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The map label for this gene is mrdB [H]

Identifier: 116623272

GI number: 116623272

Start: 5300553

End: 5301644

Strand: Reverse

Name: mrdB [H]

Synonym: Acid_4179

Alternate gene names: 116623272

Gene position: 5301644-5300553 (Counterclockwise)

Preceding gene: 116623273

Following gene: 116623271

Centisome position: 53.2

GC content: 54.03

Gene sequence:

>1092_bases
ATGTCCAAATACCTTTCTCCGCGCGACATCGACTGGACGGTCCTGCTGATCGTCCTGTTGATCTGCGCCGTCGGAGTCTT
GCAGATCTATAGCGCGACGCGCGACACGGATTACACCTCGGCATGGTGGAAACAAGTGGTTTATGTGCTTGGCGGCCTGC
TCTTTCTGTGGATCGCGATGATGATCGATTACCACACCATGCTGCACTATGTCCCCGCCCTATATATAGGGAGTGTGGGA
GCGCTGCTGGTCACGTACCTGATCGGCGAGAAGGCCTACGGCTCCAAACGCTGGATTCCGATGGGTTTCGGGGTGCATTT
GCAGGTATCGGAATTCGTCAAGCTGGTGATAGTATTATTGGTAGCTCGTTACCTCACCGAATTGAGGACGGATGAACTAG
AGATTCGGGAGATGTTGAAACTGGCGGGCTTAGTGTTGATTCCAACCGCGCTGGTGATGAAACAGCCGGATTTAGGAACC
TCGTTGACGTACGTGGCAGTCCTGATCGCATGCGCATTTCTGGCAGGATTGCGGTGGAAGTATGTGGCGGCCATCGCCGT
GATCACGGTGGTTGTGCTTCCCATTAGCTGGCAGTTTTTGAATGAGTACCAGAGGGGCCGGATAGTCAGTTTCATGGATC
CGGAGCGCGATCCTCAAGGGAAGGGATATCAATTGATCCAGTCCCAGATCGCGGTCGGTTCCGGTGGCATGTTCGGCAAA
GGGGTTACCAAGGGGACGCAGACGCAGCTGCGGTTCCTGCCGGTGCCTCATAAAGATTTCATCTTCTCGGCCTTTGCCGA
GGAGCACGGTTTCGTAGGCGTAGTGGTTTTGTTGTCGTTGTTTTTCGTGCTGGTCATGCGAATTGTTCAGAATGCGCAGA
CCGCACCGGACCGCGTAGGGATGTATATATGTATGGGGGTGGCGGCCTTGCTGCTCTTCCACGTTCTGGTGAATGTGGGG
ATGGTGGCGGGGTTAATGCCGGTAACCGGTATCCCGCTGCCGTTTATGAGTTTCGGCGGATCCAGTATTTGGACATTTTT
CCTGGCCTTGGGGCTGGTAAACAATGTTCGCCTTAGAAGGTTTGTGAATTAG

Upstream 100 bases:

>100_bases
CCGCGCCCGCTCCCACCGCGCCGGCGGCCCCACCGGATGCGGCCATCATCACCGGCGCTGTAATGTCCACACAAGTAGCG
GCGACGCCCAATCACTGATC

Downstream 100 bases:

>100_bases
CCGGACGGCTCGCAAGAGGACGTTCGAGAAGAATTTGATTCGGGAGCCTGCAGGAAACCCCCCGCATTCTGGCGCGCAGG
CGCGCCGGGCGGGGTAGAGG

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSKYLSPRDIDWTVLLIVLLICAVGVLQIYSATRDTDYTSAWWKQVVYVLGGLLFLWIAMMIDYHTMLHYVPALYIGSVG
ALLVTYLIGEKAYGSKRWIPMGFGVHLQVSEFVKLVIVLLVARYLTELRTDELEIREMLKLAGLVLIPTALVMKQPDLGT
SLTYVAVLIACAFLAGLRWKYVAAIAVITVVVLPISWQFLNEYQRGRIVSFMDPERDPQGKGYQLIQSQIAVGSGGMFGK
GVTKGTQTQLRFLPVPHKDFIFSAFAEEHGFVGVVVLLSLFFVLVMRIVQNAQTAPDRVGMYICMGVAALLLFHVLVNVG
MVAGLMPVTGIPLPFMSFGGSSIWTFFLALGLVNNVRLRRFVN

Sequences:

>Translated_363_residues
MSKYLSPRDIDWTVLLIVLLICAVGVLQIYSATRDTDYTSAWWKQVVYVLGGLLFLWIAMMIDYHTMLHYVPALYIGSVG
ALLVTYLIGEKAYGSKRWIPMGFGVHLQVSEFVKLVIVLLVARYLTELRTDELEIREMLKLAGLVLIPTALVMKQPDLGT
SLTYVAVLIACAFLAGLRWKYVAAIAVITVVVLPISWQFLNEYQRGRIVSFMDPERDPQGKGYQLIQSQIAVGSGGMFGK
GVTKGTQTQLRFLPVPHKDFIFSAFAEEHGFVGVVVLLSLFFVLVMRIVQNAQTAPDRVGMYICMGVAALLLFHVLVNVG
MVAGLMPVTGIPLPFMSFGGSSIWTFFLALGLVNNVRLRRFVN
>Mature_362_residues
SKYLSPRDIDWTVLLIVLLICAVGVLQIYSATRDTDYTSAWWKQVVYVLGGLLFLWIAMMIDYHTMLHYVPALYIGSVGA
LLVTYLIGEKAYGSKRWIPMGFGVHLQVSEFVKLVIVLLVARYLTELRTDELEIREMLKLAGLVLIPTALVMKQPDLGTS
LTYVAVLIACAFLAGLRWKYVAAIAVITVVVLPISWQFLNEYQRGRIVSFMDPERDPQGKGYQLIQSQIAVGSGGMFGKG
VTKGTQTQLRFLPVPHKDFIFSAFAEEHGFVGVVVLLSLFFVLVMRIVQNAQTAPDRVGMYICMGVAALLLFHVLVNVGM
VAGLMPVTGIPLPFMSFGGSSIWTFFLALGLVNNVRLRRFVN

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=292, Percent_Identity=40.0684931506849, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1786277, Length=348, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40396; Mature: 40265

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYLSPRDIDWTVLLIVLLICAVGVLQIYSATRDTDYTSAWWKQVVYVLGGLLFLWIAM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MIDYHTMLHYVPALYIGSVGALLVTYLIGEKAYGSKRWIPMGFGVHLQVSEFVKLVIVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEHHHHHHHHHHHH
VARYLTELRTDELEIREMLKLAGLVLIPTALVMKQPDLGTSLTYVAVLIACAFLAGLRWK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
YVAAIAVITVVVLPISWQFLNEYQRGRIVSFMDPERDPQGKGYQLIQSQIAVGSGGMFGK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCC
GVTKGTQTQLRFLPVPHKDFIFSAFAEEHGFVGVVVLLSLFFVLVMRIVQNAQTAPDRVG
CCCCCCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MYICMGVAALLLFHVLVNVGMVAGLMPVTGIPLPFMSFGGSSIWTFFLALGLVNNVRLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
FVN
HCC
>Mature Secondary Structure 
SKYLSPRDIDWTVLLIVLLICAVGVLQIYSATRDTDYTSAWWKQVVYVLGGLLFLWIAM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MIDYHTMLHYVPALYIGSVGALLVTYLIGEKAYGSKRWIPMGFGVHLQVSEFVKLVIVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEHHHHHHHHHHHH
VARYLTELRTDELEIREMLKLAGLVLIPTALVMKQPDLGTSLTYVAVLIACAFLAGLRWK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
YVAAIAVITVVVLPISWQFLNEYQRGRIVSFMDPERDPQGKGYQLIQSQIAVGSGGMFGK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCC
GVTKGTQTQLRFLPVPHKDFIFSAFAEEHGFVGVVVLLSLFFVLVMRIVQNAQTAPDRVG
CCCCCCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MYICMGVAALLLFHVLVNVGMVAGLMPVTGIPLPFMSFGGSSIWTFFLALGLVNNVRLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
FVN
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]