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The map label for this gene is yfiS [H]

Identifier: 116621930

GI number: 116621930

Start: 3567729

End: 3568925

Strand: Direct

Name: yfiS [H]

Synonym: Acid_2815

Alternate gene names: 116621930

Gene position: 3567729-3568925 (Clockwise)

Preceding gene: 116621929

Following gene: 116621936

Centisome position: 35.8

GC content: 66.5

Gene sequence:

>1197_bases
ATGCGTGAGCCTGACTTCCTGAAGCTCTGGGCCGGGCAAACCATCTCGCAGATCGGTTCGACCATCTCCAGCATCGGATT
ACCTCTGCTGGCGGTGCTGGTGTTGCATGCCTCGCCGGTCCAGATGGGAATGTTAGGTGGTGCCAGCGCAGCCAGCGTGC
TGCTCTTCGGCCTCTTCGCGGGTGCCTGGGCGGACCGGATGCGGCGCCGGCCGATCCTGATCGCGGCCGATCTGGGGCGC
GCGCTGGTGGTGGGATCCGTGCCCCTGGCCGCCGCGCTGCACCGGTTGACTATGGCGCACCTCTACGTGGTCGCGGCGGC
GGGTGCGGTGCTCACGGTGTTGTTCGACGTAACCTACCAGGCCTACCTGCCTTCGTTGGTAGATCGCGAGAGCCTTCTGG
CGGGTAACAGCCGGCTCGCCATGACGGAGTCCCTCGCCGAGGTCGCGGGCCCGGGGCTCACCGGCCTCCTGGTGCAATGG
ATTACGGCCCCGATGGCGATTCTCTTCGACGCCGTCTCCTTCCTCTGCTCGGCGATTTCCGTATGGATGATCCGCAAGCC
GGAGCTACCGCCAACACCGGCGGCGGAGCCGGACATGGCCAGGGAAATCCGCGAGGGGCTGAGTACTTCGTGGGGCGATC
CGGTGCTGCGGGCGCTGGCCGGGCGCGCAGGCAGCGGCGCCTTTTTCCTCGGATTCGGCGGCAGCCTGTACTTCTTATTC
ACCGTGCGCGAACTCGGGTTGAGCGCGGCGACCGTGGGCATCATTATCTCGCTCGGTGGGGCGGGAAGTTTCGCGGGCGC
GTGGATGGCGGAACGGCTGGCCGCGCGTTTCGGCACGGCGCGCTGCCTGATCGGTTCCAGCCTGTTGATTGGCTTCGCGA
TGCTGATGGTACCCCTGGCACATGGACCGGGGCTCCTGCTAGCCGCGCAACTGGGCGACGTGGGATGGCCGCTCTACAAC
ATCAATGAACGGACGCTGCGTCAGAAAATCACTCCGGACCACCTGCTGGGCCGCGTCAATTCCGCCATGCAGCTGGTCTT
TCAGGGCGTGCTGCCGCTGGGCGCGCTGGCCGGCGGCGCGCTCGCGCAACTAATCGGCGTGCGCGCGGCGATGTTCGCTG
GAGCATTGGGATTCCTGCTCTCAACGGCCTGGCTGGTAGGGCTGAGAACGGTTGACGACCGGGTTTCAGCGCTGTGA

Upstream 100 bases:

>100_bases
TTCTTCCGGCACTGCGGGCCAGCACCATCGATCCCGTGCGTGCGTTGCGCTCGGAATGAGTTGTCCGTCCGAGAACGATC
TCTTGTGCAAGACTTGAGCG

Downstream 100 bases:

>100_bases
AACGTGGACCCAATCGACCAGCATTTGCTGGGGGAAAGTGGTGGTCGCGTCGGGGTTGCCGGGCCATGTGCCGCCGGTGG
CGACGTTGAGGATGAGGAAA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MREPDFLKLWAGQTISQIGSTISSIGLPLLAVLVLHASPVQMGMLGGASAASVLLFGLFAGAWADRMRRRPILIAADLGR
ALVVGSVPLAAALHRLTMAHLYVVAAAGAVLTVLFDVTYQAYLPSLVDRESLLAGNSRLAMTESLAEVAGPGLTGLLVQW
ITAPMAILFDAVSFLCSAISVWMIRKPELPPTPAAEPDMAREIREGLSTSWGDPVLRALAGRAGSGAFFLGFGGSLYFLF
TVRELGLSAATVGIIISLGGAGSFAGAWMAERLAARFGTARCLIGSSLLIGFAMLMVPLAHGPGLLLAAQLGDVGWPLYN
INERTLRQKITPDHLLGRVNSAMQLVFQGVLPLGALAGGALAQLIGVRAAMFAGALGFLLSTAWLVGLRTVDDRVSAL

Sequences:

>Translated_398_residues
MREPDFLKLWAGQTISQIGSTISSIGLPLLAVLVLHASPVQMGMLGGASAASVLLFGLFAGAWADRMRRRPILIAADLGR
ALVVGSVPLAAALHRLTMAHLYVVAAAGAVLTVLFDVTYQAYLPSLVDRESLLAGNSRLAMTESLAEVAGPGLTGLLVQW
ITAPMAILFDAVSFLCSAISVWMIRKPELPPTPAAEPDMAREIREGLSTSWGDPVLRALAGRAGSGAFFLGFGGSLYFLF
TVRELGLSAATVGIIISLGGAGSFAGAWMAERLAARFGTARCLIGSSLLIGFAMLMVPLAHGPGLLLAAQLGDVGWPLYN
INERTLRQKITPDHLLGRVNSAMQLVFQGVLPLGALAGGALAQLIGVRAAMFAGALGFLLSTAWLVGLRTVDDRVSAL
>Mature_398_residues
MREPDFLKLWAGQTISQIGSTISSIGLPLLAVLVLHASPVQMGMLGGASAASVLLFGLFAGAWADRMRRRPILIAADLGR
ALVVGSVPLAAALHRLTMAHLYVVAAAGAVLTVLFDVTYQAYLPSLVDRESLLAGNSRLAMTESLAEVAGPGLTGLLVQW
ITAPMAILFDAVSFLCSAISVWMIRKPELPPTPAAEPDMAREIREGLSTSWGDPVLRALAGRAGSGAFFLGFGGSLYFLF
TVRELGLSAATVGIIISLGGAGSFAGAWMAERLAARFGTARCLIGSSLLIGFAMLMVPLAHGPGLLLAAQLGDVGWPLYN
INERTLRQKITPDHLLGRVNSAMQLVFQGVLPLGALAGGALAQLIGVRAAMFAGALGFLLSTAWLVGLRTVDDRVSAL

Specific function: Multidrug Resistance Pump That Participates In A Low Energy Shock Adaptative Response. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41581; Mature: 41581

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREPDFLKLWAGQTISQIGSTISSIGLPLLAVLVLHASPVQMGMLGGASAASVLLFGLFA
CCCCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHH
GAWADRMRRRPILIAADLGRALVVGSVPLAAALHRLTMAHLYVVAAAGAVLTVLFDVTYQ
HHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYLPSLVDRESLLAGNSRLAMTESLAEVAGPGLTGLLVQWITAPMAILFDAVSFLCSAIS
HHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWMIRKPELPPTPAAEPDMAREIREGLSTSWGDPVLRALAGRAGSGAFFLGFGGSLYFLF
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHH
TVRELGLSAATVGIIISLGGAGSFAGAWMAERLAARFGTARCLIGSSLLIGFAMLMVPLA
HHHHHCCHHHEEEHEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
HGPGLLLAAQLGDVGWPLYNINERTLRQKITPDHLLGRVNSAMQLVFQGVLPLGALAGGA
CCCCEEEEEHHCCCCCCEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQLIGVRAAMFAGALGFLLSTAWLVGLRTVDDRVSAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MREPDFLKLWAGQTISQIGSTISSIGLPLLAVLVLHASPVQMGMLGGASAASVLLFGLFA
CCCCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHH
GAWADRMRRRPILIAADLGRALVVGSVPLAAALHRLTMAHLYVVAAAGAVLTVLFDVTYQ
HHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYLPSLVDRESLLAGNSRLAMTESLAEVAGPGLTGLLVQWITAPMAILFDAVSFLCSAIS
HHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWMIRKPELPPTPAAEPDMAREIREGLSTSWGDPVLRALAGRAGSGAFFLGFGGSLYFLF
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHH
TVRELGLSAATVGIIISLGGAGSFAGAWMAERLAARFGTARCLIGSSLLIGFAMLMVPLA
HHHHHCCHHHEEEHEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
HGPGLLLAAQLGDVGWPLYNINERTLRQKITPDHLLGRVNSAMQLVFQGVLPLGALAGGA
CCCCEEEEEHHCCCCCCEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQLIGVRAAMFAGALGFLLSTAWLVGLRTVDDRVSAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]