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The map label for this gene is guaD [H]

Identifier: 116621653

GI number: 116621653

Start: 3213354

End: 3213818

Strand: Reverse

Name: guaD [H]

Synonym: Acid_2535

Alternate gene names: 116621653

Gene position: 3213818-3213354 (Counterclockwise)

Preceding gene: 116621654

Following gene: 116621651

Centisome position: 32.25

GC content: 68.6

Gene sequence:

>465_bases
ATGTCCAACACCTTCATGCAGCAGGCCATCGAGATGGCGGTGGCTAACGTGCGCCGCGGGGGCGGCCCCTTCGCTGCCCT
GGTGGTGAAGGACGGCATCGTGATCGCCTCGGGCGCCAACCAGGTGACGCGCTCGAACGACCCGACGGCGCACGCCGAAA
TCGTCGCCATCCGCGAGGCCTGCCGCGTCCTCGGGGACTTCCAACTCCCCGGCTGCGAGATCTATACCACCTGCGAGCCC
TGCCCGATGTGCCTCGGCGCGATCTACTGGGCCCGTCCCGCGGCCGTGTACTACGCCGCCACTCACCAGGCCGCCGCCCT
CGCCGGCTTCGACGACTCCTTCATCTACCACGAAATCCAGCATCCGCCCGACCGCCGCGCCATCCCGATGATCCGGACCG
GCGAAGAATCCGCCGTTCTGCCGTTCGAGGAGTGGTCCCGCAAGCCTGACCGGCGCCGCTACTGA

Upstream 100 bases:

>100_bases
TGGAAAAGCTTGGCGTCCACGAAACCGCCAGCATGGTCCGGTACGCTATCCGCGCCGGCCTGATCGAAGCATGATCGGGG
CCTAGACGCTTCGCCCCTGG

Downstream 100 bases:

>100_bases
GAATTACGCTGCCGGGACACACGGATCGCGACCGGTGCGTCGCGACAGCTGAGATCGAGGATCAAACCGGGCATTTCCGC
GTCGATTTCAGCGGAAAATG

Product: guanine deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MSNTFMQQAIEMAVANVRRGGGPFAALVVKDGIVIASGANQVTRSNDPTAHAEIVAIREACRVLGDFQLPGCEIYTTCEP
CPMCLGAIYWARPAAVYYAATHQAAALAGFDDSFIYHEIQHPPDRRAIPMIRTGEESAVLPFEEWSRKPDRRRY

Sequences:

>Translated_154_residues
MSNTFMQQAIEMAVANVRRGGGPFAALVVKDGIVIASGANQVTRSNDPTAHAEIVAIREACRVLGDFQLPGCEIYTTCEP
CPMCLGAIYWARPAAVYYAATHQAAALAGFDDSFIYHEIQHPPDRRAIPMIRTGEESAVLPFEEWSRKPDRRRY
>Mature_153_residues
SNTFMQQAIEMAVANVRRGGGPFAALVVKDGIVIASGANQVTRSNDPTAHAEIVAIREACRVLGDFQLPGCEIYTTCEPC
PMCLGAIYWARPAAVYYAATHQAAALAGFDDSFIYHEIQHPPDRRAIPMIRTGEESAVLPFEEWSRKPDRRRY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=95, Percent_Identity=35.7894736842105, Blast_Score=68, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554608, Length=153, Percent_Identity=45.7516339869281, Blast_Score=149, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17555996, Length=151, Percent_Identity=44.3708609271523, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17001; Mature: 16869

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTFMQQAIEMAVANVRRGGGPFAALVVKDGIVIASGANQVTRSNDPTAHAEIVAIREA
CCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHH
CRVLGDFQLPGCEIYTTCEPCPMCLGAIYWARPAAVYYAATHQAAALAGFDDSFIYHEIQ
HHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHEECCCCCCCEEEECC
HPPDRRAIPMIRTGEESAVLPFEEWSRKPDRRRY
CCCCCCCCCEEEECCCCEECCHHHHCCCCCCCCC
>Mature Secondary Structure 
SNTFMQQAIEMAVANVRRGGGPFAALVVKDGIVIASGANQVTRSNDPTAHAEIVAIREA
CHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHH
CRVLGDFQLPGCEIYTTCEPCPMCLGAIYWARPAAVYYAATHQAAALAGFDDSFIYHEIQ
HHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHEECCCCCCCEEEECC
HPPDRRAIPMIRTGEESAVLPFEEWSRKPDRRRY
CCCCCCCCCEEEECCCCEECCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]