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The map label for this gene is pntAA [H]

Identifier: 116622477

GI number: 116622477

Start: 4276247

End: 4277416

Strand: Reverse

Name: pntAA [H]

Synonym: Acid_3375

Alternate gene names: 116622477

Gene position: 4277416-4276247 (Counterclockwise)

Preceding gene: 116622478

Following gene: 116622476

Centisome position: 42.92

GC content: 66.67

Gene sequence:

>1170_bases
GTGCCTATCACAGTCGGATTCGTTGGCGAAGGATCACCGGGCGAGCGGCGGGTGGCAATGGCGCCGAGCGCGATCTCCGT
GCTGAATAAGACGGGGGTGGAACTGCTGATGGAGCCGGGGGCCGGAGTACAGGCCGGGTTTCCGGATTCCGATTATGTGG
AAAAGGGCGTCCGCGTGGCAGGTGGGCGCGAGGAAGTTTTTCAGAGTGCGGAAGTGATCCTGCAGGTGCGGGGGCTGGGG
GCCAATCCGGAGACGGGAGCCCGCGACCTCGCGATGATGCGGCAGGGGCAGACCGCGATCGGGTTCGGAGAACCGCTGAC
GGCAATCGATGCGGCCCGGCAACTGGCCGCTCGCGGAGTCACCTTCCTGGCGATGGAGCTCATGCCGCGCATCACGCGCG
CGCAGAGCATGGACGCGCTCTCTTCGATGGCCACCATCGCGGGCTACAAGGCGGCGCTGATGGCGGCGGACGGACTGCCG
CGCATGTTCCCGATGCTGATGACGGCCGCGGGGACGGTAGCGCCGGCGCGGGTGCTGGTGATCGGCGCGGGAGTCGCGGG
TCTGCAGGCGATCGCAACCGCGCGGCGATTGGGCGCGGTGGTCTCGGGCTACGACATCCGCGCGGCGGTGAAGGAACAGA
TCGAAAGCCTGGGCGCGCGCTTTGTGGTGCTGGATCTGGAAGGCGCGGGCGCCGAGGATAAGGGCGGCTACGCCAAGGCG
ATGGGCGAGGCATTCTATAAGCGCCAGCGTGAGCTGCTGGGCAACGTCCTGGCCGAGCAGAACGTGGTCATCACCACGGC
CGCGGTGCCTGGACGCAAGGCGCCGATCCTGATCACACGCGAGATGGCGGCGCGCATGGCGCCGGGCTCGATGATCGTGG
ATATCGCGGCGGAGCGCGGCGGCAACTGCGAACTGACCCAGCCGGGCGTGATGGTGGAAGCCGGCGGGGTACGAATCCTG
GGGCCGGTCAACCTGCCTTCGACGATTCCCTATCACGCGAGCCAGATGTACGCGAAGAACATCGCGACCTTTTTGAAATA
CCTGGTGAAGGACGGCAAACTGGCCCTCAACCGCGAGGACGAAATCGTGCGCGAGACGCTGGTTACGTATGGCGGAGAAG
TGGTGCATGCGCGGGTGCGGGAAGCAATGGGGCTGCCGGTAGCGGGGTAA

Upstream 100 bases:

>100_bases
GAGACGCAGAGCCGCAGAGTAACGCCAAGAAGAACAGGCCAAGAATTTCTTTGCGTGACTCTGCGGCTCTGCGGCTCTGC
GAGAAATAAATAGGATCCAC

Downstream 100 bases:

>100_bases
GAAGGAGGGGGCTGATGCCTTCGAATCTGGAAATCGGATTGTACGTCTTCATGCTGGCGACCTTCGTCGGGCTGGAAGTG
ATCCGCAAGGTCTCGCCGCT

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MPITVGFVGEGSPGERRVAMAPSAISVLNKTGVELLMEPGAGVQAGFPDSDYVEKGVRVAGGREEVFQSAEVILQVRGLG
ANPETGARDLAMMRQGQTAIGFGEPLTAIDAARQLAARGVTFLAMELMPRITRAQSMDALSSMATIAGYKAALMAADGLP
RMFPMLMTAAGTVAPARVLVIGAGVAGLQAIATARRLGAVVSGYDIRAAVKEQIESLGARFVVLDLEGAGAEDKGGYAKA
MGEAFYKRQRELLGNVLAEQNVVITTAAVPGRKAPILITREMAARMAPGSMIVDIAAERGGNCELTQPGVMVEAGGVRIL
GPVNLPSTIPYHASQMYAKNIATFLKYLVKDGKLALNREDEIVRETLVTYGGEVVHARVREAMGLPVAG

