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The map label for this gene is aphA [H]

Identifier: 116621166

GI number: 116621166

Start: 2600014

End: 2601573

Strand: Direct

Name: aphA [H]

Synonym: Acid_2047

Alternate gene names: 116621166

Gene position: 2600014-2601573 (Clockwise)

Preceding gene: 116621165

Following gene: 116621169

Centisome position: 26.09

GC content: 61.6

Gene sequence:

>1560_bases
ATGAGGATGCCTGCCAATGCGGCGCAACGGGCGCAGGAGTCTGCGATAGAGCGCAGGACAAAAATTCTCCTGGTGGACGA
CACGCCGGAGAATCTCGTCTCGCTCGAGGCAGCGCTCGCCGGTTTGGGCGAGGAGCTGGTACTGGCAAGCTCCGGAAAGC
AGGCGCTCCGCCATCTGCTGGAGGACGATTTTGCGGCCATCCTGCTGGATGTAAGGATGCCGGAAATGGATGGCTTCGAG
ACCGCCGAGCTGATTCGCAGCCGGCCGCGGTCGCGCCAGACTCCGATTCTGTTTCTGACCGGTTACCGCAACGAGGAGCA
CCTGTTCCGCGGCTACGACTTAGGGGCGGTGGATTTTCTGTTCAAGCCGATTGTGCCGGAGGTGCTGCGCTCCAAGGTCG
CGGTGTTCGTGGAACTTAGCCGGACGAACGCCAAGCTGAAGGAACAGACCGATGCGCTCCGCGTGCAGGCGGAAGTGCTG
CAGAAGGCGGAACAGCGATTTCGCTCGCTGCTGGAAGCGGCGCCGGACGCGATGCTGGTGTGCCGGGAAGACGGCGAGAT
CGTAATGGTGAATTCGCAGGCCGAGATTCTGTTCAACAGCCATCGCGACAAGCTGGTCTCGCGGAGCATACGTTCGATTG
TGCCCGGGTGGGGATGGCAGAGCGGGCAGCCGGTGCAGCGGGGCATCGAACTTCTCGCTTATCCCGACGGCCGCGCTCCG
TTTCAGGCGGAGATCAGTTTCAGCCCGGTGCAGACGGAGGAGGGGGTGGTGGTGACCTGCTCGATCCGCGACATTACCGA
GCGGAAGAAGACCGAGGAGCGGATCCGGGAGCTGAATTCCAATCTGGAGGAGCGCGTGGTGGAGCGGACCGAGGCTTTGA
TGCGCTCCAACGAGGAACTGCAGCAGTTCGCGTATGTCGCCAGCCACGATCTTCAGGAGCCGCTGCGGACGGTTTCCATT
TATGCGCAACTGCTCGCAAAACGATATCAGGGGCAGCTCGCCGGAGACGCGGATCAGTTCATCCGCTTCATCGTGGAGGG
CTCCGAGCGCATGGAGAAGCTGATTCACGATCTGCTGGATTTTTCACGCGTGGACGCGCGCGGCACGGACTACTTCACGC
GCATGAGCTGCGACGAGGCGCTCAACGACGCTATCGGCAACCTTTATTCGCTGATCGATGAGAACGCGGCGGTGATCACG
CGCGGGCCGCTCCCCAGCCTCACTGGAGACCCGGTGCAGCTGACCCGGCTATTCCAGAACCTGCTGGTAAATTCGATCCG
GTACCGCTCCGAGGCGGCACCGCGAATCCAGGTTGAGGCGCAAGAGCAGAATGGGGAATGGCTGTTCTCGGTGCAGGATA
ACGGAATCGGAATCGAGCCCCAGTACGCGGAGAAGATTTTCGGTATTTTCCGTTGTCTGCAGCCGCGTGACAAGAGCTCG
GGCAGCGGAATGGGGCTGGCGATCTGCCGCAAGATCGTGAGCCGGCACGAGGGCCGTATCTGGGTAGAATCGGCCCTCGG
TGAAGGCGCGAAGTTTTATTTCACGCTGCCGCGCAAGTGA

Upstream 100 bases:

>100_bases
CAAGCCGGTGGATCTGGACCAGTTGTTCTCGGTGCTGCGCGTATGGTTGATTCGCAGCCGGGAATCACAGGCCGCCCTGA
CCACCGGGAAATAGGAGCGC

Downstream 100 bases:

>100_bases
GTCTCGCTTTAGAGGTTTTCAGGTATAGGGGTAGAATCTGAAGTCTAAGTCTTTGACCGCGTAATCTTGTGCTTTATTGA
GCGATCGTTCTGTGAGAGGA

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MRMPANAAQRAQESAIERRTKILLVDDTPENLVSLEAALAGLGEELVLASSGKQALRHLLEDDFAAILLDVRMPEMDGFE
TAELIRSRPRSRQTPILFLTGYRNEEHLFRGYDLGAVDFLFKPIVPEVLRSKVAVFVELSRTNAKLKEQTDALRVQAEVL
QKAEQRFRSLLEAAPDAMLVCREDGEIVMVNSQAEILFNSHRDKLVSRSIRSIVPGWGWQSGQPVQRGIELLAYPDGRAP
FQAEISFSPVQTEEGVVVTCSIRDITERKKTEERIRELNSNLEERVVERTEALMRSNEELQQFAYVASHDLQEPLRTVSI
YAQLLAKRYQGQLAGDADQFIRFIVEGSERMEKLIHDLLDFSRVDARGTDYFTRMSCDEALNDAIGNLYSLIDENAAVIT
RGPLPSLTGDPVQLTRLFQNLLVNSIRYRSEAAPRIQVEAQEQNGEWLFSVQDNGIGIEPQYAEKIFGIFRCLQPRDKSS
GSGMGLAICRKIVSRHEGRIWVESALGEGAKFYFTLPRK

Sequences:

>Translated_519_residues
MRMPANAAQRAQESAIERRTKILLVDDTPENLVSLEAALAGLGEELVLASSGKQALRHLLEDDFAAILLDVRMPEMDGFE
TAELIRSRPRSRQTPILFLTGYRNEEHLFRGYDLGAVDFLFKPIVPEVLRSKVAVFVELSRTNAKLKEQTDALRVQAEVL
QKAEQRFRSLLEAAPDAMLVCREDGEIVMVNSQAEILFNSHRDKLVSRSIRSIVPGWGWQSGQPVQRGIELLAYPDGRAP
FQAEISFSPVQTEEGVVVTCSIRDITERKKTEERIRELNSNLEERVVERTEALMRSNEELQQFAYVASHDLQEPLRTVSI
YAQLLAKRYQGQLAGDADQFIRFIVEGSERMEKLIHDLLDFSRVDARGTDYFTRMSCDEALNDAIGNLYSLIDENAAVIT
RGPLPSLTGDPVQLTRLFQNLLVNSIRYRSEAAPRIQVEAQEQNGEWLFSVQDNGIGIEPQYAEKIFGIFRCLQPRDKSS
GSGMGLAICRKIVSRHEGRIWVESALGEGAKFYFTLPRK
>Mature_519_residues
MRMPANAAQRAQESAIERRTKILLVDDTPENLVSLEAALAGLGEELVLASSGKQALRHLLEDDFAAILLDVRMPEMDGFE
TAELIRSRPRSRQTPILFLTGYRNEEHLFRGYDLGAVDFLFKPIVPEVLRSKVAVFVELSRTNAKLKEQTDALRVQAEVL
QKAEQRFRSLLEAAPDAMLVCREDGEIVMVNSQAEILFNSHRDKLVSRSIRSIVPGWGWQSGQPVQRGIELLAYPDGRAP
FQAEISFSPVQTEEGVVVTCSIRDITERKKTEERIRELNSNLEERVVERTEALMRSNEELQQFAYVASHDLQEPLRTVSI
YAQLLAKRYQGQLAGDADQFIRFIVEGSERMEKLIHDLLDFSRVDARGTDYFTRMSCDEALNDAIGNLYSLIDENAAVIT
RGPLPSLTGDPVQLTRLFQNLLVNSIRYRSEAAPRIQVEAQEQNGEWLFSVQDNGIGIEPQYAEKIFGIFRCLQPRDKSS
GSGMGLAICRKIVSRHEGRIWVESALGEGAKFYFTLPRK

