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The map label for this gene is cpxA [H]

Identifier: 116622736

GI number: 116622736

Start: 4602461

End: 4603756

Strand: Reverse

Name: cpxA [H]

Synonym: Acid_3635

Alternate gene names: 116622736

Gene position: 4603756-4602461 (Counterclockwise)

Preceding gene: 116622737

Following gene: 116622734

Centisome position: 46.2

GC content: 63.27

Gene sequence:

>1296_bases
ATGAAGGTCTATACCAAAGTTCTTCTCTGGTGCTTCGGCACGCTGCTGCTTTCCCTGATCGCTTTCGGCGGCGTCTCCTA
CGTCTCGATGCGCAGCGTGGATCACGGCAGCTTTGTGCCGCGCTGGAATGCGCTGCTCATGGAGCAGGCGATCGATGCTT
ATGAAGCTCACGGGAAATCCGCGCTGGCTGCCGAACTGGCACGCATGAGCAGTCACATCCCCGGCCAGCATTTCCTGACC
GATGCCCGCGGCACCGATCTGGCCAGCGGCGAGGACCACTCGAAATTGTTGGCGGCGGCGCGCCTGGATAATGGGCCACC
GAAACGCTTTGAGCGCCGCCACATGATTTACTATCCCTCCGGGGACGGCAAGTATCGCTTCCTGGTGGTCTTCGACACGG
CCTTTGATCCGTGGCAGTATTTGCCCTATTATTTGATGATCCTGCTCGCCATCGCGCTCCTGTGCTGGATCCTCGCCACC
AATATCGCGTCCCCGCTCGGCGGTCTGGCGCGCGTGGTAGACCGCTTCGGTGCGGGAGATCTTTCGGTGCGCGTCAATTC
CACCCGCAAGGATGAAATTGGCGAAGTCGGGCGCGCCTTCGATCGTATGGCGGAGCGCATCGCCACGCTGCTCACCGCAG
AGCGCCGGCTGCTGCAGGATATCTCGCACGAACTCCGCTCGCCGCTGGCCCGCCTCAGTTTCGCCGCCGAACTGGCGCGC
ACGGCAGAGAATCGCGGTGCCGCCATCGACCGCCTGAACAAAGAGATCGCGCGCCTCACCGACCTGGTCGGCGGCTTGAT
CCAGGTCACCCGCGTGGAGGGCGACCCCGAGGCTCACAACACCGAAGACCTCCGGCTCGATGGTCTGCTCACCGAAGTGG
TGGACGATTGCCGGATGGAAGCCGAGGCTCGCGGCTTTAAGATCGCGCTGGACGCCGAGCCGCAGCTGACCTTGCGCGGC
GATCGAGAAGTCCTCCGCCGCGCGATTGAAAACGTAATTCGCAATTCCATCCGCTACAACCCTTCGGGCAGGAGCATCGA
GGTCAACCTCGCCGCCACCACCGACGCCGCGCGCATCGCGGTTCGCGATTACGGTCCCGGCGTCCCCGAAGAAGTGCTGC
CGAAAATCTTCCAACCGTTCTTCCGCGTTGACGATTCGCGCGACACCGCCACCGGCGGCGTGGGACTCGGCCTCGCCATC
GCCTCGCGCGCCATCGGCCTGCATCACGGCAGACTCTGGGCGGAGAACGTCGCGCCCGGATTAAAGGTCTGGATCGAAAT
CCCTCTCGTAGGTTAA

Upstream 100 bases:

>100_bases
ATGTCCACATCAGCCACCTGCGCAAGAAGCTCGAGCGCGACGATCGCTCCGTGATCCGCACCATCCGCGGCGTCGGCTAT
CAATTCATGGCGGGTGAGCG

Downstream 100 bases:

>100_bases
ATTGTGAGCCGTCGGACTCTGGCAGTCCCGATGCCAGGAGATTGGCGGATACGATCCTGGGGCCGGGGGGCTCCGCAAAA
AGTGGAACAGGTCAAACGCA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKVYTKVLLWCFGTLLLSLIAFGGVSYVSMRSVDHGSFVPRWNALLMEQAIDAYEAHGKSALAAELARMSSHIPGQHFLT
DARGTDLASGEDHSKLLAAARLDNGPPKRFERRHMIYYPSGDGKYRFLVVFDTAFDPWQYLPYYLMILLAIALLCWILAT
NIASPLGGLARVVDRFGAGDLSVRVNSTRKDEIGEVGRAFDRMAERIATLLTAERRLLQDISHELRSPLARLSFAAELAR
TAENRGAAIDRLNKEIARLTDLVGGLIQVTRVEGDPEAHNTEDLRLDGLLTEVVDDCRMEAEARGFKIALDAEPQLTLRG
DREVLRRAIENVIRNSIRYNPSGRSIEVNLAATTDAARIAVRDYGPGVPEEVLPKIFQPFFRVDDSRDTATGGVGLGLAI
ASRAIGLHHGRLWAENVAPGLKVWIEIPLVG

Sequences:

>Translated_431_residues
MKVYTKVLLWCFGTLLLSLIAFGGVSYVSMRSVDHGSFVPRWNALLMEQAIDAYEAHGKSALAAELARMSSHIPGQHFLT
DARGTDLASGEDHSKLLAAARLDNGPPKRFERRHMIYYPSGDGKYRFLVVFDTAFDPWQYLPYYLMILLAIALLCWILAT
NIASPLGGLARVVDRFGAGDLSVRVNSTRKDEIGEVGRAFDRMAERIATLLTAERRLLQDISHELRSPLARLSFAAELAR
TAENRGAAIDRLNKEIARLTDLVGGLIQVTRVEGDPEAHNTEDLRLDGLLTEVVDDCRMEAEARGFKIALDAEPQLTLRG
DREVLRRAIENVIRNSIRYNPSGRSIEVNLAATTDAARIAVRDYGPGVPEEVLPKIFQPFFRVDDSRDTATGGVGLGLAI
ASRAIGLHHGRLWAENVAPGLKVWIEIPLVG
>Mature_431_residues
MKVYTKVLLWCFGTLLLSLIAFGGVSYVSMRSVDHGSFVPRWNALLMEQAIDAYEAHGKSALAAELARMSSHIPGQHFLT
DARGTDLASGEDHSKLLAAARLDNGPPKRFERRHMIYYPSGDGKYRFLVVFDTAFDPWQYLPYYLMILLAIALLCWILAT
NIASPLGGLARVVDRFGAGDLSVRVNSTRKDEIGEVGRAFDRMAERIATLLTAERRLLQDISHELRSPLARLSFAAELAR
TAENRGAAIDRLNKEIARLTDLVGGLIQVTRVEGDPEAHNTEDLRLDGLLTEVVDDCRMEAEARGFKIALDAEPQLTLRG
DREVLRRAIENVIRNSIRYNPSGRSIEVNLAATTDAARIAVRDYGPGVPEEVLPKIFQPFFRVDDSRDTATGGVGLGLAI
ASRAIGLHHGRLWAENVAPGLKVWIEIPLVG

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=37.7118644067797, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788393, Length=305, Percent_Identity=31.1475409836066, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787894, Length=309, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786783, Length=332, Percent_Identity=26.2048192771084, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=27.4914089347079, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=29.5275590551181, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1789403, Length=320, Percent_Identity=29.375, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789808, Length=296, Percent_Identity=27.7027027027027, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=286, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=24.4813278008299, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787374, Length=351, Percent_Identity=25.0712250712251, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=315, Percent_Identity=23.1746031746032, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=209, Percent_Identity=28.2296650717703, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=214, Percent_Identity=27.1028037383178, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=291, Percent_Identity=23.3676975945017, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786912, Length=212, Percent_Identity=25.9433962264151, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47607; Mature: 47607

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYTKVLLWCFGTLLLSLIAFGGVSYVSMRSVDHGSFVPRWNALLMEQAIDAYEAHGKS
CHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCH
ALAAELARMSSHIPGQHFLTDARGTDLASGEDHSKLLAAARLDNGPPKRFERRHMIYYPS
HHHHHHHHHHHCCCCHHHEECCCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCEEEEEEC
GDGKYRFLVVFDTAFDPWQYLPYYLMILLAIALLCWILATNIASPLGGLARVVDRFGAGD
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LSVRVNSTRKDEIGEVGRAFDRMAERIATLLTAERRLLQDISHELRSPLARLSFAAELAR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAENRGAAIDRLNKEIARLTDLVGGLIQVTRVEGDPEAHNTEDLRLDGLLTEVVDDCRME
HHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
AEARGFKIALDAEPQLTLRGDREVLRRAIENVIRNSIRYNPSGRSIEVNLAATTDAARIA
HHCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHCEECCCCCEEEEEEEECCCCCEEE
VRDYGPGVPEEVLPKIFQPFFRVDDSRDTATGGVGLGLAIASRAIGLHHGRLWAENVAPG
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCC
LKVWIEIPLVG
EEEEEEEECCC
>Mature Secondary Structure
MKVYTKVLLWCFGTLLLSLIAFGGVSYVSMRSVDHGSFVPRWNALLMEQAIDAYEAHGKS
CHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCH
ALAAELARMSSHIPGQHFLTDARGTDLASGEDHSKLLAAARLDNGPPKRFERRHMIYYPS
HHHHHHHHHHHCCCCHHHEECCCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCEEEEEEC
GDGKYRFLVVFDTAFDPWQYLPYYLMILLAIALLCWILATNIASPLGGLARVVDRFGAGD
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LSVRVNSTRKDEIGEVGRAFDRMAERIATLLTAERRLLQDISHELRSPLARLSFAAELAR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAENRGAAIDRLNKEIARLTDLVGGLIQVTRVEGDPEAHNTEDLRLDGLLTEVVDDCRME
HHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
AEARGFKIALDAEPQLTLRGDREVLRRAIENVIRNSIRYNPSGRSIEVNLAATTDAARIA
HHCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHCEECCCCCEEEEEEEECCCCCEEE
VRDYGPGVPEEVLPKIFQPFFRVDDSRDTATGGVGLGLAIASRAIGLHHGRLWAENVAPG
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCC
LKVWIEIPLVG
EEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]