Sequences:

>Translated_389_residues
MPITVGFVGEGSPGERRVAMAPSAISVLNKTGVELLMEPGAGVQAGFPDSDYVEKGVRVAGGREEVFQSAEVILQVRGLG
ANPETGARDLAMMRQGQTAIGFGEPLTAIDAARQLAARGVTFLAMELMPRITRAQSMDALSSMATIAGYKAALMAADGLP
RMFPMLMTAAGTVAPARVLVIGAGVAGLQAIATARRLGAVVSGYDIRAAVKEQIESLGARFVVLDLEGAGAEDKGGYAKA
MGEAFYKRQRELLGNVLAEQNVVITTAAVPGRKAPILITREMAARMAPGSMIVDIAAERGGNCELTQPGVMVEAGGVRIL
GPVNLPSTIPYHASQMYAKNIATFLKYLVKDGKLALNREDEIVRETLVTYGGEVVHARVREAMGLPVAG
>Mature_388_residues
PITVGFVGEGSPGERRVAMAPSAISVLNKTGVELLMEPGAGVQAGFPDSDYVEKGVRVAGGREEVFQSAEVILQVRGLGA
NPETGARDLAMMRQGQTAIGFGEPLTAIDAARQLAARGVTFLAMELMPRITRAQSMDALSSMATIAGYKAALMAADGLPR
MFPMLMTAAGTVAPARVLVIGAGVAGLQAIATARRLGAVVSGYDIRAAVKEQIESLGARFVVLDLEGAGAEDKGGYAKAM
GEAFYKRQRELLGNVLAEQNVVITTAAVPGRKAPILITREMAARMAPGSMIVDIAAERGGNCELTQPGVMVEAGGVRILG
PVNLPSTIPYHASQMYAKNIATFLKYLVKDGKLALNREDEIVRETLVTYGGEVVHARVREAMGLPVAG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=382, Percent_Identity=38.2198952879581, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI122939153, Length=382, Percent_Identity=38.2198952879581, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1787887, Length=376, Percent_Identity=43.3510638297872, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17550456, Length=362, Percent_Identity=45.3038674033149, Blast_Score=301, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40722; Mature: 40591

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITVGFVGEGSPGERRVAMAPSAISVLNKTGVELLMEPGAGVQAGFPDSDYVEKGVRVA
CCEEEEECCCCCCCCCEEEECCHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHCCCCCC
GGREEVFQSAEVILQVRGLGANPETGARDLAMMRQGQTAIGFGEPLTAIDAARQLAARGV
CCHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCH
TFLAMELMPRITRAQSMDALSSMATIAGYKAALMAADGLPRMFPMLMTAAGTVAPARVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEE
IGAGVAGLQAIATARRLGAVVSGYDIRAAVKEQIESLGARFVVLDLEGAGAEDKGGYAKA
EECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHH
MGEAFYKRQRELLGNVLAEQNVVITTAAVPGRKAPILITREMAARMAPGSMIVDIAAERG
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEHHHHHHCCCCCEEEEEECCCC
GNCELTQPGVMVEAGGVRILGPVNLPSTIPYHASQMYAKNIATFLKYLVKDGKLALNRED
CCCEECCCCEEEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCHH
EIVRETLVTYGGEVVHARVREAMGLPVAG
HHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PITVGFVGEGSPGERRVAMAPSAISVLNKTGVELLMEPGAGVQAGFPDSDYVEKGVRVA
CEEEEECCCCCCCCCEEEECCHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHCCCCCC
GGREEVFQSAEVILQVRGLGANPETGARDLAMMRQGQTAIGFGEPLTAIDAARQLAARGV
CCHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCH
TFLAMELMPRITRAQSMDALSSMATIAGYKAALMAADGLPRMFPMLMTAAGTVAPARVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEE
IGAGVAGLQAIATARRLGAVVSGYDIRAAVKEQIESLGARFVVLDLEGAGAEDKGGYAKA
EECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHH
MGEAFYKRQRELLGNVLAEQNVVITTAAVPGRKAPILITREMAARMAPGSMIVDIAAERG
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEHHHHHHCCCCCEEEEEECCCC
GNCELTQPGVMVEAGGVRILGPVNLPSTIPYHASQMYAKNIATFLKYLVKDGKLALNRED
CCCEECCCCEEEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCHH
EIVRETLVTYGGEVVHARVREAMGLPVAG
HHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]