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The map label for this gene is icd [H]

Identifier: 116621939

GI number: 116621939

Start: 3579710

End: 3581182

Strand: Direct

Name: icd [H]

Synonym: Acid_2824

Alternate gene names: 116621939

Gene position: 3579710-3581182 (Clockwise)

Preceding gene: 116621938

Following gene: 116621942

Centisome position: 35.92

GC content: 60.42

Gene sequence:

>1473_bases
GTGCATTCCAATATCCTTAGTATTCCGCTTATGGCCAAGAAGACTCCTATCACGGTCGCCCATGGCGACGGCATCGGTCC
TGAAATCATGAACGCCACCCTCCAGATCCTGGAAGCGGCCGGCGCGGCTCTCGAGATTGAGACCATTGAAATCGGCGAAA
AGGTCTATTTGCGCGGCAATTCCGCCGGCATTGAACCCAGCGCCTGGGACTCGCTCCTGCGCACGCAGGTCTTCCTTAAG
GCTCCGATTACGACCCCTCAGGGCGGCGGATTCAAGAGCCTGAACGTCACCACGCGCAAAACCCTCGGCCAGTATGCCAA
TGTACGCCCGTGCGTTTCCTATCACCCGTTCATCGACACCAAACATCCCAATATGGATGTCGTGATCGTGCGCGAGAACG
AGGAAGATCTGTACGCGGGCATCGAGTACCAGAACACTCCCGAAGTGATGTCGTGCATCAAGCTGATTTCGCGCCCTGGC
AGCGAGAAGATCGTGCGCTACGCCTTCGAGTACGCGCGCCTGCACAATCGCAAAAAGGTCACCTGCTTCATGAAGGACAA
CATCATGAAGATGACCGACGGGCTCTTCCACAAGGTCTTCGACGAAATCGGCGCCCAGTATCCGGATATCGAGAAGGAGG
TCTGGATCGTGGACATCGGCGCGGCCAAGATGGCCGACACGCCCGAGGCCTTCGACGTGATCGTGATGCCGAATCTTTAC
GGCGATATCCTGAGCGACGTGGCCGCGCAAATCGCGGGCTCCGTCGGCCTTGCGGGCTCGGCCAATATCGGCGAGAAGTG
CGCGATGTTTGAAGCCATTCACGGCTCGGCGCCGCGCCGCGCGGGCCAGAACCTGGCCAATCCCTCGGGCCTGCTGTTGG
GTGCGGTTCTCATGCTGGTGCACATCAATCAGCCGGAAGCCGCGGCCAAGGTTCACAACGCCTGGCTGCGCACTATTGAA
GACGGAGTGCACACTTACGACGTTTTCACAGAAGGCGTCAGTTCGAAGAAGGTAGGCACCAAGGAGTTCGCAGCGGCGGT
CATCGAGCGCATTGGCCAGAAGCCCAACATCCTGAAGCCGGTGACCTATGCGCACCGTCCGGAAAAGGCCGCGCCCGCGG
TCCAGGCTGAGCGCCCCGCGGTTGCCATGGAGTTGAAGGGCATTGACGTGTTCGTCTACTGGCCCTCGCGCAACCCCAAC
ACGCTGGCCGAGGCCGTCGGCAAACTGGCCGTCGATGGCGTGAAGTTGCAAATGATCGACAATCGCGGTGTCAAGGTATG
GCCTGCCGGCAGGGCGGAAACCTTCTGCACCGACAGCTTCCGCTGCCGCTTCATGGCCGATGGCGCCACCGACATGGGCA
AACTGCTCGATGTGGCGCGCCGTATCTCGGACGCCGGCATCGATATCGCGGTCACCGAGACCCTCCGCAATTTCGATGGC
GTCGCAGGCTTCACGCTGGCGCAAGGACAGTAG

Upstream 100 bases:

>100_bases
CCTAATCGCCCTCGATGGTGGCAGCGCCATTTGGCGCTATTCCGGTGCTCAGGCTACAAACTTTGTAGAAAAAGACTACT
GCATCCTGTTGCGTGATGTG

Downstream 100 bases:

>100_bases
CAGAGCCGCGATCTTTACGGAGAGCGATGTTCGACGATCTTCGACTTTGATCGCCGAGATCCCAATCCAAAAAAAATCGC
TCCCCGGCGCGAAGCCGGGG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MHSNILSIPLMAKKTPITVAHGDGIGPEIMNATLQILEAAGAALEIETIEIGEKVYLRGNSAGIEPSAWDSLLRTQVFLK
APITTPQGGGFKSLNVTTRKTLGQYANVRPCVSYHPFIDTKHPNMDVVIVRENEEDLYAGIEYQNTPEVMSCIKLISRPG
SEKIVRYAFEYARLHNRKKVTCFMKDNIMKMTDGLFHKVFDEIGAQYPDIEKEVWIVDIGAAKMADTPEAFDVIVMPNLY
GDILSDVAAQIAGSVGLAGSANIGEKCAMFEAIHGSAPRRAGQNLANPSGLLLGAVLMLVHINQPEAAAKVHNAWLRTIE
DGVHTYDVFTEGVSSKKVGTKEFAAAVIERIGQKPNILKPVTYAHRPEKAAPAVQAERPAVAMELKGIDVFVYWPSRNPN
TLAEAVGKLAVDGVKLQMIDNRGVKVWPAGRAETFCTDSFRCRFMADGATDMGKLLDVARRISDAGIDIAVTETLRNFDG
VAGFTLAQGQ

Sequences:

>Translated_490_residues
MHSNILSIPLMAKKTPITVAHGDGIGPEIMNATLQILEAAGAALEIETIEIGEKVYLRGNSAGIEPSAWDSLLRTQVFLK
APITTPQGGGFKSLNVTTRKTLGQYANVRPCVSYHPFIDTKHPNMDVVIVRENEEDLYAGIEYQNTPEVMSCIKLISRPG
SEKIVRYAFEYARLHNRKKVTCFMKDNIMKMTDGLFHKVFDEIGAQYPDIEKEVWIVDIGAAKMADTPEAFDVIVMPNLY
GDILSDVAAQIAGSVGLAGSANIGEKCAMFEAIHGSAPRRAGQNLANPSGLLLGAVLMLVHINQPEAAAKVHNAWLRTIE
DGVHTYDVFTEGVSSKKVGTKEFAAAVIERIGQKPNILKPVTYAHRPEKAAPAVQAERPAVAMELKGIDVFVYWPSRNPN
TLAEAVGKLAVDGVKLQMIDNRGVKVWPAGRAETFCTDSFRCRFMADGATDMGKLLDVARRISDAGIDIAVTETLRNFDG
VAGFTLAQGQ
>Mature_490_residues
MHSNILSIPLMAKKTPITVAHGDGIGPEIMNATLQILEAAGAALEIETIEIGEKVYLRGNSAGIEPSAWDSLLRTQVFLK
APITTPQGGGFKSLNVTTRKTLGQYANVRPCVSYHPFIDTKHPNMDVVIVRENEEDLYAGIEYQNTPEVMSCIKLISRPG
SEKIVRYAFEYARLHNRKKVTCFMKDNIMKMTDGLFHKVFDEIGAQYPDIEKEVWIVDIGAAKMADTPEAFDVIVMPNLY
GDILSDVAAQIAGSVGLAGSANIGEKCAMFEAIHGSAPRRAGQNLANPSGLLLGAVLMLVHINQPEAAAKVHNAWLRTIE
DGVHTYDVFTEGVSSKKVGTKEFAAAVIERIGQKPNILKPVTYAHRPEKAAPAVQAERPAVAMELKGIDVFVYWPSRNPN
TLAEAVGKLAVDGVKLQMIDNRGVKVWPAGRAETFCTDSFRCRFMADGATDMGKLLDVARRISDAGIDIAVTETLRNFDG
VAGFTLAQGQ

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=307, Percent_Identity=42.0195439739414, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4758582, Length=339, Percent_Identity=35.3982300884956, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI28178838, Length=321, Percent_Identity=35.8255451713396, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI28178816, Length=292, Percent_Identity=35.958904109589, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI28178821, Length=292, Percent_Identity=35.958904109589, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI28178819, Length=173, Percent_Identity=38.150289017341, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1787381, Length=390, Percent_Identity=33.8461538461538, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1788101, Length=332, Percent_Identity=30.7228915662651, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87081683, Length=357, Percent_Identity=30.812324929972, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71986051, Length=336, Percent_Identity=42.2619047619048, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI25144293, Length=346, Percent_Identity=36.4161849710983, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17505779, Length=313, Percent_Identity=36.4217252396166, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=34.8441926345609, Blast_Score=186, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324709, Length=341, Percent_Identity=42.8152492668622, Blast_Score=256, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6324291, Length=313, Percent_Identity=38.3386581469649, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322097, Length=331, Percent_Identity=33.5347432024169, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319830, Length=248, Percent_Identity=27.8225806451613, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24643270, Length=310, Percent_Identity=43.2258064516129, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24643268, Length=310, Percent_Identity=43.2258064516129, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24661184, Length=342, Percent_Identity=39.766081871345, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI161078635, Length=315, Percent_Identity=36.5079365079365, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161078637, Length=315, Percent_Identity=36.5079365079365, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161078633, Length=315, Percent_Identity=36.5079365079365, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24650122, Length=315, Percent_Identity=36.5079365079365, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161078639, Length=310, Percent_Identity=36.7741935483871, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI281362242, Length=343, Percent_Identity=34.9854227405248, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24648872, Length=343, Percent_Identity=34.9854227405248, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI20130355, Length=338, Percent_Identity=30.1775147928994, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI45550436, Length=213, Percent_Identity=23.0046948356808, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 53292; Mature: 53292

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSNILSIPLMAKKTPITVAHGDGIGPEIMNATLQILEAAGAALEIETIEIGEKVYLRGN
CCCCEEECCEEECCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEECC
SAGIEPSAWDSLLRTQVFLKAPITTPQGGGFKSLNVTTRKTLGQYANVRPCVSYHPFIDT
CCCCCHHHHHHHHHHHHHEECCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCC
KHPNMDVVIVRENEEDLYAGIEYQNTPEVMSCIKLISRPGSEKIVRYAFEYARLHNRKKV
CCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
TCFMKDNIMKMTDGLFHKVFDEIGAQYPDIEKEVWIVDIGAAKMADTPEAFDVIVMPNLY
EEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCHHH
GDILSDVAAQIAGSVGLAGSANIGEKCAMFEAIHGSAPRRAGQNLANPSGLLLGAVLMLV
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHH
HINQPEAAAKVHNAWLRTIEDGVHTYDVFTEGVSSKKVGTKEFAAAVIERIGQKPNILKP
CCCCCHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
VTYAHRPEKAAPAVQAERPAVAMELKGIDVFVYWPSRNPNTLAEAVGKLAVDGVKLQMID
CHHCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEC
NRGVKVWPAGRAETFCTDSFRCRFMADGATDMGKLLDVARRISDAGIDIAVTETLRNFDG
CCCEEEEECCCCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEHHHHHCCCC
VAGFTLAQGQ
CCCEEECCCC
>Mature Secondary Structure
MHSNILSIPLMAKKTPITVAHGDGIGPEIMNATLQILEAAGAALEIETIEIGEKVYLRGN
CCCCEEECCEEECCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEECC
SAGIEPSAWDSLLRTQVFLKAPITTPQGGGFKSLNVTTRKTLGQYANVRPCVSYHPFIDT
CCCCCHHHHHHHHHHHHHEECCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCC
KHPNMDVVIVRENEEDLYAGIEYQNTPEVMSCIKLISRPGSEKIVRYAFEYARLHNRKKV
CCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
TCFMKDNIMKMTDGLFHKVFDEIGAQYPDIEKEVWIVDIGAAKMADTPEAFDVIVMPNLY
EEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCHHH
GDILSDVAAQIAGSVGLAGSANIGEKCAMFEAIHGSAPRRAGQNLANPSGLLLGAVLMLV
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHH
HINQPEAAAKVHNAWLRTIEDGVHTYDVFTEGVSSKKVGTKEFAAAVIERIGQKPNILKP
CCCCCHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
VTYAHRPEKAAPAVQAERPAVAMELKGIDVFVYWPSRNPNTLAEAVGKLAVDGVKLQMID
CHHCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEC
NRGVKVWPAGRAETFCTDSFRCRFMADGATDMGKLLDVARRISDAGIDIAVTETLRNFDG
CCCEEEEECCCCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEHHHHHCCCC
VAGFTLAQGQ
CCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA