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The map label for this gene is 116622554

Identifier: 116622554

GI number: 116622554

Start: 4365889

End: 4367256

Strand: Reverse

Name: 116622554

Synonym: Acid_3452

Alternate gene names: NA

Gene position: 4367256-4365889 (Counterclockwise)

Preceding gene: 116622555

Following gene: 116622552

Centisome position: 43.82

GC content: 61.04

Gene sequence:

>1368_bases
ATGTCACGCAGACTCCATATTTCGGTGCGAATCTCACTACTGATCGCGCTCTTTTCTTTGGGGGCTTTCGCCGAGGATCG
GTTCTTAGTCAAGGTGAACGGCGATATCAACGCGCTCGCCCGGCATTACGGATTAACGGTAGTACAGTCGCTGGGCGGCA
GCGCCACCGGAATGCACGTGCTTTCCTCCAAAGGCGCCAATCCCCACGACCTGGCACGCAGCCTGGCCGCCGAGTTTTCG
GTCCGCAGCGTGGAGCCCGATAACGCCGTCATCCTGCCGGGAATCAAACCGGCATCCGCGGTGGTCCGTTCGCCGGCATC
CACGTCCGGCTTTTCGATTTCGAGCACGCTGGTGAGGTATCACAATTCGTATGTCGCCTCGGGGTATGTGAATCAACCCG
CGGTGGGCCTGATCAACATGGCCAGCGCGCAGAAAATGTCAACGGGCGGCGGAATCGTGGCCACCATCGATACGGGCGCG
GATTTCACCCATCCGGGCCTGCTGGGGTCGCTAACGCCGGGCTGGGATTTCGTCAACAATCTGCCCTTTGGGCAGGAACA
GGCGGACATCAATAAAGCCGGCGCCACCGTCGCCCAGGAAACCACGCCGATTCTGGACCAGGAGACCACCCCGATTCTGG
ACGGGGGAACCGCAATCATCCTTACGCAGGAGACCACGCCGATTTTGGATCAGGAAACCACGCCGATTCTGGACGGGACC
AAGTATCCGGCATTCGGTCACGGCACCATGGTGGCCAGCCTGATTCACCTGGTGGCTCCCGACGCGCGGATCATGCCGCT
GCGCGCATTCGGCGCGAACGGCAGTTCCAGCATTTCGCAGATCGTGGCCGCGGTTCACTATGCGGTAGAGCACAACGTCG
ATGTCATCAATATGAGCTTCAGTGTTTCGTCGGACTCGCCGGCTCTGAAAGACGCCATGGAATTCGCTTTCAATAGCGGG
CTGGTGCTGGTGGCGGCAGCGGGGAACAGCGGACAGGCTGCGACCGTCTATCCGGCGGCATACTCCACCGTCATGGGCGT
GGGCGCGACGGACAATTTCCTGCAGCGCGCCTTCTTTTCGAATTTCGGCCAACCGTTGGTTACCCTGGCCGCGCCGGGAC
AGGACATCATCGCGATGTATCCGATGAATCATTACGCCAAGGTCTCCGGCACCTCCTTCAGCGCACCGCTGGTAGCGGGG
GGCGCAGCCCTGCTGGTGGACCTTAATAAGAAGCTCAACGAGACGTCAGCCACGGCGGCGTTGTCGCATGCGCACGCACT
TGCTCCCGGACTGGAATTGGGGGCGGGCGAATTGGACCTGTTCCAGGCCTGCATGAGTCTGCCGAGATCGGCCGGCGGTA
ACTGGTAG

Upstream 100 bases:

>100_bases
CGCTAAAGAAATTTACGTCGGATCAACCGGCCGTCCAGAGCCAGACCGGCGTTCGGAGTCGATCCGAAGAGCAGTAACCG
GGGTCAAAAGGGAAACTCAC

Downstream 100 bases:

>100_bases
TTAAGCGGGAGACTGTTCCGGTAATCCAAAGCCGGGACAGAAGGACCTTGAAATGGGGAAAGCCTAGCCTATGTCTATGA
GAGCGAAGACCGCGGAACAT

Product: fervidolysin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSRRLHISVRISLLIALFSLGAFAEDRFLVKVNGDINALARHYGLTVVQSLGGSATGMHVLSSKGANPHDLARSLAAEFS
VRSVEPDNAVILPGIKPASAVVRSPASTSGFSISSTLVRYHNSYVASGYVNQPAVGLINMASAQKMSTGGGIVATIDTGA
DFTHPGLLGSLTPGWDFVNNLPFGQEQADINKAGATVAQETTPILDQETTPILDGGTAIILTQETTPILDQETTPILDGT
KYPAFGHGTMVASLIHLVAPDARIMPLRAFGANGSSSISQIVAAVHYAVEHNVDVINMSFSVSSDSPALKDAMEFAFNSG
LVLVAAAGNSGQAATVYPAAYSTVMGVGATDNFLQRAFFSNFGQPLVTLAAPGQDIIAMYPMNHYAKVSGTSFSAPLVAG
GAALLVDLNKKLNETSATAALSHAHALAPGLELGAGELDLFQACMSLPRSAGGNW

Sequences:

