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The map label for this gene is fabD [H]

Identifier: 116621716

GI number: 116621716

Start: 3280384

End: 3281316

Strand: Direct

Name: fabD [H]

Synonym: Acid_2598

Alternate gene names: 116621716

Gene position: 3280384-3281316 (Clockwise)

Preceding gene: 116621715

Following gene: 116621718

Centisome position: 32.92

GC content: 66.99

Gene sequence:

>933_bases
TTGCTACCCAAGACTGCTTTTCTCTTTCCGGGCCAGGGCTCGCAGGCCCCAGGCATGGGCAAGGCCCTCGCCGACACGCA
CGCCGCCGCGCGGCGCGTCTTCGAAGAGGCCGACGACGCCCTCGGTTTCCCCCTCTCCCGCCTCTGTTTCGAAGGCCCCG
AGGATCAGCTCAAGCTCACCGAAAACACCCAGCCCGCGCTGCTCACTGTGTCCATCGCCGCCTTCGAAGTGTTGCGCGAA
ACCGGCCGCGTCCCGGATTACGTCGCCGGCCACAGCCTCGGCGAATACTCGGCGCTCGTCGCCGCCGGCAGTCTTCGCTT
TGCCGATGCCGTTCGTCTGGTGCGCAAACGCGGCCAGTACATGCAGGAAGCCGTTCCCCAGGGTATCGGCGCCATGGCCG
CGATCCTGAAACTCCCGGAGGGCAAGCTCGACTCCATCATCGCCGAGGCCGCCCAGGGTGAAGTCCTCAGCGCCGCCAAC
CTGAACTCTCCCGACCAGGTCGTGATCGCCGGCCACACCGGCGCGGTCAATCGCGCCTGCGAACTGGCCAAGGCCGCCGG
CGCCAAGCGCGCCATCCTGCTGCCTGTCAGCGCGCCCTTCCATTGCGCCTTGATGCGGCCGGCCCAAGAGCGGCTGCGTG
CCGACCTTGACGCCGCCGAATTCCACGACCTCACGTGTCCACTGGTCAACAACTGGCAGGCCCGCGAAATCCGCGCCGCC
GCCGAAGCTCGCGAGGGACTTTACCAGCAGGTGCCCAATCCCGTCCGCTGGGTCGAGACCATTCGCTACCTGGCGGGGCA
GGGCACTGCCGGCTTCGTCGAAGTCGGCGCCGGTTCTGTGCTCACCGGACTCCTGCGCGCTATCGATCCCAAACTGCAGG
GTGTGAAATTCGGCGAACCCGCCGACCTGGAAAAACTACCGGCTGCCTGCTAA

Upstream 100 bases:

>100_bases
CCGTGTCCCCTGACGGGATTGGAAATTTCGATCCAGTACCCGGTAATTCCTACCCTCCGCCCGGCCGTGCCGACCGGACG
CGGGCAGTTATAATCTCTGT

Downstream 100 bases:

>100_bases
ACGGCCCGGTGGGGCAGCCAATCCTGGCTGCCGCCGGCTTCAGCCGGCGTCCCGCGCATGCAGACACGGCTCCGCGAACC
GCGACCGTGAGGGAGCGATC

Product: [Acyl-carrier-protein] S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MLPKTAFLFPGQGSQAPGMGKALADTHAAARRVFEEADDALGFPLSRLCFEGPEDQLKLTENTQPALLTVSIAAFEVLRE
TGRVPDYVAGHSLGEYSALVAAGSLRFADAVRLVRKRGQYMQEAVPQGIGAMAAILKLPEGKLDSIIAEAAQGEVLSAAN
LNSPDQVVIAGHTGAVNRACELAKAAGAKRAILLPVSAPFHCALMRPAQERLRADLDAAEFHDLTCPLVNNWQAREIRAA
AEAREGLYQQVPNPVRWVETIRYLAGQGTAGFVEVGAGSVLTGLLRAIDPKLQGVKFGEPADLEKLPAAC

Sequences:

>Translated_310_residues
MLPKTAFLFPGQGSQAPGMGKALADTHAAARRVFEEADDALGFPLSRLCFEGPEDQLKLTENTQPALLTVSIAAFEVLRE
TGRVPDYVAGHSLGEYSALVAAGSLRFADAVRLVRKRGQYMQEAVPQGIGAMAAILKLPEGKLDSIIAEAAQGEVLSAAN
LNSPDQVVIAGHTGAVNRACELAKAAGAKRAILLPVSAPFHCALMRPAQERLRADLDAAEFHDLTCPLVNNWQAREIRAA
AEAREGLYQQVPNPVRWVETIRYLAGQGTAGFVEVGAGSVLTGLLRAIDPKLQGVKFGEPADLEKLPAAC
>Mature_310_residues
MLPKTAFLFPGQGSQAPGMGKALADTHAAARRVFEEADDALGFPLSRLCFEGPEDQLKLTENTQPALLTVSIAAFEVLRE
TGRVPDYVAGHSLGEYSALVAAGSLRFADAVRLVRKRGQYMQEAVPQGIGAMAAILKLPEGKLDSIIAEAAQGEVLSAAN
LNSPDQVVIAGHTGAVNRACELAKAAGAKRAILLPVSAPFHCALMRPAQERLRADLDAAEFHDLTCPLVNNWQAREIRAA
AEAREGLYQQVPNPVRWVETIRYLAGQGTAGFVEVGAGSVLTGLLRAIDPKLQGVKFGEPADLEKLPAAC

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=304, Percent_Identity=32.8947368421053, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI27477045, Length=109, Percent_Identity=39.4495412844037, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787334, Length=303, Percent_Identity=48.5148514851485, Blast_Score=254, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71984332, Length=298, Percent_Identity=32.5503355704698, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17550940, Length=323, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI212642053, Length=213, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24665753, Length=305, Percent_Identity=34.7540983606557, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32883; Mature: 32883

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKTAFLFPGQGSQAPGMGKALADTHAAARRVFEEADDALGFPLSRLCFEGPEDQLKLT
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEC
ENTQPALLTVSIAAFEVLRETGRVPDYVAGHSLGEYSALVAAGSLRFADAVRLVRKRGQY
CCCCCEEEEHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
MQEAVPQGIGAMAAILKLPEGKLDSIIAEAAQGEVLSAANLNSPDQVVIAGHTGAVNRAC
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCHHHHHH
ELAKAAGAKRAILLPVSAPFHCALMRPAQERLRADLDAAEFHDLTCPLVNNWQAREIRAA
HHHHHCCCCEEEEEECCCCCHHHHHCHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHH
AEAREGLYQQVPNPVRWVETIRYLAGQGTAGFVEVGAGSVLTGLLRAIDPKLQGVKFGEP
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCHHHCCCCCCCC
ADLEKLPAAC
CCHHHCCCCC
>Mature Secondary Structure
MLPKTAFLFPGQGSQAPGMGKALADTHAAARRVFEEADDALGFPLSRLCFEGPEDQLKLT
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEC
ENTQPALLTVSIAAFEVLRETGRVPDYVAGHSLGEYSALVAAGSLRFADAVRLVRKRGQY
CCCCCEEEEHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
MQEAVPQGIGAMAAILKLPEGKLDSIIAEAAQGEVLSAANLNSPDQVVIAGHTGAVNRAC
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCHHHHHH
ELAKAAGAKRAILLPVSAPFHCALMRPAQERLRADLDAAEFHDLTCPLVNNWQAREIRAA
HHHHHCCCCEEEEEECCCCCHHHHHCHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHH
AEAREGLYQQVPNPVRWVETIRYLAGQGTAGFVEVGAGSVLTGLLRAIDPKLQGVKFGEP
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCHHHCCCCCCCC
ADLEKLPAAC
CCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]