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The map label for this gene is gyrA [H]

Identifier: 116623071

GI number: 116623071

Start: 5035565

End: 5038039

Strand: Reverse

Name: gyrA [H]

Synonym: Acid_3975

Alternate gene names: 116623071

Gene position: 5038039-5035565 (Counterclockwise)

Preceding gene: 116623072

Following gene: 116623070

Centisome position: 50.55

GC content: 61.01

Gene sequence:

>2475_bases
ATGGGCGGCGGCGACGGCGGGCGCAGAAACATGATTCCCGTCAACATCGAAGACGAAATGAAGCAGTCGTACCTGGATTA
CGCGATGAGCGTAATCGTAGGGCGCGCGCTGCCGGACATTCGCGACGGGCTGAAGCCGGTACACCGGCGCATCCTTTATG
GGATGCACGAGATGGGGTTGGCGCCGAACCGGCCGACCACCAAATCGGCGAAAATTACCGGGCAGGTGATGGGTAAGTAT
CACCCGCACGGCGACTCGGCGATTTACGATTCGTTGGTGCGCATGGCGCAGCCGTTCGCGATGCGCTATCCGCTGGTGGA
CGGGCAGGGGAATTTCGGTTCGGTGGACGGCGATCCGCCGGCGGCGATGCGATACACGGAAGCGCGGCTTTCGAAATTCG
CGACCGCGCTGCTGGAAGACATCGACAAGGAAACGGTCGATTTCAAACCGAACTACGACGATACCGAAAGCGAGCCGGAA
GTACTGCCGACGCGCGTTCCCAATTTGCTGGTGAACGGGTCGAGCGGCATCGCGGTCGGCATGGCGACCAATATTCCGCC
GCACAACCTGACGGAAATCATCAACGCCACGATTCACCTGATCCAGCATCCGACGGCAAACCTGGCGAAGATCATGGAGT
TTGTGCAGGGGCCGGACTTCCCGACGGGCGGCTTCATTCTGGGGCGGCAGGGGATTCTGGACGCGTTCATCCGCGGCCGC
GGACAGTTGAAGCTGCGCGCCAAGGCGGCCATCGAGAAGATGGGCAAGGATCGCGAGCAGATCATCGTGACGGAGATTCC
GTACCAGGTGAACAAATCGCGGCTGATCGAGGCGGCGAGCGCGCTGGTGAACGAGAAGAAGCTGGAAGGCATCGGCGACA
TTCGCGACGAGAGCGACCGCGACGGAATGCGGATCGTGTTCGAGCTGAAGCGCGGCGAGCAGGCGGAGGTGATTCTTAAT
AACCTCTACAAGCACACTCAGCTGCAGGTCGGGTTCGGCATCATCATGCTCTCGATTGTGAACGGGCAGCCGCGCGAACT
GGGCCTGGTCGATATGATCAAGCACTTCATCGATCACCGGATCGAAGTAGTGCGGCGGCGGACCGAGTACGAACTGCGCA
AGGCGCGGGATCGCGAGCACATTTTGCTCGGCTTCCAGAAGGCGCTGGATCATCTGGATGAAGTGATCCGGCTGATCCGC
GCGTCGAAATCGCCGAAGGACGCGCGCGATTCGTTGATCACGACATTCCAGTTCAGCGATAAGCAGGCGCAGGCGATTAT
CGAACTGCAGTTGCAGCGCCTCACCGGGATGGAGCGGCAGAAGATCCTGGATGAACTCGGGGAAATCCAGCGGCGCATCG
CCGAATACGTGGAAATCCTGGGGTCGGACAAAGTGCTGCGCGACCTGATCATCAAAGAGCTGAAGGAAGTGCAGAAGAAT
TACGGCGACGAGCGGCGCACGCAGATCATCGAGGACACGGGCGAGATCCGGCTCGAGGACCTGGTGGCGGTGGAAGACGT
CGCGATCACGGTGACGCGCGGCGGATATTTGAAGCGCACGAGCGTGGATACGTACCGCCGGCAGACGCGCGGCGGTAAGG
GCCGGATCGGCATGGGCACGCGCGCCGAGGATTTCGTGGAACGGCTGATTGTGGCCTCCACGCACAGCTACCTGCTGATC
TTCACGACGCGCGGGCGGGTCTACTGGCTGAAGGCCTACGAGATTCCGGACGCGACCACGATCGGCAAGGGCAAGCACCT
GACCAACCTGATCAACCTGCAGGGCGATGAAGAGGCCAAGGCCTTCCTAAGCGTGAAGGATTTCGTCGCGAACCAGTACA
TCGTAATGGTGACCAAGCACGGCGTGATCAAGAAGAGCGAGTTGACGGAGTTCGATAATCCGCTATCGCGCGGCATCATC
GCGGTGTCGCTGGACGAGGGCGACGAACTGATCGGCGCCAAGATCACGATGGGCGACAACTACATCTTCCTGGGGTCGCA
CGAAGGACAGGCGATCCGCTTCCGGGAAGAGGATGTGCGCGCCATGGGACGGCAGGCACGCGGCGTGCGGGCAATGAGCC
TGGCGGATGGCGACTACCTGGTCGGGATGGAAGTGGTGGAGAAGGATGGCCTCATCCTCTCGATCGCGGAGAACGGGTAC
GGCAAACGCACTCCGCTGGAGGATTACCGGCTGACCTCGCGCGGCGGCAAGGGCGTCATCAATATGAAGACGACCAACAA
GACGGGCCGAGTGGTGGGGATTCTTTCGGTGAAGGAAGATTCGGAGTTGATGATTGTCAGCCAGAACGGCAAGATGATCC
GCATCGAATCTTCGACGATCCGGCAGGCGGGACGTTCGACGCAGGGCGTACGGCTGGTGAATCTGGAGCCGGACGATAAG
GTAGCGGCGGCGAGTGTGATTCCGGAGAGCGACGTGGTTCCGGACGACGGGCAGGAGACCCTGCCGGTTCAGTAG

