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The map label for this gene is nuoI1

Identifier: 116622976

GI number: 116622976

Start: 4913395

End: 4913898

Strand: Reverse

Name: nuoI1

Synonym: Acid_3879

Alternate gene names: 116622976

Gene position: 4913898-4913395 (Counterclockwise)

Preceding gene: 116622977

Following gene: 116622975

Centisome position: 49.31

GC content: 59.52

Gene sequence:

>504_bases
ATGGCAAATCCAATCGAAGAAATCCTCGGAACGGCGGCAGCAATCGCTAAGGGTATGGGCATCACTTTCAAGGAGATGAT
GGGCCCGACCGTTACGGACGATTATCCCGATGCACCTCCGAAGTTCGAAGAGCGGTTCCGCGGCGTTCACGTATTGCAGC
GCGACGTCAACGGAATGGAGAAATGTGTGGCCTGCTTCCTCTGCGCGGCGGCCTGCCCCTCCAACTGCATTTACATCGAA
GCGGCGGAGAATACCGACAAAATCCGCATGTCCGGCGGCGAGCGGTACGCCAAGGTCTATAACATCGATTACAACCGCTG
CATCTTCTGCGGCTACTGCGTGGAGGCCTGCCCGACTGACGCCATCACGCACGGCCACGGATTCGAAGCCGCGAGTTACA
ACACCTCCACGCTGGTCAAACGCAAAGAGGATATGCTCGTCCCCGTGCCGCCGGGCGCCAAACCGCCGTCCATGGCGGAT
GAAGTGCCCGCTGGGGCACACTAG

Upstream 100 bases:

>100_bases
ACGCGCAGGATAACGTACCCGCATGGAAGGCCGGTTGAGGGTCGCGGAACTAGGTTCCCGGCGGGAACCGCGAAAGGCAC
GCTAGAATAAAGTAGACCGA

Downstream 100 bases:

>100_bases
GGTCAAGTGTTCCGCGCCATCAGGGAGCAGATCGACACGATCTTCCGGGAAGATCCGGCCGCGAAGAGTGTGCTCGAGAT
CGTCCTGTGTTACCCGGGAT

Product: NADH-quinone oxidoreductase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 1; NDH-1 subunit I 1

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MANPIEEILGTAAAIAKGMGITFKEMMGPTVTDDYPDAPPKFEERFRGVHVLQRDVNGMEKCVACFLCAAACPSNCIYIE
AAENTDKIRMSGGERYAKVYNIDYNRCIFCGYCVEACPTDAITHGHGFEAASYNTSTLVKRKEDMLVPVPPGAKPPSMAD
EVPAGAH

Sequences:

>Translated_167_residues
MANPIEEILGTAAAIAKGMGITFKEMMGPTVTDDYPDAPPKFEERFRGVHVLQRDVNGMEKCVACFLCAAACPSNCIYIE
AAENTDKIRMSGGERYAKVYNIDYNRCIFCGYCVEACPTDAITHGHGFEAASYNTSTLVKRKEDMLVPVPPGAKPPSMAD
EVPAGAH
>Mature_166_residues
ANPIEEILGTAAAIAKGMGITFKEMMGPTVTDDYPDAPPKFEERFRGVHVLQRDVNGMEKCVACFLCAAACPSNCIYIEA
AENTDKIRMSGGERYAKVYNIDYNRCIFCGYCVEACPTDAITHGHGFEAASYNTSTLVKRKEDMLVPVPPGAKPPSMADE
VPAGAH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=132, Percent_Identity=39.3939393939394, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1788617, Length=119, Percent_Identity=46.218487394958, Blast_Score=107, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17555194, Length=133, Percent_Identity=38.3458646616541, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17864306, Length=132, Percent_Identity=39.3939393939394, Blast_Score=103, Evalue=7e-23,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI1_SOLUE (Q01ZR8)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825132.1
- ProteinModelPortal:   Q01ZR8
- SMR:   Q01ZR8
- STRING:   Q01ZR8
- GeneID:   4427860
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_3879
- NMPDR:   fig|234267.9.peg.3687
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   VEGGDNT
- PhylomeDB:   Q01ZR8
- ProtClustDB:   CLSK774642
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 18088; Mature: 17957

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
10.2 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
9.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPIEEILGTAAAIAKGMGITFKEMMGPTVTDDYPDAPPKFEERFRGVHVLQRDVNGME
CCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KCVACFLCAAACPSNCIYIEAAENTDKIRMSGGERYAKVYNIDYNRCIFCGYCVEACPTD
HHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCEEEEEEECCCCCEEEEEHHHHHCCCC
AITHGHGFEAASYNTSTLVKRKEDMLVPVPPGAKPPSMADEVPAGAH
CCCCCCCCCCCCCCHHHHHCCCCCCEEECCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
ANPIEEILGTAAAIAKGMGITFKEMMGPTVTDDYPDAPPKFEERFRGVHVLQRDVNGME
CCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KCVACFLCAAACPSNCIYIEAAENTDKIRMSGGERYAKVYNIDYNRCIFCGYCVEACPTD
HHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCEEEEEEECCCCCEEEEEHHHHHCCCC
AITHGHGFEAASYNTSTLVKRKEDMLVPVPPGAKPPSMADEVPAGAH
CCCCCCCCCCCCCCHHHHHCCCCCCEEECCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA