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The map label for this gene is mmlH [H]

Identifier: 116623651

GI number: 116623651

Start: 5769664

End: 5770875

Strand: Reverse

Name: mmlH [H]

Synonym: Acid_4563

Alternate gene names: 116623651

Gene position: 5770875-5769664 (Counterclockwise)

Preceding gene: 116623654

Following gene: 116623650

Centisome position: 57.91

GC content: 65.76

Gene sequence:

>1212_bases
GTGCAGGCCTGGTACCGGGAAATCAATCGCGCGCAATGGCGTACCCTGATCGCCGCCCAACTGGGATGGATGCTCGACGC
CATGGACGTGATGCTCTATTCCTTTGCGCTGACTGCGATTCGTACCGAATTCCACCTGACCGCGGCCGCCGCCGGGGCAC
TGGGTGCCGCTCCCCTGGTCACTTCCGCCCTGGGCGGCATGCTCTTCGGCTGGCTCAGCGACCGTTACGGGCGATCCCGC
GCGCTGGTCTGGTCTATTCTGACGTTTTCCGCCTTCACTGCCTTCACCGCGACCGCCCGCACCATTCCCGAATTGATCTT
CTGGCGCTCGATCGTCGGTATCGGGCTCGGCGGCGAGTGGGCGGCCGGCGCGGTACTGGTGGCCGAAACGTGGCCGGAGC
GGCACCGGGGCAAGGCCATCGGGCTGATGCAATCGGCGTGGGCGATCGGCTACCTGCTGGCGGCGCTGCTGGCGGGGTTC
ATGCTGCCCCGATTTGGCTGGAGGCCGTTGTTCCTCGCCGGAATTGTACCGGCGCTGATCACCCTCTGGATCCGCCGCAA
CATTCCCGAGCCGCCCAAATGGCAACAGCCGTCGCACAGTCTGTGGGGCGCGCTGGGGGCGCTTTTCCGGGCGCCGCTGC
TGCGCAATGTCATGTTGTTCACCGCGCTTTGTTCGAGCGTCCTGTTCGGCTATTGGGGAATGTTCACCTGGCTGCCGGCC
TATCTTTCCATGCCGGTGTCGCAGGGCGGCGCCGGCCTCAGTATCCTGCGCTCGTCCGCCTGGATCATTCCCTTACAGAT
CGGCGCGTTTTTCGGTTACATGTCTTTCGGTTTCTACGCCGACCGGGTGGGCCGGCGGGCCGCGTTTCTTACGTTCGTCC
TCACCACCGCGGTGCTGGTGCCGGTTTATGGTCTGTTCGGCCGCAACGCCGCCCTGCTGCTGGCGCTCGGTCCACTGGTC
GGGTTTTTCGGGCATGGATATTTCAGCGCATTGGGAGCGATGGCGGCCGAGCTTTTTCCCGCGGCTGTGCGAACCACCGC
GCAGGGGTTCGGTTATAACGCCGGCCGCGCGCTCAGCGGCCTCGCGCCGGTGACCGTGGGCGCGCTTGCGGACCGCCACG
GCATCGGCGCCGCCCTTGCCTTCACGTCCATCTTCTTTATCCTGGGCGCTGGGCTGATGATGTTGGTGCCTGCGGAGACA
CCCCCCGTGTGA

Upstream 100 bases:

>100_bases
ACCGGGATGGAAGTGCCAAATAAATTGGAACTTCCTGCAAAGAAAAGGCAAACCGCTTTGCGAGCACCCCGATTGCCTTT
CGCGGTACCTTTATAAGACC

Downstream 100 bases:

>100_bases
CACGTCTCGTCCGCAGCGAGCTTCGCTCGGCTGCGCGCAAGCTCAAGCGTGCGCCACCAACGACGACGCTGTTCAGTGGT
GGGGCATGCTTTTGCCTGCC

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MQAWYREINRAQWRTLIAAQLGWMLDAMDVMLYSFALTAIRTEFHLTAAAAGALGAAPLVTSALGGMLFGWLSDRYGRSR
ALVWSILTFSAFTAFTATARTIPELIFWRSIVGIGLGGEWAAGAVLVAETWPERHRGKAIGLMQSAWAIGYLLAALLAGF
MLPRFGWRPLFLAGIVPALITLWIRRNIPEPPKWQQPSHSLWGALGALFRAPLLRNVMLFTALCSSVLFGYWGMFTWLPA
YLSMPVSQGGAGLSILRSSAWIIPLQIGAFFGYMSFGFYADRVGRRAAFLTFVLTTAVLVPVYGLFGRNAALLLALGPLV
GFFGHGYFSALGAMAAELFPAAVRTTAQGFGYNAGRALSGLAPVTVGALADRHGIGAALAFTSIFFILGAGLMMLVPAET
PPV

Sequences:

>Translated_403_residues
MQAWYREINRAQWRTLIAAQLGWMLDAMDVMLYSFALTAIRTEFHLTAAAAGALGAAPLVTSALGGMLFGWLSDRYGRSR
ALVWSILTFSAFTAFTATARTIPELIFWRSIVGIGLGGEWAAGAVLVAETWPERHRGKAIGLMQSAWAIGYLLAALLAGF
MLPRFGWRPLFLAGIVPALITLWIRRNIPEPPKWQQPSHSLWGALGALFRAPLLRNVMLFTALCSSVLFGYWGMFTWLPA
YLSMPVSQGGAGLSILRSSAWIIPLQIGAFFGYMSFGFYADRVGRRAAFLTFVLTTAVLVPVYGLFGRNAALLLALGPLV
GFFGHGYFSALGAMAAELFPAAVRTTAQGFGYNAGRALSGLAPVTVGALADRHGIGAALAFTSIFFILGAGLMMLVPAET
PPV
>Mature_403_residues
MQAWYREINRAQWRTLIAAQLGWMLDAMDVMLYSFALTAIRTEFHLTAAAAGALGAAPLVTSALGGMLFGWLSDRYGRSR
ALVWSILTFSAFTAFTATARTIPELIFWRSIVGIGLGGEWAAGAVLVAETWPERHRGKAIGLMQSAWAIGYLLAALLAGF
MLPRFGWRPLFLAGIVPALITLWIRRNIPEPPKWQQPSHSLWGALGALFRAPLLRNVMLFTALCSSVLFGYWGMFTWLPA
YLSMPVSQGGAGLSILRSSAWIIPLQIGAFFGYMSFGFYADRVGRRAAFLTFVLTTAVLVPVYGLFGRNAALLLALGPLV
GFFGHGYFSALGAMAAELFPAAVRTTAQGFGYNAGRALSGLAPVTVGALADRHGIGAALAFTSIFFILGAGLMMLVPAET
PPV

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=201, Percent_Identity=30.3482587064677, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI213021148, Length=196, Percent_Identity=30.6122448979592, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI7662270, Length=198, Percent_Identity=24.7474747474747, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082404, Length=401, Percent_Identity=28.1795511221945, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082231, Length=194, Percent_Identity=40.2061855670103, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1790550, Length=398, Percent_Identity=26.3819095477387, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI87081723, Length=317, Percent_Identity=31.5457413249211, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082159, Length=191, Percent_Identity=32.4607329842932, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788292, Length=394, Percent_Identity=25.6345177664975, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786229, Length=191, Percent_Identity=26.7015706806283, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790463, Length=212, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788942, Length=328, Percent_Identity=24.0853658536585, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789515, Length=396, Percent_Identity=25, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=214, Percent_Identity=29.4392523364486, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323735, Length=228, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19922874, Length=418, Percent_Identity=22.9665071770335, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43426; Mature: 43426

Theoretical pI: Translated: 10.86; Mature: 10.86

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAWYREINRAQWRTLIAAQLGWMLDAMDVMLYSFALTAIRTEFHLTAAAAGALGAAPLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
TSALGGMLFGWLSDRYGRSRALVWSILTFSAFTAFTATARTIPELIFWRSIVGIGLGGEW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AAGAVLVAETWPERHRGKAIGLMQSAWAIGYLLAALLAGFMLPRFGWRPLFLAGIVPALI
HCCEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TLWIRRNIPEPPKWQQPSHSLWGALGALFRAPLLRNVMLFTALCSSVLFGYWGMFTWLPA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLSMPVSQGGAGLSILRSSAWIIPLQIGAFFGYMSFGFYADRVGRRAAFLTFVLTTAVLV
HHHCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVYGLFGRNAALLLALGPLVGFFGHGYFSALGAMAAELFPAAVRTTAQGFGYNAGRALSG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCC
LAPVTVGALADRHGIGAALAFTSIFFILGAGLMMLVPAETPPV
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHEEECCCCCCC
>Mature Secondary Structure
MQAWYREINRAQWRTLIAAQLGWMLDAMDVMLYSFALTAIRTEFHLTAAAAGALGAAPLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
TSALGGMLFGWLSDRYGRSRALVWSILTFSAFTAFTATARTIPELIFWRSIVGIGLGGEW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AAGAVLVAETWPERHRGKAIGLMQSAWAIGYLLAALLAGFMLPRFGWRPLFLAGIVPALI
HCCEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TLWIRRNIPEPPKWQQPSHSLWGALGALFRAPLLRNVMLFTALCSSVLFGYWGMFTWLPA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLSMPVSQGGAGLSILRSSAWIIPLQIGAFFGYMSFGFYADRVGRRAAFLTFVLTTAVLV
HHHCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVYGLFGRNAALLLALGPLVGFFGHGYFSALGAMAAELFPAAVRTTAQGFGYNAGRALSG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCC
LAPVTVGALADRHGIGAALAFTSIFFILGAGLMMLVPAETPPV
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]