>Translated_455_residues
MSRRLHISVRISLLIALFSLGAFAEDRFLVKVNGDINALARHYGLTVVQSLGGSATGMHVLSSKGANPHDLARSLAAEFS
VRSVEPDNAVILPGIKPASAVVRSPASTSGFSISSTLVRYHNSYVASGYVNQPAVGLINMASAQKMSTGGGIVATIDTGA
DFTHPGLLGSLTPGWDFVNNLPFGQEQADINKAGATVAQETTPILDQETTPILDGGTAIILTQETTPILDQETTPILDGT
KYPAFGHGTMVASLIHLVAPDARIMPLRAFGANGSSSISQIVAAVHYAVEHNVDVINMSFSVSSDSPALKDAMEFAFNSG
LVLVAAAGNSGQAATVYPAAYSTVMGVGATDNFLQRAFFSNFGQPLVTLAAPGQDIIAMYPMNHYAKVSGTSFSAPLVAG
GAALLVDLNKKLNETSATAALSHAHALAPGLELGAGELDLFQACMSLPRSAGGNW
>Mature_454_residues
SRRLHISVRISLLIALFSLGAFAEDRFLVKVNGDINALARHYGLTVVQSLGGSATGMHVLSSKGANPHDLARSLAAEFSV
RSVEPDNAVILPGIKPASAVVRSPASTSGFSISSTLVRYHNSYVASGYVNQPAVGLINMASAQKMSTGGGIVATIDTGAD
FTHPGLLGSLTPGWDFVNNLPFGQEQADINKAGATVAQETTPILDQETTPILDGGTAIILTQETTPILDQETTPILDGTK
YPAFGHGTMVASLIHLVAPDARIMPLRAFGANGSSSISQIVAAVHYAVEHNVDVINMSFSVSSDSPALKDAMEFAFNSGL
VLVAAAGNSGQAATVYPAAYSTVMGVGATDNFLQRAFFSNFGQPLVTLAAPGQDIIAMYPMNHYAKVSGTSFSAPLVAGG
AALLVDLNKKLNETSATAALSHAHALAPGLELGAGELDLFQACMSLPRSAGGNW

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=228, Percent_Identity=32.0175438596491, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319893, Length=178, Percent_Identity=35.3932584269663, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320775, Length=196, Percent_Identity=33.6734693877551, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324576, Length=174, Percent_Identity=32.183908045977, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 47136; Mature: 47005

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRLHISVRISLLIALFSLGAFAEDRFLVKVNGDINALARHYGLTVVQSLGGSATGMHV
CCCEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHH
LSSKGANPHDLARSLAAEFSVRSVEPDNAVILPGIKPASAVVRSPASTSGFSISSTLVRY
HHCCCCCHHHHHHHHHHHHHEEEECCCCEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHH
HNSYVASGYVNQPAVGLINMASAQKMSTGGGIVATIDTGADFTHPGLLGSLTPGWDFVNN
HCCEEECCCCCCCCCCEEECCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHC
LPFGQEQADINKAGATVAQETTPILDQETTPILDGGTAIILTQETTPILDQETTPILDGT
CCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCCCCCC
KYPAFGHGTMVASLIHLVAPDARIMPLRAFGANGSSSISQIVAAVHYAVEHNVDVINMSF
CCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEE
SVSSDSPALKDAMEFAFNSGLVLVAAAGNSGQAATVYPAAYSTVMGVGATDNFLQRAFFS
EECCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEHHHHHHHEECCCCHHHHHHHHHH
NFGQPLVTLAAPGQDIIAMYPMNHYAKVSGTSFSAPLVAGGAALLVDLNKKLNETSATAA
HCCCCEEEEECCCCCEEEECCCCCEEEECCCCCCCCHHCCCEEEEEECCHHCCHHHHHHH
LSHAHALAPGLELGAGELDLFQACMSLPRSAGGNW
HHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRRLHISVRISLLIALFSLGAFAEDRFLVKVNGDINALARHYGLTVVQSLGGSATGMHV
CCEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHH
LSSKGANPHDLARSLAAEFSVRSVEPDNAVILPGIKPASAVVRSPASTSGFSISSTLVRY
HHCCCCCHHHHHHHHHHHHHEEEECCCCEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHH
HNSYVASGYVNQPAVGLINMASAQKMSTGGGIVATIDTGADFTHPGLLGSLTPGWDFVNN
HCCEEECCCCCCCCCCEEECCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHC
LPFGQEQADINKAGATVAQETTPILDQETTPILDGGTAIILTQETTPILDQETTPILDGT
CCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCCCCCC
KYPAFGHGTMVASLIHLVAPDARIMPLRAFGANGSSSISQIVAAVHYAVEHNVDVINMSF
CCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEE
SVSSDSPALKDAMEFAFNSGLVLVAAAGNSGQAATVYPAAYSTVMGVGATDNFLQRAFFS
EECCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEHHHHHHHEECCCCHHHHHHHHHH
NFGQPLVTLAAPGQDIIAMYPMNHYAKVSGTSFSAPLVAGGAALLVDLNKKLNETSATAA
HCCCCEEEEECCCCCEEEECCCCCEEEECCCCCCCCHHCCCEEEEEECCHHCCHHHHHHH
LSHAHALAPGLELGAGELDLFQACMSLPRSAGGNW
HHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]