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The map label for this gene is garR [H]

Identifier: 116623078

GI number: 116623078

Start: 5049079

End: 5049975

Strand: Reverse

Name: garR [H]

Synonym: Acid_3982

Alternate gene names: 116623078

Gene position: 5049975-5049079 (Counterclockwise)

Preceding gene: 116623079

Following gene: 116623077

Centisome position: 50.67

GC content: 64.44

Gene sequence:

>897_bases
GTGGCTGATATTGGATTCATAGGTCTCGGAATCATGGGCAAGCCCATGAGCCGCAATTTGATGAAGGCCGGCTATTCGCT
GGTGGTCTACGACATTTTTCCCGGTCCCGTTGCGGAACTGAAGGAAGCGGGGGCGGGGGCTGGCGCGTCGTGCGCAGCGA
CGGCCGCGGCGGCGCCGATCGTGATCACCATGCTGCCCGATGGTCCTGAGGTGGAGACGGCGGTGCTCGGGCCGGGCGGC
GTGCTGGAAGGCGCGAAGGCCGGGACCGTGGTGGTCGATATGAGTTCGATCAGCCCGATGGTGTCGCAGAAGGTGGCGGC
GGCCTGCGCGGCGAAGGGCGTGGAGTTCCTGGACGCGCCGGTGAGCGGCGGCGAGCCGAAGGCGATCGATGGCACGCTGG
CGATCATGGTTGGCGGCAAGCCGGAGGTCTTCGAGCGCGTGCAGCCGGTGCTGGCGAAGATGGGCGCGAGCGTGACGTTG
ACGGGCGCGGTGGGCGCGGGCAACGTGACCAAGCTGGCCAACCAGATCATGGTGGCGTGCAACATCGCGGCAATGGGCGA
GGCGCTGGTGCTGGCGACCAAGGCCGGCCTGGATCCCGAAGTCGTGTTCAACGCGGTGAAGGGCGGGCTTGCGGGCAGCA
CGGTGTTAAACGCCAAGGCGCCGATGGTGATCGGGCGCAACTTCAAGCCGGGATTCCGAATCAACTTGCACGAAAAAGAT
CTGCGCAACGCGCTGCAGGCGGCGGAGTCGATGAAGGTCTCGCTGCCGTTCACCAGCCTGGCTCAGCAGATGCTGATCGC
GCTCATGAATGACGGTAAGGGCAATCTGGATCACTCGGCGATCGTAAACTTCATCGAGCATATGGCAGGCATCGAAGTGA
AGAAGCCGCAGGCATGA

Upstream 100 bases:

>100_bases
GGAAGTGGCCGAGCACTTCGACGCGGGGAAGCAGCCCGACGGGATGGCGTGGTCGACGCGCTGAAGCGATTCGGTATGCT
CGTAGGGTAAAGGAGAATCG

Downstream 100 bases:

>100_bases
GCGCACCTATCGTCGAAGAAATGCGCGTGATCCCGGTGGCGGGGCACGACAGCATGCTGCTCAATTTGAGCGGCGCGCAT
GCTCCGCTGTTCACGCGAAA

Product: tartronate semialdehyde reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MADIGFIGLGIMGKPMSRNLMKAGYSLVVYDIFPGPVAELKEAGAGAGASCAATAAAAPIVITMLPDGPEVETAVLGPGG
VLEGAKAGTVVVDMSSISPMVSQKVAAACAAKGVEFLDAPVSGGEPKAIDGTLAIMVGGKPEVFERVQPVLAKMGASVTL
TGAVGAGNVTKLANQIMVACNIAAMGEALVLATKAGLDPEVVFNAVKGGLAGSTVLNAKAPMVIGRNFKPGFRINLHEKD
LRNALQAAESMKVSLPFTSLAQQMLIALMNDGKGNLDHSAIVNFIEHMAGIEVKKPQA

Sequences:

>Translated_298_residues
MADIGFIGLGIMGKPMSRNLMKAGYSLVVYDIFPGPVAELKEAGAGAGASCAATAAAAPIVITMLPDGPEVETAVLGPGG
VLEGAKAGTVVVDMSSISPMVSQKVAAACAAKGVEFLDAPVSGGEPKAIDGTLAIMVGGKPEVFERVQPVLAKMGASVTL
TGAVGAGNVTKLANQIMVACNIAAMGEALVLATKAGLDPEVVFNAVKGGLAGSTVLNAKAPMVIGRNFKPGFRINLHEKD
LRNALQAAESMKVSLPFTSLAQQMLIALMNDGKGNLDHSAIVNFIEHMAGIEVKKPQA
>Mature_297_residues
ADIGFIGLGIMGKPMSRNLMKAGYSLVVYDIFPGPVAELKEAGAGAGASCAATAAAAPIVITMLPDGPEVETAVLGPGGV
LEGAKAGTVVVDMSSISPMVSQKVAAACAAKGVEFLDAPVSGGEPKAIDGTLAIMVGGKPEVFERVQPVLAKMGASVTLT
GAVGAGNVTKLANQIMVACNIAAMGEALVLATKAGLDPEVVFNAVKGGLAGSTVLNAKAPMVIGRNFKPGFRINLHEKDL
RNALQAAESMKVSLPFTSLAQQMLIALMNDGKGNLDHSAIVNFIEHMAGIEVKKPQA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=36.7697594501718, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=27.8169014084507, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=56.5068493150685, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=46.3414634146341, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1790315, Length=295, Percent_Identity=35.9322033898305, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=31.5789473684211, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17557316, Length=280, Percent_Identity=36.7857142857143, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24655230, Length=293, Percent_Identity=35.1535836177474, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19922568, Length=293, Percent_Identity=35.1535836177474, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=25.089605734767, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30205; Mature: 30074

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIGFIGLGIMGKPMSRNLMKAGYSLVVYDIFPGPVAELKEAGAGAGASCAATAAAAPI
CCCCCEEECCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCCCHHHHHHCCCCE
VITMLPDGPEVETAVLGPGGVLEGAKAGTVVVDMSSISPMVSQKVAAACAAKGVEFLDAP
EEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHCCCHHEECC
VSGGEPKAIDGTLAIMVGGKPEVFERVQPVLAKMGASVTLTGAVGAGNVTKLANQIMVAC
CCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHEE
NIAAMGEALVLATKAGLDPEVVFNAVKGGLAGSTVLNAKAPMVIGRNFKPGFRINLHEKD
CHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCEEECCHHH
LRNALQAAESMKVSLPFTSLAQQMLIALMNDGKGNLDHSAIVNFIEHMAGIEVKKPQA
HHHHHHHHHHCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADIGFIGLGIMGKPMSRNLMKAGYSLVVYDIFPGPVAELKEAGAGAGASCAATAAAAPI
CCCCEEECCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCCCHHHHHHCCCCE
VITMLPDGPEVETAVLGPGGVLEGAKAGTVVVDMSSISPMVSQKVAAACAAKGVEFLDAP
EEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHCCCHHEECC
VSGGEPKAIDGTLAIMVGGKPEVFERVQPVLAKMGASVTLTGAVGAGNVTKLANQIMVAC
CCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHEE
NIAAMGEALVLATKAGLDPEVVFNAVKGGLAGSTVLNAKAPMVIGRNFKPGFRINLHEKD
CHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCEEECCHHH
LRNALQAAESMKVSLPFTSLAQQMLIALMNDGKGNLDHSAIVNFIEHMAGIEVKKPQA
HHHHHHHHHHCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]