCGAGTTCTCCCACTTCGGA
CTCGGCGGCGAAGCTCCCATCCTGATCCGCACCAGGGACGGCAAGGTCCACGCCATCGCCGGCGTCGGCACCATGCCCAA
GCTCGCCACGGCGCAGTTCTTCCGCGATCACAAACTGACGGACGAGGAAATGGTCTCGCCGCCCGAGGCCGGCGGTCTGA
AAAACTGGGTGCCGGTCGCCGGCATTCTCCCCGCGCTCGTGCCCGGCGTCGTCGAAGCCGCCATGGTCGCCCTCCGCGAG
TACGGCACACGCTCGGCCGCCGAGGTGCTCCAACCCGCCATCGAACTCGCCGACGGCTTCCCGATCGATGAACTCCGCGT
CAGCTCCATCGCCAATAGCGTCAAGTACCTGGAAGCCTGGCCCGATTCCCGCCGCACCTTCCTCCCCGGCGGACGCGTGC
CGCAGGCCGGCGACATCTTCCGCCAGCCCGACCTGGCCCGCACCCTGCGCTCCCTCGCCGATGCCGAAAAGCGCGCGCTC
GCCAACGGCGCCAACCGCGCCAAGGCCATCGACGCCGTCCGCGACTTTTTCTACCGCGGCGAAATCGCCCACCGCATCGA
CGCCTTCTCCAAGGCCCACAACGGACTCATCCGGTATGAAGACATGGCGGCCTTCCGTGTCGAACCCGAGGAGCCCGTCT
CCACCACCTTCAAGGGCTACACCGTCTACAAGGGAGGCTTCTGGAGCCAGGGTCCGGCCATGCTTGAGACTCTCAACATC
CTGGATGGTTACGACATTCCCTCGCTCAAGCAAAACTCCGCCGAGTACATTCACGTGCTCGTCGAAGCCCTCAAGCTCGC
GTACGCCGACCGCGACACGTACTACGGCGATCCCAAGTTCAGCAAGATTCCCACCGCCACGCTCTTGAGCAAGGAGTATG
CCGCCGATCGCCGCAAGCTGATCGGCGAAATGGCCTCGCTCGATTTCCGCCCCGGAAAGATCGGCGACACTGTCGGCAAG
CATCCCTTCTACGCGGACATCCAGCGCTACAAAATCCCCGACGCCCTGATGGCCAAGGACACCACCTGCGTCGATGCCAT
CGATAAGGACGGCGTGGCCTTCTCCGCCACTCCCTCCGGCGCCTGGATGCCCACGTACCTCGCCGGCGACACCGGCGTGC
CGCTCACCCAGCGCGCGCAAAGCTTCCTGCTGGTTCCCGGCCATCCCAACGAGCTTGCGCCCGGCAAGCGTCCGCGCGTC
ACGCTCAGCCCGACGCTCGTCACCGCGCCCGATAAAACCATCATCGCCCTCTCCACTCCGGGCGGCGATAATCAGGATCA
ATCGCTGCTTCAGGTGCTCTTCAACTCCATCTTCTTCGGCATGAATGCCGAGGGCGCCGTAGAGGCCGGACGCTTCCAGA
CCGAACACCTGGTCTCCAGCTTCGATAACCACGCCATGAGCCCCGGCACTCTGCTGCTGGATGAGCGCACCGCCGCGGCG
GTCGTCGCCGAGTTGCAAAGGCGTAAGCACGTGGTGGAGATGCGGACGCGCTTCGCCAGCGGCGCAGCGCCAGTAATGAT
CCGCTTCTGGCCCAGCGGCCTCATCGAAGCCGGCGCCGACCCCTACTACTTCCGCGCCGCACAGGCCTGGTAG

Upstream 100 bases:

>100_bases
CGGACAATACAACATCGGCTCGTCTTCGTTCTTCTTTTTCACTGGTTCAGGTTCGCTCACGGATGAAGAAATTATACCGA
TCCCCTACAATGGATGGCAT

Downstream 100 bases:

