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The map label for this gene is mta [H]

Identifier: 116621484

GI number: 116621484

Start: 3016660

End: 3017403

Strand: Reverse

Name: mta [H]

Synonym: Acid_2366

Alternate gene names: 116621484

Gene position: 3017403-3016660 (Counterclockwise)

Preceding gene: 116621489

Following gene: 116621479

Centisome position: 30.28

GC content: 62.37

Gene sequence:

>744_bases
GTGAACGTTCGGGAGTTCGGAAAACTCGCAGGAGTCACGGTGCGGGCGCTGCATCACTACGACCGCCTTGGACTTTTGCG
GCCGCGGCGCACGGAGGCGGGATACCGCGTCTATTGCGCGCGCGACCTGGAACGGCTGGAGCAGATTGTCGCGCTCAAGT
TTCTGGGAATTCCTTTGAAGCAGATCAAGACCATGCTGGAGCGGGCGTCGCTCGAATTACCGGAGGCGCTGCGCATGCAG
AGAACGGTGCTCGAGGAAAAACGCAAGCTGCTGGATCGCGCGATACTGGCGATCCGGGCGGCGGAGCGCTCGATCGCACC
GGGCCGGCCGGCCGTCTCTGCGCTGCTGACCAAAATCATCGAGGTGATCGAAATGCAAAACGACAACAGTTGGAGCGAGA
AATATTACAGCCCGGAGGCGAGAGCAAGAATCGACGAGCGCAAGAAGGAGTGGACTCCGGAACTGCAGGCCAAGGTTTCG
AAGCAGTGGACGGAGTTGTTCGCCGATGTGGAGGCGGCGCTCGACGAGGACCCGGCCGGAGAGAAGGCGCAGGCGCTGGC
GGCGCGATGGAAGGCGCTGGTCGCAGGCTTCACGGGCGGCGATCCGGAGATCGGGAAAGGTCTGAATAAGCTTTACGCGG
ACCGGTCGAATTGGCCCGCCGCGGCGAAGGAGCAGATGGCGCCGGCTGGAAATCCCAAGGTGTGGGAGTTCATGGGGCGC
GTGATGAAGTGCGGGATTAAGTAG

Upstream 100 bases:

>100_bases
GTTCCAGAATGATCGCCATTGAATAATAGAAATGGTACAACACAGGACTTGACCCTCACGCTGCGTCAGGCCCGACGATG
ATTTCGGAAGGAACTTTCCA

Downstream 100 bases:

>100_bases
GAGATCGCTGAAAAGGCGTGGGGCAGGTGATGCTCAATTTGGAGGAAGCCGCCTGAAAGCCGGCTGCAGCCAGGATTGGC
TGCCCCACATTGCGGCAAGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Multidrug transporter activation protein [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MNVREFGKLAGVTVRALHHYDRLGLLRPRRTEAGYRVYCARDLERLEQIVALKFLGIPLKQIKTMLERASLELPEALRMQ
RTVLEEKRKLLDRAILAIRAAERSIAPGRPAVSALLTKIIEVIEMQNDNSWSEKYYSPEARARIDERKKEWTPELQAKVS
KQWTELFADVEAALDEDPAGEKAQALAARWKALVAGFTGGDPEIGKGLNKLYADRSNWPAAAKEQMAPAGNPKVWEFMGR
VMKCGIK

Sequences:

>Translated_247_residues
MNVREFGKLAGVTVRALHHYDRLGLLRPRRTEAGYRVYCARDLERLEQIVALKFLGIPLKQIKTMLERASLELPEALRMQ
RTVLEEKRKLLDRAILAIRAAERSIAPGRPAVSALLTKIIEVIEMQNDNSWSEKYYSPEARARIDERKKEWTPELQAKVS
KQWTELFADVEAALDEDPAGEKAQALAARWKALVAGFTGGDPEIGKGLNKLYADRSNWPAAAKEQMAPAGNPKVWEFMGR
VMKCGIK
>Mature_247_residues
MNVREFGKLAGVTVRALHHYDRLGLLRPRRTEAGYRVYCARDLERLEQIVALKFLGIPLKQIKTMLERASLELPEALRMQ
RTVLEEKRKLLDRAILAIRAAERSIAPGRPAVSALLTKIIEVIEMQNDNSWSEKYYSPEARARIDERKKEWTPELQAKVS
KQWTELFADVEAALDEDPAGEKAQALAARWKALVAGFTGGDPEIGKGLNKLYADRSNWPAAAKEQMAPAGNPKVWEFMGR
VMKCGIK

Specific function: Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 27939; Mature: 27939

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVREFGKLAGVTVRALHHYDRLGLLRPRRTEAGYRVYCARDLERLEQIVALKFLGIPLK
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHH
QIKTMLERASLELPEALRMQRTVLEEKRKLLDRAILAIRAAERSIAPGRPAVSALLTKII
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EVIEMQNDNSWSEKYYSPEARARIDERKKEWTPELQAKVSKQWTELFADVEAALDEDPAG
HHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EKAQALAARWKALVAGFTGGDPEIGKGLNKLYADRSNWPAAAKEQMAPAGNPKVWEFMGR
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHH
VMKCGIK
HHHCCCC
>Mature Secondary Structure
MNVREFGKLAGVTVRALHHYDRLGLLRPRRTEAGYRVYCARDLERLEQIVALKFLGIPLK
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHH
QIKTMLERASLELPEALRMQRTVLEEKRKLLDRAILAIRAAERSIAPGRPAVSALLTKII
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EVIEMQNDNSWSEKYYSPEARARIDERKKEWTPELQAKVSKQWTELFADVEAALDEDPAG
HHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EKAQALAARWKALVAGFTGGDPEIGKGLNKLYADRSNWPAAAKEQMAPAGNPKVWEFMGR
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHH
VMKCGIK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377 [H]