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The map label for this gene is ribBA [H]

Identifier: 116621301

GI number: 116621301

Start: 2794943

End: 2795560

Strand: Direct

Name: ribBA [H]

Synonym: Acid_2182

Alternate gene names: 116621301

Gene position: 2794943-2795560 (Clockwise)

Preceding gene: 116621296

Following gene: 116621303

Centisome position: 28.05

GC content: 58.09

Gene sequence:

>618_bases
ATGAACAAACCAGCCGTTCCGCGGCTCAAAAAAGTAGCTGAAGCGGAATTTCCCACCCAGTTCGGATTATTTCGAATCTA
TGGATTCGAAGGCTGCGCCGGCTCCCGGCCTGAAGAAGCAGTCGTGCTGAAAATGGGGGAATTCGCCAAGGGCGAGCCTC
CGCTGGTTCGAATTCACTCCCAATGCCTCACCGGCGACGTCTTCCATAGCCTGCGCTGCGATTGCCGAGCGCAGCTCGAG
ATCGCCCTTAAGAGCATCGCCCAGGAAGGCGTCGGCCTGTTGATTTACGAGCACCAGGAAGGCCGCGGCATCGGCCTGTT
GAATAAGTTGCGCGCCTACGAACTCCAGGACCACGGCGCCGATACCATCGAGGCCAACGAACAACTCGGCTTTGAAAGCG
ATCTGCGCAATTACGAACTGCCCGGCGCCATTCTGCAATACTTCGGCCTCAAGGCGATCCGTCTGATGTCGAACAATCCC
GAAAAAGTGGAAGCCGTCGAAAAGGCCGGAGTCCGCGTGGTCGAGCGCGTCCCCTGCCTCGCCGACGTCCTCGATACCCG
CATCGATTACCTCCGCACCAAGCGCGAAAAAATGGGCCACCTCCTCGAAGATTTCTAG

Upstream 100 bases:

>100_bases
GGCCATCGCACCGAGTTTGACCAGCAGCGGAAAATAGCTTTCGAGCATTCGGTCTCGGAAGCCATTATAATAAAAGCATT
AAGCTTCACATAGTTAACGC

Downstream 100 bases:

>100_bases
CTCCCGCCGACCGCGCGCCCTTCATCCAAGCCGTTTCCCAGCCTGCGACCTGCCGCATGTATTACACTGCTCTTCTTTTC
TCGCAGGCCGCAAACATCCG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MNKPAVPRLKKVAEAEFPTQFGLFRIYGFEGCAGSRPEEAVVLKMGEFAKGEPPLVRIHSQCLTGDVFHSLRCDCRAQLE
IALKSIAQEGVGLLIYEHQEGRGIGLLNKLRAYELQDHGADTIEANEQLGFESDLRNYELPGAILQYFGLKAIRLMSNNP
EKVEAVEKAGVRVVERVPCLADVLDTRIDYLRTKREKMGHLLEDF

Sequences:

>Translated_205_residues
MNKPAVPRLKKVAEAEFPTQFGLFRIYGFEGCAGSRPEEAVVLKMGEFAKGEPPLVRIHSQCLTGDVFHSLRCDCRAQLE
IALKSIAQEGVGLLIYEHQEGRGIGLLNKLRAYELQDHGADTIEANEQLGFESDLRNYELPGAILQYFGLKAIRLMSNNP
EKVEAVEKAGVRVVERVPCLADVLDTRIDYLRTKREKMGHLLEDF
>Mature_205_residues
MNKPAVPRLKKVAEAEFPTQFGLFRIYGFEGCAGSRPEEAVVLKMGEFAKGEPPLVRIHSQCLTGDVFHSLRCDCRAQLE
IALKSIAQEGVGLLIYEHQEGRGIGLLNKLRAYELQDHGADTIEANEQLGFESDLRNYELPGAILQYFGLKAIRLMSNNP
EKVEAVEKAGVRVVERVPCLADVLDTRIDYLRTKREKMGHLLEDF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=51.7948717948718, Blast_Score=199, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319438, Length=185, Percent_Identity=42.1621621621622, Blast_Score=125, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 23001; Mature: 23001

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPAVPRLKKVAEAEFPTQFGLFRIYGFEGCAGSRPEEAVVLKMGEFAKGEPPLVRIHS
CCCCCCHHHHHHHHHCCCCHHCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEHHH
QCLTGDVFHSLRCDCRAQLEIALKSIAQEGVGLLIYEHQEGRGIGLLNKLRAYELQDHGA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC
DTIEANEQLGFESDLRNYELPGAILQYFGLKAIRLMSNNPEKVEAVEKAGVRVVERVPCL
CCCCCCHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ADVLDTRIDYLRTKREKMGHLLEDF
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKPAVPRLKKVAEAEFPTQFGLFRIYGFEGCAGSRPEEAVVLKMGEFAKGEPPLVRIHS
CCCCCCHHHHHHHHHCCCCHHCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEHHH
QCLTGDVFHSLRCDCRAQLEIALKSIAQEGVGLLIYEHQEGRGIGLLNKLRAYELQDHGA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC
DTIEANEQLGFESDLRNYELPGAILQYFGLKAIRLMSNNPEKVEAVEKAGVRVVERVPCL
CCCCCCHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ADVLDTRIDYLRTKREKMGHLLEDF
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA