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The map label for this gene is hisC [H]

Identifier: 116621149

GI number: 116621149

Start: 2571077

End: 2572195

Strand: Direct

Name: hisC [H]

Synonym: Acid_2030

Alternate gene names: 116621149

Gene position: 2571077-2572195 (Clockwise)

Preceding gene: 116621148

Following gene: 116621150

Centisome position: 25.8

GC content: 63.99

Gene sequence:

>1119_bases
ATGCTGACCCGACGAAACTTTGCCACGCGGCTGGGGCTGGGCGCCGCCGCAATTCGAATGCTCCCGGAGATGGCCTACGC
GCAGCGCACAGCGTTTCGCGGGGCCGATCTCTCGAAGAACATGGTCTGGCTGAACTCCAACGAGAATCCCGCGGGACCGC
CGCAGGTATCGATCGATGCCATGCGCGAAGTGCTGCCGCTCTCGGGCCGCTACCACTACCAGGAGTTTCGCGACATCCAG
GCGACGATCGCGGCCAGCGAGGGGCTCACGCTCGACCAGATCGTCCTCGGCGCGGGGTCGAGCGAACCTCTGCATACGGC
GGTGGATGTGTTTACCTCGCCGACGCGGCCGTTGATCAGCGTGACCCCGGCCTACGAAGGACCGATCGAACTGGCGCGCG
CATTGGGGCATCCTGTCGTGCTCACCAAGCTGCGCGAGGACTATACCGCCGATGTGAAGAAACTGGCCGAGGCGGCCGAC
AAGGCGCACGGCGGCTTGATCTATCTCTGCAATCCCAACAACCCCACGGCGGCGGCGGTGAAGAGCACGGACGTTGACTG
GCTGGTCGCCAATCTGCCGGCCAACACTACGCTGCTGGTGGACGAGGCGTACATTCACTTCGTGGAATCGCCCGACGTGA
AGAGCGCGATGCCGTATGTACGCCAGGGCAAGGACGTGATCGTGGCGCGGACGTTCTCGAAGATCTACGGCATGGCGGGT
TTGCGCGCGGGCTTCGCCGCCGCGAAGCCGGAGATCATCGGGCGGCTGGCGCCGCTGCAGATGAACGTGATCTCTTACGT
CACCGCGCGTGCCGTGGTGGCAGCGCTCAAGGATTCCGCCACTATCGTGCCGGAGCGCCGCGCCACCCTGGCCAAGACGC
GCCGCGAATTATGTATGTGGCTCAAGGAGCGGAACCTCAAGTACATCGAGCCCCACGCCAATTTCCTGATGATCGATACC
GGGCGCAATGCCAAACAGTTCATCAGCGAAATGCCGAAGCTGGGAGTGGCCCCCGGCCGTCCCTTCCCGCCGCTCGATAA
CATGCTGCGCGTGACCATCGGGACCGACGCGGAGATGGCCAAATTCCGCGACGTCTTCTGGAAGGTCTACAAGGGCTGA

Upstream 100 bases:

>100_bases
CCTCGGCTCGATGAGCGGCTAGAGCGGCGCATATTTCGAAAATCGACGGCGGGTGGCTTCGGCTGCCCGCCGTTTTCTTT
TTCGGGGGTATCATATTCCC

Downstream 100 bases:

>100_bases
GCCTTTCGGGGTGCCGGAGCCCACTTGGAATGTAAGTCTTCGTAATCGCAATTGATTTCACCCCCGAATTAAACGAGAAT
TGTAAACAGTGAAGATTGAG

Product: aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MLTRRNFATRLGLGAAAIRMLPEMAYAQRTAFRGADLSKNMVWLNSNENPAGPPQVSIDAMREVLPLSGRYHYQEFRDIQ
ATIAASEGLTLDQIVLGAGSSEPLHTAVDVFTSPTRPLISVTPAYEGPIELARALGHPVVLTKLREDYTADVKKLAEAAD
KAHGGLIYLCNPNNPTAAAVKSTDVDWLVANLPANTTLLVDEAYIHFVESPDVKSAMPYVRQGKDVIVARTFSKIYGMAG
LRAGFAAAKPEIIGRLAPLQMNVISYVTARAVVAALKDSATIVPERRATLAKTRRELCMWLKERNLKYIEPHANFLMIDT
GRNAKQFISEMPKLGVAPGRPFPPLDNMLRVTIGTDAEMAKFRDVFWKVYKG

Sequences:

>Translated_372_residues
MLTRRNFATRLGLGAAAIRMLPEMAYAQRTAFRGADLSKNMVWLNSNENPAGPPQVSIDAMREVLPLSGRYHYQEFRDIQ
ATIAASEGLTLDQIVLGAGSSEPLHTAVDVFTSPTRPLISVTPAYEGPIELARALGHPVVLTKLREDYTADVKKLAEAAD
KAHGGLIYLCNPNNPTAAAVKSTDVDWLVANLPANTTLLVDEAYIHFVESPDVKSAMPYVRQGKDVIVARTFSKIYGMAG
LRAGFAAAKPEIIGRLAPLQMNVISYVTARAVVAALKDSATIVPERRATLAKTRRELCMWLKERNLKYIEPHANFLMIDT
GRNAKQFISEMPKLGVAPGRPFPPLDNMLRVTIGTDAEMAKFRDVFWKVYKG
>Mature_372_residues
MLTRRNFATRLGLGAAAIRMLPEMAYAQRTAFRGADLSKNMVWLNSNENPAGPPQVSIDAMREVLPLSGRYHYQEFRDIQ
ATIAASEGLTLDQIVLGAGSSEPLHTAVDVFTSPTRPLISVTPAYEGPIELARALGHPVVLTKLREDYTADVKKLAEAAD
KAHGGLIYLCNPNNPTAAAVKSTDVDWLVANLPANTTLLVDEAYIHFVESPDVKSAMPYVRQGKDVIVARTFSKIYGMAG
LRAGFAAAKPEIIGRLAPLQMNVISYVTARAVVAALKDSATIVPERRATLAKTRRELCMWLKERNLKYIEPHANFLMIDT
GRNAKQFISEMPKLGVAPGRPFPPLDNMLRVTIGTDAEMAKFRDVFWKVYKG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=337, Percent_Identity=23.1454005934718, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322075, Length=361, Percent_Identity=24.6537396121884, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40864; Mature: 40864

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTRRNFATRLGLGAAAIRMLPEMAYAQRTAFRGADLSKNMVWLNSNENPAGPPQVSIDA
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEHHH
MREVLPLSGRYHYQEFRDIQATIAASEGLTLDQIVLGAGSSEPLHTAVDVFTSPTRPLIS
HHHHHCCCCCCHHHHHHHHHHHEECCCCCCHHHHEECCCCCCCHHHHHHHHCCCCCCEEE
VTPAYEGPIELARALGHPVVLTKLREDYTADVKKLAEAADKAHGGLIYLCNPNNPTAAAV
ECCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEE
KSTDVDWLVANLPANTTLLVDEAYIHFVESPDVKSAMPYVRQGKDVIVARTFSKIYGMAG
ECCCCCEEEEECCCCCEEEEEEEEEEEECCCCHHHHCHHHHCCCCEEEEEHHHHHHHHHH
LRAGFAAAKPEIIGRLAPLQMNVISYVTARAVVAALKDSATIVPERRATLAKTRRELCMW
HHHCHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LKERNLKYIEPHANFLMIDTGRNAKQFISEMPKLGVAPGRPFPPLDNMLRVTIGTDAEMA
HHHCCCEEECCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
KFRDVFWKVYKG
HHHHHHHHHHCC
>Mature Secondary Structure
MLTRRNFATRLGLGAAAIRMLPEMAYAQRTAFRGADLSKNMVWLNSNENPAGPPQVSIDA
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEHHH
MREVLPLSGRYHYQEFRDIQATIAASEGLTLDQIVLGAGSSEPLHTAVDVFTSPTRPLIS
HHHHHCCCCCCHHHHHHHHHHHEECCCCCCHHHHEECCCCCCCHHHHHHHHCCCCCCEEE
VTPAYEGPIELARALGHPVVLTKLREDYTADVKKLAEAADKAHGGLIYLCNPNNPTAAAV
ECCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEE
KSTDVDWLVANLPANTTLLVDEAYIHFVESPDVKSAMPYVRQGKDVIVARTFSKIYGMAG
ECCCCCEEEEECCCCCEEEEEEEEEEEECCCCHHHHCHHHHCCCCEEEEEHHHHHHHHHH
LRAGFAAAKPEIIGRLAPLQMNVISYVTARAVVAALKDSATIVPERRATLAKTRRELCMW
HHHCHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LKERNLKYIEPHANFLMIDTGRNAKQFISEMPKLGVAPGRPFPPLDNMLRVTIGTDAEMA
HHHCCCEEECCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
KFRDVFWKVYKG
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]