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The map label for this gene is dhaT [H]

Identifier: 116622993

GI number: 116622993

Start: 4925646

End: 4926788

Strand: Direct

Name: dhaT [H]

Synonym: Acid_3896

Alternate gene names: 116622993

Gene position: 4925646-4926788 (Clockwise)

Preceding gene: 116622992

Following gene: 116622994

Centisome position: 49.43

GC content: 69.47

Gene sequence:

>1143_bases
ATGCCGCCTTCTAACTTCGAATTCGCCACCGCCGGCCGCATCCTCTTCGGCGAAGCCGTTGTCCGCGACGTCCCCGCCGC
CGCCCGCGCCTTCGGCGCCAGCGCACTCTTCGTCACCGGGGCCAACCCCGACCGCGCCGCCCCACTGCGCGCCGCGCTCC
AGAACGCCAGTGTCGAGTGCATCCCCTTCGCGGTCCCCGCCGAGCCCACGCTCGATCTCATCCGCTCCGCACCGCGCGAA
GCTGACTTCGTCATCTCCATCGGTGGCGGTAGCGTCCTTGACGCCGGCAAGGCCCTTGCCGCCATGCTCACCAATCCGGG
CGACCCGCTCGATTACCTCGAAGTCATCGGACAGGCCCAGCCACTCAAGCACCCGGCCGCCCCCTGCATCGCCATCCCCA
CCACCGCCGGCACCGGCAGCGAAGTCACCCGCAACGCCGTCCTCGCCAGCCCCGAGCATCGCGTCAAAGCCAGCCTGCGC
GCCGCCGGCATGCTCCCCCGCCTCGCCGTCGTCGATCCCGAACTCACCCGCGATCTTCCCCGCGCCATCACCGCCTACAC
GGGCCTCGACGCCCTCACCCAATTGATCGAACCGTACCTCGGCATTCGCGCCAACGCCATGACCGACCTCTTCTGCGTCG
ATGGCATACGCCGCGCCGCCGTAGCGCTGCCGCGTGTCTGCCAGAATGGCGGCGATCGCGAAGCCCGCTCCGAAATGGCC
TTCTGCAGCCTGCTCGGCGGACTCGCGCTCGCCAACTCCGGACTTGGCGCCGTCCACGGTTTCGCCGCGCCCATCGGGGG
CATGTTCGATGCACCCCACGGCGCCGTCTGTGCCGCCCTCCTGCCGCACGCGATGGATATCAACGTGGAGGCAGTCGCCG
CCCGCCAGCCCCACCGCCTCGTAAGATTCACCGAGGTCGCCCGTCTCCTCACCAGGATGCCTCACGCAACCGCCGGCGAC
GGCGTGGAATGGCTCGCCGCCCTCTGCCGCCGCCTCGAAATCCCGCCACTCCGCGCCTACGGCATCACCGACGCCGACAT
TCCCGCGCTCGTCGAAAAGGCCGCGCAAGCCAGCAGCATGAAAGGCAACCCCGTCGTCCTCACCACGGAGGAACTACGCG
AAATCGTCTCACGCGCGCTCTGA

Upstream 100 bases:

>100_bases
CACAAGGCCACCGCGCACTACAACACCTGGATCGAAACCGTGAACGATATGTTCGTCACCCCGCGCACCCGCGCCTTCTA
CACCAACATCTCCCCGCCCG

Downstream 100 bases:

>100_bases
TTTTCCTGCTCGCCAGCCGCGTCCTCGCGCAGGACGGCGTCATTGCAGGGACCGTACGCGACTCGCTCACCCACGCCCCC
GTCGCCGGCTTCGCCATCGA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MPPSNFEFATAGRILFGEAVVRDVPAAARAFGASALFVTGANPDRAAPLRAALQNASVECIPFAVPAEPTLDLIRSAPRE
ADFVISIGGGSVLDAGKALAAMLTNPGDPLDYLEVIGQAQPLKHPAAPCIAIPTTAGTGSEVTRNAVLASPEHRVKASLR
AAGMLPRLAVVDPELTRDLPRAITAYTGLDALTQLIEPYLGIRANAMTDLFCVDGIRRAAVALPRVCQNGGDREARSEMA
FCSLLGGLALANSGLGAVHGFAAPIGGMFDAPHGAVCAALLPHAMDINVEAVAARQPHRLVRFTEVARLLTRMPHATAGD
GVEWLAALCRRLEIPPLRAYGITDADIPALVEKAAQASSMKGNPVVLTTEELREIVSRAL

Sequences:

