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The map label for this gene is metR [H]

Identifier: 116621303

GI number: 116621303

Start: 2798514

End: 2799419

Strand: Direct

Name: metR [H]

Synonym: Acid_2184

Alternate gene names: 116621303

Gene position: 2798514-2799419 (Clockwise)

Preceding gene: 116621301

Following gene: 116621304

Centisome position: 28.08

GC content: 62.14

Gene sequence:

>906_bases
ATGGTTGATATGGAGCTTGAAATTCGTCATTTGAAGCTGGTGGAAACCATCGCCGCCGAAGGCGCCATGACCCGCGCCGC
CGCGCGCCTCTACATGACACAATCGGCGTTGAGCCACCAGCTCGCCGGTCTCGAGGAATCGATTGGAATCAGTCTCTTCC
GGCGCGTGCCCCGCGGCATGATCCTGACTCCGGCCGGCGAAAAGCTCCTGGCTTGCGCCCGATCGGTGTTGCCCATGGTC
CGTGAAGCGCTCGAGTCCGTGACCGCCGCCGAATCCGAGGCTCAGTGCACTCTTCGCATCTCCACCGAGTGCTACACCTG
CTACCACTGGCTCCCGTCCCGGCTCAAAGCATTCCAGGCGAGCTTCCCTCGTGTGGAAGTAGAGATTGTCGCTGAGGCCA
CGCGCCGCCCTATCGACGCGCTTCTCGCGGGCGAACTGGATCTCGCCATCGTCTCTGACTTGCCCGCTCAGGCTGCGATC
ACCAGCTGCCCCCTCTTCGAAGACGAAATGGTCGCGATTCTCAGCCCCGAACATCGCCTGGCCCATCGGCGTAATTTGAG
CCCTCGCGACTTCGTGGCCGAGCGCCTCATTACCTATTCCGTGCCCCTTCAGCAGCTTGGTGTCTACCGGCAATTCCTGC
ATCCCGCCGGCGTCACCCCCGCGCGAGTTTCCCGCGTGGATCTCACCGAGGCCATCATCGAAATGGTCAAGGCGAATCTG
GGCATCGCAATCCTTGCGCGTTGGGCGATCTCCCGCCACCTCAACATCGCGACCCTCAAGGCGCTTCCACTGGGCCGCCG
CGGCTTCCATCGGAAATGGTATGCCATAACTATGAAGTCACGCCGGCCATCGACGCATCTCCGAGCCTTCGTCGAGCTCC
TTGCAGAAAGAGGCGCGCTGGTCTGA

Upstream 100 bases:

>100_bases
AGACCTCCGCTTCGTCGGAGAAGCCGCAAGCAATGATCGTGCGGCCGGCATATGCCATGAGTCAAATTAATTGTGTGCAT
GGCAACCATGCGGAATCATA

Downstream 100 bases:

>100_bases
ACAACAGTCACCGCAACTTGAAATTTATATTTCCCTTCCCTTCAAGTATTTGCGATTTTCGAGCCCGAAGCTCTCCATCC
TGCCGTGCTCCAATCGCTAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MVDMELEIRHLKLVETIAAEGAMTRAAARLYMTQSALSHQLAGLEESIGISLFRRVPRGMILTPAGEKLLACARSVLPMV
REALESVTAAESEAQCTLRISTECYTCYHWLPSRLKAFQASFPRVEVEIVAEATRRPIDALLAGELDLAIVSDLPAQAAI
TSCPLFEDEMVAILSPEHRLAHRRNLSPRDFVAERLITYSVPLQQLGVYRQFLHPAGVTPARVSRVDLTEAIIEMVKANL
GIAILARWAISRHLNIATLKALPLGRRGFHRKWYAITMKSRRPSTHLRAFVELLAERGALV

Sequences:

>Translated_301_residues
MVDMELEIRHLKLVETIAAEGAMTRAAARLYMTQSALSHQLAGLEESIGISLFRRVPRGMILTPAGEKLLACARSVLPMV
REALESVTAAESEAQCTLRISTECYTCYHWLPSRLKAFQASFPRVEVEIVAEATRRPIDALLAGELDLAIVSDLPAQAAI
TSCPLFEDEMVAILSPEHRLAHRRNLSPRDFVAERLITYSVPLQQLGVYRQFLHPAGVTPARVSRVDLTEAIIEMVKANL
GIAILARWAISRHLNIATLKALPLGRRGFHRKWYAITMKSRRPSTHLRAFVELLAERGALV
>Mature_301_residues
MVDMELEIRHLKLVETIAAEGAMTRAAARLYMTQSALSHQLAGLEESIGISLFRRVPRGMILTPAGEKLLACARSVLPMV
REALESVTAAESEAQCTLRISTECYTCYHWLPSRLKAFQASFPRVEVEIVAEATRRPIDALLAGELDLAIVSDLPAQAAI
TSCPLFEDEMVAILSPEHRLAHRRNLSPRDFVAERLITYSVPLQQLGVYRQFLHPAGVTPARVSRVDLTEAIIEMVKANL
GIAILARWAISRHLNIATLKALPLGRRGFHRKWYAITMKSRRPSTHLRAFVELLAERGALV

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=245, Percent_Identity=39.5918367346939, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=28.8617886178862, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787530, Length=242, Percent_Identity=25.6198347107438, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787806, Length=291, Percent_Identity=23.0240549828179, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082132, Length=262, Percent_Identity=25.1908396946565, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693105, Length=194, Percent_Identity=24.2268041237113, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789173, Length=166, Percent_Identity=30.1204819277108, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI157672245, Length=294, Percent_Identity=24.1496598639456, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789204, Length=249, Percent_Identity=29.718875502008, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790399, Length=295, Percent_Identity=25.7627118644068, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788887, Length=183, Percent_Identity=28.9617486338798, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788481, Length=307, Percent_Identity=23.7785016286645, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786401, Length=312, Percent_Identity=22.1153846153846, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789506, Length=234, Percent_Identity=23.5042735042735, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786448, Length=237, Percent_Identity=28.2700421940928, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787589, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788748, Length=255, Percent_Identity=24.3137254901961, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=177, Percent_Identity=26.5536723163842, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87081904, Length=177, Percent_Identity=27.683615819209, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790208, Length=250, Percent_Identity=26.8, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788706, Length=176, Percent_Identity=26.7045454545455, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1788296, Length=198, Percent_Identity=27.2727272727273, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33506; Mature: 33506

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDMELEIRHLKLVETIAAEGAMTRAAARLYMTQSALSHQLAGLEESIGISLFRRVPRGM
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCE
ILTPAGEKLLACARSVLPMVREALESVTAAESEAQCTLRISTECYTCYHWLPSRLKAFQA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
SFPRVEVEIVAEATRRPIDALLAGELDLAIVSDLPAQAAITSCPLFEDEMVAILSPEHRL
CCCCEEEEEEEHHHCCCHHHHHHCCCCCHHHHCCCHHHHHHHCCCCCCCCCEEECCHHHH
AHRRNLSPRDFVAERLITYSVPLQQLGVYRQFLHPAGVTPARVSRVDLTEAIIEMVKANL
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
GIAILARWAISRHLNIATLKALPLGRRGFHRKWYAITMKSRRPSTHLRAFVELLAERGAL
CHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
V
C
>Mature Secondary Structure
MVDMELEIRHLKLVETIAAEGAMTRAAARLYMTQSALSHQLAGLEESIGISLFRRVPRGM
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCE
ILTPAGEKLLACARSVLPMVREALESVTAAESEAQCTLRISTECYTCYHWLPSRLKAFQA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
SFPRVEVEIVAEATRRPIDALLAGELDLAIVSDLPAQAAITSCPLFEDEMVAILSPEHRL
CCCCEEEEEEEHHHCCCHHHHHHCCCCCHHHHCCCHHHHHHHCCCCCCCCCEEECCHHHH
AHRRNLSPRDFVAERLITYSVPLQQLGVYRQFLHPAGVTPARVSRVDLTEAIIEMVKANL
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
GIAILARWAISRHLNIATLKALPLGRRGFHRKWYAITMKSRRPSTHLRAFVELLAERGAL
CHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]