>100_bases
TGACCGGCTCGCTCTTCGACGAACCCAACGATTTCCCGCGCGACCACCTCGCCGCGCGTCTTCGCGAATTGGCCGAGCGT
AAAATCTTCATCGGCGGCAG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTLRLAVSVAVLAAVVVGQQPQRRERPVRLPARGTHGSVAGGTEYATEAGMQMYFKGGNAVDAGIAAMLAATVTEFSHFG
LGGEAPILIRTRDGKVHAIAGVGTMPKLATAQFFRDHKLTDEEMVSPPEAGGLKNWVPVAGILPALVPGVVEAAMVALRE
YGTRSAAEVLQPAIELADGFPIDELRVSSIANSVKYLEAWPDSRRTFLPGGRVPQAGDIFRQPDLARTLRSLADAEKRAL
ANGANRAKAIDAVRDFFYRGEIAHRIDAFSKAHNGLIRYEDMAAFRVEPEEPVSTTFKGYTVYKGGFWSQGPAMLETLNI
LDGYDIPSLKQNSAEYIHVLVEALKLAYADRDTYYGDPKFSKIPTATLLSKEYAADRRKLIGEMASLDFRPGKIGDTVGK
HPFYADIQRYKIPDALMAKDTTCVDAIDKDGVAFSATPSGAWMPTYLAGDTGVPLTQRAQSFLLVPGHPNELAPGKRPRV
TLSPTLVTAPDKTIIALSTPGGDNQDQSLLQVLFNSIFFGMNAEGAVEAGRFQTEHLVSSFDNHAMSPGTLLLDERTAAA
VVAELQRRKHVVEMRTRFASGAAPVMIRFWPSGLIEAGADPYYFRAAQAW

Sequences:

>Translated_610_residues
MTLRLAVSVAVLAAVVVGQQPQRRERPVRLPARGTHGSVAGGTEYATEAGMQMYFKGGNAVDAGIAAMLAATVTEFSHFG
LGGEAPILIRTRDGKVHAIAGVGTMPKLATAQFFRDHKLTDEEMVSPPEAGGLKNWVPVAGILPALVPGVVEAAMVALRE
YGTRSAAEVLQPAIELADGFPIDELRVSSIANSVKYLEAWPDSRRTFLPGGRVPQAGDIFRQPDLARTLRSLADAEKRAL
ANGANRAKAIDAVRDFFYRGEIAHRIDAFSKAHNGLIRYEDMAAFRVEPEEPVSTTFKGYTVYKGGFWSQGPAMLETLNI
LDGYDIPSLKQNSAEYIHVLVEALKLAYADRDTYYGDPKFSKIPTATLLSKEYAADRRKLIGEMASLDFRPGKIGDTVGK
HPFYADIQRYKIPDALMAKDTTCVDAIDKDGVAFSATPSGAWMPTYLAGDTGVPLTQRAQSFLLVPGHPNELAPGKRPRV
TLSPTLVTAPDKTIIALSTPGGDNQDQSLLQVLFNSIFFGMNAEGAVEAGRFQTEHLVSSFDNHAMSPGTLLLDERTAAA
VVAELQRRKHVVEMRTRFASGAAPVMIRFWPSGLIEAGADPYYFRAAQAW
>Mature_609_residues
TLRLAVSVAVLAAVVVGQQPQRRERPVRLPARGTHGSVAGGTEYATEAGMQMYFKGGNAVDAGIAAMLAATVTEFSHFGL
GGEAPILIRTRDGKVHAIAGVGTMPKLATAQFFRDHKLTDEEMVSPPEAGGLKNWVPVAGILPALVPGVVEAAMVALREY
GTRSAAEVLQPAIELADGFPIDELRVSSIANSVKYLEAWPDSRRTFLPGGRVPQAGDIFRQPDLARTLRSLADAEKRALA
NGANRAKAIDAVRDFFYRGEIAHRIDAFSKAHNGLIRYEDMAAFRVEPEEPVSTTFKGYTVYKGGFWSQGPAMLETLNIL
DGYDIPSLKQNSAEYIHVLVEALKLAYADRDTYYGDPKFSKIPTATLLSKEYAADRRKLIGEMASLDFRPGKIGDTVGKH
PFYADIQRYKIPDALMAKDTTCVDAIDKDGVAFSATPSGAWMPTYLAGDTGVPLTQRAQSFLLVPGHPNELAPGKRPRVT
LSPTLVTAPDKTIIALSTPGGDNQDQSLLQVLFNSIFFGMNAEGAVEAGRFQTEHLVSSFDNHAMSPGTLLLDERTAAAV
VAELQRRKHVVEMRTRFASGAAPVMIRFWPSGLIEAGADPYYFRAAQAW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=570, Percent_Identity=24.9122807017544, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI73915090, Length=570, Percent_Identity=24.9122807017544, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI73915096, Length=570, Percent_Identity=24.9122807017544, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI73915094, Length=570, Percent_Identity=24.9122807017544, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI113429324, Length=569, Percent_Identity=24.9560632688928, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI113429326, Length=567, Percent_Identity=24.1622574955908, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI109148539, Length=457, Percent_Identity=26.2582056892779, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1789856, Length=556, Percent_Identity=31.294964028777, Blast_Score=213, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17506189, Length=620, Percent_Identity=24.1935483870968, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI193208247, Length=557, Percent_Identity=25.673249551167, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193208245, Length=518, Percent_Identity=26.0617760617761, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17542894, Length=560, Percent_Identity=23.2142857142857, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161077496, Length=555, Percent_Identity=21.981981981982, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 66080; Mature: 65949

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLAVSVAVLAAVVVGQQPQRRERPVRLPARGTHGSVAGGTEYATEAGMQMYFKGGNA
CEEEHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCCCCCCCHHHHHCCCEEEEECCCC
VDAGIAAMLAATVTEFSHFGLGGEAPILIRTRDGKVHAIAGVGTMPKLATAQFFRDHKLT
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCC
DEEMVSPPEAGGLKNWVPVAGILPALVPGVVEAAMVALREYGTRSAAEVLQPAIELADGF
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
PIDELRVSSIANSVKYLEAWPDSRRTFLPGGRVPQAGDIFRQPDLARTLRSLADAEKRAL
CHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ANGANRAKAIDAVRDFFYRGEIAHRIDAFSKAHNGLIRYEDMAAFRVEPEEPVSTTFKGY
HCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCCCCCCE
TVYKGGFWSQGPAMLETLNILDGYDIPSLKQNSAEYIHVLVEALKLAYADRDTYYGDPKF
EEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SKIPTATLLSKEYAADRRKLIGEMASLDFRPGKIGDTVGKHPFYADIQRYKIPDALMAKD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCC
TTCVDAIDKDGVAFSATPSGAWMPTYLAGDTGVPLTQRAQSFLLVPGHPNELAPGKRPRV
CHHHHHHCCCCEEEECCCCCCCCEEEECCCCCCCHHHCCCEEEEECCCCCCCCCCCCCEE
TLSPTLVTAPDKTIIALSTPGGDNQDQSLLQVLFNSIFFGMNAEGAVEAGRFQTEHLVSS
EECCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
FDNHAMSPGTLLLDERTAAAVVAELQRRKHVVEMRTRFASGAAPVMIRFWPSGLIEAGAD
HHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHCCCC
PYYFRAAQAW
CCEEEECCCC
>Mature Secondary Structure 
TLRLAVSVAVLAAVVVGQQPQRRERPVRLPARGTHGSVAGGTEYATEAGMQMYFKGGNA
EEEHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCCCCCCCHHHHHCCCEEEEECCCC
VDAGIAAMLAATVTEFSHFGLGGEAPILIRTRDGKVHAIAGVGTMPKLATAQFFRDHKLT
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCC
DEEMVSPPEAGGLKNWVPVAGILPALVPGVVEAAMVALREYGTRSAAEVLQPAIELADGF
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
PIDELRVSSIANSVKYLEAWPDSRRTFLPGGRVPQAGDIFRQPDLARTLRSLADAEKRAL
CHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ANGANRAKAIDAVRDFFYRGEIAHRIDAFSKAHNGLIRYEDMAAFRVEPEEPVSTTFKGY
HCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCCCCCCE
TVYKGGFWSQGPAMLETLNILDGYDIPSLKQNSAEYIHVLVEALKLAYADRDTYYGDPKF
EEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SKIPTATLLSKEYAADRRKLIGEMASLDFRPGKIGDTVGKHPFYADIQRYKIPDALMAKD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCC
TTCVDAIDKDGVAFSATPSGAWMPTYLAGDTGVPLTQRAQSFLLVPGHPNELAPGKRPRV
CHHHHHHCCCCEEEECCCCCCCCEEEECCCCCCCHHHCCCEEEEECCCCCCCCCCCCCEE
TLSPTLVTAPDKTIIALSTPGGDNQDQSLLQVLFNSIFFGMNAEGAVEAGRFQTEHLVSS
EECCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
FDNHAMSPGTLLLDERTAAAVVAELQRRKHVVEMRTRFASGAAPVMIRFWPSGLIEAGAD
HHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHCCCC
PYYFRAAQAW
CCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]