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The map label for this gene is hisB

Identifier: 116622950

GI number: 116622950

Start: 4886848

End: 4887435

Strand: Reverse

Name: hisB

Synonym: Acid_3852

Alternate gene names: 116622950

Gene position: 4887435-4886848 (Counterclockwise)

Preceding gene: 116622951

Following gene: 116622949

Centisome position: 49.04

GC content: 61.56

Gene sequence:

>588_bases
ATGAGATCCGCCACCATTCAGCGCGATACCAAAGAGACGCGAATCGGCGGCACGCTCAAACTCGAAGGTCGCGGCCGCTA
CGAGATCGCGACCGGCATTCGCTTCCTCGACCACATGCTGGAGCTCTTCGCCAAACACGGCGGCTTCGATCTCAAGTTCC
AGGCCGATGGCGATCTCGACGTCGATCAGCACCACACCGTGGAGGATGCCGGCATCGTGCTCGGTCAGCTCTTCGCCAAG
GCGCTCGGCGATCGCAAAGGCATCAACCGCGCCGGCTACTTCGTGCTCCCCATGGACGAGACGCTCGCCGTGGTGGCGGT
CGATCTCGGCGGACGCCCCGCGCTGGTCTACAAGGACCGCGTGAAGGTGCGCCTGGTCGGCGACCTGCAGACGGAGCTCG
TCCACGATTTCTTCGATGGCTTCGTGGTCCACGCCGGCGCCAACCTTCACGCCAAAGTTCTGTACGGCCGTTCCAACCAC
CACAAGCTGGAAGCCATCTTCAAATGCTTCGCGCGTGCCATGAAATACGCCTGCTCCAAAGATGCACGCCTCAAAGATCA
ACTGCCCTCCACCAAGGGATTGCTATGA

Upstream 100 bases:

>100_bases
CATCCAACCCGCTCTATATAGACCTCGTTTTCCTGTTCCAGGAAGAGGGCGCCTACGCCATCATCGACGACATCAACTAT
CTCGAGGAGGTCTTCACCGC

Downstream 100 bases:

>100_bases
TCACCATCCTCGATTACGGCGCCGGTAACCTGCGCAGCGTGCAAAACACGTTGGCCGAATTGAACTGCGAGTACCGCCTG
GTCAACGACGCTGCCGGCCT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRSATIQRDTKETRIGGTLKLEGRGRYEIATGIRFLDHMLELFAKHGGFDLKFQADGDLDVDQHHTVEDAGIVLGQLFAK
ALGDRKGINRAGYFVLPMDETLAVVAVDLGGRPALVYKDRVKVRLVGDLQTELVHDFFDGFVVHAGANLHAKVLYGRSNH
HKLEAIFKCFARAMKYACSKDARLKDQLPSTKGLL

Sequences:

>Translated_195_residues
MRSATIQRDTKETRIGGTLKLEGRGRYEIATGIRFLDHMLELFAKHGGFDLKFQADGDLDVDQHHTVEDAGIVLGQLFAK
ALGDRKGINRAGYFVLPMDETLAVVAVDLGGRPALVYKDRVKVRLVGDLQTELVHDFFDGFVVHAGANLHAKVLYGRSNH
HKLEAIFKCFARAMKYACSKDARLKDQLPSTKGLL
>Mature_195_residues
MRSATIQRDTKETRIGGTLKLEGRGRYEIATGIRFLDHMLELFAKHGGFDLKFQADGDLDVDQHHTVEDAGIVLGQLFAK
ALGDRKGINRAGYFVLPMDETLAVVAVDLGGRPALVYKDRVKVRLVGDLQTELVHDFFDGFVVHAGANLHAKVLYGRSNH
HKLEAIFKCFARAMKYACSKDARLKDQLPSTKGLL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=45.8762886597938, Blast_Score=166, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=37.1559633027523, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_SOLUE (Q01ZU4)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825106.1
- ProteinModelPortal:   Q01ZU4
- SMR:   Q01ZU4
- STRING:   Q01ZU4
- GeneID:   4426652
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_3852
- NMPDR:   fig|234267.9.peg.3661
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q01ZU4
- ProtClustDB:   CLSK775024
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21664; Mature: 21664

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSATIQRDTKETRIGGTLKLEGRGRYEIATGIRFLDHMLELFAKHGGFDLKFQADGDLD
CCCCCCCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
VDQHHTVEDAGIVLGQLFAKALGDRKGINRAGYFVLPMDETLAVVAVDLGGRPALVYKDR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEECC
VKVRLVGDLQTELVHDFFDGFVVHAGANLHAKVLYGRSNHHKLEAIFKCFARAMKYACSK
EEEEEECHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
DARLKDQLPSTKGLL
CCCHHHHCCCCCCCC
>Mature Secondary Structure
MRSATIQRDTKETRIGGTLKLEGRGRYEIATGIRFLDHMLELFAKHGGFDLKFQADGDLD
CCCCCCCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
VDQHHTVEDAGIVLGQLFAKALGDRKGINRAGYFVLPMDETLAVVAVDLGGRPALVYKDR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEECC
VKVRLVGDLQTELVHDFFDGFVVHAGANLHAKVLYGRSNHHKLEAIFKCFARAMKYACSK
EEEEEECHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
DARLKDQLPSTKGLL
CCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA