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The map label for this gene is ctaB

Identifier: 116623472

GI number: 116623472

Start: 5543279

End: 5544157

Strand: Reverse

Name: ctaB

Synonym: Acid_4382

Alternate gene names: 116623472

Gene position: 5544157-5543279 (Counterclockwise)

Preceding gene: 116623473

Following gene: 116623471

Centisome position: 55.63

GC content: 63.14

Gene sequence:

>879_bases
ATGCGCGACTATATCGAACTGACGAAACCGCGGATCACCTGGCTTATCCTGATGAGCACTGGCATCGGGTATTTCTTCGG
GCTGCCGCAGGCGAGCAACTGGCTGACGTTCCTGAAGAACATCGACCTGCTTCGCCTGCTGCACACGATCATCGGCACGG
GGTTAATCGCGAGCGGGACGGCGGCGCTCAACCAGTGGTACGAGCGCGAGGGCGATCTGAAGATGCATCGCACGGCGGGG
CGTCCGCTGCCCTCGGGGCGGCTGATCGCGGGGCGTGCGCTGGCCTTCGGCGTGGCGCTTTCAATCGCGGGCTTCGTGGA
ATTGTGGCTGGGAGTGAATCTGCTGAGCGCCGGAATCGGTGCCTTCACGCTGGCGAGCTACCTGTTCCTGTACACACCGA
TGAAGCGCCGCACGTGGTGGAGCACGACGGTGGGCGCGATTCCGGGCGCGATGCCGCCGGTGATCGGCTTCGCGGCGGCG
GCGGGCGGGCTGACCCGGGAATCCTGGGTGCTGTTCGCGATCCTGTTCCTGTGGCAGTTCCCGCACTTCTATTCGATCGC
GTGGATGTACAAGGAAGACTACGCGCGCGCCGGCATACAGATGCTGCCGGTGGTTGATCCGGACTGCCGGTCCACGGCGC
GGCAGATTGTGATTTACGGGATCGCTCTGATTCCGGTGAGCCTGGTTCCCGCATTGCTCGGGATGTCGGGCCGCCTGTAT
TTGGTGGGAGCGTTGCTGTTGGGCCTCTGGTTTTTATATTCGGGTGTACGTGTCGCGCTGGAGCGGACTCTGGTGCGCGC
ACGTGGTGTGCTGATCACCTCGGTACTGTACCTCCCGCTGATTTATGGCCTGATGCTGCTGGATAGGCCGGGTCTGTGA

Upstream 100 bases:

>100_bases
GTTCTCTGGCGTTGGGCGCCGCGGTGGCGCTTGCGATGATAGTGTATCGCCAGCCGCGCAATCAGGCGGTGATGGCAAAT
GGGGGGATCGCGATCGCCTG

Downstream 100 bases:

>100_bases
TCGCGGTCCATAATTTAACCCATCGTTACGGAGACCGGGTCGCTCTCGCGAACGTGAGTTTCGAAGTGAAGAAGGGCGAG
ATCTTCGGCCTGCTGGGGCC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MRDYIELTKPRITWLILMSTGIGYFFGLPQASNWLTFLKNIDLLRLLHTIIGTGLIASGTAALNQWYEREGDLKMHRTAG
RPLPSGRLIAGRALAFGVALSIAGFVELWLGVNLLSAGIGAFTLASYLFLYTPMKRRTWWSTTVGAIPGAMPPVIGFAAA
AGGLTRESWVLFAILFLWQFPHFYSIAWMYKEDYARAGIQMLPVVDPDCRSTARQIVIYGIALIPVSLVPALLGMSGRLY
LVGALLLGLWFLYSGVRVALERTLVRARGVLITSVLYLPLIYGLMLLDRPGL

Sequences:

>Translated_292_residues
MRDYIELTKPRITWLILMSTGIGYFFGLPQASNWLTFLKNIDLLRLLHTIIGTGLIASGTAALNQWYEREGDLKMHRTAG
RPLPSGRLIAGRALAFGVALSIAGFVELWLGVNLLSAGIGAFTLASYLFLYTPMKRRTWWSTTVGAIPGAMPPVIGFAAA
AGGLTRESWVLFAILFLWQFPHFYSIAWMYKEDYARAGIQMLPVVDPDCRSTARQIVIYGIALIPVSLVPALLGMSGRLY
LVGALLLGLWFLYSGVRVALERTLVRARGVLITSVLYLPLIYGLMLLDRPGL
>Mature_292_residues
MRDYIELTKPRITWLILMSTGIGYFFGLPQASNWLTFLKNIDLLRLLHTIIGTGLIASGTAALNQWYEREGDLKMHRTAG
RPLPSGRLIAGRALAFGVALSIAGFVELWLGVNLLSAGIGAFTLASYLFLYTPMKRRTWWSTTVGAIPGAMPPVIGFAAA
AGGLTRESWVLFAILFLWQFPHFYSIAWMYKEDYARAGIQMLPVVDPDCRSTARQIVIYGIALIPVSLVPALLGMSGRLY
LVGALLLGLWFLYSGVRVALERTLVRARGVLITSVLYLPLIYGLMLLDRPGL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=208, Percent_Identity=37.5, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1786631, Length=269, Percent_Identity=34.2007434944238, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71998235, Length=254, Percent_Identity=30.7086614173228, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325085, Length=309, Percent_Identity=28.8025889967638, Blast_Score=119, Evalue=8e-28,
Organism=Drosophila melanogaster, GI19921064, Length=290, Percent_Identity=32.7586206896552, Blast_Score=151, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_SOLUE (Q01YC2)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825628.1
- STRING:   Q01YC2
- GeneID:   4427341
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_4382
- NMPDR:   fig|234267.9.peg.4169
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- PhylomeDB:   Q01YC2
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32269; Mature: 32269

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a258d08)-; HASH(0x1ba8b3b4)-; HASH(0x1ba7ceb8)-; HASH(0x1bad8158)-; HASH(0x1adaffdc)-; HASH(0x1b4d03bc)-; HASH(0x1b214118)-; HASH(0x1a5e0f2c)-; HASH(0x1ba74018)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDYIELTKPRITWLILMSTGIGYFFGLPQASNWLTFLKNIDLLRLLHTIIGTGLIASGT
CCCCHHHCCCHHEEEEEEHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCH
AALNQWYEREGDLKMHRTAGRPLPSGRLIAGRALAFGVALSIAGFVELWLGVNLLSAGIG
HHHHHHHHCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
AFTLASYLFLYTPMKRRTWWSTTVGAIPGAMPPVIGFAAAAGGLTRESWVLFAILFLWQF
HHHHHHHHHHHCCHHHCHHHCCHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
PHFYSIAWMYKEDYARAGIQMLPVVDPDCRSTARQIVIYGIALIPVSLVPALLGMSGRLY
CHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LVGALLLGLWFLYSGVRVALERTLVRARGVLITSVLYLPLIYGLMLLDRPGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MRDYIELTKPRITWLILMSTGIGYFFGLPQASNWLTFLKNIDLLRLLHTIIGTGLIASGT
CCCCHHHCCCHHEEEEEEHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCH
AALNQWYEREGDLKMHRTAGRPLPSGRLIAGRALAFGVALSIAGFVELWLGVNLLSAGIG
HHHHHHHHCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
AFTLASYLFLYTPMKRRTWWSTTVGAIPGAMPPVIGFAAAAGGLTRESWVLFAILFLWQF
HHHHHHHHHHHCCHHHCHHHCCHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
PHFYSIAWMYKEDYARAGIQMLPVVDPDCRSTARQIVIYGIALIPVSLVPALLGMSGRLY
CHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LVGALLLGLWFLYSGVRVALERTLVRARGVLITSVLYLPLIYGLMLLDRPGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA