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The map label for this gene is hemL

Identifier: 116623342

GI number: 116623342

Start: 5377364

End: 5378617

Strand: Direct

Name: hemL

Synonym: Acid_4251

Alternate gene names: 116623342

Gene position: 5377364-5378617 (Clockwise)

Preceding gene: 116623341

Following gene: 116623343

Centisome position: 53.96

GC content: 64.67

Gene sequence:

>1254_bases
ATGACCCACACAAAATCCGAAGAATTGTTTCGCCGCGCCGTGGAGAAGATTCCGGGCGGCGTGAACTCGCCGGTGCGCGC
CTTCCGCAGCGTGGGTGGACAGCCGGTCTTCATCGCGCGCGGGCAGGGCTCGCATCTGTTCGACGTGGACGGCAACGAGT
ACATCGATTACGTGGGGTCCTGGGGTCCGCTGATTCTGGGACACCGGCATCCGGAAATTCTGGCGGCGCTCGAGCGCGCC
CTCGAGATCGGCACCAGCTTCGGCGCCCCGACGGAGCAGGAAATCGACCTGGCCGACGCCATCATCGACGCTGTGCCCTC
GGTGGAGATGGTGCGGCTGGTGAATTCGGGCACCGAAGCCACGATGTCGGCGATCCGCGTAGCGCGCGGTTTCACCGGAC
GAGATCTGGTGGTGAAATTCGAAGGCTGCTATCACGGCCACGTGGACTCGCTGCTGGTAAAAGCGGGGTCGGGCATGGCG
ACGCTCGGCATCGCCGATACACAAGGCGTGCCCAAGGCCTTCGCCGATACCACCATTCCCCTGCCCTACAATTCGCTGGA
TGCGCTGGAAGAGGCATTCCGCGCGCATGGCGACCGCATCGCGGCCGTAATCGTGGAGCCGGTGGTCGGCAACATGGGCT
GCGTGCCGCCGCTGCCCGGATATCTGGAAGGCATGCGCGCCATCACGGAGCGCTACGGCGCGCTCCTGATTTTCGACGAG
GTGATGACCGGCTTCCGCGTGGCCTTCGGCGGGGCGCAGCAGCTTTATGGAATTAAGCCCGACCTGACCACGCTCGGCAA
AGTGATCGGCGGCGGACTCCCGGTGGGCGCATATGGCGGGCGCAAGGACATCATGAGTAAGGTGGCCCCGGCGGGTCCGA
TTTACCAGGCGGGGACGCTCTCGGGCAATCCGCTGGCGGTGGCGGCGGGGCTCGCGATGCTGCGGCACCTCAAGCGGAAT
CCGCAAGTGTATACGCGGCTGGAGGAATGCGGAGCGCGGTTGGCGGCGGCGGCTCCGAAGGGCGTGACGGTGAATCGCGT
GGGATCGATGTTCACGTTCTTCTTCACCGATGGTCCGGTGACCGATTGGGAATCGGCTAAGCGGTGCGACACGTCGCGCT
TCGGTGAGTTCTTCCGCGGGATGCTGGATCGTGGCGTGTACCTGGCGCCATCGCAATTCGAGGCAGCCTTCGTGGGTGCC
GCACATTCCGACGAAGATATCGCGAAGACCATCGAGGCTGCGAAGACGGCATAA

Upstream 100 bases:

>100_bases
CTGCGCAACCTCAACGGCAGCCTGTATGAGATCGCGATGAGTTTCGGCTTTAGCCGCGTAGTTCCCAAGGCAGGATAACG
GCCGCCGCTTCGACATCGAT

Downstream 100 bases:

>100_bases
GTAGCCCTTCTAGCGCCAACGTCGCACCCGCATCATCAGAACCGCGACCGTCAGGGAGCGATCTCATACTTTGCTTGCGC
CGGCCCGACAATGCGTGGTA

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTHTKSEELFRRAVEKIPGGVNSPVRAFRSVGGQPVFIARGQGSHLFDVDGNEYIDYVGSWGPLILGHRHPEILAALERA
LEIGTSFGAPTEQEIDLADAIIDAVPSVEMVRLVNSGTEATMSAIRVARGFTGRDLVVKFEGCYHGHVDSLLVKAGSGMA
TLGIADTQGVPKAFADTTIPLPYNSLDALEEAFRAHGDRIAAVIVEPVVGNMGCVPPLPGYLEGMRAITERYGALLIFDE
VMTGFRVAFGGAQQLYGIKPDLTTLGKVIGGGLPVGAYGGRKDIMSKVAPAGPIYQAGTLSGNPLAVAAGLAMLRHLKRN
PQVYTRLEECGARLAAAAPKGVTVNRVGSMFTFFFTDGPVTDWESAKRCDTSRFGEFFRGMLDRGVYLAPSQFEAAFVGA
AHSDEDIAKTIEAAKTA

Sequences:

>Translated_417_residues
MTHTKSEELFRRAVEKIPGGVNSPVRAFRSVGGQPVFIARGQGSHLFDVDGNEYIDYVGSWGPLILGHRHPEILAALERA
LEIGTSFGAPTEQEIDLADAIIDAVPSVEMVRLVNSGTEATMSAIRVARGFTGRDLVVKFEGCYHGHVDSLLVKAGSGMA
TLGIADTQGVPKAFADTTIPLPYNSLDALEEAFRAHGDRIAAVIVEPVVGNMGCVPPLPGYLEGMRAITERYGALLIFDE
VMTGFRVAFGGAQQLYGIKPDLTTLGKVIGGGLPVGAYGGRKDIMSKVAPAGPIYQAGTLSGNPLAVAAGLAMLRHLKRN
PQVYTRLEECGARLAAAAPKGVTVNRVGSMFTFFFTDGPVTDWESAKRCDTSRFGEFFRGMLDRGVYLAPSQFEAAFVGA
AHSDEDIAKTIEAAKTA
>Mature_416_residues
THTKSEELFRRAVEKIPGGVNSPVRAFRSVGGQPVFIARGQGSHLFDVDGNEYIDYVGSWGPLILGHRHPEILAALERAL
EIGTSFGAPTEQEIDLADAIIDAVPSVEMVRLVNSGTEATMSAIRVARGFTGRDLVVKFEGCYHGHVDSLLVKAGSGMAT
LGIADTQGVPKAFADTTIPLPYNSLDALEEAFRAHGDRIAAVIVEPVVGNMGCVPPLPGYLEGMRAITERYGALLIFDEV
MTGFRVAFGGAQQLYGIKPDLTTLGKVIGGGLPVGAYGGRKDIMSKVAPAGPIYQAGTLSGNPLAVAAGLAMLRHLKRNP
QVYTRLEECGARLAAAAPKGVTVNRVGSMFTFFFTDGPVTDWESAKRCDTSRFGEFFRGMLDRGVYLAPSQFEAAFVGAA
HSDEDIAKTIEAAKTA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=295, Percent_Identity=31.1864406779661, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI24119277, Length=302, Percent_Identity=29.8013245033113, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI284507298, Length=141, Percent_Identity=39.0070921985816, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786349, Length=420, Percent_Identity=59.2857142857143, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1789016, Length=379, Percent_Identity=30.3430079155673, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1788044, Length=311, Percent_Identity=34.7266881028939, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1787560, Length=363, Percent_Identity=32.2314049586777, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1789759, Length=280, Percent_Identity=32.8571428571429, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693181, Length=343, Percent_Identity=29.1545189504373, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1786991, Length=295, Percent_Identity=27.7966101694915, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71992977, Length=362, Percent_Identity=27.6243093922652, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=306, Percent_Identity=28.7581699346405, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=317, Percent_Identity=29.0220820189274, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=145, Percent_Identity=35.8620689655172, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=328, Percent_Identity=28.0487804878049, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=336, Percent_Identity=25.8928571428571, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356575, Length=302, Percent_Identity=29.1390728476821, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357415, Length=296, Percent_Identity=26.6891891891892, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_SOLUE (Q01YQ2)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825498.1
- ProteinModelPortal:   Q01YQ2
- SMR:   Q01YQ2
- STRING:   Q01YQ2
- GeneID:   4427506
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_4251
- NMPDR:   fig|234267.9.peg.4043
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- PhylomeDB:   Q01YQ2
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 44347; Mature: 44216

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTKSEELFRRAVEKIPGGVNSPVRAFRSVGGQPVFIARGQGSHLFDVDGNEYIDYVGS
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHCC
WGPLILGHRHPEILAALERALEIGTSFGAPTEQEIDLADAIIDAVPSVEMVRLVNSGTEA
CCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHH
TMSAIRVARGFTGRDLVVKFEGCYHGHVDSLLVKAGSGMATLGIADTQGVPKAFADTTIP
HHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCCC
LPYNSLDALEEAFRAHGDRIAAVIVEPVVGNMGCVPPLPGYLEGMRAITERYGALLIFDE
CCCCHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCEEEEHHH
VMTGFRVAFGGAQQLYGIKPDLTTLGKVIGGGLPVGAYGGRKDIMSKVAPAGPIYQAGTL
HHHHHHHHCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCC
SGNPLAVAAGLAMLRHLKRNPQVYTRLEECGARLAAAAPKGVTVNRVGSMFTFFFTDGPV
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEEEECCCC
TDWESAKRCDTSRFGEFFRGMLDRGVYLAPSQFEAAFVGAAHSDEDIAKTIEAAKTA
CCCHHHHHCCHHHHHHHHHHHHHCCEEECCCCCCHHEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
THTKSEELFRRAVEKIPGGVNSPVRAFRSVGGQPVFIARGQGSHLFDVDGNEYIDYVGS
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHCC
WGPLILGHRHPEILAALERALEIGTSFGAPTEQEIDLADAIIDAVPSVEMVRLVNSGTEA
CCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHH
TMSAIRVARGFTGRDLVVKFEGCYHGHVDSLLVKAGSGMATLGIADTQGVPKAFADTTIP
HHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCCC
LPYNSLDALEEAFRAHGDRIAAVIVEPVVGNMGCVPPLPGYLEGMRAITERYGALLIFDE
CCCCHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCEEEEHHH
VMTGFRVAFGGAQQLYGIKPDLTTLGKVIGGGLPVGAYGGRKDIMSKVAPAGPIYQAGTL
HHHHHHHHCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCC
SGNPLAVAAGLAMLRHLKRNPQVYTRLEECGARLAAAAPKGVTVNRVGSMFTFFFTDGPV
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEEEECCCC
TDWESAKRCDTSRFGEFFRGMLDRGVYLAPSQFEAAFVGAAHSDEDIAKTIEAAKTA
CCCHHHHHCCHHHHHHHHHHHHHCCEEECCCCCCHHEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA