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The map label for this gene is lysA [H]

Identifier: 116621306

GI number: 116621306

Start: 2803454

End: 2804692

Strand: Reverse

Name: lysA [H]

Synonym: Acid_2187

Alternate gene names: 116621306

Gene position: 2804692-2803454 (Counterclockwise)

Preceding gene: 116621307

Following gene: 116621305

Centisome position: 28.14

GC content: 63.68

Gene sequence:

>1239_bases
ATGTTCGCCTATTCGCACAACGACTATTACTGTGAGCAGGTCCCGCTGGCCGACCTGGCTCATCGCGTGGGAACGCCGGT
CTACGTGTATTCCAGCGCCGTCATTCTCGGCAACTACCGCGCCTATGCGGACGCGTTCGCCGGCCTGCCGAATACCATCT
GCTACGCGGTCAAAGCCAATTCGTCGCTCGCCATCCTGGCGCTGCTCGCGAAGGCCGGCGCCGGATTCGACATCGTTTCC
GGCGGCGAACTCTATCGCGTGCTGGCGGCGGGGGGCGACCCTTCCAAGGTCGTGTTCTCGGGTGTCGGCAAGACCGCCGG
CGAAGTGGAATACGCGCTCTCGAGCGGCATTCGATCTTTCAATTGCGAATCGGAATCCGAACTGGCGCTGATCGATGCCA
TGGCCGCGCGACTGGGCAAGCAGGCGAGCTTCTCGATTCGCGTCAATCCCGACGTGGATGCGGTCACGCATCCATACATC
TCCACCGGCCTCAGCCAGCACAAATTCGGCATCGCCATCGCCGATGCGCCGGCGGTTTACGAGCGGGCGCGCCAGTTCCG
CCACCTGGTGGCCGAAGGCGTGAGCTGCCACATCGGCTCGCAGATACTGGACCTCAGCCCGATTCAGGAAGCCGTGGACA
AGGTGCTGGCACTTGCCAACGCGCTACGGGAGCAGGGTCACCCGATTCGCCACCTCGACCTGGGCGGCGGCCTTGGCGTT
CCGTACCGGCCGACCGAGATCGCCCCGGCGATTGCCGATTTCGTGTGCGGCCTGCGCAAGCGGGTCACCGCCAGCAATCT
CGCGGTCACGATCGAACCGGGCCGGAGCATCGTGGGCGCGGCCGGCATTCTGCTCACCCGCGTGCTTTATCGCAAACGCA
ACGGCGACAAAGAATTTATGGTGGTGGATGCCGCGATGAACGATCTGATTCGTCCGTCGCTGTATCGAGCGCATCACGAG
ATCCTGCCGCTGCGCCGCAACGCGCTGCCACCGGTGACGGTGGATGTAGTCGGCCCGGTTTGCGAGACCGGCGACTTTCT
GGCGCGCGATCGCGAAATGGCAAACGCGATGCCCGGCGATTACCTGGCGATCTGCACCGCCGGGGCTTATGGGTTCGTAC
TGAGTTCCAACTACAACTCACGTCCGCGCGCGCCCGAGGTCCTGGTTACAGGCGACACATGGCGAGTCATTCGCGAGCGC
GAATGTTATGCCGACCTGGTGCGCGGCGAAGAGATCTAA

Upstream 100 bases:

>100_bases
CTGCGCGGTGACGGGCGCATCCGCTGCGTGCGGTGAAGGCGCATCCGCTGCGCGTGAAAATGCGGTGTGGCATACTTGAA
ATTCACCTCAGCCACTCCGC

Downstream 100 bases:

>100_bases
AGCGACCGATTTAGTCCGCTTTTGACTTTCAAAGTGTAAATTACTTCTGCTATATTAGTTCCTCCAAAGCAGCTATTCTT
ACGCTCTACCGGAGACACTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MFAYSHNDYYCEQVPLADLAHRVGTPVYVYSSAVILGNYRAYADAFAGLPNTICYAVKANSSLAILALLAKAGAGFDIVS
GGELYRVLAAGGDPSKVVFSGVGKTAGEVEYALSSGIRSFNCESESELALIDAMAARLGKQASFSIRVNPDVDAVTHPYI
STGLSQHKFGIAIADAPAVYERARQFRHLVAEGVSCHIGSQILDLSPIQEAVDKVLALANALREQGHPIRHLDLGGGLGV
PYRPTEIAPAIADFVCGLRKRVTASNLAVTIEPGRSIVGAAGILLTRVLYRKRNGDKEFMVVDAAMNDLIRPSLYRAHHE
ILPLRRNALPPVTVDVVGPVCETGDFLARDREMANAMPGDYLAICTAGAYGFVLSSNYNSRPRAPEVLVTGDTWRVIRER
ECYADLVRGEEI

Sequences:

