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The map label for this gene is arsM [C]

Identifier: 116623500

GI number: 116623500

Start: 5579598

End: 5580443

Strand: Reverse

Name: arsM [C]

Synonym: Acid_4410

Alternate gene names: 116623500

Gene position: 5580443-5579598 (Counterclockwise)

Preceding gene: 116623501

Following gene: 116623499

Centisome position: 56.0

GC content: 65.01

Gene sequence:

>846_bases
ATGGCTACTCAAAACATCACCGATGTCGTGAAAGAGAAGTACGGACAGGCCGCCTTGCGCGTAGTCGCCGGCGGATCCAG
CTCCTGTTGTGGAGCTGCTCCCTCGAACCAGTGCGGGGACCCGATCACGGACAACCTGTATGGCGCCGAAGTGTCGGAAT
TGCCCGCCGACGCGATCGCGGCCAGCCTCGGCTGCGGGAATCCGACGGCGCTCGCGCAATTGAACCCCGGCGAGACCGTG
CTCGACCTGGGCAGCGGCGGCGGCATCGACGTGCTCCTCTCCGCGCGCCGGGTGGGCCCTACCGGGAAGGCCTACGGGCT
GGATATGACGGACGAGATGCTGGCGCTTGCCAATGCCAACAAGGCGAAGGCGGGACTGGAGAACGTGGAGTTCCTCAAGG
GGCAGATCGAAAGCATTCCGCTGCCCGATAATTCGGTGGACGTGATTATCTCCAACTGCGTGATCAATCTCTCCGCCAAC
AAAGATCGCGTGCTGGCGGAAGCCTTCCGCGTGCTCAAACCCGGCGGCCGTTTCGCCGTATCCGACGTGGTGACGCACGG
CGAGATCCCCGCTGAGATCCGCGAACACGTGCTGCTCTGGGTAGGGTGCCTGGCCGGCGCACTCGAAGACACGGATTACC
AGGCCAAATTGGCCGCGGCCGGCTTCGAAGCTGTCGGCGTGGAACCAACGCGAGTCTACCGCGTGGACGACGCCCGCGCG
TTTCTGAGCGGCAAAGGTCTGGACGTGGACGCCGTCGCGCCGCTGGTGGACGGAAAGTTCTTCAGCGCTTTCATTCGCGC
GCGCAAGCCGGCCGCGGCCTGCTGCGGCCCCGCCTGCTGTTCGTAG

Upstream 100 bases:

>100_bases
AGTCGTTGCAGGAATTGCTCGGCTTCCTCTACGCGGAGTGCTGCACCCGTAACCAGGCGGTCAAACCGGAAACGATCGTG
AAACTCTGCAGGTAAACCTT

Downstream 100 bases:

>100_bases
GGCAAATATGCAGTCCAAACCTCGCCTGGCGTTCTTTGAGCGCTATCTCTCGCTGTGGGTAGCGCTCTGCATGGCGGCCG
GAATTCTGCTGGGCAGAAGC

Product: arsenite S-adenosylmethyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MATQNITDVVKEKYGQAALRVVAGGSSSCCGAAPSNQCGDPITDNLYGAEVSELPADAIAASLGCGNPTALAQLNPGETV
LDLGSGGGIDVLLSARRVGPTGKAYGLDMTDEMLALANANKAKAGLENVEFLKGQIESIPLPDNSVDVIISNCVINLSAN
KDRVLAEAFRVLKPGGRFAVSDVVTHGEIPAEIREHVLLWVGCLAGALEDTDYQAKLAAAGFEAVGVEPTRVYRVDDARA
FLSGKGLDVDAVAPLVDGKFFSAFIRARKPAAACCGPACCS

Sequences:

>Translated_281_residues
MATQNITDVVKEKYGQAALRVVAGGSSSCCGAAPSNQCGDPITDNLYGAEVSELPADAIAASLGCGNPTALAQLNPGETV
LDLGSGGGIDVLLSARRVGPTGKAYGLDMTDEMLALANANKAKAGLENVEFLKGQIESIPLPDNSVDVIISNCVINLSAN
KDRVLAEAFRVLKPGGRFAVSDVVTHGEIPAEIREHVLLWVGCLAGALEDTDYQAKLAAAGFEAVGVEPTRVYRVDDARA
FLSGKGLDVDAVAPLVDGKFFSAFIRARKPAAACCGPACCS
>Mature_280_residues
ATQNITDVVKEKYGQAALRVVAGGSSSCCGAAPSNQCGDPITDNLYGAEVSELPADAIAASLGCGNPTALAQLNPGETVL
DLGSGGGIDVLLSARRVGPTGKAYGLDMTDEMLALANANKAKAGLENVEFLKGQIESIPLPDNSVDVIISNCVINLSANK
DRVLAEAFRVLKPGGRFAVSDVVTHGEIPAEIREHVLLWVGCLAGALEDTDYQAKLAAAGFEAVGVEPTRVYRVDDARAF
LSGKGLDVDAVAPLVDGKFFSAFIRARKPAAACCGPACCS

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI109389364, Length=208, Percent_Identity=36.5384615384615, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI48994983, Length=105, Percent_Identity=38.0952380952381, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR005149
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08241 Methyltransf_11; PF03551 PadR [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 28965; Mature: 28834

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQNITDVVKEKYGQAALRVVAGGSSSCCGAAPSNQCGDPITDNLYGAEVSELPADAIA
CCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHH
ASLGCGNPTALAQLNPGETVLDLGSGGGIDVLLSARRVGPTGKAYGLDMTDEMLALANAN
HHCCCCCCCEEEEECCCCEEEECCCCCCEEEEEECHHCCCCCCEECCCCHHHHHHHHCCC
KAKAGLENVEFLKGQIESIPLPDNSVDVIISNCVINLSANKDRVLAEAFRVLKPGGRFAV
HHHHCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEH
SDVVTHGEIPAEIREHVLLWVGCLAGALEDTDYQAKLAAAGFEAVGVEPTRVYRVDDARA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHCCCCCEEEEEECCHHH
FLSGKGLDVDAVAPLVDGKFFSAFIRARKPAAACCGPACCS
HHCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure 
ATQNITDVVKEKYGQAALRVVAGGSSSCCGAAPSNQCGDPITDNLYGAEVSELPADAIA
CCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHH
ASLGCGNPTALAQLNPGETVLDLGSGGGIDVLLSARRVGPTGKAYGLDMTDEMLALANAN
HHCCCCCCCEEEEECCCCEEEECCCCCCEEEEEECHHCCCCCCEECCCCHHHHHHHHCCC
KAKAGLENVEFLKGQIESIPLPDNSVDVIISNCVINLSANKDRVLAEAFRVLKPGGRFAV
HHHHCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEH
SDVVTHGEIPAEIREHVLLWVGCLAGALEDTDYQAKLAAAGFEAVGVEPTRVYRVDDARA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHCCCCCEEEEEECCHHH
FLSGKGLDVDAVAPLVDGKFFSAFIRARKPAAACCGPACCS
HHCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2155856 [H]