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The map label for this gene is ubiE [H]

Identifier: 116621824

GI number: 116621824

Start: 3432056

End: 3432715

Strand: Reverse

Name: ubiE [H]

Synonym: Acid_2706

Alternate gene names: 116621824

Gene position: 3432715-3432056 (Counterclockwise)

Preceding gene: 116621825

Following gene: 116621823

Centisome position: 34.45

GC content: 59.09

Gene sequence:

>660_bases
ATGCGAGCCATGTTTAGTACTGTGGCTCCGCGCTATGATTTCATCACCCGGACATTTTCTTACGGTATGGACCGGCGGTG
GAAGCGTACCGGCCTCGAACGAGCCGCGCTACCGGATAGGCCTGTAGTCCTGGACCTCGCGGCTGGTACCGGCGATTTCT
CGCTCATGGTCAACCAGCGCTATCCCGGATCGCAAGCCGTCGCCGTCGATATCACCGAACGCATGTTGCAACTCGCCCGC
GACCGCGGCGTGCAACATACAGTCTGCGGCGACGCCGGCCGTCTTCCCTTCCCCGATCACTCCTTCGATTGTGTCTTTGT
CGGGTACGGCCTGCGCAACTTCCCCAAACTCGACCTCGCCGTGCAGGAAATCGAACGCGTCACCCGCCCCGGCGGCATGC
TGGTCAGCCTGGATTTTTTTCTTCCCTCCAACTTCCTGATGCAACGTCTCTATCTCGGCTACCTCTATGCACAGGGCGCC
TTCTGGGGCATGGTGTTACACGGTAAGCCGCGCGTCTATACGTACATCCCCGATTCTCTGCGCAGCTTCGTTTCAATCGA
TGACTTCTCCTCTCTCCTGCGGCGCAAAGGGTATCAAAACGTCGATACCCGGCGCTTCATTTTGGGCGGCATCGGGCTGC
ATTGGGCGGAGAAGCGTTAA

Upstream 100 bases:

>100_bases
TACCACGTAAATCTTTGTTTTCATAACACGCTCCTCGATCGCAGTTTGCTACAATCCCGCGTAAGTGAAACCCCCAGCAG
AACAGCAAAGTTCCCGACTC

Downstream 100 bases:

>100_bases
ACTGGTGGCCGCTTTCCACCACAACGGCTGAACACCACCATATGAAAGAACGTCTGCGTGCGTCAGACTACCGGTTTATC
GCGATCTGCGTGCTCCTGCT

Product: demethylmenaquinone methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MRAMFSTVAPRYDFITRTFSYGMDRRWKRTGLERAALPDRPVVLDLAAGTGDFSLMVNQRYPGSQAVAVDITERMLQLAR
DRGVQHTVCGDAGRLPFPDHSFDCVFVGYGLRNFPKLDLAVQEIERVTRPGGMLVSLDFFLPSNFLMQRLYLGYLYAQGA
FWGMVLHGKPRVYTYIPDSLRSFVSIDDFSSLLRRKGYQNVDTRRFILGGIGLHWAEKR

Sequences:

>Translated_219_residues
MRAMFSTVAPRYDFITRTFSYGMDRRWKRTGLERAALPDRPVVLDLAAGTGDFSLMVNQRYPGSQAVAVDITERMLQLAR
DRGVQHTVCGDAGRLPFPDHSFDCVFVGYGLRNFPKLDLAVQEIERVTRPGGMLVSLDFFLPSNFLMQRLYLGYLYAQGA
FWGMVLHGKPRVYTYIPDSLRSFVSIDDFSSLLRRKGYQNVDTRRFILGGIGLHWAEKR
>Mature_219_residues
MRAMFSTVAPRYDFITRTFSYGMDRRWKRTGLERAALPDRPVVLDLAAGTGDFSLMVNQRYPGSQAVAVDITERMLQLAR
DRGVQHTVCGDAGRLPFPDHSFDCVFVGYGLRNFPKLDLAVQEIERVTRPGGMLVSLDFFLPSNFLMQRLYLGYLYAQGA
FWGMVLHGKPRVYTYIPDSLRSFVSIDDFSSLLRRKGYQNVDTRRFILGGIGLHWAEKR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=252, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI48994983, Length=226, Percent_Identity=31.4159292035398, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17557039, Length=220, Percent_Identity=27.7272727272727, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323526, Length=238, Percent_Identity=24.7899159663866, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24641702, Length=235, Percent_Identity=30.2127659574468, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 25032; Mature: 25032

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMFSTVAPRYDFITRTFSYGMDRRWKRTGLERAALPDRPVVLDLAAGTGDFSLMVNQR
CCCCHHHHCCCHHHHHHHHHHCCCCHHHHCCCCHHCCCCCCEEEEEECCCCCEEEEEECC
YPGSQAVAVDITERMLQLARDRGVQHTVCGDAGRLPFPDHSFDCVFVGYGLRNFPKLDLA
CCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHHHH
VQEIERVTRPGGMLVSLDFFLPSNFLMQRLYLGYLYAQGAFWGMVLHGKPRVYTYIPDSL
HHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCHHH
RSFVSIDDFSSLLRRKGYQNVDTRRFILGGIGLHWAEKR
HHHHCHHHHHHHHHHCCCCCCCCCEEEEECCCCEECCCC
>Mature Secondary Structure
MRAMFSTVAPRYDFITRTFSYGMDRRWKRTGLERAALPDRPVVLDLAAGTGDFSLMVNQR
CCCCHHHHCCCHHHHHHHHHHCCCCHHHHCCCCHHCCCCCCEEEEEECCCCCEEEEEECC
YPGSQAVAVDITERMLQLARDRGVQHTVCGDAGRLPFPDHSFDCVFVGYGLRNFPKLDLA
CCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHHHH
VQEIERVTRPGGMLVSLDFFLPSNFLMQRLYLGYLYAQGAFWGMVLHGKPRVYTYIPDSL
HHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCHHH
RSFVSIDDFSSLLRRKGYQNVDTRRFILGGIGLHWAEKR
HHHHCHHHHHHHHHHCCCCCCCCCEEEEECCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA