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The map label for this gene is mrdA [H]

Identifier: 116623273

GI number: 116623273

Start: 5301647

End: 5303623

Strand: Reverse

Name: mrdA [H]

Synonym: Acid_4180

Alternate gene names: 116623273

Gene position: 5303623-5301647 (Counterclockwise)

Preceding gene: 116623274

Following gene: 116623272

Centisome position: 53.22

GC content: 60.95

Gene sequence:

>1977_bases
GTGATCCTTCCGCCGACCGATCCAAATCTCGGACAACGTGTATCGGACAAACCCCCGCTGCGTGATGATACGCGCTTTGC
GGCGGGTAAGATCGCGGTATTTCAATACGCCACGGTCGTCATCTTCCTCTTCCTGATTTCCGGTTTTTGGCGGCTGCAGG
TGCAGAATCCGCAGTTCTACGGAGAGCGAGCCCTTCAGAACAGTATCAAATCGGTGCCGATTCCCGGGCCGCGCGGCCGT
CTTCTGGATCGCGACGGGCGGATCATCGTGGATAACCACTCGTCTTTCCAGTTGATTCTGGCCCGTGAATCGGCCAAGGA
AGAGCACCTGCGCTCCATCGCCCAGGGTTTGGACCTCGATTACACGGACCTGTTGCTGCGCATGCGGCGTGTCAGCCGGC
AGCCGAAGTACGTACCGATCGTGATCAAGGATGAACTCACCCCTGCCGACCTCGCGTTCGTGAACTCGCATCAGGATTTC
TTTCCGGAGATGGTGCTGATTCAGGCCCAGCGCCGCCTGTATCCGCAGAACGGTATGCTGGCTCACGTTATCGGGTACAC
CGGTGAAATCAGCGAGCAGGAGTTGGACCTGCCGGAATACGGTAAATACAATGCCGGTGAAATGGTCGGCAAGTTCGGGA
TCGAAAAACAGTACAACGACAGCCTGATGGGCGTGGATGGACAGCGCCAGGTGGTGGTGGACAACCGCGGACAGGTGCGG
CAGACCATCGGCACCAAGCCCGCGGTGCCGGGTAAGGACCTCGAACTAACGATCGATCTGGACCTGCAGACGGTCGCCGA
ACTGGCGATGGCAGGCAAGAGCGGTTCCATAGTGGCGCTCGATCCGCGCTCGGGCGAGGTGCTGGCCATGGTCAGCCGCC
CGACCTTCGACCCCAACAAATTCACAGTTCGCATCAAAACCAAGGACTGGCGCGAGATCGCCGACAACCCCGATCATCCT
CTGATGAACCGCGCGATTCAGGCGCAGCAGGCGCCCGGATCGACCTTCAAGCCCATCGTCGCCTTGGCCGGCCTGGAGAC
GGGCACGGTCGATGACAAGTGGAGTGTCCACTGCTCGGGCGGCGTGGCCCTTTACGGCAAGTATCAGCGCTGCTGGCAGA
AGGGGGGACATGGCACGCTTTCCATGCACTCCGGCATCGTGCACTCCTGCGACGTTTATTTTTACACGCTGGGCTCGAAA
ATCGGGATCAATAACCTCGCCTTCTACGGCGACCTGGTCGGTTTCGGTCAGGCGACGGGCATCGACCTGCCGCACGAGAA
CATCGGTCTGATGCCGTCGGAAAAGTGGAAGCTGCGCAACTACCGCACCAAGTGGTACGCCGGCGAAACTCCTTCGGTGG
CCATCGGGCAGGGCGCGGTGATCGTGACCCCGCTGCAGCTGGCGCGCGCGATTGGCGGGATGGCGATCGGCGGCCGCTGG
TATCAACCGCATATGGTGCGGAGACCGGTCGAAGAGGTCAAGGAGACCGAGTGGAAGCTGGATCCCGAGCATGTGAAGAT
CGTCAAGGATGGCATGTACGGCGTAGTCAATGAAGGGGGCACCGGAATTCGCGCCGCATTGCCGCACCTTGAGATTTGCG
GCAAGACGGGCTCGGCGCAGCTGGCCTCCAACGAATTTGTGAAGGGCTCGAGCAGCAAAGATTTGAAGGACAACGCCTGG
TTTGTCGGTTTCGCTCCGCGTGAAAACCCGGAGATCGTGGTTGTGGCGCTTTGGGAGCATGGGGAGCACGGACAATTCGC
CGCAGCCCTTGTGCGCGACGTGATGAAGGCGTACTTCGATAAGAAACAGCGAATTACCGAGATCCAGGCCGGACAGAATC
GCCTGCGGGCGGGATTCGGGCTGGGACTGCCGGCGCGTACCGCGCCCGCTCCCACCGCGCCGGCGGCCCCACCGGATGCG
GCCATCATCACCGGCGCTGTAATGTCCACACAAGTAGCGGCGACGCCCAATCACTGA

Upstream 100 bases:

>100_bases
CGACGGCCGCGACCGCATGCAGCTGAATTGGGACCGGAAGTAGGCGGATTAGTCAGATCGGTTAGGTTAGAATGAAAGAA
GAGCCGCCGCTCTATAGTTT

Downstream 100 bases:

>100_bases
TCATGTCCAAATACCTTTCTCCGCGCGACATCGACTGGACGGTCCTGCTGATCGTCCTGTTGATCTGCGCCGTCGGAGTC
TTGCAGATCTATAGCGCGAC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MILPPTDPNLGQRVSDKPPLRDDTRFAAGKIAVFQYATVVIFLFLISGFWRLQVQNPQFYGERALQNSIKSVPIPGPRGR
LLDRDGRIIVDNHSSFQLILARESAKEEHLRSIAQGLDLDYTDLLLRMRRVSRQPKYVPIVIKDELTPADLAFVNSHQDF
FPEMVLIQAQRRLYPQNGMLAHVIGYTGEISEQELDLPEYGKYNAGEMVGKFGIEKQYNDSLMGVDGQRQVVVDNRGQVR
QTIGTKPAVPGKDLELTIDLDLQTVAELAMAGKSGSIVALDPRSGEVLAMVSRPTFDPNKFTVRIKTKDWREIADNPDHP
LMNRAIQAQQAPGSTFKPIVALAGLETGTVDDKWSVHCSGGVALYGKYQRCWQKGGHGTLSMHSGIVHSCDVYFYTLGSK
IGINNLAFYGDLVGFGQATGIDLPHENIGLMPSEKWKLRNYRTKWYAGETPSVAIGQGAVIVTPLQLARAIGGMAIGGRW
YQPHMVRRPVEEVKETEWKLDPEHVKIVKDGMYGVVNEGGTGIRAALPHLEICGKTGSAQLASNEFVKGSSSKDLKDNAW
FVGFAPRENPEIVVVALWEHGEHGQFAAALVRDVMKAYFDKKQRITEIQAGQNRLRAGFGLGLPARTAPAPTAPAAPPDA
AIITGAVMSTQVAATPNH

Sequences:

>Translated_658_residues
MILPPTDPNLGQRVSDKPPLRDDTRFAAGKIAVFQYATVVIFLFLISGFWRLQVQNPQFYGERALQNSIKSVPIPGPRGR
LLDRDGRIIVDNHSSFQLILARESAKEEHLRSIAQGLDLDYTDLLLRMRRVSRQPKYVPIVIKDELTPADLAFVNSHQDF
FPEMVLIQAQRRLYPQNGMLAHVIGYTGEISEQELDLPEYGKYNAGEMVGKFGIEKQYNDSLMGVDGQRQVVVDNRGQVR
QTIGTKPAVPGKDLELTIDLDLQTVAELAMAGKSGSIVALDPRSGEVLAMVSRPTFDPNKFTVRIKTKDWREIADNPDHP
LMNRAIQAQQAPGSTFKPIVALAGLETGTVDDKWSVHCSGGVALYGKYQRCWQKGGHGTLSMHSGIVHSCDVYFYTLGSK
IGINNLAFYGDLVGFGQATGIDLPHENIGLMPSEKWKLRNYRTKWYAGETPSVAIGQGAVIVTPLQLARAIGGMAIGGRW
YQPHMVRRPVEEVKETEWKLDPEHVKIVKDGMYGVVNEGGTGIRAALPHLEICGKTGSAQLASNEFVKGSSSKDLKDNAW
FVGFAPRENPEIVVVALWEHGEHGQFAAALVRDVMKAYFDKKQRITEIQAGQNRLRAGFGLGLPARTAPAPTAPAAPPDA
AIITGAVMSTQVAATPNH
>Mature_658_residues
MILPPTDPNLGQRVSDKPPLRDDTRFAAGKIAVFQYATVVIFLFLISGFWRLQVQNPQFYGERALQNSIKSVPIPGPRGR
LLDRDGRIIVDNHSSFQLILARESAKEEHLRSIAQGLDLDYTDLLLRMRRVSRQPKYVPIVIKDELTPADLAFVNSHQDF
FPEMVLIQAQRRLYPQNGMLAHVIGYTGEISEQELDLPEYGKYNAGEMVGKFGIEKQYNDSLMGVDGQRQVVVDNRGQVR
QTIGTKPAVPGKDLELTIDLDLQTVAELAMAGKSGSIVALDPRSGEVLAMVSRPTFDPNKFTVRIKTKDWREIADNPDHP
LMNRAIQAQQAPGSTFKPIVALAGLETGTVDDKWSVHCSGGVALYGKYQRCWQKGGHGTLSMHSGIVHSCDVYFYTLGSK
IGINNLAFYGDLVGFGQATGIDLPHENIGLMPSEKWKLRNYRTKWYAGETPSVAIGQGAVIVTPLQLARAIGGMAIGGRW
YQPHMVRRPVEEVKETEWKLDPEHVKIVKDGMYGVVNEGGTGIRAALPHLEICGKTGSAQLASNEFVKGSSSKDLKDNAW
FVGFAPRENPEIVVVALWEHGEHGQFAAALVRDVMKAYFDKKQRITEIQAGQNRLRAGFGLGLPARTAPAPTAPAAPPDA
AIITGAVMSTQVAATPNH

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=607, Percent_Identity=33.1136738056013, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI1786272, Length=599, Percent_Identity=24.8747913188648, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 72374; Mature: 72374

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPPTDPNLGQRVSDKPPLRDDTRFAAGKIAVFQYATVVIFLFLISGFWRLQVQNPQFY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCHHH
GERALQNSIKSVPIPGPRGRLLDRDGRIIVDNHSSFQLILARESAKEEHLRSIAQGLDLD
HHHHHHHHHCCCCCCCCCCCEECCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCC
YTDLLLRMRRVSRQPKYVPIVIKDELTPADLAFVNSHQDFFPEMVLIQAQRRLYPQNGML
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCE
AHVIGYTGEISEQELDLPEYGKYNAGEMVGKFGIEKQYNDSLMGVDGQRQVVVDNRGQVR
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECCCCCCEEEECCCCHHH
QTIGTKPAVPGKDLELTIDLDLQTVAELAMAGKSGSIVALDPRSGEVLAMVSRPTFDPNK
HHCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCCCE
FTVRIKTKDWREIADNPDHPLMNRAIQAQQAPGSTFKPIVALAGLETGTVDDKWSVHCSG
EEEEEECCHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHEECCCCCCCCCCEEEEECC
GVALYGKYQRCWQKGGHGTLSMHSGIVHSCDVYFYTLGSKIGINNLAFYGDLVGFGQATG
CEEEEEHHHHHHHCCCCEEEEECCCCEEECEEEEEECCCCCCCCCEEEHHHHHCCCCCCC
IDLPHENIGLMPSEKWKLRNYRTKWYAGETPSVAIGQGAVIVTPLQLARAIGGMAIGGRW
CCCCCCCCCCCCCCCCHHCCCEEEEECCCCCCEEECCCEEEEEHHHHHHHHCCEEECCEE
YQPHMVRRPVEEVKETEWKLDPEHVKIVKDGMYGVVNEGGTGIRAALPHLEICGKTGSAQ
CCCHHHHHHHHHHHHHCCCCCHHHEEEEECCCEEEECCCCCCHHHHCCCCEECCCCCCCC
LASNEFVKGSSSKDLKDNAWFVGFAPRENPEIVVVALWEHGEHGQFAAALVRDVMKAYFD
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
KKQRITEIQAGQNRLRAGFGLGLPARTAPAPTAPAAPPDAAIITGAVMSTQVAATPNH
HHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHEEEECCCCC
>Mature Secondary Structure
MILPPTDPNLGQRVSDKPPLRDDTRFAAGKIAVFQYATVVIFLFLISGFWRLQVQNPQFY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCHHH
GERALQNSIKSVPIPGPRGRLLDRDGRIIVDNHSSFQLILARESAKEEHLRSIAQGLDLD
HHHHHHHHHCCCCCCCCCCCEECCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCC
YTDLLLRMRRVSRQPKYVPIVIKDELTPADLAFVNSHQDFFPEMVLIQAQRRLYPQNGML
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCE
AHVIGYTGEISEQELDLPEYGKYNAGEMVGKFGIEKQYNDSLMGVDGQRQVVVDNRGQVR
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECCCCCCEEEECCCCHHH
QTIGTKPAVPGKDLELTIDLDLQTVAELAMAGKSGSIVALDPRSGEVLAMVSRPTFDPNK
HHCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCCCE
FTVRIKTKDWREIADNPDHPLMNRAIQAQQAPGSTFKPIVALAGLETGTVDDKWSVHCSG
EEEEEECCHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHEECCCCCCCCCCEEEEECC
GVALYGKYQRCWQKGGHGTLSMHSGIVHSCDVYFYTLGSKIGINNLAFYGDLVGFGQATG
CEEEEEHHHHHHHCCCCEEEEECCCCEEECEEEEEECCCCCCCCCEEEHHHHHCCCCCCC
IDLPHENIGLMPSEKWKLRNYRTKWYAGETPSVAIGQGAVIVTPLQLARAIGGMAIGGRW
CCCCCCCCCCCCCCCCHHCCCEEEEECCCCCCEEECCCEEEEEHHHHHHHHCCEEECCEE
YQPHMVRRPVEEVKETEWKLDPEHVKIVKDGMYGVVNEGGTGIRAALPHLEICGKTGSAQ
CCCHHHHHHHHHHHHHCCCCCHHHEEEEECCCEEEECCCCCCHHHHCCCCEECCCCCCCC
LASNEFVKGSSSKDLKDNAWFVGFAPRENPEIVVVALWEHGEHGQFAAALVRDVMKAYFD
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
KKQRITEIQAGQNRLRAGFGLGLPARTAPAPTAPAAPPDAAIITGAVMSTQVAATPNH
HHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]