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The map label for this gene is epsD [H]

Identifier: 116623685

GI number: 116623685

Start: 5811904

End: 5813232

Strand: Reverse

Name: epsD [H]

Synonym: Acid_4597

Alternate gene names: 116623685

Gene position: 5813232-5811904 (Counterclockwise)

Preceding gene: 116623686

Following gene: 116623684

Centisome position: 58.33

GC content: 60.35

Gene sequence:

>1329_bases
ATGATTGAGCCACAGATTGTCTCGCCGACGGCGACCACGGAAATTCTTGCCGAGAAGATCAGGACGCGGAAGGCCCGGGT
AGGCATCGTCGGGCTAGGCTACGTCGGACTTCCGCTCGCGGTGGAATTCGCGAAGGCGGGTTTCGAGGTGACCGGCATCG
ATATCAGCGAGGAGAAGGCCAACCGGGTGAACGCCGGCGACTCCTACATCGGGGATATCGCTAGTTCCGCGCTGGCTCCG
CTGGTGGAATCGGGGAAGCTCCGCGCGACCACCGATTTTTCGGCGGTCTTGGATCTGGACACGATCAATATCTGCGTCCC
GACACCGCTGCGCAAAACGAAGGACCCGGACATGAGCTTCATCGTGTCCTCCTGCCAGGAGATCGCGCGGCATTTCCACG
CGGGGATGCTGGTCATTCTGGAATCCACCACGTATCCAGGGACCACGGACGAAGTGGTGCTGCCGATGCTGGCCAAGACC
GGGTTGGAAGTCGGGCGCGACTTTTTCCTGTGCTTCTCGCCGGAGCGCGTCGATCCGGGGAATCCCAGGTACCAGACATC
GAACATTCCGAAGGTCGTGGGCGGTTGCACGCCCGAATGCACCGAGATGGGGCGCCGGTTTTACTCCGAGGCGCTGCAGC
ACGTGGTTCCGGTGAGTTCGACGCAGGTGGCGGAGATGGTCAAGCTGCTCGAAAACACCTTTCGGATGATCAATATCGGG
CTGGTCAACGAGATCGCGATGATGTGCGACCGGATCGGCATCAACGTCTGGGAAGTGATCGATGCCGCGGCTACGAAACC
CTTTGGTTTCATGCCGTTCTACCCTGGACCCGGCCTGGGCGGACATTGCATTCCGATTGATCCGTTTTACCTCTCCTGGA
AGACCAAGCAGGCGGGGATCGAGGCGCGGTTTATCGAACTGGCGGGTTACATCAACGGTCAGATGCCGCACTTCGTGGTG
GATAAGATCCAGAATGCGCTCAATGACGCGGGACTGGCGGTCAAGGGGTCGAAAATCCACGTAATGGGAGTGGCGTACAA
GCGCGACATCGACGATGTTCGGGAATCCCCGGCGCTGGACGTGCTGCTGTTGCTGCAGCGGAAGGGCGCGACCGTAACTT
ACAGCGATCCGCACGTACCGTCGCTCCGGCTGGACGGTGTGGAATTGCAGGGGGCGCCGGAAAGCACGGCGGCGGGGGCC
GATTGCGTTGTGATTATCACTGATCATGCGGCCTTCGACTACGCGGCACTGTTGGAGCGATCGCGATTGATCGTGGACAC
CCGCAACGCCTTGAAGGGCGTCAGCTCGAACAAGATTGTCCGGTTGTAA

Upstream 100 bases:

>100_bases
GACGGCGATATTTTCCTCACCGGTCCGGCGGAGATTGTGGCCGAAGGCGAGTTTTTCGCGCCGTCAACTTAATCCGCCGC
TATGCGAAAATCGAGTTTGC

Downstream 100 bases:

>100_bases
AACTGTTGCGGATATCCGCGTCAGCCCTAAAGATACAGTCGGTTCCGGTTGACATCAGGGTGAAAAGTCCGCAAGCTATG
TTTAGCGAGGTGTCTATGCA

Product: UDP-glucose 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MIEPQIVSPTATTEILAEKIRTRKARVGIVGLGYVGLPLAVEFAKAGFEVTGIDISEEKANRVNAGDSYIGDIASSALAP
LVESGKLRATTDFSAVLDLDTINICVPTPLRKTKDPDMSFIVSSCQEIARHFHAGMLVILESTTYPGTTDEVVLPMLAKT
GLEVGRDFFLCFSPERVDPGNPRYQTSNIPKVVGGCTPECTEMGRRFYSEALQHVVPVSSTQVAEMVKLLENTFRMINIG
LVNEIAMMCDRIGINVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLSWKTKQAGIEARFIELAGYINGQMPHFVV
DKIQNALNDAGLAVKGSKIHVMGVAYKRDIDDVRESPALDVLLLLQRKGATVTYSDPHVPSLRLDGVELQGAPESTAAGA
DCVVIITDHAAFDYAALLERSRLIVDTRNALKGVSSNKIVRL

Sequences:

>Translated_442_residues
MIEPQIVSPTATTEILAEKIRTRKARVGIVGLGYVGLPLAVEFAKAGFEVTGIDISEEKANRVNAGDSYIGDIASSALAP
LVESGKLRATTDFSAVLDLDTINICVPTPLRKTKDPDMSFIVSSCQEIARHFHAGMLVILESTTYPGTTDEVVLPMLAKT
GLEVGRDFFLCFSPERVDPGNPRYQTSNIPKVVGGCTPECTEMGRRFYSEALQHVVPVSSTQVAEMVKLLENTFRMINIG
LVNEIAMMCDRIGINVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLSWKTKQAGIEARFIELAGYINGQMPHFVV
DKIQNALNDAGLAVKGSKIHVMGVAYKRDIDDVRESPALDVLLLLQRKGATVTYSDPHVPSLRLDGVELQGAPESTAAGA
DCVVIITDHAAFDYAALLERSRLIVDTRNALKGVSSNKIVRL
>Mature_442_residues
MIEPQIVSPTATTEILAEKIRTRKARVGIVGLGYVGLPLAVEFAKAGFEVTGIDISEEKANRVNAGDSYIGDIASSALAP
LVESGKLRATTDFSAVLDLDTINICVPTPLRKTKDPDMSFIVSSCQEIARHFHAGMLVILESTTYPGTTDEVVLPMLAKT
GLEVGRDFFLCFSPERVDPGNPRYQTSNIPKVVGGCTPECTEMGRRFYSEALQHVVPVSSTQVAEMVKLLENTFRMINIG
LVNEIAMMCDRIGINVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLSWKTKQAGIEARFIELAGYINGQMPHFVV
DKIQNALNDAGLAVKGSKIHVMGVAYKRDIDDVRESPALDVLLLLQRKGATVTYSDPHVPSLRLDGVELQGAPESTAAGA
DCVVIITDHAAFDYAALLERSRLIVDTRNALKGVSSNKIVRL

Specific function: Probably involved in the synthesis of sugar components of EPS I, by converting NDP-N-acetyl-D-galactosamine into NDP-N- acetyl-D-galactosaminuronic acid [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=458, Percent_Identity=24.6724890829694, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI296040438, Length=361, Percent_Identity=23.2686980609418, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994968, Length=405, Percent_Identity=35.0617283950617, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788340, Length=370, Percent_Identity=24.8648648648649, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560350, Length=458, Percent_Identity=23.1441048034935, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136908, Length=426, Percent_Identity=22.7699530516432, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47939; Mature: 47939

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEPQIVSPTATTEILAEKIRTRKARVGIVGLGYVGLPLAVEFAKAGFEVTGIDISEEKA
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCEEEECCCCHHHH
NRVNAGDSYIGDIASSALAPLVESGKLRATTDFSAVLDLDTINICVPTPLRKTKDPDMSF
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECEEEEEECCCCCCCCCCCHHH
IVSSCQEIARHFHAGMLVILESTTYPGTTDEVVLPMLAKTGLEVGRDFFLCFSPERVDPG
HHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCC
NPRYQTSNIPKVVGGCTPECTEMGRRFYSEALQHVVPVSSTQVAEMVKLLENTFRMINIG
CCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEHH
LVNEIAMMCDRIGINVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLSWKTKQAGI
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECHHCCC
EARFIELAGYINGQMPHFVVDKIQNALNDAGLAVKGSKIHVMGVAYKRDIDDVRESPALD
CEEEEEEHHHHCCCCCHHHHHHHHHHHHHCCEEEECCEEEEEEEEHHCCHHHHHCCCCCE
VLLLLQRKGATVTYSDPHVPSLRLDGVELQGAPESTAAGADCVVIITDHAAFDYAALLER
EEEEEECCCCEEEECCCCCCCEEECCEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHC
SRLIVDTRNALKGVSSNKIVRL
CCEEEECHHHHCCCCCCCEEEC
>Mature Secondary Structure
MIEPQIVSPTATTEILAEKIRTRKARVGIVGLGYVGLPLAVEFAKAGFEVTGIDISEEKA
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCEEEECCCCHHHH
NRVNAGDSYIGDIASSALAPLVESGKLRATTDFSAVLDLDTINICVPTPLRKTKDPDMSF
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECEEEEEECCCCCCCCCCCHHH
IVSSCQEIARHFHAGMLVILESTTYPGTTDEVVLPMLAKTGLEVGRDFFLCFSPERVDPG
HHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCC
NPRYQTSNIPKVVGGCTPECTEMGRRFYSEALQHVVPVSSTQVAEMVKLLENTFRMINIG
CCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEHH
LVNEIAMMCDRIGINVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLSWKTKQAGI
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECHHCCC
EARFIELAGYINGQMPHFVVDKIQNALNDAGLAVKGSKIHVMGVAYKRDIDDVRESPALD
CEEEEEEHHHHCCCCCHHHHHHHHHHHHHCCEEEECCEEEEEEEEHHCCHHHHHCCCCCE
VLLLLQRKGATVTYSDPHVPSLRLDGVELQGAPESTAAGADCVVIITDHAAFDYAALLER
EEEEEECCCCEEEECCCCCCCEEECCEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHC
SRLIVDTRNALKGVSSNKIVRL
CCEEEECHHHHCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]