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The map label for this gene is aslA [H]

Identifier: 116623176

GI number: 116623176

Start: 5189403

End: 5191085

Strand: Reverse

Name: aslA [H]

Synonym: Acid_4083

Alternate gene names: 116623176

Gene position: 5191085-5189403 (Counterclockwise)

Preceding gene: 116623182

Following gene: 116623175

Centisome position: 52.09

GC content: 60.96

Gene sequence:

>1683_bases
ATGATGCTAGCGCTCGCAGCCTTTGGCATTGCCGGAAGCGCGTTCGCGCAAACGCAGAAACCGAACATCCTCTTCATCAT
GGGAGACGACATTGGTTGGATGCAGCCCAGCATCTACCATCGCGGCCTCATGGTCGGCGAAACTCCCAATATCGACCGCA
TCGGCAACGAAGGCGCTATCTTCATGGACTATGTCGCCATGCAGAGCTGTACGTCCGGCCGCAACGCCTTTTTCACCGGC
ATGTATCCCCTGCGCACCGGTATGATTCCGCCCCAACTTCCCGGCAGTCCGTCCTATCTGCGCCCAGGAACTCCCGCGCT
CGCCGTCTTCCTGCACGATCTCGGCTACACCACCGGTGAGTTCGGCAAGAATCACCTGGGCGACCATACCGAGGCTCTGC
CCACCGCGCACGGCTTCCAGGAATACTGGGGCTATCTCTACCACCTTGACGCCATGCAGGGCGTGAGCTTTCCCGACATC
AATAGCACCCCGACTCAGCAAGTCATCGCGCCTCCCTGCAAGAACACGCCCATCCCCGGCCTCTCCGAAGTACCCGGCGC
CGTGGATCCCAAAACCACCACCTGCCTGACCCCGCCGCGCCCCGTGCTCTGGTGCCACTCCTCCGACGGCACCGAGAAGA
ATCAGACGTGCAAAGATCAAGGCCCGCTCACTCTCGACCGTTCCCGCACCGTGGATGAGGAAATCTCCGCCAAGGTCGTG
GACTTCCTCGACCGCAACGACCCGCGCAAAACCAACAAGCCCTTCTTCGTCTGGTACAACCCCGCGCGCATGCACGTCAC
CACCATGCTCTCTCCCAAGTACGAGGCCATGCTGGGGACCAGGGGCGGCAAGGACTGGGGCGTCAACGAAGCCGGCATGA
AGCAGATGGACGACAACATCGGTGTCGTGCTCGCCAAGCTCGAACAGATGGGCCAGCTCGATAACACCATCGTGGTTTTC
ACCACCGATAACGGCGCCGAGACCATCAGCTTCCCCGATGGCGGCATCACGCCGTTCAAAGGCCAGAAAGGCGAAGCCTG
GGAAGGCGGCTACCGCGCCCCCTGCGTCATCCGCTGGCCCGGTCACATCAAGCCCGGCACCGTGTACAAGGAACTCTTTG
CAGCCCTCGATTGGCTGCCGACCTTTGTCGAATTCGCCGGCGGCCCCAAAGGCGATGCCCTGAAGCAGCAGATCGAAGCC
GGAAAATATCCCGGCATCGTGAAGACCACCCTCGATGGCGTCAACCAGAGCGATTATCTCCAGGGCAAGTGCGACACCTC
GGCGCGCGATTACTTCTTCTACTTCTCCGGCGCCACGCCATCCGCCGTCCGTTACAAGAACTGGAAGATGTACTACACCA
TGTCGCAGCCCGGTCCTGCCGGATGGATCATGCCGCTCATCCCCTTCCACTTTACGCTGGTGCAAAACATCAAGCGCGAT
CCCTTTGAACAAGCCGTCGGCATCGATCAGAAGACCGCCATGGGCCTCGGCGGCGCGCTCGCCGGACCGATCACCGCCTT
CCAGTACGACTGGAACATGCTCCCCATCGGCCAGCAGTTGTGGCTCAAGCACCTTGAGTCGTACATCAAATACCCGCCGC
TTCAGGAAGCGGCGTCCTACAACCTGAGTCAGGTGATCGAAGAGGTCAAGAAGGCCCAATCGGTCAGCCACGCAGGCCAG
TAG

Upstream 100 bases:

>100_bases
TCAGGAACGCATCTCTCGAAATGTATGCCCGTGCGCCGGGCCAGATTCAGCAAACCAGGACTCAGGCGGTACTATGCTCA
TTCCTTCGCAAAGACGTTTT

Downstream 100 bases:

