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The map label for this gene is mdtA [H]

Identifier: 116622510

GI number: 116622510

Start: 4312488

End: 4313687

Strand: Reverse

Name: mdtA [H]

Synonym: Acid_3408

Alternate gene names: 116622510

Gene position: 4313687-4312488 (Counterclockwise)

Preceding gene: 116622511

Following gene: 116622509

Centisome position: 43.29

GC content: 64.33

Gene sequence:

>1200_bases
ATGACCACTGAGCAACCCGAACAAGAAGTCACTCCCAAGACAGAAATTCCCCAGCCGGGCCGTGCTACAACCTGGCTCAT
CCTCATGCTCCTGGCACTCTTCGGCGCAGGCGTCGCCGCCGTCGTCCACTCCGGAATCCTGAGCCGCAGCGCATCCGCGG
CCGCGCTGGCGCGCGAAACTCGCGAGAATGCGGCGCTCACCGTAGCCGTGGTGCATCCCAAAAACGGTGGCAGCGAGGAA
GAAGTCGTCCTCCCTGGCAACACGCAGGCCTTCACCGACTCGCCCATTTACGCCCGTACTACCGGCTATCTGAAGAAGTG
GTACGTCGATATCGGTACCCAGGTGAAGGCCGGCGAGCTGCTGGCTGAAATCGATGCCCCCGAACTCGATCATCAACTGC
AGCAGGCACGCGCCGACCTGGAGACCGCCCGCGCCAATCTCACGCTCTCCCAATCCACCGCCGATCGCTGGCAGTTTCTC
CTCAAGACCCAGTCGGTCTCCCGCCAGGAAACCGATGAGAAGACCGGCGACCTAAACGCCAAGAAAGCCATGGTGGACGC
TTCCTCCTCCGCCGTCCGGCGCCTCGAAGACCTGCAGTCCTACGAGAAAGTCACGGCGCCCTTCGATGGCGTGATCACCG
CGCGCAATACCGACGTCGGGGCGCTCATCGACTCCGGATCCAATACCCCAGGCAAGGAGCTCTTCCACCTCGCCGCCACT
CACCAGCTACGCGTCTTTGTCAATGTCCCGGAAGTCTACGATCGCGCCGCACGCAACGGCGCCCGCGCCACCCTGCAGCT
TTCCGAATTCCCCGGCCGCAATTTCTCCGGCACGTTGGTCCGCAATGCCAATGCGATCGACCCGGTATCGCGCACGCTGC
TGGTGGAAGTGGAGGTCGATAACGCCGGCGGCGAGTTGCTGCCGGGCTCCTACGTGCTGGTTCACTTGAAGCTGCCGGGA
CGCGCGAGCCACGGCCTCACGGTCCCGGTCAGCACTTTGCTATTCCGGGCCGAAGGTCTGCGCGTCGCCGTGGTGCGCGA
GGGCAAAGCGCAACTCCTGCCCGTCACCATCGGCCGCGACTACGGCAACGAAGTCGAGATCATCTCCGGCTTGAATCCGC
GCGATGAGGTGATCGCCAATCCCGCCGACTCGCTCACCTCCGGCGAGCCGGTCCGCATCGCCGCTGGAGGTGCCCGGTGA

Upstream 100 bases:

>100_bases
TGGCGACCCTGTTCTTTGTTCCCGCGATCTTCAGCCTGTTGCACGGCTGGCGAAAACCGGCCTCTTCCCAACCGGTCCGC
CCAGCAGTAGAGATGACCTT

Downstream 100 bases:

>100_bases
GACTCGCGGTCGCGCTGCTCGCCCTTCTCGCCGTGGGCTGCTCGGTCGGTCCCAAATACCAGCGGCCAATGATCCAGGCG
CCCCCTGCCTACAAAGAGTC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTTEQPEQEVTPKTEIPQPGRATTWLILMLLALFGAGVAAVVHSGILSRSASAAALARETRENAALTVAVVHPKNGGSEE
EVVLPGNTQAFTDSPIYARTTGYLKKWYVDIGTQVKAGELLAEIDAPELDHQLQQARADLETARANLTLSQSTADRWQFL
LKTQSVSRQETDEKTGDLNAKKAMVDASSSAVRRLEDLQSYEKVTAPFDGVITARNTDVGALIDSGSNTPGKELFHLAAT
HQLRVFVNVPEVYDRAARNGARATLQLSEFPGRNFSGTLVRNANAIDPVSRTLLVEVEVDNAGGELLPGSYVLVHLKLPG
RASHGLTVPVSTLLFRAEGLRVAVVREGKAQLLPVTIGRDYGNEVEIISGLNPRDEVIANPADSLTSGEPVRIAAGGAR

Sequences:

>Translated_399_residues
MTTEQPEQEVTPKTEIPQPGRATTWLILMLLALFGAGVAAVVHSGILSRSASAAALARETRENAALTVAVVHPKNGGSEE
EVVLPGNTQAFTDSPIYARTTGYLKKWYVDIGTQVKAGELLAEIDAPELDHQLQQARADLETARANLTLSQSTADRWQFL
LKTQSVSRQETDEKTGDLNAKKAMVDASSSAVRRLEDLQSYEKVTAPFDGVITARNTDVGALIDSGSNTPGKELFHLAAT
HQLRVFVNVPEVYDRAARNGARATLQLSEFPGRNFSGTLVRNANAIDPVSRTLLVEVEVDNAGGELLPGSYVLVHLKLPG
RASHGLTVPVSTLLFRAEGLRVAVVREGKAQLLPVTIGRDYGNEVEIISGLNPRDEVIANPADSLTSGEPVRIAAGGAR
>Mature_398_residues
TTEQPEQEVTPKTEIPQPGRATTWLILMLLALFGAGVAAVVHSGILSRSASAAALARETRENAALTVAVVHPKNGGSEEE
VVLPGNTQAFTDSPIYARTTGYLKKWYVDIGTQVKAGELLAEIDAPELDHQLQQARADLETARANLTLSQSTADRWQFLL
KTQSVSRQETDEKTGDLNAKKAMVDASSSAVRRLEDLQSYEKVTAPFDGVITARNTDVGALIDSGSNTPGKELFHLAATH
QLRVFVNVPEVYDRAARNGARATLQLSEFPGRNFSGTLVRNANAIDPVSRTLLVEVEVDNAGGELLPGSYVLVHLKLPGR
ASHGLTVPVSTLLFRAEGLRVAVVREGKAQLLPVTIGRDYGNEVEIISGLNPRDEVIANPADSLTSGEPVRIAAGGAR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=305, Percent_Identity=28.5245901639344, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87081796, Length=331, Percent_Identity=25.9818731117825, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789929, Length=306, Percent_Identity=27.1241830065359, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786668, Length=312, Percent_Identity=27.5641025641026, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789665, Length=344, Percent_Identity=24.4186046511628, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42753; Mature: 42621

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEQPEQEVTPKTEIPQPGRATTWLILMLLALFGAGVAAVVHSGILSRSASAAALARET
CCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHH
RENAALTVAVVHPKNGGSEEEVVLPGNTQAFTDSPIYARTTGYLKKWYVDIGTQVKAGEL
CCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCEEEHHHHHHEEEEECCCEEEHHHH
LAEIDAPELDHQLQQARADLETARANLTLSQSTADRWQFLLKTQSVSRQETDEKTGDLNA
HHHCCCCHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHCCHHHCCHHCCCCCH
KKAMVDASSSAVRRLEDLQSYEKVTAPFDGVITARNTDVGALIDSGSNTPGKELFHLAAT
HHHEECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHEEE
HQLRVFVNVPEVYDRAARNGARATLQLSEFPGRNFSGTLVRNANAIDPVSRTLLVEVEVD
EEEEEEEECHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCEEEEEEEEEC
NAGGELLPGSYVLVHLKLPGRASHGLTVPVSTLLFRAEGLRVAVVREGKAQLLPVTIGRD
CCCCCCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHCCCEEEEEECCCCEEEEEEECCC
YGNEVEIISGLNPRDEVIANPADSLTSGEPVRIAAGGAR
CCCCEEEEECCCCHHHHHCCCCHHCCCCCCEEEECCCCC
>Mature Secondary Structure 
TTEQPEQEVTPKTEIPQPGRATTWLILMLLALFGAGVAAVVHSGILSRSASAAALARET
CCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHH
RENAALTVAVVHPKNGGSEEEVVLPGNTQAFTDSPIYARTTGYLKKWYVDIGTQVKAGEL
CCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCEEEHHHHHHEEEEECCCEEEHHHH
LAEIDAPELDHQLQQARADLETARANLTLSQSTADRWQFLLKTQSVSRQETDEKTGDLNA
HHHCCCCHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHCCHHHCCHHCCCCCH
KKAMVDASSSAVRRLEDLQSYEKVTAPFDGVITARNTDVGALIDSGSNTPGKELFHLAAT
HHHEECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHEEE
HQLRVFVNVPEVYDRAARNGARATLQLSEFPGRNFSGTLVRNANAIDPVSRTLLVEVEVD
EEEEEEEECHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCEEEEEEEEEC
NAGGELLPGSYVLVHLKLPGRASHGLTVPVSTLLFRAEGLRVAVVREGKAQLLPVTIGRD
CCCCCCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHCCCEEEEEECCCCEEEEEEECCC
YGNEVEIISGLNPRDEVIANPADSLTSGEPVRIAAGGAR
CCCCEEEEECCCCHHHHHCCCCHHCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA