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The map label for this gene is atoC [H]

Identifier: 116621160

GI number: 116621160

Start: 2587614

End: 2589044

Strand: Reverse

Name: atoC [H]

Synonym: Acid_2041

Alternate gene names: 116621160

Gene position: 2589044-2587614 (Counterclockwise)

Preceding gene: 116621161

Following gene: 116621158

Centisome position: 25.98

GC content: 62.12

Gene sequence:

>1431_bases
ATGCCGGCTCATATTCTGGTTGTGGATGATGATGCGCAGCAGCGCTCCGACATGGCCGAAATGGTACGCTCGCTGGGCTA
CCACGTCACCACTGCAGCCGATGGACGCGAGGCTCTGGATCGTTTGGCCTCCGCGCCGGCTAACGCAATTCTTACCGATC
TCGTGATGCCGCGCATGGATGGCATGGCTTTGCTTAAGGAACTCGTTTCCCGCGGCGACCGCACTCCCACCGTGGTGCTC
ACCGGCTTCGGCAGTATTGATCAGGCGATTTCAGTAGTCCATGACCTGAAAGCCTTCTGGTTCCTGGAAAAACCTGTGCT
GCCCGGCGCCATGGCCACGCTGTTGGAGCGCGCCATTCAGCAGAACCAGTTGCTGAAGGAAACCGAACGCCTGCATTCCC
AACTCAGCTTTGCCGGCATTCTGGGAGACCTGGTCGGTGACTCGCCCTGCATGAAGGAGATTTTCTCGCTGATCCGGCAG
GTGGCGCCCACCACCGCCTCCGTCCTGATCAGCGGCGAAAGCGGCACCGGCAAGGAACTGGTCGCGCGCGCTATCCATAC
TCTAAGTTCACGCAGCGGCGGCCCCTTCGTGGCCGTGAACTGCGCCGCCTTGCCAGAAAGCCTGATGGAAAGCGAACTTT
TCGGCCACGAAAAGGGAGCCTTTACCGGCGCGGTGGAGCGCCGGGCGGGCTGCTTCGAACAGGCCCAGAACGGCACCTTG
CTCCTCGATGAGATCGGCGACATGCCGATCGGTACCCAAGCCAAATTGCTGCGCGTGATCGAAGAATCGAAGGTGCGCCG
CCTGGGCGGATCCACCGATATTCCGATCGCCGTGCGCGTCCTCGCAGCCACCAACCGGTCGCCCGAGCAGGCCGTTCAAA
ACAAACTTCTGCGCGAAGATCTCTACTATCGCCTGAACGTCTTCAATATCTCCCTGCCACCGCTGCGCGATCGCAAACAG
GACATCCCCTCGATCGCCACCGCCATGATTCGCGATCTGAATCGCAAGCACAGTTGCCGCGTGACCCATCTCAGTCCGGA
AGTGCTGGCCTGGTTCGCGGACCGGTCCTGGCCCGGCAATGTGCGCGAACTGCGCAACATGGTGGAGCGTGCCGTGATCA
TGGCTTCCGAAGGCGAGGTTCAACTGCGCCACCTGCCGGGCGCCGTCCAGGCGCCTCCGCAGGCTGCCGTCGCCGCCGCC
GCCGCGACGCCGGCGCCGGTTCCCGAGGATGTCCTCCAGGTGCCGGTTGGCATGACCATGGCCGATGTCGAACAGGCCTA
CGTTCGCCTCACCCTGAAGCACACCCGCAACAACAAAAAGCGCGCCGCCGAATTCCTCGGACTGTGCCTTCGCACCTTGC
ACAACAAACTGCAATCTTACGAAGCCGGCAAAGTCCGCGGCGTCGCCGTCGGCGACAGCAAAGTCGAATAA

Upstream 100 bases:

>100_bases
GGCTAATCGGGTTACGCGCTTTGTTCGTGCGGTTGAAAACAGCAGGAGGTTTGTTATTTCAAGCTACAATAGTTCCAGGT
ACCACGCAGCGGAGTCCAAA

Downstream 100 bases:

>100_bases
AGACACGCCTCCTGGCTGGGTCTCCTCGCGTGTCTCTTGCCGCTGTGTACTTAGTTTGTTTGTGGCTTTCTTAGCCTTCC
AATCAAACTAACTTCCGGGA

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MPAHILVVDDDAQQRSDMAEMVRSLGYHVTTAADGREALDRLASAPANAILTDLVMPRMDGMALLKELVSRGDRTPTVVL
TGFGSIDQAISVVHDLKAFWFLEKPVLPGAMATLLERAIQQNQLLKETERLHSQLSFAGILGDLVGDSPCMKEIFSLIRQ
VAPTTASVLISGESGTGKELVARAIHTLSSRSGGPFVAVNCAALPESLMESELFGHEKGAFTGAVERRAGCFEQAQNGTL
LLDEIGDMPIGTQAKLLRVIEESKVRRLGGSTDIPIAVRVLAATNRSPEQAVQNKLLREDLYYRLNVFNISLPPLRDRKQ
DIPSIATAMIRDLNRKHSCRVTHLSPEVLAWFADRSWPGNVRELRNMVERAVIMASEGEVQLRHLPGAVQAPPQAAVAAA
AATPAPVPEDVLQVPVGMTMADVEQAYVRLTLKHTRNNKKRAAEFLGLCLRTLHNKLQSYEAGKVRGVAVGDSKVE

Sequences:

>Translated_476_residues
MPAHILVVDDDAQQRSDMAEMVRSLGYHVTTAADGREALDRLASAPANAILTDLVMPRMDGMALLKELVSRGDRTPTVVL
TGFGSIDQAISVVHDLKAFWFLEKPVLPGAMATLLERAIQQNQLLKETERLHSQLSFAGILGDLVGDSPCMKEIFSLIRQ
VAPTTASVLISGESGTGKELVARAIHTLSSRSGGPFVAVNCAALPESLMESELFGHEKGAFTGAVERRAGCFEQAQNGTL
LLDEIGDMPIGTQAKLLRVIEESKVRRLGGSTDIPIAVRVLAATNRSPEQAVQNKLLREDLYYRLNVFNISLPPLRDRKQ
DIPSIATAMIRDLNRKHSCRVTHLSPEVLAWFADRSWPGNVRELRNMVERAVIMASEGEVQLRHLPGAVQAPPQAAVAAA
AATPAPVPEDVLQVPVGMTMADVEQAYVRLTLKHTRNNKKRAAEFLGLCLRTLHNKLQSYEAGKVRGVAVGDSKVE
>Mature_475_residues
PAHILVVDDDAQQRSDMAEMVRSLGYHVTTAADGREALDRLASAPANAILTDLVMPRMDGMALLKELVSRGDRTPTVVLT
GFGSIDQAISVVHDLKAFWFLEKPVLPGAMATLLERAIQQNQLLKETERLHSQLSFAGILGDLVGDSPCMKEIFSLIRQV
APTTASVLISGESGTGKELVARAIHTLSSRSGGPFVAVNCAALPESLMESELFGHEKGAFTGAVERRAGCFEQAQNGTLL
LDEIGDMPIGTQAKLLRVIEESKVRRLGGSTDIPIAVRVLAATNRSPEQAVQNKLLREDLYYRLNVFNISLPPLRDRKQD
IPSIATAMIRDLNRKHSCRVTHLSPEVLAWFADRSWPGNVRELRNMVERAVIMASEGEVQLRHLPGAVQAPPQAAVAAAA
ATPAPVPEDVLQVPVGMTMADVEQAYVRLTLKHTRNNKKRAAEFLGLCLRTLHNKLQSYEAGKVRGVAVGDSKVE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=41.6666666666667, Blast_Score=350, Evalue=9e-98,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=39.4396551724138, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1790437, Length=453, Percent_Identity=39.9558498896247, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1788905, Length=375, Percent_Identity=43.2, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI87082117, Length=262, Percent_Identity=48.8549618320611, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1789087, Length=290, Percent_Identity=45.8620689655172, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=40.8668730650155, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI87081872, Length=326, Percent_Identity=39.2638036809816, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1786524, Length=337, Percent_Identity=40.6528189910979, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=48.2758620689655, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1787583, Length=342, Percent_Identity=34.7953216374269, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87081858, Length=322, Percent_Identity=28.8819875776398, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=245, Percent_Identity=36.3265306122449, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51771; Mature: 51640

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAHILVVDDDAQQRSDMAEMVRSLGYHVTTAADGREALDRLASAPANAILTDLVMPRMD
CCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCC
GMALLKELVSRGDRTPTVVLTGFGSIDQAISVVHDLKAFWFLEKPVLPGAMATLLERAIQ
HHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QNQLLKETERLHSQLSFAGILGDLVGDSPCMKEIFSLIRQVAPTTASVLISGESGTGKEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
VARAIHTLSSRSGGPFVAVNCAALPESLMESELFGHEKGAFTGAVERRAGCFEQAQNGTL
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCE
LLDEIGDMPIGTQAKLLRVIEESKVRRLGGSTDIPIAVRVLAATNRSPEQAVQNKLLRED
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEHHCCCCHHHHHHHHHHHHH
LYYRLNVFNISLPPLRDRKQDIPSIATAMIRDLNRKHSCRVTHLSPEVLAWFADRSWPGN
HHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHCCCCCCC
VRELRNMVERAVIMASEGEVQLRHLPGAVQAPPQAAVAAAAATPAPVPEDVLQVPVGMTM
HHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCHH
ADVEQAYVRLTLKHTRNNKKRAAEFLGLCLRTLHNKLQSYEAGKVRGVAVGDSKVE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
PAHILVVDDDAQQRSDMAEMVRSLGYHVTTAADGREALDRLASAPANAILTDLVMPRMD
CCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCC
GMALLKELVSRGDRTPTVVLTGFGSIDQAISVVHDLKAFWFLEKPVLPGAMATLLERAIQ
HHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QNQLLKETERLHSQLSFAGILGDLVGDSPCMKEIFSLIRQVAPTTASVLISGESGTGKEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
VARAIHTLSSRSGGPFVAVNCAALPESLMESELFGHEKGAFTGAVERRAGCFEQAQNGTL
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCE
LLDEIGDMPIGTQAKLLRVIEESKVRRLGGSTDIPIAVRVLAATNRSPEQAVQNKLLRED
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEHHCCCCHHHHHHHHHHHHH
LYYRLNVFNISLPPLRDRKQDIPSIATAMIRDLNRKHSCRVTHLSPEVLAWFADRSWPGN
HHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHCCCCCCC
VRELRNMVERAVIMASEGEVQLRHLPGAVQAPPQAAVAAAAATPAPVPEDVLQVPVGMTM
HHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCHH
ADVEQAYVRLTLKHTRNNKKRAAEFLGLCLRTLHNKLQSYEAGKVRGVAVGDSKVE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]