>100_bases
AGCTTGAGGAAACAAATGCCTGAACTACCGGAAGCAGCGTCGAAGCGAGTGATCACTTGGTCGATCATCTGGTCGATCCT
GTTGATGGTTGTCGGATGCG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MMLALAAFGIAGSAFAQTQKPNILFIMGDDIGWMQPSIYHRGLMVGETPNIDRIGNEGAIFMDYVAMQSCTSGRNAFFTG
MYPLRTGMIPPQLPGSPSYLRPGTPALAVFLHDLGYTTGEFGKNHLGDHTEALPTAHGFQEYWGYLYHLDAMQGVSFPDI
NSTPTQQVIAPPCKNTPIPGLSEVPGAVDPKTTTCLTPPRPVLWCHSSDGTEKNQTCKDQGPLTLDRSRTVDEEISAKVV
DFLDRNDPRKTNKPFFVWYNPARMHVTTMLSPKYEAMLGTRGGKDWGVNEAGMKQMDDNIGVVLAKLEQMGQLDNTIVVF
TTDNGAETISFPDGGITPFKGQKGEAWEGGYRAPCVIRWPGHIKPGTVYKELFAALDWLPTFVEFAGGPKGDALKQQIEA
GKYPGIVKTTLDGVNQSDYLQGKCDTSARDYFFYFSGATPSAVRYKNWKMYYTMSQPGPAGWIMPLIPFHFTLVQNIKRD
PFEQAVGIDQKTAMGLGGALAGPITAFQYDWNMLPIGQQLWLKHLESYIKYPPLQEAASYNLSQVIEEVKKAQSVSHAGQ

Sequences:

>Translated_560_residues
MMLALAAFGIAGSAFAQTQKPNILFIMGDDIGWMQPSIYHRGLMVGETPNIDRIGNEGAIFMDYVAMQSCTSGRNAFFTG
MYPLRTGMIPPQLPGSPSYLRPGTPALAVFLHDLGYTTGEFGKNHLGDHTEALPTAHGFQEYWGYLYHLDAMQGVSFPDI
NSTPTQQVIAPPCKNTPIPGLSEVPGAVDPKTTTCLTPPRPVLWCHSSDGTEKNQTCKDQGPLTLDRSRTVDEEISAKVV
DFLDRNDPRKTNKPFFVWYNPARMHVTTMLSPKYEAMLGTRGGKDWGVNEAGMKQMDDNIGVVLAKLEQMGQLDNTIVVF
TTDNGAETISFPDGGITPFKGQKGEAWEGGYRAPCVIRWPGHIKPGTVYKELFAALDWLPTFVEFAGGPKGDALKQQIEA
GKYPGIVKTTLDGVNQSDYLQGKCDTSARDYFFYFSGATPSAVRYKNWKMYYTMSQPGPAGWIMPLIPFHFTLVQNIKRD
PFEQAVGIDQKTAMGLGGALAGPITAFQYDWNMLPIGQQLWLKHLESYIKYPPLQEAASYNLSQVIEEVKKAQSVSHAGQ
>Mature_560_residues
MMLALAAFGIAGSAFAQTQKPNILFIMGDDIGWMQPSIYHRGLMVGETPNIDRIGNEGAIFMDYVAMQSCTSGRNAFFTG
MYPLRTGMIPPQLPGSPSYLRPGTPALAVFLHDLGYTTGEFGKNHLGDHTEALPTAHGFQEYWGYLYHLDAMQGVSFPDI
NSTPTQQVIAPPCKNTPIPGLSEVPGAVDPKTTTCLTPPRPVLWCHSSDGTEKNQTCKDQGPLTLDRSRTVDEEISAKVV
DFLDRNDPRKTNKPFFVWYNPARMHVTTMLSPKYEAMLGTRGGKDWGVNEAGMKQMDDNIGVVLAKLEQMGQLDNTIVVF
TTDNGAETISFPDGGITPFKGQKGEAWEGGYRAPCVIRWPGHIKPGTVYKELFAALDWLPTFVEFAGGPKGDALKQQIEA
GKYPGIVKTTLDGVNQSDYLQGKCDTSARDYFFYFSGATPSAVRYKNWKMYYTMSQPGPAGWIMPLIPFHFTLVQNIKRD
PFEQAVGIDQKTAMGLGGALAGPITAFQYDWNMLPIGQQLWLKHLESYIKYPPLQEAASYNLSQVIEEVKKAQSVSHAGQ

