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The map label for this gene is adhB [H]

Identifier: 116622409

GI number: 116622409

Start: 4182812

End: 4183828

Strand: Reverse

Name: adhB [H]

Synonym: Acid_3304

Alternate gene names: 116622409

Gene position: 4183828-4182812 (Counterclockwise)

Preceding gene: 116622410

Following gene: 116622408

Centisome position: 41.98

GC content: 62.73

Gene sequence:

>1017_bases
ATGCGAGGAACAGTTTTGTACGGGCCCCGTGACATCCGGTTCGAAGATCGGGAAGATCCCAGGATCGAAAAACCGACTGA
CGCCGTGATCCGCATGGCGGCGACGTGCGTTTGCGGATCGGATCTCTGGCCGTATCGAGGCATACAAGCAACGAACGGCC
CGACGCCAATGGGGCACGAATACTGCGGATTCGTCGAAGAAGTCGGCCGTGCGGTGAAATCCGTGAAGCCGGGTCAGTTC
GTTGTGGGTTCGTTCGCGACTTCCGACAACACTTGCCCACACTGCCAACACGGTTATCAGTCCTCGTGCGCCCAGCGAGA
ATTCGTGACCAGAGCGCAAGCGCCCTTCTTGCGGGTTCCTCTCGCCGATGGGACCCTGGTGCCGGCGCCCGAGGCGCCGT
CTCGCGATCTTATACCGAGCCTGTTGGCAGCTTCCGACGTTCTCGGCACAGGGTGGTTCGCAGCCGATGCCGCCAATGTA
AAACCGGGATCGACCGCGGTGGTCGTGGGGGACGGGGCGGTGGGTCTGCTCGCGGTGCTCTCGGCCAGGCAGATGGGAGC
GGGGCGAATCATCGCCATGAGCCGCCACGAGTCGCGACAGAAGCTGGCGCGAGAGTTTGGCGCGACGGACGTTGTGTCCG
AACGCGGTGCGGAAGGCATTGCGCGGATCAAGGAGCTGACGAATGGCGTTGGCGCCGATTCTGTGCTGGAGTGCGTCGGA
ACCATGGAATCGATGCAGCAGGCCATTCAAGTAACCCGACCTGGCGGATTCGTGTCGTACGTTGGCGTTCCGCAGGGAGT
CGAACTGGACGGACAGGCGCTGTTTTTCGCGCACGTGCACCTGCACGGAGGCCCCGCCCCCGTGCGCCGCTATCTGCCGC
ATCTGATGGACCTGGTGCTAAACGAGAAAATCAATCCCGGCAGAGTGTTTGACCTGACTCTACCGCTCGAACAGGTCGCA
GAGGGGTACCGCGCGATGGACGAGCGTCGCGCCATCAAGGCGCTGTTGCGGCCGTGA

Upstream 100 bases:

>100_bases
TGAGCTGAGAGACATCGAAGAGGCCGCTGAACGGATACCAGTGCAAGGTGCTCGTTACCCGGAGCAAATGGAAAAGTTGA
GTAACCGATAAAGGAGAACT

Downstream 100 bases:

>100_bases
TGGCGCGCGAAAGGACGAACCGATGACACGCTGGGCAAGAGATGAACTGCACAGAATTGCCGAGACCGACGACCTGCACG
TCTCGCCCTTCCGCGAGGAC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRGTVLYGPRDIRFEDREDPRIEKPTDAVIRMAATCVCGSDLWPYRGIQATNGPTPMGHEYCGFVEEVGRAVKSVKPGQF
VVGSFATSDNTCPHCQHGYQSSCAQREFVTRAQAPFLRVPLADGTLVPAPEAPSRDLIPSLLAASDVLGTGWFAADAANV
KPGSTAVVVGDGAVGLLAVLSARQMGAGRIIAMSRHESRQKLAREFGATDVVSERGAEGIARIKELTNGVGADSVLECVG
TMESMQQAIQVTRPGGFVSYVGVPQGVELDGQALFFAHVHLHGGPAPVRRYLPHLMDLVLNEKINPGRVFDLTLPLEQVA
EGYRAMDERRAIKALLRP

Sequences:

>Translated_338_residues
MRGTVLYGPRDIRFEDREDPRIEKPTDAVIRMAATCVCGSDLWPYRGIQATNGPTPMGHEYCGFVEEVGRAVKSVKPGQF
VVGSFATSDNTCPHCQHGYQSSCAQREFVTRAQAPFLRVPLADGTLVPAPEAPSRDLIPSLLAASDVLGTGWFAADAANV
KPGSTAVVVGDGAVGLLAVLSARQMGAGRIIAMSRHESRQKLAREFGATDVVSERGAEGIARIKELTNGVGADSVLECVG
TMESMQQAIQVTRPGGFVSYVGVPQGVELDGQALFFAHVHLHGGPAPVRRYLPHLMDLVLNEKINPGRVFDLTLPLEQVA
EGYRAMDERRAIKALLRP
>Mature_338_residues
MRGTVLYGPRDIRFEDREDPRIEKPTDAVIRMAATCVCGSDLWPYRGIQATNGPTPMGHEYCGFVEEVGRAVKSVKPGQF
VVGSFATSDNTCPHCQHGYQSSCAQREFVTRAQAPFLRVPLADGTLVPAPEAPSRDLIPSLLAASDVLGTGWFAADAANV
KPGSTAVVVGDGAVGLLAVLSARQMGAGRIIAMSRHESRQKLAREFGATDVVSERGAEGIARIKELTNGVGADSVLECVG
TMESMQQAIQVTRPGGFVSYVGVPQGVELDGQALFFAHVHLHGGPAPVRRYLPHLMDLVLNEKINPGRVFDLTLPLEQVA
EGYRAMDERRAIKALLRP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=352, Percent_Identity=26.7045454545455, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156627571, Length=355, Percent_Identity=27.887323943662, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4501929, Length=336, Percent_Identity=26.1904761904762, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI156523966, Length=343, Percent_Identity=27.1137026239067, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4501933, Length=338, Percent_Identity=26.6272189349112, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI71565152, Length=350, Percent_Identity=26.5714285714286, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073058, Length=343, Percent_Identity=24.7813411078717, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=24.2587601078167, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4501939, Length=333, Percent_Identity=27.3273273273273, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71565154, Length=339, Percent_Identity=23.3038348082596, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786825, Length=383, Percent_Identity=28.4595300261097, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1788075, Length=337, Percent_Identity=27.0029673590504, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788073, Length=317, Percent_Identity=27.7602523659306, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082125, Length=328, Percent_Identity=27.1341463414634, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786552, Length=346, Percent_Identity=28.0346820809249, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788407, Length=258, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI226510992, Length=344, Percent_Identity=22.6744186046512, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790045, Length=320, Percent_Identity=23.125, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=351, Percent_Identity=26.2108262108262, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=355, Percent_Identity=25.0704225352113, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=349, Percent_Identity=25.214899713467, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=263, Percent_Identity=25.4752851711027, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=277, Percent_Identity=29.9638989169675, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=270, Percent_Identity=31.1111111111111, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=270, Percent_Identity=31.1111111111111, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=360, Percent_Identity=25.8333333333333, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=285, Percent_Identity=27.3684210526316, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=291, Percent_Identity=24.7422680412371, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=268, Percent_Identity=26.4925373134328, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=350, Percent_Identity=27.1428571428571, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737897, Length=263, Percent_Identity=28.1368821292776, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137530, Length=264, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 36301; Mature: 36301

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGTVLYGPRDIRFEDREDPRIEKPTDAVIRMAATCVCGSDLWPYRGIQATNGPTPMGHE
CCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHH
YCGFVEEVGRAVKSVKPGQFVVGSFATSDNTCPHCQHGYQSSCAQREFVTRAQAPFLRVP
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHCCCEEEEE
LADGTLVPAPEAPSRDLIPSLLAASDVLGTGWFAADAANVKPGSTAVVVGDGAVGLLAVL
CCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCCCEEEEECCCHHHHHHHH
SARQMGAGRIIAMSRHESRQKLAREFGATDVVSERGAEGIARIKELTNGVGADSVLECVG
HHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
TMESMQQAIQVTRPGGFVSYVGVPQGVELDGQALFFAHVHLHGGPAPVRRYLPHLMDLVL
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHH
NEKINPGRVFDLTLPLEQVAEGYRAMDERRAIKALLRP
HCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGTVLYGPRDIRFEDREDPRIEKPTDAVIRMAATCVCGSDLWPYRGIQATNGPTPMGHE
CCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHH
YCGFVEEVGRAVKSVKPGQFVVGSFATSDNTCPHCQHGYQSSCAQREFVTRAQAPFLRVP
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHCCCEEEEE
LADGTLVPAPEAPSRDLIPSLLAASDVLGTGWFAADAANVKPGSTAVVVGDGAVGLLAVL
CCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCCCEEEEECCCHHHHHHHH
SARQMGAGRIIAMSRHESRQKLAREFGATDVVSERGAEGIARIKELTNGVGADSVLECVG
HHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
TMESMQQAIQVTRPGGFVSYVGVPQGVELDGQALFFAHVHLHGGPAPVRRYLPHLMDLVL
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHH
NEKINPGRVFDLTLPLEQVAEGYRAMDERRAIKALLRP
HCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]