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The map label for this gene is ffh [H]

Identifier: 116621691

GI number: 116621691

Start: 3254817

End: 3256184

Strand: Reverse

Name: ffh [H]

Synonym: Acid_2573

Alternate gene names: 116621691

Gene position: 3256184-3254817 (Counterclockwise)

Preceding gene: 116621692

Following gene: 116621690

Centisome position: 32.67

GC content: 59.06

Gene sequence:

>1368_bases
ATGTTCGACAACTTATCAGATAAACTCCAGCGGGTCTTCAAAAACCTGCGCGGCGAAGGTAAACTCTCGGCCGAAAACAT
GGAGACCGCTCTGCGCGAAATTCGCATGGCGCTCCTCGAAGCCGACGTGAACTTCAAGGTTGTCAAACAGCTCATCGAGA
ACATCAAGCAGAAGGCGGTCGGCGAGGAAGTGCTCAATGCCCTATCCCCCTCGCAACAGGTCATCAAGATCGTTCATGAG
GAGCTGATCAAGATCCTGGGCAGCCACGAGTCCAAACTCCGTTACGCCAACGATCCGCCAAGCGTCTTTATGATCGTCGG
GCTGCAAGGTTCCGGTAAGACCACCTCCACCGGCAAGCTGGCGCGCTGGCTTTCCAAGAACGGCCATGCGCCGATGGTAG
TCTCGGTGGACGTGTACCGTCCCGCCGCCCGCGAGCAGCTGAAGGTTGTGGCGCGCGACGTGAAGCAGCCGATTTATGAA
GGCGCGCCCGGCGAGACCGCGCCGCTCGACCTGGCCCGCTCCGCGCGCCGCGAAGCCACGAATTCCGGCCGCGACGTCCT
GCTGGTGGATACCGCCGGCCGCCTGCACATCGATGACGACCTGATGGTGGAGCTGCAGCAGTTGAAAGAGCAGCTCAATC
CGGTCGAAATCCTGTTCGTGGCCGACGCCATGACCGGGCAGGACGCGGTCAAATCGGCCGACGAATTTCACAAACGCCTG
GGCATTACCGGCGTCATTCTCACCAAGATGGATGGCGATGCCCGCGGCGGCGCCGCGCTCTCCATTCGCAGCGTCACCGG
GCAGCCGCTCAAGTTCGTGGGTGTGGGCGAAAAGCTGGATGCGCTCGAGGCTTTCCACCCCGATCGCGCCGCCAACCGCA
TTTTGGGGATGGGCGACATCCTCAGCTTCATCGAAAAGGCCGAAGAGGCCATCGACAAGAAGCAGGCTGTGGAAATGCAG
CGCAAGCTCATCGAGAACGATTTCACGCTCGAGGACTTCCGCAACCAGCTCCGCCAGATTCGCAAGCTCGGCCCCTTGGA
ATCGCTCCTGGGCATGATGCCGAAGGTCGGCATTCTCAAAGAGCTGAAAGACGTCAAAGTTGACGAAAAAGAGATCAACC
GCGTGGTGGCCATCATCGATTCGATGACGCCGCATGAACGCGACAATCACATGATTATCAACGGGAGCCGCCGCCGCCGC
ATCGCCAAGGGCAGCGGGACCTCCGTTCAGGAAGTAAACCAGTTGTTGAAGCAGTACGCTCAGGCCAAGAAAATGATGAA
AACCTTCTCCGGCGGCTTCATGGGCAAAAAGCTCGGTAAGATGAAGATGCCCGGAGGGTTTCCATTCGGCAATTTGCCTG
GGCAATAA

Upstream 100 bases:

>100_bases
CCGCCGCCGGCGGCGCCCGCCGCCGCGGAATAACCAGCTATACTAGAGGAACCGCACAAGGTCCCCCGCATGGCACACCT
TGCGGGGTCGGTCTGTTCTC

Downstream 100 bases:

>100_bases
ATTTAGACAAAATCCGGGCGGGCCAGCGTGCCAGCCTAATGTGGAGTATCAATGTTGATGATTCGCCTGGCGCGGTTTGG
CGCCAAAAAGAAGCCGTTTT

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFDNLSDKLQRVFKNLRGEGKLSAENMETALREIRMALLEADVNFKVVKQLIENIKQKAVGEEVLNALSPSQQVIKIVHE
ELIKILGSHESKLRYANDPPSVFMIVGLQGSGKTTSTGKLARWLSKNGHAPMVVSVDVYRPAAREQLKVVARDVKQPIYE
GAPGETAPLDLARSARREATNSGRDVLLVDTAGRLHIDDDLMVELQQLKEQLNPVEILFVADAMTGQDAVKSADEFHKRL
GITGVILTKMDGDARGGAALSIRSVTGQPLKFVGVGEKLDALEAFHPDRAANRILGMGDILSFIEKAEEAIDKKQAVEMQ
RKLIENDFTLEDFRNQLRQIRKLGPLESLLGMMPKVGILKELKDVKVDEKEINRVVAIIDSMTPHERDNHMIINGSRRRR
IAKGSGTSVQEVNQLLKQYAQAKKMMKTFSGGFMGKKLGKMKMPGGFPFGNLPGQ

Sequences:

>Translated_455_residues
MFDNLSDKLQRVFKNLRGEGKLSAENMETALREIRMALLEADVNFKVVKQLIENIKQKAVGEEVLNALSPSQQVIKIVHE
ELIKILGSHESKLRYANDPPSVFMIVGLQGSGKTTSTGKLARWLSKNGHAPMVVSVDVYRPAAREQLKVVARDVKQPIYE
GAPGETAPLDLARSARREATNSGRDVLLVDTAGRLHIDDDLMVELQQLKEQLNPVEILFVADAMTGQDAVKSADEFHKRL
GITGVILTKMDGDARGGAALSIRSVTGQPLKFVGVGEKLDALEAFHPDRAANRILGMGDILSFIEKAEEAIDKKQAVEMQ
RKLIENDFTLEDFRNQLRQIRKLGPLESLLGMMPKVGILKELKDVKVDEKEINRVVAIIDSMTPHERDNHMIINGSRRRR
IAKGSGTSVQEVNQLLKQYAQAKKMMKTFSGGFMGKKLGKMKMPGGFPFGNLPGQ
>Mature_455_residues
MFDNLSDKLQRVFKNLRGEGKLSAENMETALREIRMALLEADVNFKVVKQLIENIKQKAVGEEVLNALSPSQQVIKIVHE
ELIKILGSHESKLRYANDPPSVFMIVGLQGSGKTTSTGKLARWLSKNGHAPMVVSVDVYRPAAREQLKVVARDVKQPIYE
GAPGETAPLDLARSARREATNSGRDVLLVDTAGRLHIDDDLMVELQQLKEQLNPVEILFVADAMTGQDAVKSADEFHKRL
GITGVILTKMDGDARGGAALSIRSVTGQPLKFVGVGEKLDALEAFHPDRAANRILGMGDILSFIEKAEEAIDKKQAVEMQ
RKLIENDFTLEDFRNQLRQIRKLGPLESLLGMMPKVGILKELKDVKVDEKEINRVVAIIDSMTPHERDNHMIINGSRRRR
IAKGSGTSVQEVNQLLKQYAQAKKMMKTFSGGFMGKKLGKMKMPGGFPFGNLPGQ

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=462, Percent_Identity=33.7662337662338, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI226371618, Length=404, Percent_Identity=33.1683168316832, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI23308697, Length=306, Percent_Identity=30.718954248366, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI295424842, Length=306, Percent_Identity=30.718954248366, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI89061728, Length=145, Percent_Identity=35.8620689655172, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=50.8849557522124, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1789874, Length=257, Percent_Identity=34.6303501945525, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=421, Percent_Identity=32.7790973871734, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=31.986531986532, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6325345, Length=446, Percent_Identity=34.7533632286996, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320498, Length=323, Percent_Identity=25.3869969040248, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17647949, Length=438, Percent_Identity=32.1917808219178, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24641198, Length=321, Percent_Identity=29.2834890965732, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50406; Mature: 50406

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLSDKLQRVFKNLRGEGKLSAENMETALREIRMALLEADVNFKVVKQLIENIKQKAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVLNALSPSQQVIKIVHEELIKILGSHESKLRYANDPPSVFMIVGLQGSGKTTSTGKL
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHH
ARWLSKNGHAPMVVSVDVYRPAAREQLKVVARDVKQPIYEGAPGETAPLDLARSARREAT
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
NSGRDVLLVDTAGRLHIDDDLMVELQQLKEQLNPVEILFVADAMTGQDAVKSADEFHKRL
CCCCEEEEEECCCCEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHH
GITGVILTKMDGDARGGAALSIRSVTGQPLKFVGVGEKLDALEAFHPDRAANRILGMGDI
CCCEEEEEECCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHCCCCHHHHHHCCHHHH
LSFIEKAEEAIDKKQAVEMQRKLIENDFTLEDFRNQLRQIRKLGPLESLLGMMPKVGILK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
ELKDVKVDEKEINRVVAIIDSMTPHERDNHMIINGSRRRRIAKGSGTSVQEVNQLLKQYA
HHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHH
QAKKMMKTFSGGFMGKKLGKMKMPGGFPFGNLPGQ
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFDNLSDKLQRVFKNLRGEGKLSAENMETALREIRMALLEADVNFKVVKQLIENIKQKAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVLNALSPSQQVIKIVHEELIKILGSHESKLRYANDPPSVFMIVGLQGSGKTTSTGKL
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHH
ARWLSKNGHAPMVVSVDVYRPAAREQLKVVARDVKQPIYEGAPGETAPLDLARSARREAT
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
NSGRDVLLVDTAGRLHIDDDLMVELQQLKEQLNPVEILFVADAMTGQDAVKSADEFHKRL
CCCCEEEEEECCCCEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHH
GITGVILTKMDGDARGGAALSIRSVTGQPLKFVGVGEKLDALEAFHPDRAANRILGMGDI
CCCEEEEEECCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHCCCCHHHHHHCCHHHH
LSFIEKAEEAIDKKQAVEMQRKLIENDFTLEDFRNQLRQIRKLGPLESLLGMMPKVGILK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
ELKDVKVDEKEINRVVAIIDSMTPHERDNHMIINGSRRRRIAKGSGTSVQEVNQLLKQYA
HHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHH
QAKKMMKTFSGGFMGKKLGKMKMPGGFPFGNLPGQ
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]