>Translated_412_residues
MFAYSHNDYYCEQVPLADLAHRVGTPVYVYSSAVILGNYRAYADAFAGLPNTICYAVKANSSLAILALLAKAGAGFDIVS
GGELYRVLAAGGDPSKVVFSGVGKTAGEVEYALSSGIRSFNCESESELALIDAMAARLGKQASFSIRVNPDVDAVTHPYI
STGLSQHKFGIAIADAPAVYERARQFRHLVAEGVSCHIGSQILDLSPIQEAVDKVLALANALREQGHPIRHLDLGGGLGV
PYRPTEIAPAIADFVCGLRKRVTASNLAVTIEPGRSIVGAAGILLTRVLYRKRNGDKEFMVVDAAMNDLIRPSLYRAHHE
ILPLRRNALPPVTVDVVGPVCETGDFLARDREMANAMPGDYLAICTAGAYGFVLSSNYNSRPRAPEVLVTGDTWRVIRER
ECYADLVRGEEI
>Mature_412_residues
MFAYSHNDYYCEQVPLADLAHRVGTPVYVYSSAVILGNYRAYADAFAGLPNTICYAVKANSSLAILALLAKAGAGFDIVS
GGELYRVLAAGGDPSKVVFSGVGKTAGEVEYALSSGIRSFNCESESELALIDAMAARLGKQASFSIRVNPDVDAVTHPYI
STGLSQHKFGIAIADAPAVYERARQFRHLVAEGVSCHIGSQILDLSPIQEAVDKVLALANALREQGHPIRHLDLGGGLGV
PYRPTEIAPAIADFVCGLRKRVTASNLAVTIEPGRSIVGAAGILLTRVLYRKRNGDKEFMVVDAAMNDLIRPSLYRAHHE
ILPLRRNALPPVTVDVVGPVCETGDFLARDREMANAMPGDYLAICTAGAYGFVLSSNYNSRPRAPEVLVTGDTWRVIRER
ECYADLVRGEEI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=375, Percent_Identity=25.0666666666667, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI16506287, Length=351, Percent_Identity=24.7863247863248, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI22538418, Length=355, Percent_Identity=24.2253521126761, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21361583, Length=355, Percent_Identity=24.2253521126761, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=32.3741007194245, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562780, Length=371, Percent_Identity=24.7978436657682, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322664, Length=367, Percent_Identity=24.2506811989101, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24586472, Length=338, Percent_Identity=25.7396449704142, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586474, Length=335, Percent_Identity=24.7761194029851, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44339; Mature: 44339

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAYSHNDYYCEQVPLADLAHRVGTPVYVYSSAVILGNYRAYADAFAGLPNTICYAVKAN
CCEECCCCEEECCCCHHHHHHHHCCCEEEEECEEEEECHHHHHHHHCCCCCCEEEEEECC
SSLAILALLAKAGAGFDIVSGGELYRVLAAGGDPSKVVFSGVGKTAGEVEYALSSGIRSF
CCHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCC
NCESESELALIDAMAARLGKQASFSIRVNPDVDAVTHPYISTGLSQHKFGIAIADAPAVY
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCHHHCCCCCCCCEEEEECCHHHH
ERARQFRHLVAEGVSCHIGSQILDLSPIQEAVDKVLALANALREQGHPIRHLDLGGGLGV
HHHHHHHHHHHCCCCEECCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PYRPTEIAPAIADFVCGLRKRVTASNLAVTIEPGRSIVGAAGILLTRVLYRKRNGDKEFM
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEE
VVDAAMNDLIRPSLYRAHHEILPLRRNALPPVTVDVVGPVCETGDFLARDREMANAMPGD
EEEHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
YLAICTAGAYGFVLSSNYNSRPRAPEVLVTGDTWRVIRERECYADLVRGEEI
EEEEEECCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFAYSHNDYYCEQVPLADLAHRVGTPVYVYSSAVILGNYRAYADAFAGLPNTICYAVKAN
CCEECCCCEEECCCCHHHHHHHHCCCEEEEECEEEEECHHHHHHHHCCCCCCEEEEEECC
SSLAILALLAKAGAGFDIVSGGELYRVLAAGGDPSKVVFSGVGKTAGEVEYALSSGIRSF
CCHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCC
NCESESELALIDAMAARLGKQASFSIRVNPDVDAVTHPYISTGLSQHKFGIAIADAPAVY
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCHHHCCCCCCCCEEEEECCHHHH
ERARQFRHLVAEGVSCHIGSQILDLSPIQEAVDKVLALANALREQGHPIRHLDLGGGLGV
HHHHHHHHHHHCCCCEECCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PYRPTEIAPAIADFVCGLRKRVTASNLAVTIEPGRSIVGAAGILLTRVLYRKRNGDKEFM
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEE
VVDAAMNDLIRPSLYRAHHEILPLRRNALPPVTVDVVGPVCETGDFLARDREMANAMPGD
EEEHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
YLAICTAGAYGFVLSSNYNSRPRAPEVLVTGDTWRVIRERECYADLVRGEEI
EEEEEECCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]