Upstream 100 bases:

>100_bases
AATTCTTGGTAAAATAAGACTTAACCCTATGGCAGACCAGGAACAACCACCGCAGGGTCCACCTGCGCCACCACCGGATG
GGCCGGGGACTTTACCCGGC

Downstream 100 bases:

>100_bases
ACTGTAAGGGTGGGCTTAACAATCCCACCCTTTATTTCTATGGCGGCACTCACAGGCATTACAACCCGCGGATCGCTGGA
AGAGAAAGAGCGCAAGCTGT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 824; Mature: 823

Protein sequence:

>824_residues
MGGGDGGRRNMIPVNIEDEMKQSYLDYAMSVIVGRALPDIRDGLKPVHRRILYGMHEMGLAPNRPTTKSAKITGQVMGKY
HPHGDSAIYDSLVRMAQPFAMRYPLVDGQGNFGSVDGDPPAAMRYTEARLSKFATALLEDIDKETVDFKPNYDDTESEPE
VLPTRVPNLLVNGSSGIAVGMATNIPPHNLTEIINATIHLIQHPTANLAKIMEFVQGPDFPTGGFILGRQGILDAFIRGR
GQLKLRAKAAIEKMGKDREQIIVTEIPYQVNKSRLIEAASALVNEKKLEGIGDIRDESDRDGMRIVFELKRGEQAEVILN
NLYKHTQLQVGFGIIMLSIVNGQPRELGLVDMIKHFIDHRIEVVRRRTEYELRKARDREHILLGFQKALDHLDEVIRLIR
ASKSPKDARDSLITTFQFSDKQAQAIIELQLQRLTGMERQKILDELGEIQRRIAEYVEILGSDKVLRDLIIKELKEVQKN
YGDERRTQIIEDTGEIRLEDLVAVEDVAITVTRGGYLKRTSVDTYRRQTRGGKGRIGMGTRAEDFVERLIVASTHSYLLI
FTTRGRVYWLKAYEIPDATTIGKGKHLTNLINLQGDEEAKAFLSVKDFVANQYIVMVTKHGVIKKSELTEFDNPLSRGII
AVSLDEGDELIGAKITMGDNYIFLGSHEGQAIRFREEDVRAMGRQARGVRAMSLADGDYLVGMEVVEKDGLILSIAENGY
GKRTPLEDYRLTSRGGKGVINMKTTNKTGRVVGILSVKEDSELMIVSQNGKMIRIESSTIRQAGRSTQGVRLVNLEPDDK
VAAASVIPESDVVPDDGQETLPVQ

Sequences:

>Translated_824_residues
MGGGDGGRRNMIPVNIEDEMKQSYLDYAMSVIVGRALPDIRDGLKPVHRRILYGMHEMGLAPNRPTTKSAKITGQVMGKY
HPHGDSAIYDSLVRMAQPFAMRYPLVDGQGNFGSVDGDPPAAMRYTEARLSKFATALLEDIDKETVDFKPNYDDTESEPE
VLPTRVPNLLVNGSSGIAVGMATNIPPHNLTEIINATIHLIQHPTANLAKIMEFVQGPDFPTGGFILGRQGILDAFIRGR
GQLKLRAKAAIEKMGKDREQIIVTEIPYQVNKSRLIEAASALVNEKKLEGIGDIRDESDRDGMRIVFELKRGEQAEVILN
NLYKHTQLQVGFGIIMLSIVNGQPRELGLVDMIKHFIDHRIEVVRRRTEYELRKARDREHILLGFQKALDHLDEVIRLIR
ASKSPKDARDSLITTFQFSDKQAQAIIELQLQRLTGMERQKILDELGEIQRRIAEYVEILGSDKVLRDLIIKELKEVQKN
YGDERRTQIIEDTGEIRLEDLVAVEDVAITVTRGGYLKRTSVDTYRRQTRGGKGRIGMGTRAEDFVERLIVASTHSYLLI
FTTRGRVYWLKAYEIPDATTIGKGKHLTNLINLQGDEEAKAFLSVKDFVANQYIVMVTKHGVIKKSELTEFDNPLSRGII
AVSLDEGDELIGAKITMGDNYIFLGSHEGQAIRFREEDVRAMGRQARGVRAMSLADGDYLVGMEVVEKDGLILSIAENGY
GKRTPLEDYRLTSRGGKGVINMKTTNKTGRVVGILSVKEDSELMIVSQNGKMIRIESSTIRQAGRSTQGVRLVNLEPDDK
VAAASVIPESDVVPDDGQETLPVQ
>Mature_823_residues
GGGDGGRRNMIPVNIEDEMKQSYLDYAMSVIVGRALPDIRDGLKPVHRRILYGMHEMGLAPNRPTTKSAKITGQVMGKYH
PHGDSAIYDSLVRMAQPFAMRYPLVDGQGNFGSVDGDPPAAMRYTEARLSKFATALLEDIDKETVDFKPNYDDTESEPEV
LPTRVPNLLVNGSSGIAVGMATNIPPHNLTEIINATIHLIQHPTANLAKIMEFVQGPDFPTGGFILGRQGILDAFIRGRG
QLKLRAKAAIEKMGKDREQIIVTEIPYQVNKSRLIEAASALVNEKKLEGIGDIRDESDRDGMRIVFELKRGEQAEVILNN
LYKHTQLQVGFGIIMLSIVNGQPRELGLVDMIKHFIDHRIEVVRRRTEYELRKARDREHILLGFQKALDHLDEVIRLIRA
SKSPKDARDSLITTFQFSDKQAQAIIELQLQRLTGMERQKILDELGEIQRRIAEYVEILGSDKVLRDLIIKELKEVQKNY
GDERRTQIIEDTGEIRLEDLVAVEDVAITVTRGGYLKRTSVDTYRRQTRGGKGRIGMGTRAEDFVERLIVASTHSYLLIF
TTRGRVYWLKAYEIPDATTIGKGKHLTNLINLQGDEEAKAFLSVKDFVANQYIVMVTKHGVIKKSELTEFDNPLSRGIIA
VSLDEGDELIGAKITMGDNYIFLGSHEGQAIRFREEDVRAMGRQARGVRAMSLADGDYLVGMEVVEKDGLILSIAENGYG
KRTPLEDYRLTSRGGKGVINMKTTNKTGRVVGILSVKEDSELMIVSQNGKMIRIESSTIRQAGRSTQGVRLVNLEPDDKV
AAASVIPESDVVPDDGQETLPVQ

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=356, Percent_Identity=24.438202247191, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI19913406, Length=354, Percent_Identity=24.8587570621469, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1788562, Length=836, Percent_Identity=49.4019138755981, Blast_Score=818, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=613, Percent_Identity=37.5203915171289, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645657, Length=210, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17535065, Length=191, Percent_Identity=29.3193717277487, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=171, Percent_Identity=30.9941520467836, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91995; Mature: 91864

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGGDGGRRNMIPVNIEDEMKQSYLDYAMSVIVGRALPDIRDGLKPVHRRILYGMHEMGL
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
APNRPTTKSAKITGQVMGKYHPHGDSAIYDSLVRMAQPFAMRYPLVDGQGNFGSVDGDPP
CCCCCCCCCCEEEEEEHCCCCCCCCHHHHHHHHHHHCCHHHCCCEECCCCCCCCCCCCCC
AAMRYTEARLSKFATALLEDIDKETVDFKPNYDDTESEPEVLPTRVPNLLVNGSSGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEE
MATNIPPHNLTEIINATIHLIQHPTANLAKIMEFVQGPDFPTGGFILGRQGILDAFIRGR
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCC
GQLKLRAKAAIEKMGKDREQIIVTEIPYQVNKSRLIEAASALVNEKKLEGIGDIRDESDR
CCEEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DGMRIVFELKRGEQAEVILNNLYKHTQLQVGFGIIMLSIVNGQPRELGLVDMIKHFIDHR
CCEEEEEEECCCCHHHHHHHHHHHHHEEHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHH
IEVVRRRTEYELRKARDREHILLGFQKALDHLDEVIRLIRASKSPKDARDSLITTFQFSD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEEECC
KQAQAIIELQLQRLTGMERQKILDELGEIQRRIAEYVEILGSDKVLRDLIIKELKEVQKN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
YGDERRTQIIEDTGEIRLEDLVAVEDVAITVTRGGYLKRTSVDTYRRQTRGGKGRIGMGT
CCHHHHHHHHHCCCCEEEHHHEEEEEEEEEEECCCEEEECCHHHHHHHCCCCCCCCCCCC
RAEDFVERLIVASTHSYLLIFTTRGRVYWLKAYEIPDATTIGKGKHLTNLINLQGDEEAK
CHHHHHHHHHHHCCCCEEEEEEECCEEEEEEEEECCCCCCCCCCCHHHHHCCCCCCHHHH
AFLSVKDFVANQYIVMVTKHGVIKKSELTEFDNPLSRGIIAVSLDEGDELIGAKITMGDN
HHHHHHHHHCCCEEEEEECCCCEECHHHHHHCCHHHCCEEEEEECCCCCEEEEEEEECCC
YIFLGSHEGQAIRFREEDVRAMGRQARGVRAMSLADGDYLVGMEVVEKDGLILSIAENGY
EEEEECCCCCEEEECHHHHHHHHHHHCCCEEEEECCCCEEEEEEEECCCCEEEEEECCCC
GKRTPLEDYRLTSRGGKGVINMKTTNKTGRVVGILSVKEDSELMIVSQNGKMIRIESSTI
CCCCCCHHCEEECCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEECCCCEEEEEHHHH
RQAGRSTQGVRLVNLEPDDKVAAASVIPESDVVPDDGQETLPVQ
HHCCCCCCCEEEEEECCCCCEEHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GGGDGGRRNMIPVNIEDEMKQSYLDYAMSVIVGRALPDIRDGLKPVHRRILYGMHEMGL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
APNRPTTKSAKITGQVMGKYHPHGDSAIYDSLVRMAQPFAMRYPLVDGQGNFGSVDGDPP
CCCCCCCCCCEEEEEEHCCCCCCCCHHHHHHHHHHHCCHHHCCCEECCCCCCCCCCCCCC
AAMRYTEARLSKFATALLEDIDKETVDFKPNYDDTESEPEVLPTRVPNLLVNGSSGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEE
MATNIPPHNLTEIINATIHLIQHPTANLAKIMEFVQGPDFPTGGFILGRQGILDAFIRGR
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCC
GQLKLRAKAAIEKMGKDREQIIVTEIPYQVNKSRLIEAASALVNEKKLEGIGDIRDESDR
CCEEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DGMRIVFELKRGEQAEVILNNLYKHTQLQVGFGIIMLSIVNGQPRELGLVDMIKHFIDHR
CCEEEEEEECCCCHHHHHHHHHHHHHEEHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHH
IEVVRRRTEYELRKARDREHILLGFQKALDHLDEVIRLIRASKSPKDARDSLITTFQFSD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEEECC
KQAQAIIELQLQRLTGMERQKILDELGEIQRRIAEYVEILGSDKVLRDLIIKELKEVQKN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
YGDERRTQIIEDTGEIRLEDLVAVEDVAITVTRGGYLKRTSVDTYRRQTRGGKGRIGMGT
CCHHHHHHHHHCCCCEEEHHHEEEEEEEEEEECCCEEEECCHHHHHHHCCCCCCCCCCCC
RAEDFVERLIVASTHSYLLIFTTRGRVYWLKAYEIPDATTIGKGKHLTNLINLQGDEEAK
CHHHHHHHHHHHCCCCEEEEEEECCEEEEEEEEECCCCCCCCCCCHHHHHCCCCCCHHHH
AFLSVKDFVANQYIVMVTKHGVIKKSELTEFDNPLSRGIIAVSLDEGDELIGAKITMGDN
HHHHHHHHHCCCEEEEEECCCCEECHHHHHHCCHHHCCEEEEEECCCCCEEEEEEEECCC
YIFLGSHEGQAIRFREEDVRAMGRQARGVRAMSLADGDYLVGMEVVEKDGLILSIAENGY
EEEEECCCCCEEEECHHHHHHHHHHHCCCEEEEECCCCEEEEEEEECCCCEEEEEECCCC
GKRTPLEDYRLTSRGGKGVINMKTTNKTGRVVGILSVKEDSELMIVSQNGKMIRIESSTI
CCCCCCHHCEEECCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEECCCCEEEEEHHHH
RQAGRSTQGVRLVNLEPDDKVAAASVIPESDVVPDDGQETLPVQ
HHCCCCCCCEEEEEECCCCCEEHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]