>Translated_380_residues
MPPSNFEFATAGRILFGEAVVRDVPAAARAFGASALFVTGANPDRAAPLRAALQNASVECIPFAVPAEPTLDLIRSAPRE
ADFVISIGGGSVLDAGKALAAMLTNPGDPLDYLEVIGQAQPLKHPAAPCIAIPTTAGTGSEVTRNAVLASPEHRVKASLR
AAGMLPRLAVVDPELTRDLPRAITAYTGLDALTQLIEPYLGIRANAMTDLFCVDGIRRAAVALPRVCQNGGDREARSEMA
FCSLLGGLALANSGLGAVHGFAAPIGGMFDAPHGAVCAALLPHAMDINVEAVAARQPHRLVRFTEVARLLTRMPHATAGD
GVEWLAALCRRLEIPPLRAYGITDADIPALVEKAAQASSMKGNPVVLTTEELREIVSRAL
>Mature_379_residues
PPSNFEFATAGRILFGEAVVRDVPAAARAFGASALFVTGANPDRAAPLRAALQNASVECIPFAVPAEPTLDLIRSAPREA
DFVISIGGGSVLDAGKALAAMLTNPGDPLDYLEVIGQAQPLKHPAAPCIAIPTTAGTGSEVTRNAVLASPEHRVKASLRA
AGMLPRLAVVDPELTRDLPRAITAYTGLDALTQLIEPYLGIRANAMTDLFCVDGIRRAAVALPRVCQNGGDREARSEMAF
CSLLGGLALANSGLGAVHGFAAPIGGMFDAPHGAVCAALLPHAMDINVEAVAARQPHRLVRFTEVARLLTRMPHATAGDG
VEWLAALCRRLEIPPLRAYGITDADIPALVEKAAQASSMKGNPVVLTTEELREIVSRAL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=392, Percent_Identity=30.1020408163265, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789163, Length=308, Percent_Identity=35.3896103896104, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI48994951, Length=303, Percent_Identity=33.6633663366337, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87082107, Length=295, Percent_Identity=34.5762711864407, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1787493, Length=373, Percent_Identity=28.4182305630027, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1789386, Length=373, Percent_Identity=24.3967828418231, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537053, Length=398, Percent_Identity=28.643216080402, Blast_Score=134, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=302, Percent_Identity=35.7615894039735, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24657991, Length=422, Percent_Identity=28.1990521327014, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 39670; Mature: 39539

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSNFEFATAGRILFGEAVVRDVPAAARAFGASALFVTGANPDRAAPLRAALQNASVEC
CCCCCCCHHHCCHHHHHHHHHHHCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCEE
IPFAVPAEPTLDLIRSAPREADFVISIGGGSVLDAGKALAAMLTNPGDPLDYLEVIGQAQ
EEEECCCCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PLKHPAAPCIAIPTTAGTGSEVTRNAVLASPEHRVKASLRAAGMLPRLAVVDPELTRDLP
CCCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEECCCHHHHHHH
RAITAYTGLDALTQLIEPYLGIRANAMTDLFCVDGIRRAAVALPRVCQNGGDREARSEMA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FCSLLGGLALANSGLGAVHGFAAPIGGMFDAPHGAVCAALLPHAMDINVEAVAARQPHRL
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHCCCEEEECCCCCHHH
VRFTEVARLLTRMPHATAGDGVEWLAALCRRLEIPPLRAYGITDADIPALVEKAAQASSM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
KGNPVVLTTEELREIVSRAL
CCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
PPSNFEFATAGRILFGEAVVRDVPAAARAFGASALFVTGANPDRAAPLRAALQNASVEC
CCCCCCHHHCCHHHHHHHHHHHCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCEE
IPFAVPAEPTLDLIRSAPREADFVISIGGGSVLDAGKALAAMLTNPGDPLDYLEVIGQAQ
EEEECCCCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PLKHPAAPCIAIPTTAGTGSEVTRNAVLASPEHRVKASLRAAGMLPRLAVVDPELTRDLP
CCCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEECCCHHHHHHH
RAITAYTGLDALTQLIEPYLGIRANAMTDLFCVDGIRRAAVALPRVCQNGGDREARSEMA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FCSLLGGLALANSGLGAVHGFAAPIGGMFDAPHGAVCAALLPHAMDINVEAVAARQPHRL
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHCCCEEEECCCCCHHH
VRFTEVARLLTRMPHATAGDGVEWLAALCRRLEIPPLRAYGITDADIPALVEKAAQASSM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
KGNPVVLTTEELREIVSRAL
CCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]