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=442, Percent_Identity=30.5429864253394, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI146229329, Length=442, Percent_Identity=30.5429864253394, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI6005990, Length=442, Percent_Identity=30.5429864253394, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI146229324, Length=442, Percent_Identity=30.5429864253394, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4503899, Length=399, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI45430057, Length=502, Percent_Identity=27.0916334661355, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI53831991, Length=494, Percent_Identity=26.3157894736842, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI31742482, Length=529, Percent_Identity=25.1417769376182, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI157266309, Length=523, Percent_Identity=25.2390057361377, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI38569405, Length=489, Percent_Identity=25.5623721881391, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI38569407, Length=379, Percent_Identity=27.4406332453826, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI58743319, Length=494, Percent_Identity=25.3036437246964, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI146229327, Length=352, Percent_Identity=28.9772727272727, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI71852584, Length=500, Percent_Identity=24.4, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI59797060, Length=452, Percent_Identity=25, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI109389362, Length=184, Percent_Identity=29.3478260869565, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1790233, Length=442, Percent_Identity=30.7692307692308, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87081924, Length=434, Percent_Identity=22.8110599078341, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533416, Length=136, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24666175, Length=472, Percent_Identity=24.7881355932203, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24666109, Length=393, Percent_Identity=24.9363867684478, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281366397, Length=142, Percent_Identity=33.8028169014084, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281366395, Length=142, Percent_Identity=33.8028169014084, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24666163, Length=142, Percent_Identity=33.8028169014084, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281363223, Length=112, Percent_Identity=34.8214285714286, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 61744; Mature: 61744

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLALAAFGIAGSAFAQTQKPNILFIMGDDIGWMQPSIYHRGLMVGETPNIDRIGNEGAI
CEEEEEECCCCCHHHHHCCCCCEEEEECCCCCCCCCHHHHCCEEECCCCCHHCCCCCCCE
FMDYVAMQSCTSGRNAFFTGMYPLRTGMIPPQLPGSPSYLRPGTPALAVFLHDLGYTTGE
EHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
FGKNHLGDHTEALPTAHGFQEYWGYLYHLDAMQGVSFPDINSTPTQQVIAPPCKNTPIPG
CCCHHCCCCHHHCCCCCCHHHHHHHEEEEHHHCCCCCCCCCCCCCHHEECCCCCCCCCCC
LSEVPGAVDPKTTTCLTPPRPVLWCHSSDGTEKNQTCKDQGPLTLDRSRTVDEEISAKVV
HHHCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
DFLDRNDPRKTNKPFFVWYNPARMHVTTMLSPKYEAMLGTRGGKDWGVNEAGMKQMDDNI
HHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHCCCH
GVVLAKLEQMGQLDNTIVVFTTDNGAETISFPDGGITPFKGQKGEAWEGGYRAPCVIRWP
HHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECC
GHIKPGTVYKELFAALDWLPTFVEFAGGPKGDALKQQIEAGKYPGIVKTTLDGVNQSDYL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEHHHCCCCCCCCC
QGKCDTSARDYFFYFSGATPSAVRYKNWKMYYTMSQPGPAGWIMPLIPFHFTLVQNIKRD
CCCCCCCCCEEEEEECCCCCCCEEEECEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
PFEQAVGIDQKTAMGLGGALAGPITAFQYDWNMLPIGQQLWLKHLESYIKYPPLQEAASY
CHHHHHCCCHHHHHCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHCC
NLSQVIEEVKKAQSVSHAGQ
CHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMLALAAFGIAGSAFAQTQKPNILFIMGDDIGWMQPSIYHRGLMVGETPNIDRIGNEGAI
CEEEEEECCCCCHHHHHCCCCCEEEEECCCCCCCCCHHHHCCEEECCCCCHHCCCCCCCE
FMDYVAMQSCTSGRNAFFTGMYPLRTGMIPPQLPGSPSYLRPGTPALAVFLHDLGYTTGE
EHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
FGKNHLGDHTEALPTAHGFQEYWGYLYHLDAMQGVSFPDINSTPTQQVIAPPCKNTPIPG
CCCHHCCCCHHHCCCCCCHHHHHHHEEEEHHHCCCCCCCCCCCCCHHEECCCCCCCCCCC
LSEVPGAVDPKTTTCLTPPRPVLWCHSSDGTEKNQTCKDQGPLTLDRSRTVDEEISAKVV
HHHCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
DFLDRNDPRKTNKPFFVWYNPARMHVTTMLSPKYEAMLGTRGGKDWGVNEAGMKQMDDNI
HHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHCCCH
GVVLAKLEQMGQLDNTIVVFTTDNGAETISFPDGGITPFKGQKGEAWEGGYRAPCVIRWP
HHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECC
GHIKPGTVYKELFAALDWLPTFVEFAGGPKGDALKQQIEAGKYPGIVKTTLDGVNQSDYL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEHHHCCCCCCCCC
QGKCDTSARDYFFYFSGATPSAVRYKNWKMYYTMSQPGPAGWIMPLIPFHFTLVQNIKRD
CCCCCCCCCEEEEEECCCCCCCEEEECEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
PFEQAVGIDQKTAMGLGGALAGPITAFQYDWNMLPIGQQLWLKHLESYIKYPPLQEAASY
CHHHHHCCCHHHHHCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHCC
NLSQVIEEVKKAQSVSHAGQ
CHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]