Specific function: Photoreceptor which exists in two forms that are reversibly interconvertible by light:the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region [H]

COG id: COG4251

COG function: function code T; Bacteriophytochrome (light-regulated signal transduction histidine kinase)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=393, Percent_Identity=25.9541984732824, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788549, Length=367, Percent_Identity=23.9782016348774, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=385, Percent_Identity=25.1948051948052, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786912, Length=398, Percent_Identity=27.1356783919598, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=26.4957264957265, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI48994928, Length=397, Percent_Identity=24.6851385390428, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081816, Length=261, Percent_Identity=26.0536398467433, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=39.8058252427184, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=26.2931034482759, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788550, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789149, Length=110, Percent_Identity=34.5454545454545, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786783, Length=175, Percent_Identity=30.8571428571429, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082012, Length=103, Percent_Identity=34.9514563106796, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR013654
- InterPro:   IPR016132
- InterPro:   IPR001294
- InterPro:   IPR013515
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF00512 HisKA; PF08446 PAS_2; PF00360 Phytochrome [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58631; Mature: 58631

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMPANAAQRAQESAIERRTKILLVDDTPENLVSLEAALAGLGEELVLASSGKQALRHLL
CCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
EDDFAAILLDVRMPEMDGFETAELIRSRPRSRQTPILFLTGYRNEEHLFRGYDLGAVDFL
HHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCHHHHCCCCCCHHHHH
FKPIVPEVLRSKVAVFVELSRTNAKLKEQTDALRVQAEVLQKAEQRFRSLLEAAPDAMLV
HHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
CREDGEIVMVNSQAEILFNSHRDKLVSRSIRSIVPGWGWQSGQPVQRGIELLAYPDGRAP
EECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCEEEECCCCCCC
FQAEISFSPVQTEEGVVVTCSIRDITERKKTEERIRELNSNLEERVVERTEALMRSNEEL
EEEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHH
QQFAYVASHDLQEPLRTVSIYAQLLAKRYQGQLAGDADQFIRFIVEGSERMEKLIHDLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHH
FSRVDARGTDYFTRMSCDEALNDAIGNLYSLIDENAAVITRGPLPSLTGDPVQLTRLFQN
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHH
LLVNSIRYRSEAAPRIQVEAQEQNGEWLFSVQDNGIGIEPQYAEKIFGIFRCLQPRDKSS
HHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
GSGMGLAICRKIVSRHEGRIWVESALGEGAKFYFTLPRK
CCCCHHHHHHHHHHHCCCCEEEEHHCCCCCEEEEECCCC
>Mature Secondary Structure
MRMPANAAQRAQESAIERRTKILLVDDTPENLVSLEAALAGLGEELVLASSGKQALRHLL
CCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
EDDFAAILLDVRMPEMDGFETAELIRSRPRSRQTPILFLTGYRNEEHLFRGYDLGAVDFL
HHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCHHHHCCCCCCHHHHH
FKPIVPEVLRSKVAVFVELSRTNAKLKEQTDALRVQAEVLQKAEQRFRSLLEAAPDAMLV
HHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
CREDGEIVMVNSQAEILFNSHRDKLVSRSIRSIVPGWGWQSGQPVQRGIELLAYPDGRAP
EECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCEEEECCCCCCC
FQAEISFSPVQTEEGVVVTCSIRDITERKKTEERIRELNSNLEERVVERTEALMRSNEEL
EEEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHH
QQFAYVASHDLQEPLRTVSIYAQLLAKRYQGQLAGDADQFIRFIVEGSERMEKLIHDLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHH
FSRVDARGTDYFTRMSCDEALNDAIGNLYSLIDENAAVITRGPLPSLTGDPVQLTRLFQN
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHH
LLVNSIRYRSEAAPRIQVEAQEQNGEWLFSVQDNGIGIEPQYAEKIFGIFRCLQPRDKSS
HHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
GSGMGLAICRKIVSRHEGRIWVESALGEGAKFYFTLPRK
CCCCHHHHHHHHHHHCCCCEEEEHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]